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Article ; Online: Airborne microplastic particle concentrations and characterization in indoor urban microenvironments.

Torres-Agullo, A / Karanasiou, A / Moreno, T / Lacorte, S

Environmental pollution (Barking, Essex : 1987)

2022 Volume 308, Page(s) 119707

Abstract: Airborne microplastics (MPs) have recently drawn the attention of the scientific community due to their possible human inhalation risk. Indoor environments are of relevance as people spend about 90% of their time indoors. This study evaluated MPs ... ...

Abstract	Airborne microplastics (MPs) have recently drawn the attention of the scientific community due to their possible human inhalation risk. Indoor environments are of relevance as people spend about 90% of their time indoors. This study evaluated MPs concentrations in three indoor environments: houses, public transport and working places, which are representative of urban life. Sampling involved the collection of airborne particulate matter on nylon 20 μm pore size filters. Samples were first visually inspected, and particles were characterized (colour, length or area). Polymer identification was performed through μFTIR analysis. Working conditions were controlled to guarantee quality assurance and avoid background contamination. Limits of detection, recovery tests and repeatability were performed with home-made polyethylene (PE), polypropylene (PP), and polystyrene (PS) standards. The highest average MP concentrations were found in buses (17.3 ± 2.4 MPs/m
MeSH term(s)	Environmental Monitoring ; Humans ; Microplastics ; Plastics/analysis ; Polyethylene/analysis ; Polymers
Chemical Substances	Microplastics ; Plastics ; Polymers ; Polyethylene (9002-88-4)
Language	English
Publishing date	2022-07-05
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2022.119707
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Article ; Online: Gender Dysphoria in a Patient With Ovotesticular Disorder of Sex Development.

Moreno, Telma / Ribeiro, Sara / Rodrigues, Pedro

JCEM case reports

2023 Volume 2, Issue 1, Page(s) luad159

Abstract: Ovotesticular disorder of sex development (OT-DSD) is a rare condition characterized by the presence of both ovarian and testicular tissue in the gonads. Management and sex designation of these patients depend on several factors, and an underlying ... ...

Abstract	Ovotesticular disorder of sex development (OT-DSD) is a rare condition characterized by the presence of both ovarian and testicular tissue in the gonads. Management and sex designation of these patients depend on several factors, and an underlying potential for gender dysphoria should be acknowledged. We present a case of a patient diagnosed with 46,XX OT-DSD at 12 months old who was attributed a female sex designation but started manifesting gender dysphoria during adolescence. Gender identity is an important factor to consider on long-term follow-up of OT-DSD patients.
Language	English
Publishing date	2023-12-22
Publishing country	England
Document type	Case Reports
ISSN	2755-1520
ISSN (online)	2755-1520
DOI	10.1210/jcemcr/luad159
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Article ; Online: Assessment of Daily Exposure to Organophosphate Esters through PM

Balasch, Aleix / Moreno, Teresa / Eljarrat, Ethel

Environmental science & technology

2023 Volume 57, Issue 49, Page(s) 20669–20677

Abstract: Inhalation of airborne fine particulate matter ( ... ...

Abstract	Inhalation of airborne fine particulate matter (PM
MeSH term(s)	Adult ; Humans ; Dust/analysis ; Environmental Pollutants ; Organophosphates/analysis ; Flame Retardants/analysis ; Eating ; Esters/analysis ; Environmental Monitoring ; Air Pollution, Indoor/analysis ; China
Chemical Substances	Dust ; Environmental Pollutants ; Organophosphates ; Flame Retardants ; Esters
Language	English
Publishing date	2023-11-30
Publishing country	United States
Document type	Journal Article
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.3c06174
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Article ; Online: AARDVARK: an automated reversion detector for variants affecting resistance kinetics.

Moreno, Thaidy / Magana, Joaquin / Quigley, David A

Bioinformatics (Oxford, England)

2023 Volume 39, Issue 8

Abstract: Summary: Resistance to two classes of FDA-approved therapies that target DNA repair-deficient tumors is caused by mutations that restore the tumor cell's DNA repair function. Identifying these "reversion" mutations currently requires manual annotation ... ...

Abstract	Summary: Resistance to two classes of FDA-approved therapies that target DNA repair-deficient tumors is caused by mutations that restore the tumor cell's DNA repair function. Identifying these "reversion" mutations currently requires manual annotation of patient tumor sequence data. Here we present AARDVARK, an R package that automatically identifies reversion mutations from DNA sequence data. Availability and implementation: AARDVARK is implemented in R (≥3.5). It is available on GitHub at https://github.com/davidquigley/aardvark. It is licensed under the MIT license.
MeSH term(s)	Humans ; Software ; Kinetics ; DNA ; Mutation
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-08-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1422668-6
ISSN	1367-4811 ; 1367-4803
ISSN (online)	1367-4811
ISSN	1367-4803
DOI	10.1093/bioinformatics/btad509
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Article ; Online: Human exposure to organophosphate esters in water and packed beverages.

