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  1. AU="Moreno, Jessica L"
  2. AU="Guimaraes-Ferreira, Lucas"
  3. AU="Bhandari, Ruchi"
  4. AU="Fichtner, Maximilian"
  5. AU="Dina, Yemisi"

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  1. Artikel ; Online: Training medical students in opioid overdose prevention and response: Comparison of In-Person versus online formats.

    Moses, Tabitha E H / Moreno, Jessica L / Greenwald, Mark K / Waineo, Eva

    Medical education online

    2021  Band 26, Heft 1, Seite(n) 1994906

    Abstract: Medical education has increasingly shifted towards replacing large lectures with a combination of online and smaller in-person group sessions. This study compares the efficacy of a virtual Opioid Overdose Prevention and Response Training (OOPRT) for ... ...

    Abstract Medical education has increasingly shifted towards replacing large lectures with a combination of online and smaller in-person group sessions. This study compares the efficacy of a virtual Opioid Overdose Prevention and Response Training (OOPRT) for first-year medical students with an identical in-person training. During their first unit of medical school, students in the class of 2023 (cohort 1) received OOPRT in-person and students in the class of 2024 (cohort 2) received training via Zoom. Aside from the delivery format, trainings were identical. Both cohorts completed identical surveys at medical school entry and post-training to evaluate knowledge and experiences using the Opioid Overdose Knowledge Scale, Opioid Overdose Attitudes Scale, Medical Conditions Regard Scale, and Naloxone Related Risk Compensation Beliefs. Of 430 students, 84.2% (362: 124 in cohort 1; 238 in cohort 2) completed baseline and post-training surveys. Students reported significantly improved opioid overdose knowledge and attitudes in all 4 knowledge and 3 attitudes subscales after training. Only one outcome differed by training type: knowledge of opioid overdose signs. Cohorts did not differ in opinions of training; 97.2% enjoyed it and 99.4% believed future classes should receive it. Medical students' attitudes and knowledge significantly improved after OOPRT; only one of 13 outcomes showed a cohort difference. There were no differences in enjoyment, indicating that switching to virtual learning does not undermine the learning experience. Further studies are needed to confirm that these results can be extended to other medical school topics where small group interactive discussion is preferred.
    Mesh-Begriff(e) Drug Overdose/drug therapy ; Drug Overdose/prevention & control ; Health Knowledge, Attitudes, Practice ; Humans ; Narcotic Antagonists/therapeutic use ; Opiate Overdose ; Students, Medical
    Chemische Substanzen Narcotic Antagonists
    Sprache Englisch
    Erscheinungsdatum 2021-11-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1087-2981
    ISSN (online) 1087-2981
    DOI 10.1080/10872981.2021.1994906
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Developing and validating an opioid overdose prevention and response curriculum for undergraduate medical education.

    Moses, Tabitha E / Moreno, Jessica L / Greenwald, Mark K / Waineo, Eva

    Substance abuse

    2021  Band 43, Heft 1, Seite(n) 309–318

    Abstract: Introduction: ...

    Abstract Introduction:
    Mesh-Begriff(e) Curriculum ; Drug Overdose/drug therapy ; Drug Overdose/prevention & control ; Education, Medical, Undergraduate ; Humans ; Opiate Overdose ; Pilot Projects ; Students, Medical ; United States
    Sprache Englisch
    Erscheinungsdatum 2021-07-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1458030-5
    ISSN 1547-0164 ; 0889-7077
    ISSN (online) 1547-0164
    ISSN 0889-7077
    DOI 10.1080/08897077.2021.1941515
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Access to naloxone at community pharmacies under the Massachusetts statewide standing order.

    Wu, Cindy / Brown, Todd / Moreno, Jessica L

    Journal of the American Pharmacists Association : JAPhA

    2019  Band 60, Heft 4, Seite(n) 647–652

    Abstract: Objective: This study aimed to evaluate access to, and barriers to accessing, naloxone at community pharmacies throughout Massachusetts following implementation of new legislation that requires all community pharmacies to maintain a sufficient supply ... ...

