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  1. Article ; Online: Epidemiology and molecular characterization of adult genetic myopathies in a southeastern region of Spain.

    Ros-Arlanzón, P / Pelegrín-Durá, L / Aledo-Sala, C / Moreno-Navarro, L / Vaamonde-Esteban, Y / Muñoz-Ambit, A / Sánchez-Pérez, R / Díaz-Marín, C

    Revista de neurologia

    2024  Volume 78, Issue 9, Page(s) 239–246

    Abstract: Introduction: Genetic myopathies constitute a collection of rare diseases that significantly impact patient functionality and quality of life. Early diagnosis of genetic myopathies can prevent future complications and provide families with genetic ... ...

    Title translation Epidemiología y caracterización molecular de las miopatías genéticas en adultos en una región del sureste de España.
    Abstract Introduction: Genetic myopathies constitute a collection of rare diseases that significantly impact patient functionality and quality of life. Early diagnosis of genetic myopathies can prevent future complications and provide families with genetic counselling. Despite the substantial impact of genetic myopathies on the adult population, the global epidemiology of these disorders is inadequately addressed in the literature.
    Aims: To enhance understanding of both the epidemiology and genetics of these disorders within the province of Alicante, situated in southeastern Spain.
    Material and methods: Between 2020 and 2022, a prospective observational study was conducted at the Alicante Health Area-General Hospital, enrolling patients aged 16 years or older with suspected genetic myopathies. Sociodemographic, clinical, and genetic data were collected. The reference date for prevalence calculation was established as December 31, 2022. Official demographic data of the health area were used to set the population at risk.
    Results: In total, 83 patients were identified with confirmed genetically related myopathy, resulting in an overall prevalence of 29.59 cases per 100,000 inhabitants. The diagnostic yield for molecular genetic testing was found to be 69.16%. The most prevalent genetic myopathies identified included myotonic dystrophy (27.5%), dystrophinopathies (15.7%), and facioscapulohumeral dystrophy (15.7%).
    Conclusion: The prevalence of GMs can vary considerably depending on the geographical region and the studied population. The analysis of diagnostic yield suggests that genetic studies should be considered useful in the diagnosis of genetic myopathies.
    MeSH term(s) Humans ; Spain/epidemiology ; Male ; Female ; Adult ; Prospective Studies ; Middle Aged ; Prevalence ; Muscular Diseases/epidemiology ; Muscular Diseases/genetics ; Aged ; Young Adult ; Adolescent
    Language English
    Publishing date 2024-04-29
    Publishing country Spain
    Document type Journal Article ; Observational Study
    ZDB-ID 1468278-3
    ISSN 1576-6578 ; 0210-0010
    ISSN (online) 1576-6578
    ISSN 0210-0010
    DOI 10.33588/rn.7809.2024071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinicoradiological application of the use of spectral cranial computed tomography in the management of acute ischemic stroke after mechanical thrombectomy.

    Moreno-Navarro, L / Farrerons-Llopart, M / López-Hernández, N / Moliner-Castellano, S / Ballesteros-Aparicio, M J / Gallego-León, J / Concepción-Aramendía, L

    Revista de neurologia

    2024  Volume 78, Issue 9, Page(s) 247–252

    Abstract: Introduction: Acute ischemic stroke is one of the leading global causes of morbidity and mortality. Mechanical thrombectomy has improved the functional prognosis of this condition; however, hemorrhagic transformation is a common complication. Spectral ... ...

