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Book ; Online ; E-Book: Pathology of the placenta

Khong, T. Yee / Mooney, Eoghan E. / Nikkels, Peter G. J. / Morgan, Terry K. / Gordijn, Sanne J.

a practical guide

2019

Author's details	T. Yee Khong, Eoghan E. Mooney, Peter G. J. Nikkels, Terry K. Morgan, Sanne J. Gordijn editors
Keywords	Pathology ; Obstetrics ; Epidemiology ; Pediatrics
Subject code	616.07
Language	English
Size	1 Online-Ressource (XVI, 395 Seiten), Illustrationen
Publisher	Springer International Publishing
Publishing place	Cham
Publishing country	Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT021323381
ISBN	978-3-319-97214-5 ; 9783319972138 ; 3-319-97214-6 ; 3319972138
DOI	10.1007/978-3-319-97214-5
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Cell- and size-specific analysis of placental extracellular vesicles in maternal plasma and pre-eclampsia.

Morgan, Terry K

Translational research : the journal of laboratory and clinical medicine

2018 Volume 201, Page(s) 40–48

Abstract: Despite decades of investigation, we cannot predict, prevent, or adequately treat the most common and deadly complications of pregnancy, including pre-eclampsia (pregnancy-induced hypertension). The current working hypothesis for the repeated failures of ...

Abstract	Despite decades of investigation, we cannot predict, prevent, or adequately treat the most common and deadly complications of pregnancy, including pre-eclampsia (pregnancy-induced hypertension). The current working hypothesis for the repeated failures of several multicenter studies that measured a wide variety of biomarkers is common pregnancy complications like pre-eclampsia are most likely heterogeneous syndromes with various etiologies; therefore, no combination of blood-based biomarkers will provide predictive power. Although the clinical syndrome of pre-eclampsia may have various causes, the current dogma is most cases share similar placental pathology, including accelerated chorionic villous maturation and an increased frequency of malperfusion-related infarctions. This pathology is thought to begin in the late first trimester of pregnancy. The challenge has been to develop an approach to monitor placental health in vivo. New contrast-enhanced imaging studies of blood flow to the placenta are providing insights, but rapid liquid-based assays using maternal blood would be more cost-effective. Recently, there has been a growing interest in placental extracellular vesicles (EVs) to determine if these complex lipid-based spheres involved in intercellular communication offer clues to the early pathophysiology of placental damage. Most EVs are nanoscale-sized exosomes (∼60-120 nm) that retain cell-specific plasma membrane surface markers. Their concentration, composition, and relative size distribution may provide clinical predictive power, but more investigation is needed. A major obstacle to advancement in this field has been the lack of EV imaging and isolation assays that can provide both cell- and size-specificity. Nanoscale multiplex high-resolution flow cytometry being developed in a number of laboratories may provide a solution. It is a potential means to quantitate both cell- and size-specific EVs from various cell sources, including the placenta.
MeSH term(s)	Alkaline Phosphatase/analysis ; Cell Communication ; Extracellular Vesicles/physiology ; Female ; Flow Cytometry/methods ; GPI-Linked Proteins/analysis ; Humans ; Isoenzymes/analysis ; Placenta/pathology ; Pre-Eclampsia/pathology ; Pregnancy/blood
Chemical Substances	GPI-Linked Proteins ; Isoenzymes ; Alkaline Phosphatase (EC 3.1.3.1) ; alkaline phosphatase, placental (EC 3.1.3.1)
Language	English
Publishing date	2018-08-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2246684-8
ISSN	1878-1810 ; 1532-6543 ; 1931-5244
ISSN (online)	1878-1810 ; 1532-6543
ISSN	1931-5244
DOI	10.1016/j.trsl.2018.08.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Role of the Placenta in Preterm Birth: A Review.

Morgan, Terry K

American journal of perinatology

2016 Volume 33, Issue 3, Page(s) 258–266

Abstract: Preterm birth is a multifactorial syndrome with a variety of risk factors and long-term health consequences for the child. Placental pathology provides important diagnostic information to ascertain the cause of preterm birth. For example, intra-amniotic ... ...

