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  1. Article ; Online: Massive Calcification in A Nonfunctioning Transplanted Kidney.

    Morimoto, Kohkichi / Yoshida, Tadashi

    Iranian journal of kidney diseases

    2021  Volume 15, Issue 3, Page(s) 168

    Abstract: No Abstract. ...

    Abstract No Abstract.
    MeSH term(s) Kidney/diagnostic imaging ; Kidney Transplantation/adverse effects
    Language English
    Publishing date 2021-05-14
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2388271-2
    ISSN 1735-8604 ; 1735-8582
    ISSN (online) 1735-8604
    ISSN 1735-8582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Calcium carbonate occluding a peritoneal dialysis catheter.

    Mitsuno, Ryunosuke / Nakayama, Takashin / Morimoto, Kohkichi

    Clinical and experimental nephrology

    2022  

    Language English
    Publishing date 2022-09-10
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-022-02269-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pyometra in a hemodialysis patient with severe constipation.

    Morimoto, Kohkichi / Yoshida, Tadashi / Oya, Mototsugu

    Clinical and experimental nephrology

    2020  Volume 24, Issue 9, Page(s) 849

    MeSH term(s) Aged, 80 and over ; Constipation/complications ; Constipation/diagnostic imaging ; Female ; Humans ; Pyometra/diagnostic imaging ; Pyometra/etiology ; Tomography, X-Ray Computed
    Language English
    Publishing date 2020-05-15
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-020-01900-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Peritoneal dialysis-related peritonitis caused by Paracoccus yeei.

    Nakayama, Takashin / Morimoto, Kohkichi / Uchiyama, Kiyotaka

    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

    2020  Volume 25, Issue 5, Page(s) 715–717

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Ceftriaxone/therapeutic use ; Gram-Negative Bacterial Infections/complications ; Gram-Negative Bacterial Infections/drug therapy ; Humans ; Male ; Middle Aged ; Paracoccus/isolation & purification ; Peritoneal Dialysis/adverse effects ; Peritonitis/drug therapy ; Peritonitis/etiology ; Peritonitis/microbiology
    Chemical Substances Anti-Bacterial Agents ; Ceftriaxone (75J73V1629)
    Language English
    Publishing date 2020-12-13
    Publishing country Australia
    Document type Case Reports ; Letter
    ZDB-ID 2119809-3
    ISSN 1744-9987 ; 1091-6660 ; 1744-9979
    ISSN (online) 1744-9987
    ISSN 1091-6660 ; 1744-9979
    DOI 10.1111/1744-9987.13604
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hemodialysis treatment of vancomycin-induced drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome in a patient undergoing peritoneal dialysis.

    Mitsuno, Ryunosuke / Nakayama, Takashin / Uchiyama, Kiyotaka / Yoshimoto, Norifumi / Kusahana, Ei / Morimoto, Kohkichi / Yoshino, Jun / Yoshida, Tadashi / Kanda, Takeshi / Yamaguchi, Shintaro / Hayashi, Kaori

    CEN case reports

    2024  

    Abstract: Drug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DIHS), is a severe drug-induced hypersensitivity reaction with 10% mortality. To date, there is insufficient evidence regarding the ... ...

    Abstract Drug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DIHS), is a severe drug-induced hypersensitivity reaction with 10% mortality. To date, there is insufficient evidence regarding the association between DRESS/DIHS and serum levels of vancomycin (VCM). Here, we report the case of a 46-year-old woman undergoing peritoneal dialysis who developed VCM-induced DRESS/DIHS. She was hospitalized for peritonitis with abdominal pain and treated with VCM. On day 10 of hospitalization, her abdominal symptoms improved; however, fever, skin rash, lymphadenopathy, eosinophilia, atypical lymphocytes, and liver and renal dysfunction developed. Based on the clinical course and laboratory findings, we diagnosed the patient with DRESS/DIHS due to VCM. Since her serum VCM concentration was high at 39.8 μg/mL, hemodialysis (HD) was performed to remove VCM, which caused her symptoms to improve. However, serum levels of VCM rebounded and the same symptoms recurred. Therefore, we re-performed HD; no further relapse occurred. This clinical course showed that increased serum VCM levels were associated with DRESS/DIHS onset and severity, suggesting that it is a blood level-dependent disease and that removal of VCM by HD is a potential therapeutic option.
    Language English
    Publishing date 2024-02-10
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2660492-9
    ISSN 2192-4449 ; 2192-4449
    ISSN (online) 2192-4449
    ISSN 2192-4449
    DOI 10.1007/s13730-023-00847-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Developments in understanding bile acid metabolism.