    Title translation Aplicación clinicorradiológica del uso de la tomografía computarizada craneal de tecnología espectral en el manejo del ictus isquémico agudo tras trombectomía mecánica.
    Abstract Introduction: Acute ischemic stroke is one of the leading global causes of morbidity and mortality. Mechanical thrombectomy has improved the functional prognosis of this condition; however, hemorrhagic transformation is a common complication. Spectral computed tomography (CT) imaging, as a neuroimaging control test, distinguishes contrast extravasation from hemorrhagic transformation due to the differential behavior of materials at dual energy levels. This distinction is valuable in its clinical therapeutic management.
    Material and methods: A single-center, observational, retrospective study was conducted in which the presence of various clinical, radiological, and therapeutic variables in patients with acute ischemic stroke treated with mechanical thrombectomy at our hospital between July 2022 and March 2023 was investigated using access to a dissociated database and medical records.
    Results: Out of 155 included patients, spectral cranial CT was performed in 63, and conventional cranial CT in 75. In the spectral CT group, 21 hyperdense images were detected, compared to 28 in the conventional CT group. In 42.8% of cases where hyperdensity was detected in the conventional CT group, it was not possible to distinguish between contrast extravasation and hemorrhagic transformation, in contrast to the 4.8% in the spectral CT group (p < 0.001).
    Conclusions: Spectral CT provides high diagnostic confidence to the radiologist in identifying the type of detected hyperdensity, thereby offering significant therapeutic confidence to the neurologist in early resuming anticoagulation therapy.
    MeSH term(s) Humans ; Ischemic Stroke/diagnostic imaging ; Ischemic Stroke/surgery ; Male ; Retrospective Studies ; Female ; Aged ; Thrombectomy ; Tomography, X-Ray Computed ; Middle Aged ; Aged, 80 and over ; Postoperative Complications/diagnostic imaging ; Postoperative Complications/etiology
    Language English
    Publishing date 2024-04-29
    Publishing country Spain
    Document type Journal Article ; Observational Study
    ZDB-ID 1468278-3
    ISSN 1576-6578 ; 0210-0010
    ISSN (online) 1576-6578
    ISSN 0210-0010
    DOI 10.33588/rn.7809.2023340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Dyspnea and Bronchoconstriction in a Young Patient With Multiple Sclerosis Treated With Ponesimod.

    Gómez Román, Marta / García Ródenas, Maria Del Mar / Moreno Navarro, Luis / Asensio Sánchez, Santos / Pérez Sempere, Ángel

    Archivos de bronconeumologia

    2023  Volume 59, Issue 10, Page(s) 676–677

    MeSH term(s) Humans ; Multiple Sclerosis ; Bronchoconstriction ; Thiazoles ; Dyspnea/etiology
    Chemical Substances ponesimod (5G7AKV2MKP) ; Thiazoles
    Language Spanish
    Publishing date 2023-06-15
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2023.05.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Fertility change in five Latin American countries: a covariance analysis of birth intervals.

    Moreno-Navarro, L

    Demography

    1987  Volume 24, Issue 1, Page(s) 23–41

    MeSH term(s) Actuarial Analysis ; Birth Intervals ; Female ; Fertility ; Humans ; Latin America ; Parity ; Statistics as Topic
    Language English
    Publishing date 1987-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 280612-5
    ISSN 1533-7790 ; 0070-3370
    ISSN (online) 1533-7790
    ISSN 0070-3370
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1487: Show issues Location:
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  5. Article: Fertility change in five Latin American countries

    Moreno-Navarro, Lorenzo

    Demography : a publication of the Population Association of America ; the statistical study of human populations 24 ,1, S. 23-41

    a covariance analysis of birth intervals

    1987  

    Author's details Lorenzo Moreno-Navarro
    Keywords Fertilität ; Kolumbien ; Mexiko ; Peru ; Panama ; Costa Rica
    Language English
    Publisher Springer
    Publishing place New York, NY
    Document type Article
    ZDB-ID 280612-5
    ISSN 1533-7790 ; 0070-3370
    ISSN (online) 1533-7790
    ISSN 0070-3370
    Database ECONomics Information System

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    In stock of ZB MED Cologne/Königswinter

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  6. Article: Application of methods of measuring the impact of family planning programmes on fertility

    Palma Cabrera, Y / Moreno Navarro, L

    United Nations. Department of International Economic and Social Affairs. Population Division. Evaluation of the impact of family planning programmes on fertility: sources of variance

    the case of Mexico

    (Population studies ; no. 76)

    1982  

    Abstract: Methods used to measure the impact of family planning programs on fertility in the case of Mexico are reviewed. Mexico's population in the future will depend primarily upon fertility behavior. 2 growth alternatives are shown: if a growth rate of 3.2% ... ...