Abstract	Preterm birth is a multifactorial syndrome with a variety of risk factors and long-term health consequences for the child. Placental pathology provides important diagnostic information to ascertain the cause of preterm birth. For example, intra-amniotic infection is one risk factor, but accumulating evidence based on placental pathology, amniotic fluid cultures, and polymerase chain reaction studies suggests infection may be a less common cause of preterm birth than previously suspected, especially after 32 weeks' gestation. Instead, many cases of spontaneous preterm labor leading to preterm birth appear to be caused by placental insufficiency, similar to preeclampsia and fetal growth restriction. Other causes of preterm birth, including retroplacental abruption, chronic villitis, and twin gestations, also have specific placental pathology related to placental insufficiency. New insights into the underlying mechanisms regulating uteroplacental blood flow and the impact of placental malperfusion on placental health may lead to improved early gestation diagnostic testing and a revolution in preventative care for both the mother and her child.
MeSH term(s)	Abruptio Placentae/pathology ; Female ; Fetal Growth Retardation/etiology ; Gestational Age ; Humans ; Infant, Newborn ; Obstetric Labor, Premature/etiology ; Placenta/pathology ; Placental Insufficiency/pathology ; Pre-Eclampsia/etiology ; Pregnancy ; Pregnancy, Twin ; Premature Birth/etiology
Language	English
Publishing date	2016-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	605671-4
ISSN	1098-8785 ; 0735-1631
ISSN (online)	1098-8785
ISSN	0735-1631
DOI	10.1055/s-0035-1570379
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Article: Role of the Placenta in Preterm Birth: A Review

Morgan, Terry K.

American Journal of Perinatology

2016 Volume 33, Issue 03, Page(s) 258–266

Abstract	Preterm birth is a multifactorial syndrome with a variety of risk factors and long-term health consequences for the child. Placental pathology provides important diagnostic information to ascertain the cause of preterm birth. For example, intra-amniotic infection is one risk factor, but accumulating evidence based on placental pathology, amniotic fluid cultures, and polymerase chain reaction studies suggests infection may be a less common cause of preterm birth than previously suspected, especially after 32 weeks' gestation. Instead, many cases of spontaneous preterm labor leading to preterm birth appear to be caused by placental insufficiency, similar to preeclampsia and fetal growth restriction. Other causes of preterm birth, including retroplacental abruption, chronic villitis, and twin gestations, also have specific placental pathology related to placental insufficiency. New insights into the underlying mechanisms regulating uteroplacental blood flow and the impact of placental malperfusion on placental health may lead to improved early gestation diagnostic testing and a revolution in preventative care for both the mother and her child.
Keywords	placental pathology ; preterm birth ; preterm labor ; preeclampsia ; fetal growth restriction
Language	English
Publishing date	2016-01-05
Publisher	Thieme Medical Publishers
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	605671-4
ISSN	1098-8785 ; 0735-1631
ISSN (online)	1098-8785
ISSN	0735-1631
DOI	10.1055/s-0035-1570379
Database	Thieme publisher's database

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Article ; Online: Autotaxin-lysolipid signaling suppresses a CCL11-eosinophil axis to promote pancreatic cancer progression.

Bhattacharyya, Sohinee / Oon, Chet / Diaz, Luis / Sandborg, Holly / Stempinski, Erin S / Saoi, Michelle / Morgan, Terry K / López, Claudia S / Cross, Justin R / Sherman, Mara H

Nature cancer

2024 Volume 5, Issue 2, Page(s) 283–298

Abstract: Lipids and their modifying enzymes regulate diverse features of the tumor microenvironment and cancer progression. The secreted enzyme autotaxin (ATX) hydrolyzes extracellular lysophosphatidylcholine to generate the multifunctional lipid mediator ... ...