    Morimoto, Kohkichi / Itoh, Hiroshi / Watanabe, Mitsuhiro

    Expert review of endocrinology & metabolism

    2019  Volume 8, Issue 1, Page(s) 59–69

    Abstract: Bile acids (BAs) are not only facilitators participating in the absorption of dietary lipids and soluble vitamins, but are also important signaling molecules exerting versatile biophysiological effects. Three major signaling pathways, including the MAPK ... ...

    Abstract Bile acids (BAs) are not only facilitators participating in the absorption of dietary lipids and soluble vitamins, but are also important signaling molecules exerting versatile biophysiological effects. Three major signaling pathways, including the MAPK pathways, the nuclear hormone receptor farnesoid X receptor a-mediated pathways and the G protein-coupled receptor TGR5/M-BAR-mediated pathways, have been identified to be the targets of BAs. BAs, the biologically many-sided and toxic molecules, regulate the homeostasis of themselves via these signaling pathways. BAs also affect diverse metabolic status including glucose metabolism, lipid metabolism, energy expenditure, immunity and others. BAs and their related signaling mechanisms are attractive therapeutic targets of various diseases such as metabolic syndrome.
    Language English
    Publishing date 2019-02-07
    Publishing country England
    Document type Journal Article
    ISSN 1744-8417
    ISSN (online) 1744-8417
    DOI 10.1586/eem.12.75
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Eosinophilic Reaction at the Time of Catheter Insertion Predicts Survival in Patients Initiating Peritoneal Dialysis.

    Uchiyama, Kiyotaka / Washida, Naoki / Kusahana, Ei / Nakayama, Takashin / Morimoto, Kohkichi / Itoh, Hiroshi

    Blood purification

    2021  Volume 51, Issue 4, Page(s) 355–364

    Abstract: Introduction: Despite excellent biocompatibility, insertion of silicone peritoneal dialysis (PD) catheters can induce minor foreign body reaction, affecting long-term patient outcomes. We evaluated the effect of eosinophilic reaction associated with PD ... ...

    Abstract Introduction: Despite excellent biocompatibility, insertion of silicone peritoneal dialysis (PD) catheters can induce minor foreign body reaction, affecting long-term patient outcomes. We evaluated the effect of eosinophilic reaction associated with PD catheter insertion on outcomes of patients initiating PD.
    Methods: Eosinophilic reaction to PD catheter insertion was defined as the ratio of peripheral blood eosinophil count at 1 week after insertion (E1W) to pre-insertion eosinophil count (E0), and the association of E1W/E0 with technique survival, peritonitis-free survival, and heart failure (HF)-related hospitalization-free survival was analyzed.
    Results: This retrospective cohort study included 116 patients (89 male patients) who underwent PD catheter insertion between January 2008 and June 2018 (61.3 ± 12.9 years). The follow-up duration was 46.2 (23.8-75.3) months. E1W was significantly higher than E0 (median, 333 vs. 234/μL, p < 0.001), with a median E1W/E0 of 1.54. The log-rank test showed that technique survival, peritonitis-free survival, and HF-related hospitalization-free survival were significantly better in patients with E1W/E0 < 1.54 than in those with E1W/E0 ≥ 1.54 (p = 0.002, <0.001, and <0.001, respectively). By the Cox regression analysis adjusted for age, sex, the Charlson comorbidity index, the estimated glomerular filtration rate, and the geriatric nutritional risk index, E1W/E0 remained a significant risk factor for technique failure, peritonitis, and hospitalization for HF (hazard ratio (HR) 1.68, p = 0.01; HR 2.19, p < 0.001; HR 2.15, p < 0.001, respectively).
    Conclusion: Eosinophilic reaction at the time of PD catheter insertion is a novel marker that may predict outcomes in patients initiating PD.
    MeSH term(s) Aged ; Catheters/adverse effects ; Catheters, Indwelling/adverse effects ; Humans ; Kidney Failure, Chronic/complications ; Male ; Peritoneal Dialysis/methods ; Peritonitis/etiology ; Retrospective Studies
    Language English
    Publishing date 2021-07-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 605548-5
    ISSN 1421-9735 ; 0253-5068
    ISSN (online) 1421-9735
    ISSN 0253-5068
    DOI 10.1159/000517349
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  8. Article ; Online: Bullous pemphigoid in patients receiving peritoneal dialysis: a case series and a literature survey.

    Morimoto, Kohkichi / Yoshida, Tadashi / Washida, Naoki / Uchiyama, Kiyotaka / Nakayama, Takashin / Itoh, Hiroshi / Oya, Mototsugu

    Renal failure

    2021  Volume 43, Issue 1, Page(s) 651–657

    Abstract: Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease. Although several cases of BP in end-stage renal disease patients receiving peritoneal dialysis (PD) or hemodialysis have been reported, the incidence of BP in these patients ... ...