    Author's details Y. Palma Cabrera, L. Moreno Navarro
    Series title Population studies ; no. 76
    Abstract Methods used to measure the impact of family planning programs on fertility in the case of Mexico are reviewed. Mexico's population in the future will depend primarily upon fertility behavior. 2 growth alternatives are shown: if a growth rate of 3.2% remains constant, there will be 70.1 million people in 1980, 96.1 million in 1990, and 131.7 million in 2000; and if the demographic goals proposed by the family planning program are reached, i.e., if Mexico experiences growth rates of 2.5% in 1982 and 1% in 2000, the population will be 69.9 million in 1980, 87.5 million in 1990, and 100.2 million in 2000. 2 important sources of information have been developed in the recent past: the Mexican Fertility Survey and the National Prevalence Survey on the Use of Contraceptive Methods. The Mexican program is still young and service statistics systems are still being implemented. Availability and quality of the information were the primary restrictions in the selection of the methodologies to be applied in this study: standardized approach; standard couple years of protection (SYCYP); component projection approach 1: CONVERSE; component projection approach 2: a model for desk calculators; reproductive process analysis; multivariate areal analysis; and fertility projection/trend analysis. The standardization approach does not appear to be a good methodology for assessing the demographic impact of a family planning program when the activities of other sectors providing contraception and abortion are significant, as in the case of Mexico. Yet, the approach is valuable because it estimates the contribution of the different variables to observed changes in fertility and the impact of a family planning program should be viewed in this light. The best use of the SCYP approach would be to employ it as an indicator for comparisons among subgroups of the population of a country, i.e., regions or socioeconomic strata, if an estimate of the demographic impact is neither desired nor possible. CONVERSE can be considered a complete and efficient methodology for estimating program impact. It allows one to obtain significant results in a straightforward way, possibly limited by the availability of data. Reproductive process analysis can be considered the clearest conceptualization to analyze the demographic impact of contraceptive use, but it is limited when applied to the specific activities of family planning programs. At this time, component projection approach 1, CONVERSE, appears to be the most adequate in the case of Mexico. The targets of the program are set in these terms: inputs (acceptors during a year); coverage (active users at end of year); and demographic change (growth rates). CONVERSE follows this sequence and allows one to understand the process of adoption, permanence, and demographic impact occurring inside a society. Such changes are a consequence of the existence of a family planning program. CONVERSE appears to overestimate the potential fertility of acceptors and therefore the number of births averted. The crude birthrate predicted by this model is 38.3/1000 for 1978, taking into account the effect of acceptors to the program and the number of total users in 1974. The observed crude birthrate of the year was approximately 38/1000, which includes the effects of the private sector, abortion, and traditional practices. Thus, the demographic impact appears to be overestimated.
    MeSH term(s) Contraception Behavior ; Demography ; Health Planning ; Information Systems ; Population Control ; Research ; Software ; Automatic Data Processing ; Birth Rate ; Contraception ; Contraceptives, Oral ; Developing Countries ; Family Planning Services ; Information Storage and Retrieval ; Injections ; Intrauterine Devices ; Maternal Age ; Patient Acceptance of Health Care ; Population ; Population Dynamics ; Pregnancy Rate ; Program Evaluation ; Sterilization, Reproductive
    Keywords Americas ; Latin America ; Mexico ; North America ; Computer Programs And Programming ; Contraceptive Usage ; Demographic Effectiveness ; Demographic Impact ; Family Planning Programs ; Information Retrieval Systems ; Research Methodology ; Acceptors ; Age Specific Fertility Rate ; Data Storage And Retrieval ; Demographic Factors ; Family Planning Program Evaluation ; Fertility Rate ; IUD ; Information ; Information Processing ; Injectables ; Oral Contraceptives
    Language English
    Document type Article
    Note ST/ESA/SER.A/76.
    Database Catalogue of the US National Library of Medicine (NLM)

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