Article ; Online: The human long non-coding RNA LINC00941 and its modes of action in health and disease.
2023 Volume 404, Issue 11-12, Page(s) 1025–1036
Abstract: Long non-coding RNAs have gained attention in recent years as they were shown to play crucial roles in the regulation of cellular processes, but the understanding of the exact mechanisms is still incomplete in most cases. This is also true for long non- ... ...
| Abstract | Long non-coding RNAs have gained attention in recent years as they were shown to play crucial roles in the regulation of cellular processes, but the understanding of the exact mechanisms is still incomplete in most cases. This is also true for long non-coding RNA LINC00941, which was recently found to be highly upregulated in various types of cancer influencing cell proliferation and metastasis. Initial studies could not elucidate the mode of action to understand the role and real impact of LINC00941 in tissue homeostasis and cancer development. However, recent analyses have demonstrated multiple potential modes of action of LINC00941 influencing the functionality of various cancer cell types. Correspondingly, LINC00941 was proposed to be involved in regulation of mRNA transcription and modulation of protein stability, respectively. In addition, several experimental approaches suggest a function of LINC00941 as competitive endogenous RNA, thus acting in a post-transcriptional regulatory fashion. This review summarizes our recent knowledge about the mechanisms of action of LINC00941 elucidated so far and discusses its putative role in miRNA sequestering processes. In addition, the functional role of LINC00941 in regulating human keratinocytes is discussed to also highlight its role in normal tissue homeostasis tissue aside from its involvement in cancer. |
|---|---|
| MeSH term(s) | Humans ; RNA, Long Noncoding/genetics ; RNA, Messenger/genetics ; MicroRNAs/genetics ; Gene Expression Regulation ; Neoplasms/genetics |
| Chemical Substances | RNA, Long Noncoding ; RNA, Messenger ; MicroRNAs |
| Language | English |
| Publishing date | 2023-07-10 |
| Publishing country | Germany |
| Document type | Journal Article ; Review ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1334659-3 |
| ISSN | 1437-4315 ; 1431-6730 ; 1432-0355 |
| ISSN (online) | 1437-4315 |
| ISSN | 1431-6730 ; 1432-0355 |
| DOI | 10.1515/hsz-2023-0183 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Uc I Zs.50: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.