    Abstract Objective: This study aimed to evaluate access to, and barriers to accessing, naloxone at community pharmacies throughout Massachusetts following implementation of new legislation that requires all community pharmacies to maintain a sufficient supply for dispensing under a statewide standing order.
    Design: From September 2018 through January 2019, we conducted a cross-sectional telephone-based survey of Massachusetts pharmacies by having an interviewer pose as a customer seeking naloxone.
    Setting and participants: Community pharmacies were identified from a list of all actively licensed pharmacies provided by the Massachusetts Department of Public Health and one-half were randomly selected for inclusion. Pharmacies that were permanently closed, duplicated on the list, or closed to the general public were excluded from analysis.
    Outcome measures: Rates of stocked naloxone, perceived need for identification or prescription, and pricing.
    Results: Of the 524 pharmacies surveyed, 97.7% (n = 512) reported routinely stocking naloxone. Of those, 90.4% (n = 463) had naloxone in stock on the day of contact. Most pharmacies with naloxone in stock did not require a prescription (96.1%; n = 445); at these pharmacies, personal identification was required by 38.9% (n = 180). The average out-of-pocket naloxone nasal spray price was $128.34 ± $40.75.
    Conclusion: Nearly all Massachusetts community pharmacies routinely stock naloxone as required by state law; however, barriers remain regarding perceived need for identification and high out-of-pocket costs.
    Mesh-Begriff(e) Cross-Sectional Studies ; Humans ; Massachusetts ; Naloxone ; Narcotic Antagonists ; Pharmacies ; Standing Orders
    Chemische Substanzen Narcotic Antagonists ; Naloxone (36B82AMQ7N)
    Sprache Englisch
    Erscheinungsdatum 2019-12-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2118585-2
    ISSN 1544-3450 ; 1544-3191 ; 1086-5802
    ISSN (online) 1544-3450
    ISSN 1544-3191 ; 1086-5802
    DOI 10.1016/j.japh.2019.11.009
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Long-term effects of opioid overdose prevention and response training on medical student knowledge and attitudes toward opioid overdose: A pilot study.

    Moses, Tabitha E H / Chou, Jody S / Moreno, Jessica L / Lundahl, Leslie H / Waineo, Eva / Greenwald, Mark K

    Addictive behaviors

    2021  Band 126, Seite(n) 107172

    Abstract: Background: Medical settings provide ideal opportunities to identify patients with substance use disorders and provide harm reduction and treatment resources. Medical students often volunteer in the community and can spend substantial time with patients, ...

    Abstract Background: Medical settings provide ideal opportunities to identify patients with substance use disorders and provide harm reduction and treatment resources. Medical students often volunteer in the community and can spend substantial time with patients, serving as touchpoints. Accordingly, medical schools have begun training in harm reduction. Initial studies show such training acutely improves knowledge, but sustained effects remain unclear. This pilot study explored longer-term impacts of Opioid Overdose Prevention and Response Training (OOPRT) on medical student knowledge about opioids, overdose, and naloxone.
    Methods: Students completed a survey about knowledge of opioid use disorder, overdoses, and attitudes towards patients. This included Opioid Overdose Knowledge (OOKS) and Opioid Overdose Attitudes (OOAS) scales. A subset of students was invited to attend OOPRT and complete a post-training survey. All who completed the baseline survey were invited to complete a 6-month follow-up. We analyzed long-term training effects on OOKS and OOAS scores.
    Results: 89 students completed baseline and 6-month follow-up surveys; of these, 22 received training. OOPRT yielded significant improvements in knowledge of signs of opioid overdose (F(2,38) = 18.04, P < .001), actions to take during overdose (F(2,38) = 8.32, P = .001), and naloxone use (F(2,38) = 35.46, P < .001), along with attitudes regarding overdose competencies (F(2,38) = 99.40, P < .001) and concerns (F(2,38) = 8.86, P < .001). When comparing over time, students who attended OOPRT retained significantly higher competency scores than those who did not attend F(1,87) = 40.82, P < .001). No other significant differences were observed.
    Conclusions: This study demonstrates immediate efficacy of OOPRT in improving opioid overdose knowledge and attitudes and sustained changes at 6 months, compared to standard undergraduate medical curricula alone. Future research with larger sample sizes is underway to validate these preliminary findings and examine the difference in attitudes and knowledge retention over time. Given that students report interest in receiving OOPRT and consider it worthwhile, systematic study is warranted.
    Mesh-Begriff(e) Analgesics, Opioid/therapeutic use ; Drug Overdose/drug therapy ; Drug Overdose/prevention & control ; Health Knowledge, Attitudes, Practice ; Humans ; Naloxone/therapeutic use ; Narcotic Antagonists/therapeutic use ; Opiate Overdose ; Opioid-Related Disorders/drug therapy ; Opioid-Related Disorders/prevention & control ; Pilot Projects ; Students, Medical
    Chemische Substanzen Analgesics, Opioid ; Narcotic Antagonists ; Naloxone (36B82AMQ7N)
    Sprache Englisch
    Erscheinungsdatum 2021-11-03
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 197618-7
    ISSN 1873-6327 ; 0306-4603
    ISSN (online) 1873-6327
    ISSN 0306-4603
    DOI 10.1016/j.addbeh.2021.107172
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Predictors for 30-Day and 90-Day Hospital Readmission Among Patients With Opioid Use Disorder.

