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Book: Principles of social psychiatry

Morgan, Craig / Bhugra, Dinesh

2010

Author's details	ed. Craig Morgan and Dinesh Bhugra
Keywords	Community Psychiatry
Language	English
Size	XVI, 586 S. : Ill.
Edition	2. ed., 1. impr.
Publisher	Wiley-Blackwell
Publishing place	Chichester u.a.
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT016348252
ISBN	978-0-470-69713-9 ; 0-470-69713-X
Database	Catalogue ZB MED Medicine, Health

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2010 A 2401	order for loan	Magazin

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Article ; Online: Algorithmic reconstruction of glioblastoma network complexity

Abicumaran Uthamacumaran / Morgan Craig

iScience, Vol 25, Iss 5, Pp 104179- (2022)

2022

Abstract: Summary: Glioblastoma is a complex disease that is difficult to treat. Network and data science offer alternative approaches to classical bioinformatics pipelines to study gene expression patterns from single-cell datasets, helping to distinguish genes ... ...

Abstract	Summary: Glioblastoma is a complex disease that is difficult to treat. Network and data science offer alternative approaches to classical bioinformatics pipelines to study gene expression patterns from single-cell datasets, helping to distinguish genes associated with the control of differentiation and aggression. To identify the key molecular regulators of the networks driving glioblastoma/GSC and predict their cell fate dynamics, we applied a host of data theoretic techniques to gene expression patterns from pediatric and adult glioblastoma, and adult glioma-derived stem cells (GSCs). We identified eight transcription factors (OLIG1/2, TAZ, GATA2, FOXG1, SOX6, SATB2, and YY1) and four signaling genes (ATL3, MTSS1, EMP1, and TPT1) as coordinators of cell state transitions and, thus, clinically targetable putative factors differentiating pediatric and adult glioblastomas from adult GSCs. Our study provides strong evidence of complex systems approaches for inferring complex dynamics from reverse-engineering gene networks, bolstering the search for new clinically relevant targets in glioblastoma.
Keywords	Gene network ; Bioinformatics ; Cancer ; Science ; Q
Subject code	570
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: Society and psychosis

Morgan, Craig / MacKenzie, Kwame / Fearon, Paul

2008

Author's details	Craig Morgan ; Kwame McKenzie ; Paul Fearon
Language	English
Size	IX, 255 S. : Ill., graph. Darst.
Publisher	Cambridge Univ. Press
Publishing place	Cambridge
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT015348630
ISBN	978-0-521-68959-5 ; 0-521-68959-7
Database	Catalogue ZB MED Medicine, Health

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2008 A 1851	order for loan	Magazin

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Article ; Online: Determinants of combination GM-CSF immunotherapy and oncolytic virotherapy success identified through in silico treatment personalization.

Tyler Cassidy / Morgan Craig

PLoS Computational Biology, Vol 15, Iss 11, p e

2019 Volume 1007495

Abstract: Oncolytic virotherapies, including the modified herpes simplex virus talimogene laherparepvec (T-VEC), have shown great promise as potent instigators of anti-tumour immune effects. The OPTiM trial, in particular, demonstrated the superior anti-cancer ... ...

Abstract	Oncolytic virotherapies, including the modified herpes simplex virus talimogene laherparepvec (T-VEC), have shown great promise as potent instigators of anti-tumour immune effects. The OPTiM trial, in particular, demonstrated the superior anti-cancer effects of T-VEC as compared to systemic immunotherapy treatment using exogenous administration of granulocyte-macrophage colony-stimulating factor (GM-CSF). Theoretically, a combined approach leveraging exogenous cytokine immunotherapy and oncolytic virotherapy would elicit an even greater immune response and improve patient outcomes. However, regimen scheduling of combination immunostimulation and T-VEC therapy has yet to be established. Here, we calibrate a computational biology model of sensitive and resistant tumour cells and immune interactions for implementation into an in silico clinical trial to test and individualize combination immuno- and virotherapy. By personalizing and optimizing combination oncolytic virotherapy and immunostimulatory therapy, we show improved simulated patient outcomes for individuals with late-stage melanoma. More crucially, through evaluation of individualized regimens, we identified determinants of combination GM-CSF and T-VEC therapy that can be translated into clinically-actionable dosing strategies without further personalization. Our results serve as a proof-of-concept for interdisciplinary approaches to determining combination therapy, and suggest promising avenues of investigation towards tailored combination immunotherapy/oncolytic virotherapy.
Keywords	Biology (General) ; QH301-705.5
Subject code	610 ; 616
Language	English
Publishing date	2019-11-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Multidisciplinary research priorities for the COVID-19 pandemic.

Morgan, Craig / Rose, Nikolas

The lancet. Psychiatry

2020 Volume 7, Issue 7, Page(s) e33

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Interdisciplinary Research ; Mental Health ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-06-18
Publishing country	England
Document type	Letter ; Comment
ISSN	2215-0374
ISSN (online)	2215-0374
DOI	10.1016/S2215-0366(20)30230-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Understanding social and clinical associations with unemployment for people with schizophrenia and bipolar disorders: large-scale health records study.

