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  1. Article ; Online: Additional Thoughts on Intrinsic Dysanapsis.

    Tepper, Robert S / Morgan, Wayne J / Taussig, Lynn M

    American journal of respiratory and critical care medicine

    2024  Volume 209, Issue 8, Page(s) 1040–1041

    MeSH term(s) Humans ; Vital Capacity ; Forced Expiratory Volume
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Letter
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202312-2226LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Omitting placebos from early-stage clinical trials of cystic fibrosis therapies.

    Simon, Richard H / Quittell, Lynne M / Morgan, Wayne J

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2023  Volume 23, Issue 1, Page(s) 65–67

    MeSH term(s) Humans ; Cystic Fibrosis/drug therapy
    Language English
    Publishing date 2023-12-27
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2023.12.010
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  3. Article ; Online: The Future of Highly Effective Modulator Therapy in Cystic Fibrosis.

    Daines, Cori L / Morgan, Wayne J

    American journal of respiratory and critical care medicine

    2021  Volume 203, Issue 12, Page(s) 1453–1455

    MeSH term(s) Aminophenols/therapeutic use ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Humans
    Chemical Substances Aminophenols ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2021-04-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202104-0850ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The impact of switching to race-neutral reference equations on FEV

    Rosenfeld, Margaret / Cromwell, Elizabeth A / Schechter, Michael S / Ren, Clement / Flume, Patrick A / Szczesniak, Rhonda D / Morgan, Wayne J / Jain, Raksha

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2024  

    Abstract: Rationale: The American Thoracic Society recommended switching to race-neutral spirometry reference equations, as race is a social construct and to avoid normalizing disparities in lung function due to structural racism. Understanding the impact of the ... ...

    Abstract Rationale: The American Thoracic Society recommended switching to race-neutral spirometry reference equations, as race is a social construct and to avoid normalizing disparities in lung function due to structural racism. Understanding the impact of the race-neutral equations on percent predicted forced expiratory volume in one second (ppFEV
    Objective(s): To quantify the impact of switching from Global Lung Initiative (GLI) 2012 race-specific to GLI 2022 Global race-neutral reference equations on the distribution of ppFEV
    Methods: Cross-sectional analysis of FEV
    Results: With the switch to GLI Global, ppFEV
    Conclusions: Switching from GLI 2012 race-specific reference equations to GLI 2022 Global race-neutral equations will result in larger reductions in ppFEV
    Language English
    Publishing date 2024-03-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2024.03.013
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  5. Article ; Online: Corrigendum to FEV1 Variability Helps Identify Patients with Cystic Fibrosis at Risk of Greater Loss of Lung Function [The Journal of Pediatrics (2016) 116-121].

    Morgan, Wayne J / VanDevanter, Donald R / Pasta, David J / Foreman, Aimee J / Wagener, Jeffrey S / Konstan, Michael W

    The Journal of pediatrics

    2023  Volume 255, Page(s) 265

    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2022.12.017
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  6. Article ; Online: Defining and Promoting Pediatric Pulmonary Health: Assessing Lung Function and Structure.

    DeBoer, Emily M / Morgan, Wayne J / Quiros-Alcala, Lesliam / Rosenfeld, Margaret / Stout, James W / Davis, Stephanie D / Gaffin, Jonathan M

    Pediatrics

    2023  Volume 152, Issue Suppl 2

    Abstract: Lifelong respiratory health is rooted in the structural and functional development of the respiratory system in early life. Exposures and interventions antenatally through childhood can influence lung development into young adulthood, the life stage with ...

    Abstract Lifelong respiratory health is rooted in the structural and functional development of the respiratory system in early life. Exposures and interventions antenatally through childhood can influence lung development into young adulthood, the life stage with the highest achievable lung function. Because early respiratory health sets the stage for adult lung function trajectories and risk of developing chronic obstructive pulmonary disease, understanding how to promote lung health in children will have far reaching personal and population benefits. To achieve this, it is critical to have accurate and precise measures of structural and functional lung development that track throughout life stages. From this foundation, evaluation of environmental, genetic, metabolic, and immune mechanisms involved in healthy lung development can be investigated. These goals require the involvement of general pediatricians, pediatric subspecialists, patients, and researchers to design and implement studies that are broadly generalizable and applicable to otherwise healthy and chronic disease populations. This National Institutes of Health workshop report details the key gaps and opportunities regarding lung function and structure.
    MeSH term(s) United States ; Adult ; Child ; Humans ; Young Adult ; Health Status ; National Institutes of Health (U.S.) ; Pediatricians ; Respiratory Rate ; Lung
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2023-062292E
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    Zs.MO 357: Show issues

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  7. Article ; Online: Planning the future of newborn screening for cystic fibrosis.