    Moreno, Jessica L / Wakeman, Sarah E / Duprey, Matthew S / Roberts, Russell J / Jacobson, Jared S / Devlin, John W

    Journal of addiction medicine

    2019  Band 13, Heft 4, Seite(n) 306–313

    Abstract: Objectives: To identify the incidence, characteristics, and predictors for 30 and 90-day readmission among acutely hospitalized patients with opioid use disorder (OUD).: Methods: This retrospective, cohort study evaluated consecutive adults with OUD ... ...

    Abstract Objectives: To identify the incidence, characteristics, and predictors for 30 and 90-day readmission among acutely hospitalized patients with opioid use disorder (OUD).
    Methods: This retrospective, cohort study evaluated consecutive adults with OUD admitted to an academic medical center over a 5-year period (10/1/11 to 9/30/16). Multivariable logistic regression was used to determine independent predictors for 30 and 90-day readmissions based on pertinent admission, hospital, and discharge variables collected via chart review and found to be different (with a P < 0.10) on univariate analysis.
    Results: Among the 470 adults (mean age 43.1 ± 12.8 years, past heroin use 77.9%; admission opioid agonist therapy use [buprenorphine 22.6%; methadone 27.0%]; medical [vs surgical] admission 75.3%, floor [vs ICU] admission 93.0%, in-hospital mortality 0.9%), 85 (18.2%) and 151 (32.1%) were readmitted within 30 and 90 days, respectively. Among the 90-day readmitted patients, median time to first readmission was 26 days. Buprenorphine use (vs no use) at index hospital admission was independently associated with reduced 30-day (odds ratio [OR] 0.47, 95% confidence interval [CI] 0.24-0.93) and 90-day (OR 0.57, 95% CI 0.34-0.96) readmission; prior heroin (vs prescription opioid) use was associated with reduced 90-day readmission (OR 0.59, 95% CI 0.37-0.94) and length of hospital stay was associated with both greater 30-day (OR 1.02, 95% CI 1.01-1.05) and 90-day (OR 1.04, 95% CI 1.01-1.06) readmission rates.
    Conclusions: Among patients with OUD taking buprenorphine at the time of hospital admission, 30-day and 90-day hospital readmission was reduced by 53% and 43%, respectively.
    Mesh-Begriff(e) Adult ; Boston/epidemiology ; Female ; Hospital Mortality ; Humans ; Incidence ; Length of Stay/statistics & numerical data ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Opioid-Related Disorders/mortality ; Opioid-Related Disorders/therapy ; Patient Readmission/statistics & numerical data ; Retrospective Studies ; Risk Factors ; Time Factors
    Sprache Englisch
    Erscheinungsdatum 2019-01-10
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1935-3227
    ISSN (online) 1935-3227
    DOI 10.1097/ADM.0000000000000499
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Exenatide as a novel weight loss modality in patients without diabetes.

    Moreno, Jessica L / Willett, Kristine C / Desilets, Alicia R

    The Annals of pharmacotherapy

    2012  Band 46, Heft 12, Seite(n) 1700–1706

    Abstract: Objective: To evaluate the potential role of exenatide for weight loss in overweight or obese adults without diabetes.: Data sources: PubMed (1946-August 2012) and EMBASE (1974-August 2012) were used to conduct a literature search utilizing the terms ...