    Abstract Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease. Although several cases of BP in end-stage renal disease patients receiving peritoneal dialysis (PD) or hemodialysis have been reported, the incidence of BP in these patients remains unknown. We recently experienced three PD patients diagnosed with BP. The skin injury was likely to be a trigger of BP in all the three PD patients. Nifedipine and icodextrin exposures were possible factors directly or indirectly affecting the onset of BP, because they were common in the three cases. We also report that the incidence of BP in PD patients was 3/478.3 person-years in a single-center 10-year study. This case series with a literature survey describes that the skin and tissue injuries are potential triggers responsible for the onset of BP in dialysis patients and that the incidence of BP in these patients seems to be much higher than that in the general population.
    MeSH term(s) Aged ; Autoantibodies/metabolism ; Female ; Humans ; Icodextrin/adverse effects ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Nifedipine/adverse effects ; Pemphigoid, Bullous/etiology ; Pemphigoid, Bullous/immunology ; Peritoneal Dialysis/adverse effects ; Skin/pathology
    Chemical Substances Autoantibodies ; Icodextrin (2NX48Z0A9G) ; Nifedipine (I9ZF7L6G2L)
    Language English
    Publishing date 2021-04-01
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 632949-4
    ISSN 1525-6049 ; 0886-022X
    ISSN (online) 1525-6049
    ISSN 0886-022X
    DOI 10.1080/0886022X.2021.1910045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Health-Related Quality of Life Sleep Score Predicts Transfer to Hemodialysis among Patients on Peritoneal Dialysis.

    Nagasaka, Tomoki / Washida, Naoki / Uchiyama, Kiyotaka / Hama, Eriko Yoshida / Kusahana, Ei / Nakayama, Takashin / Yasuda, Itaru / Morimoto, Kohkichi / Itoh, Hiroshi

    Healthcare (Basel, Switzerland)

    2022  Volume 10, Issue 6

    Abstract: Despite the superiority of peritoneal dialysis (PD) over hemodialysis (HD) regarding health-related quality of life (HRQOL), the specific HRQOL domain(s) that predict unplanned HD transfer remains uncertain. In this cohort study, we assessed the HRQOL of ...

    Abstract Despite the superiority of peritoneal dialysis (PD) over hemodialysis (HD) regarding health-related quality of life (HRQOL), the specific HRQOL domain(s) that predict unplanned HD transfer remains uncertain. In this cohort study, we assessed the HRQOL of 50 outpatients undergoing PD using the Japanese version 1.3 Kidney Disease Quality of Life-Short Form from March 2017 to March 2018 and prospectively analyzed the association of each HRQOL component with HD transfer until June 2021. During the follow-up (41.5 (13.0-50.1) months), 21 patients were transferred to HD. In a multivariate Cox proportional hazards model adjusted for age, sex, PD vintage, urine output, Charlson comorbidity index, and incremental shuttle walking test, a higher sleep score was significantly associated with lower HD transfer rates (HR 0.70 per 10,
    Language English
    Publishing date 2022-06-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare10061030
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  10. Article: Late Dialysis Modality Education Could Negatively Predict Peritoneal Dialysis Selection.

    Nakayama, Takashin / Nishioka, Ken / Uchiyama, Kiyotaka / Morimoto, Kohkichi / Kusahana, Ei / Washida, Naoki / Yamaguchi, Shintaro / Azegami, Tatsuhiko / Yoshida, Tadashi / Itoh, Hiroshi

    Journal of clinical medicine

    2022  Volume 11, Issue 14

    Abstract: Patients with end-stage renal disease are less likely to choose peritoneal dialysis (PD) as renal replacement therapy (RRT). The reasons for this biased selection are still poorly understood. In this study, we evaluated the effect of the timing of RRT ... ...

    Abstract Patients with end-stage renal disease are less likely to choose peritoneal dialysis (PD) as renal replacement therapy (RRT). The reasons for this biased selection are still poorly understood. In this study, we evaluated the effect of the timing of RRT education on PD selection. This single-center retrospective observational study included patients who initiated maintenance dialysis at our hospital between April 2014 and July 2021. A logistic regression analysis was performed to investigate the association of RRT education timing with PD selection. Among the 355 participants (median age [IQR] 70 (59−79) years; 28.7% female), 53 patients (14.9%) and 302 patients (85.1%) selected PD and hemodialysis, respectively. Multivariate analysis demonstrated that high estimated glomerular filtration (eGFR) at RRT education positively predicted PD selection (p < 0.05), whereas old age (p < 0.01) and high Charlson comorbidity index (p < 0.05) were negative predictors of PD selection. Female sex (p = 0.44), welfare public assistance (p = 0.78), living alone (p = 0.25), high geriatric nutritional risk index (p = 0.10) and high eGFR at first visit to the nephrology department (p = 0.83) were not significantly associated with PD selection. Late RRT education could increase the biased selection of dialysis modality.
    Language English
    Publishing date 2022-07-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11144042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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