Abstract	Lipids and their modifying enzymes regulate diverse features of the tumor microenvironment and cancer progression. The secreted enzyme autotaxin (ATX) hydrolyzes extracellular lysophosphatidylcholine to generate the multifunctional lipid mediator lysophosphatidic acid (LPA) and supports the growth of several tumor types, including pancreatic ductal adenocarcinoma (PDAC). Here we show that ATX suppresses the accumulation of eosinophils in the PDAC microenvironment. Genetic or pharmacologic ATX inhibition increased the number of intratumor eosinophils, which promote tumor cell apoptosis locally and suppress tumor progression. Mechanistically, ATX suppresses eosinophil accumulation via an autocrine feedback loop, wherein ATX-LPA signaling negatively regulates the activity of the AP-1 transcription factor c-Jun, in turn suppressing the expression of the potent eosinophil chemoattractant CCL11 (eotaxin-1). Eosinophils were identified in human PDAC specimens, and rare individuals with high intratumor eosinophil abundance had the longest overall survival. Together with recent findings, this study reveals the context-dependent, immune-modulatory potential of ATX-LPA signaling in cancer.
MeSH term(s)	Humans ; Eosinophils/metabolism ; Chemokine CCL11 ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Neoplastic Processes ; Lysophosphatidylcholines/metabolism ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/genetics ; Tumor Microenvironment
Chemical Substances	Chemokine CCL11 ; Lysophosphatidylcholines ; CCL11 protein, human
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article
ISSN	2662-1347
ISSN (online)	2662-1347
DOI	10.1038/s43018-023-00703-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Editorial: Uteroplacental mingling: who's kissing uNK?

Morgan, Terry K / Beristain, Alexander G

Journal of leukocyte biology

2016 Volume 100, Issue 4, Page(s) 637–639

Language	English
Publishing date	2016-10
Publishing country	United States
Document type	Editorial
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1189/jlb.1CE0316-162R
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Article: Nonhuman Primate Models of Zika Virus Infection and Disease during Pregnancy

Haese, Nicole N. / Roberts, Victoria H. J. / Chen, Athena / Streblow, Daniel N. / Morgan, Terry K. / Hirsch, Alec J.

Viruses. 2021 Oct. 16, v. 13, no. 10

2021

Abstract: Since the explosive outbreak of Zika virus in Brazil and South/Central America in 2015–2016, the frequency of infections has subsided, but Zika virus remains present in this region as well as other tropical and sub-tropical areas of the globe. The most ... ...

Abstract	Since the explosive outbreak of Zika virus in Brazil and South/Central America in 2015–2016, the frequency of infections has subsided, but Zika virus remains present in this region as well as other tropical and sub-tropical areas of the globe. The most alarming aspect of Zika virus infection is its association with severe birth defects when infection occurs in pregnant women. Understanding the mechanism of Zika virus pathogenesis, which comprises features unique to Zika virus as well as shared with other teratogenic pathogens, is key to future prophylactic or therapeutic interventions. Nonhuman primate-based research has played a significant role in advancing our knowledge of Zika virus pathogenesis, especially with regard to fetal infection. This review summarizes what we have learned from these models and potential future research directions.
Keywords	Zika virus ; pathogenesis ; pregnancy ; teratogenicity ; therapeutics ; Brazil ; Central America
Language	English
Dates of publication	2021-1016
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v13102088
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Immunocytochemical analysis of the cervical Pap smear.

Morgan, Terry K / Berlin, Michelle

Methods in molecular biology (Clifton, N.J.)

2015 Volume 1249, Page(s) 203–212

Abstract: Although immunostained cervical Pap smears are not yet FDA approved for clinical use, it is very likely that they will become widely employed in the near future to identify neoplastic squamous and iendocervical glandular cells when screening liquid-based ...

Abstract	Although immunostained cervical Pap smears are not yet FDA approved for clinical use, it is very likely that they will become widely employed in the near future to identify neoplastic squamous and iendocervical glandular cells when screening liquid-based cytological preparations (i.e., SurePath™ or ThinPrep™). The current problem with cytology complemented by high-risk human papillomavirus (HPV) testing is poor specificity. HPV testing provides superior sensitivity, but many women are infected with the virus, while very few have had persistent infections leading to carcinoma. Pathologists routinely use antibodies directed against the cyclin-dependent kinase inhibitor p16 (p16(INK4a)) or a combination of antibodies directed against topoisomerase-2-alpha and minichromosome maintenance protein-2 (as in ProEx™ C) to improve diagnostic precision and accuracy in cervical tissue biopsies. This chapter will describe the immunocytochemical methods used by our group to immunostain cervical Pap smears and provide significantly improved positive predictive value when screening for cervical cancer.
MeSH term(s)	Biopsy ; Cervix Uteri/pathology ; Cervix Uteri/virology ; Female ; Humans ; Immunohistochemistry/methods ; Papanicolaou Test/methods ; Papillomaviridae/physiology ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/pathology ; Papillomavirus Infections/virology
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-2013-6_15
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Placental adaptations in a nonhuman primate model of gestational protein restriction.