Fernández-Arribas, Julio / Moreno, Teresa / Eljarrat, Ethel

Environment international

2023 Volume 175, Page(s) 107936

Abstract: Drinks are an essential part of human diet, which makes them a source of human exposure to plasticizers such as organophosphate esters (OPEs). The current study provides new information about sixteen OPE levels in 75 different samples (tap water, packed ... ...

Abstract	Drinks are an essential part of human diet, which makes them a source of human exposure to plasticizers such as organophosphate esters (OPEs). The current study provides new information about sixteen OPE levels in 75 different samples (tap water, packed water, cola drinks, juice, wine and hot drinks). Tap water mean levels (40.9 ng/L) were statistically higher than packed water mean levels (4.82 ng/L), mainly due to the contribution of tris(2-chloroisopropyl) phosphate (TCIPP) and tris(2-butoxyethyl) phosphate (TBOEP) that may come from PVC water pipes. Over 90% of samples presented at least one OPE, where regular cola drinks had the highest mean concentrations (2876 ng/L). There was a significantly higher presence of OPEs in added sugar beverages than sugar free drinks, especially for 2-ethylhexyl diphenyl phosphate (EHDPP), which might be related not only to packaging materials but to the added sugar content. Estimated daily intakes (EDIs) in normal and high-exposure scenarios were 2.52 ng/kg bw/day and 7.43 ng/kg bw/day, respectively. Human risk associated with beverages ingestion showed regular cola drinks, juice and tap water as the groups with the highest hazard quotients (HQs). Although OPE exposure was below to safety limits, it should be noted that EHDPP values for regular cola group must be cause of concern, and other routes of exposure such as food ingestion or air inhalation should be also considered.
MeSH term(s)	Humans ; Flame Retardants/analysis ; Esters/analysis ; Organophosphates/analysis ; Phosphates ; Beverages ; Environmental Monitoring ; China
Chemical Substances	Flame Retardants ; Esters ; Organophosphates ; Phosphates
Language	English
Publishing date	2023-04-17
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2023.107936
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Article ; Online: Compact IR synchrotron beamline design.

Moreno, Thierry

Journal of synchrotron radiation

2017 Volume 24, Issue Pt 2, Page(s) 386–391

Abstract: Third-generation storage rings are massively evolving due to the very compact nature of the multi-bend achromat (MBA) lattice which allows amazing decreases of the horizontal electron beam emittance, but leaves very little place for infrared (IR) ... ...

Abstract	Third-generation storage rings are massively evolving due to the very compact nature of the multi-bend achromat (MBA) lattice which allows amazing decreases of the horizontal electron beam emittance, but leaves very little place for infrared (IR) extraction mirrors to be placed, thus prohibiting traditional IR beamlines. In order to circumvent this apparent restriction, an optimized optical layout directly integrated inside a SOLEIL synchrotron dipole chamber that delivers intense and almost aberration-free beams in the near- to mid-IR domain (1-30 µm) is proposed and analyzed, and which can be integrated into space-restricted MBA rings. Since the optics and chamber are interdependent, the feasibility of this approach depends on a large part on the technical ability to assemble mechanically the optics inside the dipole chamber and control their resulting stability and thermo-mechanical deformation. Acquiring this expertise should allow dipole chambers to provide almost aberration-free IR synchrotron sources on current and `ultimate' MBA storage rings.
Language	English
Publishing date	2017--01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2021413-3
ISSN	1600-5775 ; 0909-0495
ISSN (online)	1600-5775
ISSN	0909-0495
DOI	10.1107/S1600577516020518
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Article ; Online: A new look at rubber recycling and recreational surfaces: The inorganic and OPE chemistry of vulcanised elastomers used in playgrounds and sports facilities.

Moreno, Teresa / Balasch, Aleix / Bartrolí, Rafael / Eljarrat, Ethel

The Science of the total environment

2023 Volume 868, Page(s) 161648

Abstract: We revisit current understanding of the chemical complexity of different kinds of particulate vulcanised elastomers widely used in playgrounds and sports fields, adding new data on trace element and organophosphate ester contents of used tyre and EDPM ... ...

Abstract	We revisit current understanding of the chemical complexity of different kinds of particulate vulcanised elastomers widely used in playgrounds and sports fields, adding new data on trace element and organophosphate ester contents of used tyre and EDPM crumb rubber. Enrichments in elements such as Zn, S, Co, Bi and Nd relate to the vulcanised mixtures created during manufacture. Zinc concentrations vary across an order of magnitude, being highest in our used tyre particulate samples (up to 2.4 %). In contrast, other trace element variations are due to coloured pigments causing increases in Cu and Zr (blue), Cr (green), and Fe and Sn (red and yellow) concentrations. The use of pale fillers such as CaCO
Language	English
Publishing date	2023-01-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.161648
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Article ; Online: Aerosol transmission of human pathogens: From miasmata to modern viral pandemics and their preservation potential in the Anthropocene record.