Chilman, Natasha / Laporte, Dionne / Dorrington, Sarah / Hatch, Stephani L / Morgan, Craig / Okoroji, Celestin / Stewart, Robert / Das-Munshi, Jayati

Social psychiatry and psychiatric epidemiology

2024

Abstract: Purpose: People with severe mental illness (SMI) experience high levels of unemployment. We aimed to better understand the associations between clinical, social, and demographic inequality indicators and unemployment.: Methods: Data were extracted ... ...

Abstract	Purpose: People with severe mental illness (SMI) experience high levels of unemployment. We aimed to better understand the associations between clinical, social, and demographic inequality indicators and unemployment. Methods: Data were extracted from de-identified health records of people with SMI in contact with secondary mental health services in south London, UK. A Natural Language Processing text-mining application was applied to extract information on unemployment in the health records. Multivariable logistic regression was used to assess associations with unemployment, in people with SMI. Results: Records from 19,768 service users were used for analysis, 84.9% (n = 16,778) had experienced unemployment. In fully adjusted models, Black Caribbean and Black African service users were more likely to experience unemployment compared with White British service users (Black Caribbean: aOR 1.62, 95% CI 1.45-1.80; Black African: 1.32, 1.15-1.51). Although men were more likely to have experienced unemployment relative to women in unadjusted models (OR 1.36, 95% CI 1.26-1.47), differences were no longer apparent in the fully adjusted models (aOR 1.05, 95% CI 0.97-1.15). The presence of a non-affective (compared to affective) diagnosis (1.24, 1.13-1.35), comorbid substance use (2.02, 1.76-2.33), previous inpatient admissions (4.18, 3.71-4.70), longer inpatient stays (78 + days: 7.78, 6.34-9.54), and compulsory admissions (3.45, 3.04-3.92) were associated with unemployment, in fully adjusted models. Conclusion: People with SMI experience high levels of unemployment, and we found that unemployment was associated with several clinical and social factors. Interventions to address low employment may need to also address these broader inequalities.
Language	English
Publishing date	2024-02-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	623071-4
ISSN	1433-9285 ; 0037-7813 ; 0933-7954
ISSN (online)	1433-9285
ISSN	0037-7813 ; 0933-7954
DOI	10.1007/s00127-024-02620-6
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Article ; Online: The Thrower's Shoulder.

Medina, Giovanna / Bartolozzi, Arthur R / Spencer, Jacob A / Morgan, Craig

JBJS reviews

2022 Volume 10, Issue 3

Abstract: The thrower's shoulder has been a subject of great interest for many decades. Different theories have been proposed to clarify the pathophysiology, clinical presentation, and treatment options for this condition. In this review article, we summarize ... ...

Abstract	»: The thrower's shoulder has been a subject of great interest for many decades. Different theories have been proposed to clarify the pathophysiology, clinical presentation, and treatment options for this condition. In this review article, we summarize the relevant anatomy and pathophysiology and how these translate into signs, symptoms, and imaging findings. Also, a historical review of the treatment methodologies in the setting of an evolving concept is presented. »: The initial event in the cascade is thickening and contracture of the posteroinferior capsule resulting from repetitive tensile forces during the deceleration phase of throwing. This is known as "the essential lesion" and is clinically perceived as glenohumeral internal rotation deficit (GIRD), and a Bennett lesion may be found on radiographs. »: Change in the glenohumeral contact point leads to a series of adaptations that are beneficial for the mechanics of throwing, specifically in achieving the so-called "slot," which will maximize throwing performance. »: The complexity of the throwing shoulder is the result of an interplay of the different elements described in the cascade, as well as other factors such as pectoralis minor tightness and scapular dyskinesis. However, it is still unclear which event is the tipping point that breaks the balance between these adaptations and triggers the shift from an asymptomatic shoulder to a painful disabled joint that can jeopardize the career of a throwing athlete. Consequences are rotator cuff impingement and tear, labral injury, and scapular dyskinesis, which are seen both clinically and radiographically. »: A thorough understanding of the pathologic cascade is paramount for professionals who care for throwing athletes. The successful treatment of this condition depends on correct identification of the point in the cascade that is disturbed. The typical injuries described in the throwing shoulder rarely occur in isolation; thus, an overlap of symptoms and clinical findings is common. »: The rationale for treatment is based on the pathophysiologic biomechanics and should involve stretching, scapular stabilization, and core and lower-body strengthening, as well as correction of throwing mechanics, integrating the entire kinetic chain. When nonoperative treatment is unsuccessful, surgical options should be tailored for the specific changes within the pathologic cascade that are causing a dysfunctional throwing shoulder.
MeSH term(s)	Biomechanical Phenomena ; Humans ; Range of Motion, Articular/physiology ; Scapula ; Shoulder Impingement Syndrome ; Shoulder Joint/diagnostic imaging
Language	English
Publishing date	2022-03-18
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2329-9185
ISSN (online)	2329-9185
DOI	e21.00194
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Estimating the incidence of psychosis in diverse settings.