Roberts, Victoria H J / Gaffney, Jessica E / Morgan, Terry K / Frias, Antonio E

Journal of developmental origins of health and disease

2020 Volume 12, Issue 6, Page(s) 908–914

Abstract: We previously demonstrated decreased placental perfusion, reduced amniotic fluid protein content, and increased pregnancy loss in a nonhuman primate model of gestational protein restriction. Here, our objective was to link these detrimental findings with ...

Abstract	We previously demonstrated decreased placental perfusion, reduced amniotic fluid protein content, and increased pregnancy loss in a nonhuman primate model of gestational protein restriction. Here, our objective was to link these detrimental findings with a functional placental assessment. As blood flow is critical to maternal-fetal exchange, we hypothesized that a protein-restricted diet would impair placental taurine uptake. Pregnant rhesus macaques were maintained on either control chow (CON, n = 5), a 33% protein-restricted diet (PR33, n = 5), or a 50% PR diet (PR50, n = 5) prior to and throughout pregnancy. Animals were delivered on gestational day 135 (G135; term is G168). Taurine activity was determined in fresh placental villous explants. Taurine transporter (TauT) protein expression, placental growth factor (PLGF), and insulin-like growth factor (IGF)-1 and IGF-2 protein concentrations were measured, and histological assessment was performed. Fetal body weights and placental weights were comparable between all three groups at G135. Placental taurine uptake was decreased in PR33- and PR50-fed animals compared to CON, yet TauT expression was unchanged across groups. PLGF was significantly increased in PR50 vs. CON, with no change in IGF-1 or IGF-2 expression in placental homogenate from PR-fed animals. Accelerated villous maturation was observed in all PR50 cases, three of five PR33, and was absent in CON. We demonstrate conserved fetal growth, despite a decrease in placental taurine uptake. Increased expression of PLGF and expansion of the syncytiotrophoblast surface area in the severely protein-restricted animals suggest a compensatory mechanism by the placenta to maintain fetal growth.
MeSH term(s)	Animals ; Diet, Protein-Restricted/adverse effects ; Diet, Protein-Restricted/methods ; Disease Models, Animal ; Female ; Fetal Growth Retardation/physiopathology ; Macaca mulatta/abnormalities ; Placenta/physiopathology ; Placenta Growth Factor/metabolism ; Pregnancy
Chemical Substances	Placenta Growth Factor (144589-93-5)
Language	English
Publishing date	2020-12-14
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2554780-X
ISSN	2040-1752 ; 2040-1744
ISSN (online)	2040-1752
ISSN	2040-1744
DOI	10.1017/S204017442000121X
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Article ; Online: Deletion of the mRNA stability factor

McCarthy, Grace A / Di Niro, Roberto / Finan, Jennifer M / Jain, Aditi / Guo, Yifei / Wyatt, Cory R / Guimaraes, Alexander R / Waugh, Trent A / Keith, Dove / Morgan, Terry K / Sears, Rosalie C / Brody, Jonathan R

NAR cancer

2023 Volume 5, Issue 2, Page(s) zcad016

Abstract: Stromal cells promote extensive fibrosis in pancreatic ductal adenocarcinoma (PDAC), which is associated with poor prognosis and therapeutic resistance. We report here for the first time that loss of the RNA-binding protein human antigen R (HuR, ...

Abstract	Stromal cells promote extensive fibrosis in pancreatic ductal adenocarcinoma (PDAC), which is associated with poor prognosis and therapeutic resistance. We report here for the first time that loss of the RNA-binding protein human antigen R (HuR,
Language	English
Publishing date	2023-04-19
Publishing country	England
Document type	Journal Article
ISSN	2632-8674
ISSN (online)	2632-8674
DOI	10.1093/narcan/zcad016
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