Moreno, Teresa / Gibbons, Wes

Geoscience frontiers

2021 Volume 13, Issue 6, Page(s) 101282

Abstract: Ongoing uncertainty over the relative importance of aerosol transmission of COVID-19 is in part rooted in the history of medical science and our understanding of how epidemic diseases can spread through human populations. Ancient Greek medical theory ... ...

Abstract	Ongoing uncertainty over the relative importance of aerosol transmission of COVID-19 is in part rooted in the history of medical science and our understanding of how epidemic diseases can spread through human populations. Ancient Greek medical theory held that such illnesses are transmitted by airborne pathogenic emanations containing particulate matter ("miasmata
Language	English
Publishing date	2021-08-11
Publishing country	Netherlands
Document type	Journal Article
ISSN	2588-9192
ISSN (online)	2588-9192
DOI	10.1016/j.gsf.2021.101282
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Article ; Online: Overview on the occurrence of microplastics in air and implications from the use of face masks during the COVID-19 pandemic.

Torres-Agullo, A / Karanasiou, A / Moreno, T / Lacorte, S

The Science of the total environment

2021 Volume 800, Page(s) 149555

Abstract: Environmental pollution from microplastics (MPs) in air is a matter of growing concern because of human health implications. Airborne MPs can be directly and continuously inhaled in air environments. Especially high MPs contributions can be found in ... ...

Abstract	Environmental pollution from microplastics (MPs) in air is a matter of growing concern because of human health implications. Airborne MPs can be directly and continuously inhaled in air environments. Especially high MPs contributions can be found in indoor air due to the erosion and breakage of consumer, domestic and construction products, although there is little information available on their sources and concentrations and the risks they might pose. This is in part due to the fact that sampling and analysis of airborne MPs is a complex and multistep procedure where techniques used are not yet standardized. In this study, we provide an overview on the presence of MPs in indoor air, potential health impacts, the available methods for their sampling and detection and implications from the use of face masks during the COVID-19 pandemic.
MeSH term(s)	Air Pollution, Indoor/analysis ; COVID-19 ; Environmental Monitoring ; Humans ; Masks ; Microplastics ; Pandemics ; Plastics ; SARS-CoV-2
Chemical Substances	Microplastics ; Plastics
Language	English
Publishing date	2021-08-08
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2021.149555
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Article ; Online: COVID-19 face masks: A new source of human and environmental exposure to organophosphate esters.

Fernández-Arribas, J / Moreno, T / Bartrolí, R / Eljarrat, E

Environment international

2021 Volume 154, Page(s) 106654

Abstract: For the first time, organophosphate ester (OPE) content was studied in different types of surgical, self-filtering (KN95, FFP2, and FFP3) and reusable face masks used for COVID-19 prevention. OPEs were detected in all mask samples, although in highly ... ...

Abstract	For the first time, organophosphate ester (OPE) content was studied in different types of surgical, self-filtering (KN95, FFP2, and FFP3) and reusable face masks used for COVID-19 prevention. OPEs were detected in all mask samples, although in highly variable amounts which ranged from 0.02 to a maximum of 27.7 µg/mask, with the highest mean concentrations obtained for KN95 masks (11.6 µg/mask) and the lowest for surgical masks (0.24 µg/mask). Twelve out of 16 tested analytes were detected, with TEP, TPHP, TNBP, TEHP and TClPP being the most common OPEs as well as present at the highest concentrations. The non-carcinogenic and carcinogenic risks of OPE inhalation were calculated as being always several orders of magnitude lower than threshold levels, indicating that the use of face masks is safe with regard to OPE contamination. However, given the wide range of OPEs observed in different masks, it can be concluded that some masks (e.g. reusable) are less OPE-contaminated than others (e.g. KN95). With regard to environmental pollution, the disposal of billions of face masks is adding to the already substantial levels of microplastics and associated toxic additives worldwide, an impact that is lessened by use of reusable masks, which also have the lowest economic cost per user. However, in situations of relatively high risk of viral inhalation, such as poorly ventilated indoor public spaces, we recommend the use of FFP2 masks.
MeSH term(s)	COVID-19 ; Environmental Exposure/analysis ; Environmental Monitoring ; Esters ; Flame Retardants/analysis ; Humans ; Masks ; Organophosphates ; Plastics ; SARS-CoV-2
Chemical Substances	Esters ; Flame Retardants ; Organophosphates ; Plastics
Language	English
Publishing date	2021-05-18
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2021.106654
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