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  1. Article ; Online: Outbreak or coincidental cases of tuberculosis? Genotyping provides the clue.

    Casas-Fischer, Ricardo / Penedo-Pallares, Ana / Palacios-Gutierrez, Juan José / Moreno-Torrico, Alfonso

    American journal of infection control

    2012  Volume 40, Issue 1, Page(s) 9–10

    Abstract: We illustrate how genotyping of mycobacterial strains contributed to the discovery of an undetected outbreak of tuberculosis in a hospital ward, ruling out misleading assumptions of transmission chains. Genotyping should be taken into account in routine ... ...

    Abstract We illustrate how genotyping of mycobacterial strains contributed to the discovery of an undetected outbreak of tuberculosis in a hospital ward, ruling out misleading assumptions of transmission chains. Genotyping should be taken into account in routine tests for the control of tuberculosis.
    MeSH term(s) Cross Infection/epidemiology ; Cross Infection/microbiology ; Disease Outbreaks ; Genotype ; Humans ; Molecular Epidemiology ; Molecular Typing ; Mycobacterium tuberculosis/classification ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/isolation & purification ; Tuberculosis/epidemiology ; Tuberculosis/microbiology
    Language English
    Publishing date 2012-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2011.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effect of penicillin resistance of Streptococcus pneumoniae on the presentation, prognosis, and treatment of pneumococcal endocarditis in adults.

    Martínez, Esteban / Miró, Jose M / Almirante, Benito / Aguado, Jose M / Fernandez-Viladrich, Pedro / Fernandez-Guerrero, Manuel L / Villanueva, Jose L / Dronda, Fernando / Moreno-Torrico, Alfonso / Montejo, Miguel / Llinares, Pedro / Gatell, Jose M

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2002  Volume 35, Issue 2, Page(s) 130–139

    Abstract: We performed a clinical study of pneumococcal endocarditis (PE) in adults at 15 major Spanish hospitals during a 21-year period (1978-1998). During this time, 63 patients had PE due to Streptococcus pneumoniae diagnosed. Of the 63 isolates recovered from ...

    Abstract We performed a clinical study of pneumococcal endocarditis (PE) in adults at 15 major Spanish hospitals during a 21-year period (1978-1998). During this time, 63 patients had PE due to Streptococcus pneumoniae diagnosed. Of the 63 isolates recovered from these patients, 24 (38%) and 6 (10%) showed resistance to penicillin (minimum inhibitory concentration [MIC], 0.1-4 microg/mL) and cefotaxime (MIC, 1 microg/mL), respectively. Twenty-two (35%) of the patients died. Left-side heart failure, but not penicillin resistance, was independently associated with a higher risk of death (odds ratio, 1.33; 95% confidence interval, 1.04-1.71; P=.026). Patients without meningitis who had PE due to penicillin-resistant S. pneumoniae could be treated with high-dose penicillin or a third-generation cephalosporin if the MIC for penicillin was < or =1 microg/mL. For patients with concurrent meningitis, high doses of cefotaxime could be used if the MIC for cefotaxime was < or =1 microg/mL. Early recognition of heart failure and surgery may help to decrease mortality.
    MeSH term(s) Adult ; Aged ; Cefotaxime/administration & dosage ; Cefotaxime/metabolism ; Cefotaxime/therapeutic use ; Cephalosporins/administration & dosage ; Cephalosporins/metabolism ; Cephalosporins/therapeutic use ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Endocarditis, Bacterial/complications ; Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/drug therapy ; Endocarditis, Bacterial/epidemiology ; Female ; Heart Failure/etiology ; Heart Failure/mortality ; Humans ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Penicillin Resistance ; Penicillins/administration & dosage ; Penicillins/metabolism ; Penicillins/therapeutic use ; Pneumococcal Infections/complications ; Pneumococcal Infections/diagnosis ; Pneumococcal Infections/drug therapy ; Pneumococcal Infections/epidemiology ; Prognosis ; Prospective Studies ; Spain/epidemiology ; Streptococcus pneumoniae/drug effects ; Streptococcus pneumoniae/isolation & purification ; Treatment Outcome ; Ventricular Dysfunction, Left/complications ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/surgery
    Chemical Substances Cephalosporins ; Penicillins ; Cefotaxime (N2GI8B1GK7)
    Language English
    Publishing date 2002-07-15
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1086/341024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Role of age and comorbidities in mortality of patients with infective endocarditis.