    Abstract Objective: To evaluate the potential role of exenatide for weight loss in overweight or obese adults without diabetes.
    Data sources: PubMed (1946-August 2012) and EMBASE (1974-August 2012) were used to conduct a literature search utilizing the terms exenatide, weight loss, obesity, and overweight. Additional references were identified by bibliographic review of relevant articles.
    Study selection and data extraction: Studies assessing the use of exenatide in adult subjects without type 2 diabetes or polycystic ovary syndrome and reporting effects on body weight were included.
    Data synthesis: Five studies were identified that reported use of exenatide in nondiabetic adults and included weight change as an outcomes measure. In all 5 of these studies, subjects taking exenatide experienced statistically significant weight loss, which ranged from 2.0 ± 2.8 to 5.1 ± 0.5 kg. Two of the trials were randomized, placebo-controlled studies; 1 trial was a randomized, open-label investigation; 1 study had a prospective, open-label cohort design; and the remaining study was a chart review. Adverse events experienced with exenatide were primarily gastrointestinal in nature, although each trial reported the drug to be well tolerated.
    Conclusions: Obesity continues to be a national epidemic, while choices for effective pharmacologic treatments are extremely limited. Exenatide appears to have promising effects on weight in overweight or obese adults without type 2 diabetes. Further investigations with large, placebo-controlled trials assessing long-term weight loss as a primary outcome are warranted.
    Mesh-Begriff(e) Adult ; Anti-Obesity Agents/adverse effects ; Anti-Obesity Agents/pharmacology ; Anti-Obesity Agents/therapeutic use ; Body Weight/drug effects ; Clinical Trials as Topic ; Humans ; Obesity/drug therapy ; Overweight/drug therapy ; Peptides/adverse effects ; Peptides/pharmacology ; Peptides/therapeutic use ; Venoms/adverse effects ; Venoms/pharmacology ; Venoms/therapeutic use ; Weight Loss/drug effects
    Chemische Substanzen Anti-Obesity Agents ; Peptides ; Venoms ; exenatide (9P1872D4OL)
    Sprache Englisch
    Erscheinungsdatum 2012-12
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1101370-9
    ISSN 1542-6270 ; 1060-0280
    ISSN (online) 1542-6270
    ISSN 1060-0280
    DOI 10.1345/aph.1R372
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Agreement between self-reported psychoactive substance use and urine toxicology results for adults with opioid use disorder admitted to hospital.

    Moreno, Jessica L / Duprey, Matthew S / Hayes, Bryan D / Brooks, Kirsten / Khalil, Sabrina / Wakeman, Sarah E / Roberts, Russell J / Jacobson, Jared S / Devlin, John W

    Toxicology communications

    2019  Band 3, Heft 1, Seite(n) 94–101

    Abstract: Hospitals often perform urine drug screens (UDS) upon inpatient admission to confirm self-reported psychoactive substance use for patients with opioid use disorder (OUD). We sought to evaluate the agreement between UDS and patient self-report for ... ...

    Abstract Hospitals often perform urine drug screens (UDS) upon inpatient admission to confirm self-reported psychoactive substance use for patients with opioid use disorder (OUD). We sought to evaluate the agreement between UDS and patient self-report for psychoactive substances detected with UDS for adults with OUD admitted to hospital. For 11 substance categories, we evaluated agreement between the UDS and the documented history over a 5-year period for consecutive adults admitted to one academic center with a history of OUD. Among the 153 patients, overall agreement across the 1683 different history/UDS pairs (i.e. either history+/UDS + or history-/UDS-) was high (81.3%) but varied (from lowest to highest) by substance [opiates (56.9%), benzodiazepines (66.0%), 6-acetylmorphine (67.3%), cocaine (81.0%), cannabinoids (81.0%), methadone (83.7%), buprenorphine (85.0%), amphetamine (94.8%), barbiturates (95.4%), and phencyclidine (98.7%)]. History+/UDS- pair mismatches were most frequent for 6-acetylmorphine (32.7%), methadone (14.3%) and oxycodone (12.4%); history-/UDS + pair mismatches were most frequent for opiates (43.1%), benzodiazepines (24.8%) and cannabinoids (18.3%). The change in agreement over time of self-reported heroin use may reflect an increasing number of patients unknowingly using illicit fentanyl products. Among hospitalized patients with OUD, agreement between reported psychoactive substance use history and UDS results is strong with the exception of opiates, heroin, and benzodiazepines.
    Sprache Englisch
    Erscheinungsdatum 2019-12-09
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2473-4306
    ISSN (online) 2473-4306
    DOI 10.1080/24734306.2019.1700339
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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