    Daines, Cori L / Morgan, Wayne J

    Pediatric pulmonology

    2016  Volume 51, Issue 9, Page(s) 883–885

    Language English
    Publishing date 2016-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.23466
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  8. Article ; Online: Epidemiologic Study of Cystic Fibrosis: 25 years of observational research.

    Konstan, Michael W / Pasta, David J / VanDevanter, Donald R / Wagener, Jeffrey S / Morgan, Wayne J

    Pediatric pulmonology

    2021  Volume 56, Issue 5, Page(s) 823–836

    Abstract: The Epidemiologic Study of Cystic Fibrosis (ESCF) was a prospective observational study of over 32,000 people with cystic fibrosis (CF) from 250 clinical care sites in North America from 1994 to 2005. Begun as a pharmacovigilance study in connection with ...

    Abstract The Epidemiologic Study of Cystic Fibrosis (ESCF) was a prospective observational study of over 32,000 people with cystic fibrosis (CF) from 250 clinical care sites in North America from 1994 to 2005. Begun as a pharmacovigilance study in connection with the approval of dornase alfa in 1993, ESCF was open to all people with CF treated at any participating site in the United States or Canada. In addition to obtaining safety and effectiveness data on dornase alfa, ESCF collected encounter-based data to characterize the natural history and management of CF with a special focus on lung disease. During the study, 32,178 patients reported at least one encounter, contributing 869,136 encounters, 622,592 pulmonary function tests, 432,896 cultures, and 118,563 pulmonary exacerbations treated with intravenous antibiotics. Although ESCF data collection concluded in 2005, through a collaboration with the U.S. Cystic Fibrosis Foundation Patient Registry, additional follow-up data through 2017 was available for two-thirds of patients. This allowed for updating of CF genotype and survival information. Fifty-six peer-reviewed publications (cited over 3600 times) resulted from this study. In this manuscript we summarize the published ESCF manuscripts in thematic groups with key study findings and brief comments, and speculate on how ESCF findings will inform future data registries and patient care practices.
    MeSH term(s) Administration, Intravenous ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/epidemiology ; Deoxyribonuclease I/therapeutic use ; Humans ; Lung ; Observational Studies as Topic ; Prospective Studies ; Respiratory Function Tests ; United States/epidemiology
    Chemical Substances Deoxyribonuclease I (EC 3.1.21.1)
    Language English
    Publishing date 2021-01-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.25248
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Association of Childhood Respiratory Status with Adult Occupational Exposures in a Birth Cohort.

    Harber, Philip / Furlong, Melissa / Stern, Debra A / Morgan, Wayne J / Wright, Anne L / Guerra, Stefano / Martinez, Fernando D

    Annals of the American Thoracic Society

    2022  Volume 20, Issue 3, Page(s) 390–396

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Adolescent ; Child ; Infant, Newborn ; Adult ; Humans ; Birth Cohort ; Prospective Studies ; Occupational Exposure ; Forced Expiratory Volume ; Vital Capacity ; Dust ; Smoke ; Lung
    Chemical Substances Dust ; Smoke
    Language English
    Publishing date 2022-11-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202204-293OC
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  10. Article ; Online: Lower respiratory illnesses in childhood are associated with the presence of air trapping in early adulthood.

    Polverino, Francesca / Stern, Debra A / Snyder, Eric M / Wheatley-Guy, Courtney / Bhatt, Surya P / Martinez, Fernando D / Guerra, Stefano / Morgan, Wayne J

    Respiratory medicine

    2022  Volume 206, Page(s) 107062

    Abstract: Several factors occurring in early life, including lower respiratory tract illnesses (LRIs), are involved in determining lung structure and function in adulthood, but the effects of these factors on lung development remain largely unknown. Hereby, we ... ...

    Abstract Several factors occurring in early life, including lower respiratory tract illnesses (LRIs), are involved in determining lung structure and function in adulthood, but the effects of these factors on lung development remain largely unknown. Hereby, we evaluated the parameters from computed tomography (CT) scans performed at the age of 26 years in 39 subjects from the birth cohort of the Tucson Children's Respiratory Study (TCRS) in order to determine the relationship between early childhood factors and lung structural changes in young adult life. We found that participants with LRIs in childhood had increased air trapping at the age of 26 suggesting an association between childhood infections and lung development.
    MeSH term(s) Child ; Young Adult ; Humans ; Child, Preschool ; Adult ; Risk Factors ; Lung/diagnostic imaging
    Language English
    Publishing date 2022-11-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2022.107062
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