    Armiñanzas, Carlos / Fariñas-Alvarez, Concepción / Zarauza, Jesús / Muñoz, Patricia / González Ramallo, Víctor / Martínez Sellés, Manuel / Miró Meda, José Mª / Pericás, Juan Manuel / Goenaga, Miguel Ángel / Ojeda Burgos, Guillermo / Rodríguez Álvarez, Regino / Castelo Corral, Laura / Gálvez-Acebal, Juan / Martínez Marcos, Francisco Javier / Fariñas, Maria Carmen / Fernández Sánchez, Fernando / Noureddine, Mariam / Rosas, Gabriel / de la Torre Lima, Javier /
    Aramendi, José / Bereciartua, Elena / Blanco, María José / Blanco, Roberto / Boado, María Victoria / Campaña Lázaro, Marta / Crespo, Alejandro / Goikoetxea, Josune / Iruretagoyena, José Ramón / Irurzun Zuazabal, Josu / López-Soria, Leire / Montejo, Miguel / Nieto, Javier / Rodrigo, David / Rodríguez, David / Rodríguez, Regino / Vitoria, Yolanda / Voces, Roberto / García López, Mª Victoria / Georgieva, Radka Ivanova / Ojeda, Guillermo / Rodríguez Bailón, Isabel / Ruiz Morales, Josefa / Cuende, Ana María / Echeverría, Tomás / Fuerte, Ana / Gaminde, Eduardo / Idígoras, Pedro / Iribarren, José Antonio / Izaguirre Yarza, Alberto / Kortajarena Urkola, Xabier / Reviejo, Carlos / Carrasco, Rafael / Climent, Vicente / Llamas, Patricio / Merino, Esperanza / Plazas, Joaquín / Reus, Sergio / Álvarez, Nemesio / Bravo-Ferrer, José María / Castelo, Laura / Cuenca, José / Llinares, Pedro / Miguez Rey, Enrique / Rodríguez Mayo, María / Sánchez, Efrén / Sousa Regueiro, Dolores / Martínez, Francisco Javier / Alonso, Mª Del Mar / Castro, Beatriz / García Rosado, Dácil / Durán, Mª Del Carmen / Miguel Gómez, Mª Antonia / Lacalzada, Juan / Nassar, Ibrahim / Plata Ciezar, Antonio / Reguera Iglesias, José Mª / Asensi Álvarez, Víctor / Costas, Carlos / de la Hera, Jesús / Fernández Suárez, Jonnathan / Iglesias Fraile, Lisardo / León Arguero, Víctor / López Menéndez, José / Mencia Bajo, Pilar / Morales, Carlos / Moreno Torrico, Alfonso / Palomo, Carmen / Paya Martínez, Begoña / Rodríguez Esteban, Ángeles / Rodríguez García, Raquel / Telenti Asensio, Mauricio / Almela, Manuel / Ambrosioni, Juan / Azqueta, Manuel / Brunet, Mercè / Bodro, Marta / Cartañá, Ramón / Falces, Carlos / Fita, Guillermina / Fuster, David / García de la Mària, Cristina / Hernández-Meneses, Marta / Llopis Pérez, Jaume / Marco, Francesc / Miró, José M / Moreno, Asunción / Nicolás, David / Ninot, Salvador / Quintana, Eduardo / Paré, Carlos / Pereda, Daniel / Pericás, Juan M / Pomar, José L / Ramírez, José / Rovira, Irene / Sandoval, Elena / Sitges, Marta / Soy, Dolors / Téllez, Adrián / Tolosana, José M / Vidal, Bárbara / Vila, Jordi / Adán, Iván / Bermejo, Javier / Bouza, Emilio / Celemín, Daniel / Cuerpo Caballero, Gregorio / Delgado Montero, Antonia / Fernández Cruz, Ana / García Mansilla, Ana / García Leoni, Mª Eugenia / Kestler Hernández, Martha / Hualde, Amaia Mari / Marín, Mercedes / Martínez-Sellés, Manuel / Menárguez, Mª Cruz / Rincón, Cristina / Rodríguez-Abella, Hugo / Rodríguez-Créixems, Marta / Pinilla, Blanca / Pinto, Ángel / Valerio, Maricela / Vázquez, Pilar / Verde Moreno, Eduardo / Antorrena, Isabel / Loeches, Belén / Martín Quirós, Alejandro / Moreno, Mar / Ramírez, Ulises / Rial Bastón, Verónica / Romero, María / Saldaña, Araceli / Agüero Balbín, Jesús / Amado, Cristina / Armiñanzas Castillo, Carlos / Arnaiz García, Ana / Cobo Belaustegui, Manuel / Fariñas, María Carmen / Fariñas-Álvarez, Concepción / Gómez Izquierdo, Rubén / García, Iván / González-Rico, Claudia / Gutiérrez-Cuadra, Manuel / Gutiérrez Díez, José / Pajarón, Marcos / Parra, José Antonio / Sarralde, Aurelio / Teira, Ramón / Domínguez, Fernando / García Pavía, Pablo / González, Jesús / Orden, Beatriz / Ramos, Antonio / Centella, Tomasa / Hermida, José Manuel / Moya, José Luis / Martín-Dávila, Pilar / Navas, Enrique / Oliva, Enrique / Del Río, Alejandro / Ruiz, Soledad / Hidalgo Tenorio, Carmen / Almendro Delia, Manuel / Araji, Omar / Barquero, José Miguel / Calvo Jambrina, Román / de Cueto, Marina / Gálvez Acebal, Juan / Méndez, Irene / Morales, Isabel / López-Cortés, Luis Eduardo / de Alarcón, Arístides / García, Emilio / Haro, Juan Luis / Lepe, José Antonio / López, Francisco / Luque, Rafael / Alonso, Luis Javier / Azcárate, Pedro / Azcona Gutiérrez, José Manuel / Blanco, José Ramón / García-Álvarez, Lara / Oteo, José Antonio / Sanz, Mercedes / de Benito, Natividad / Gurguí, Mercé / Pacho, Cristina / Pericas, Roser / Pons, Guillem / Álvarez, M / Fernández, A L / Martínez, Amparo / Prieto, A / Regueiro, Benito / Tijeira, E / Vega, Marino / Canut Blasco, Andrés / Cordo Mollar, José / Gainzarain Arana, Juan Carlos / García Uriarte, Oscar / Martín López, Alejandro / Ortiz de Zárate, Zuriñe / Urturi Matos, José Antonio / García Domínguez, Gloria / Sánchez-Porto, Antonio / Arribas Leal, José Mª / García Vázquez, Elisa / Hernández Torres, Alicia / Blázquez, Ana / de la Morena Valenzuela, Gonzalo / Alonso, Ángel / Aramburu, Javier / Calvo, Felicitas Elena / Moreno Rodríguez, Anai / Tarabini-Castellani, Paola / Heredero Gálvez, Eva / Maicas Bellido, Carolina / Largo Pau, José / Sepúlveda, Mª Antonia / Toledano Sierra, Pilar / Iqbal-Mirza, Sadaf Zafar / Cascales Alcolea, Eva / Egea Serrano, Pilar / Hernández Roca, José Joaquín / Keituqwa Yañez, Ivan / Peláez Ballesta, Ana / Soriano, Víctor / Moreno Escobar, Eduardo / Peña Monje, Alejandro / Sánchez Cabrera, Valme / Vinuesa García, David / Arrizabalaga Asenjo, María / Cifuentes Luna, Carmen / Núñez Morcillo, Juana / Pérez Seco, Mª Cruz / Villoslada Gelabert, Aroa / Aured Guallar, Carmen / Fernández Abad, Nuria / García Mangas, Pilar / Matamala Adell, Marta / Palacián Ruiz, Mª Pilar / Porres, Juan Carlos / Alcaraz Vidal, Begoña / Cobos Trigueros, Nazaret / Del Amor Espín, María Jesús / Giner Caro, José Antonio / Jiménez Sánchez, Roberto / Jimeno Almazán, Amaya / Ortín Freire, Alejandro / Viqueira González, Monserrat / Pericás Ramis, Pere / Ribas Blanco, Mª Ángels / Ruiz de Gopegui Bordes, Enrique / Vidal Bonet, Laura / Bellón Munera, Mª Carmen / Escribano Garaizabal, Elena / Tercero Martínez, Antonia / Segura Luque, Juan Carlos

    European journal of internal medicine

    2019  Volume 64, Page(s) 63–71

    Abstract: Purpose: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality.: Methods: Prospective cohort study of all ... ...

    Abstract Purpose: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality.
    Methods: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk.
    Results: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32-3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39-1.88),and non-performed surgery (HR:1.64;95% CI:11.16-1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality.
    Conclusion: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group.
    MeSH term(s) Adult ; Age Factors ; Aged ; Aged, 80 and over ; Area Under Curve ; Comorbidity ; Databases, Factual ; Endocarditis/etiology ; Endocarditis/mortality ; Female ; Heart Failure/mortality ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Proportional Hazards Models ; Prospective Studies ; ROC Curve ; Risk Factors ; Spain/epidemiology ; Staphylococcal Infections/mortality
    Language English
    Publishing date 2019-03-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2019.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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