Cohen, Alex / Morgan, Craig

Psychological medicine

2019 Volume 51, Issue 3, Page(s) 527–528

MeSH term(s)	Humans ; Incidence ; Psychotic Disorders/epidemiology ; Urban Population
Language	English
Publishing date	2019-12-17
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	217420-0
ISSN	1469-8978 ; 0033-2917
ISSN (online)	1469-8978
ISSN	0033-2917
DOI	10.1017/S0033291719003702
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Article ; Online: Sociodemographic and clinical predictors of delay to and length of stay with early intervention for psychosis service: findings from the CRIS-FEP study.

Oduola, Sherifat / Craig, Tom K J / Iacoponi, Eduardo / Macdonald, Alastair / Morgan, Craig

Social psychiatry and psychiatric epidemiology

2023 Volume 59, Issue 1, Page(s) 25–36

Abstract: Purpose: We investigated the influence of sociodemographic and clinical characteristics on delay to early intervention service (EIS) and the length of stay (LOS) with EIS.: Methods: We used incidence data linked to the Clinical Record Interactive ... ...

Abstract	Purpose: We investigated the influence of sociodemographic and clinical characteristics on delay to early intervention service (EIS) and the length of stay (LOS) with EIS. Methods: We used incidence data linked to the Clinical Record Interactive Search-First Episode Psychosis (CRIS-FEP) study. We followed the patients from May 2010 to March 2016. We performed multivariable Cox regression to estimate hazard ratios of delay to EIS. Negative binomial regression was used to determine LOS with EIS by sociodemographic and clinical characteristics, controlling for confounders. Results: 343 patients were eligible for an EIS, 34.1% of whom did not receive the service. Overall, the median delay to EIS was 120 days (IQR; 15-1668); and the median LOS was 130.5 days (IQR 0-663). We found that women (adj.HR 0.58; 95%C I 0.42-0.78), living alone (adj.HR: 0.63; 95% CI 0.43-0.92) and ethnicity ('Other': adj.HR 0.47; 95% CI 0.23-0.98) were associated with prolonged delay to EIS. However, family involvement in help-seeking for psychosis (adj.HR 1.37; 95% CI 1.01-1.85) was strongly associated with a shorter delay to EIS. Patients who have used mental health services previously also experienced long delays to EIS. Conclusions: Our analyses highlight the link between sociodemographic status, help-seeking behaviours, and delay to EIS. Our findings also show the vulnerability faced by those with a previous mental health problem who later develop psychosis in receiving specialist treatment for psychosis. Initiatives that ameliorate indicators of social disadvantage are urgently needed to reduce health inequalities and improve clinical outcomes.
MeSH term(s)	Humans ; Female ; Length of Stay ; Psychotic Disorders/diagnosis ; Psychotic Disorders/epidemiology ; Psychotic Disorders/therapy ; Mental Health Services ; Ethnicity/psychology ; Early Intervention, Educational
Language	English
Publishing date	2023-06-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	623071-4
ISSN	1433-9285 ; 0037-7813 ; 0933-7954
ISSN (online)	1433-9285
ISSN	0037-7813 ; 0933-7954
DOI	10.1007/s00127-023-02522-z
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Article ; Online: Indocyanine Green Fluorescence Angiography in Minor Lower Extremity Amputations: A Useful Technique?

Sakkab, Ramez / MacRae, Tyler M / Morgan, Craig / Longobardi, James

The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons

2022 Volume 62, Issue 2, Page(s) 267–271

Abstract: Complications remain despite conventional methods aimed at improving survivorship of lower extremity amputations. High rates of wound dehiscence, readmission, and revision surgery warrant the development of innovative methods to improve amputation ... ...

Abstract	Complications remain despite conventional methods aimed at improving survivorship of lower extremity amputations. High rates of wound dehiscence, readmission, and revision surgery warrant the development of innovative methods to improve amputation survivorship. One such method employs the use of indocyanine green dye (ICG); an inert chemical injected intraoperatively which can be used to visualize dermal blood flow in real time. There is little objective data available to help guide the use of indocyanine green in limb salvage procedures. The present study compares a group of 31 patients undergoing minor lower extremity amputation with the use of indocyanine green with a control group of 62 patients in which traditional methods were used. Minimum follow-up of 9 months was obtained, leaving 93 patients in total for analysis. Success was defined as a healed amputation within 60 days of follow-up. Uneventful amputation healing occurred in 35.5% and 33.9% of indocyanine green and control patients, respectively. Overall, there was no significant difference in outcomes between groups (p = .965), or success versus failure (p = 1.0). Patient undergoing minor lower extremity amputation with the use of ICG fluorescence angiography did not have statistically inferior outcomes to patients who underwent amputations at the same level with traditional assessments of perfusion. Further research involving the use of this technique is warranted.
MeSH term(s)	Humans ; Fluorescein Angiography ; Indocyanine Green ; Amputation, Surgical ; Wound Healing ; Lower Extremity/surgery ; Treatment Outcome ; Retrospective Studies
Chemical Substances	Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2022-07-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1146972-9
ISSN	1542-2224 ; 1067-2516
ISSN (online)	1542-2224
ISSN	1067-2516
DOI	10.1053/j.jfas.2022.07.005
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