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  1. Book ; Online ; Conference proceedings: Selected Papers from the 9th Symposium on Micro-Nano Science and Technology on Micromachines

    Miki, Norihisa / Morimoto, Yuya / Miyazaki, Koji

    2019  

    Abstract: This Special Issue presents selected papers from the ... ...

    Abstract This Special Issue presents selected papers from the 8th
    Keywords Technology (General)
    Size 1 electronic resource (170 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online ; Conference proceedings
    Note eng ; Open Access
    HBZ-ID HT020324160
    ISBN 9783039216963 ; 9783039216970 ; 3039216961 ; 303921697X
    DOI 10.3390/books978-3-03921-697-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; Conference proceedings: Selected Papers from the 8th Symposium on Micro-Nano Science and Technology on Micromachines

    Miki, Norihisa / Miyazaki, Koji / Morimoto, Yuya

    2019  

    Abstract: This Special Issue presents selected papers from the ... ...

    Abstract This Special Issue presents selected papers from the 8th
    Keywords Technology (General)
    Size 1 electronic resource (154 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online ; Conference proceedings
    Note eng ; Open Access
    HBZ-ID HT020307437
    ISBN 9783038977285 ; 9783038977292 ; 3038977284 ; 3038977292
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Attosecond electron-beam technology: a review of recent progress.

    Morimoto, Yuya

    Microscopy (Oxford, England)

    2022  Volume 72, Issue 1, Page(s) 2–17

    Abstract: Electron microscopy and diffraction with ultrashort pulsed electron beams are capable of imaging transient phenomena with the combined ultrafast temporal and atomic-scale spatial resolutions. The emerging field of optical electron beam control allowed ... ...

    Abstract Electron microscopy and diffraction with ultrashort pulsed electron beams are capable of imaging transient phenomena with the combined ultrafast temporal and atomic-scale spatial resolutions. The emerging field of optical electron beam control allowed the manipulation of relativistic and sub-relativistic electron beams at the level of optical cycles. Specifically, it enabled the generation of electron beams in the form of attosecond pulse trains and individual attosecond pulses. In this review, we describe the basics of the attosecond electron beam control and overview the recent experimental progress. High-energy electron pulses of attosecond sub-optical cycle duration open up novel opportunities for space-time-resolved imaging of ultrafast chemical and physical processes, coherent photon generation, free electron quantum optics, electron-atom scattering with shaped wave packets and laser-driven particle acceleration. Graphical Abstract.
    Language English
    Publishing date 2022-11-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2707496-1
    ISSN 2050-5701 ; 2050-5698
    ISSN (online) 2050-5701
    ISSN 2050-5698
    DOI 10.1093/jmicro/dfac054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1211: Show issues Location:
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  4. Article ; Online: Pillar electrodes embedded in the skeletal muscle tissue for selective stimulation of biohybrid actuators with increased contractile distance.

    Li, Tingyu / Nie, Minghao / Morimoto, Yuya / Takeuchi, Shoji

    Biofabrication

    2024  

    Abstract: Electrodes are crucial for controlling the movements of biohybrid robots, but their external placement outside muscle tissue often leads to inefficient and non-selective stimulation of nearby biohybrid actuators. To address this, we propose embedding ... ...

    Abstract Electrodes are crucial for controlling the movements of biohybrid robots, but their external placement outside muscle tissue often leads to inefficient and non-selective stimulation of nearby biohybrid actuators. To address this, we propose embedding pillar electrodes within the skeletal muscle tissue, resulting in enhanced contraction of the target muscle without affecting the neighbor tissue with a 4 mm distance. We use finite element method (FEM) simulations to establish a selectivity model, correlating the VIE (volume integration of electric field intensity within muscle tissue) with actual contractile distances under different amplitudes of electrical pulses. The simulated selective index closely aligns with experimental results, showing the potential of pillar electrodes for effective and selective biohybrid actuator stimulation. In experiments, we validated that the contractile distance and selectivity achieved with these pillar electrodes exceed conventional Au rod electrodes. This innovation has promising implications for building biohybrid robots with densely arranged muscle tissue, ultimately achieving more human-like movements. Additionally, our selectivity model offers valuable predictive tools for assessing electrical stimulation effects with different electrode designs.
    Language English
    Publishing date 2024-05-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2500944-8
    ISSN 1758-5090 ; 1758-5082
    ISSN (online) 1758-5090
    ISSN 1758-5082
    DOI 10.1088/1758-5090/ad4ba1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Post-infarction Left Ventricular Free Wall Rupture Diagnosed by Contrast-Enhanced Computed Tomography: A Case Report.

    Morimoto, Yuya / Tamura, Shinobu / Kawashima, Shuji / Inoue, Shigeaki

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52127

    Abstract: A 70-year-old Japanese woman with hypertension, dyslipidemia, and diabetes mellitus complained of abdominal discomfort and vomiting and was brought to our emergency department by ambulance two days later with impaired consciousness. Her vital signs ... ...

    Abstract A 70-year-old Japanese woman with hypertension, dyslipidemia, and diabetes mellitus complained of abdominal discomfort and vomiting and was brought to our emergency department by ambulance two days later with impaired consciousness. Her vital signs suggested shock with a heart rate of 120 bpm. Electrocardiogram and initial transthoracic echocardiography suggested an inferior wall ST-elevation myocardial infarction, but the altered consciousness was inconsistent. Contrast-enhanced computed tomography was urgently performed to further clarify the cause. It revealed pericardial effusion and apparent extravasation from the left ventricular wall, confirming the early definitive diagnosis of left ventricular free wall rupture. The patient underwent successful emergent surgical repair without sequelae. Differential diagnosis of left ventricular free wall rupture is important in patients with ST-elevation myocardial infarction and impaired consciousness. Contrast-enhanced computed tomography allows early diagnosis and treatment of this life-threatening complication.
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Biohybrid tensegrity actuator driven by selective contractions of multiple skeletal muscle tissues.

    Morita, Kazuma / Morimoto, Yuya / Takeuchi, Shoji

    Biofabrication

    2023  Volume 15, Issue 4

    Abstract: Biohybrid robots are robots composed of both biological and artificial materials that can exhibit the unique characteristics commonly found in living organisms. Skeletal muscle tissues can be utilized as their actuators due to their flexibility and ON/ ... ...

    Abstract Biohybrid robots are robots composed of both biological and artificial materials that can exhibit the unique characteristics commonly found in living organisms. Skeletal muscle tissues can be utilized as their actuators due to their flexibility and ON/OFF controllability, but previous muscle-driven robots have been limited to one-degree of freedom (DOF) or planar motions due to their design. To overcome this limitation, we propose a biohybrid actuator with a tensegrity structure that enables multiple muscle tissues to be arranged in a 3D configuration with balanced tension. By using muscle tissues as tension members of tensegrity structure, the contraction of muscle tissues can cause the movement of the actuator in multiple-DOFs. We demonstrate the fabrication of the biohybrid tensegrity actuator by attaching three cultured skeletal muscle tissue made from C2C12 cells and fibrin-based hydrogel to an actuator skeleton using a snap-fit mechanism. When we applied an electric field of more than 4 V mm
    MeSH term(s) Muscle Contraction/physiology ; Muscle, Skeletal/physiology
    Language English
    Publishing date 2023-07-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2500944-8
    ISSN 1758-5090 ; 1758-5082
    ISSN (online) 1758-5090
    ISSN 1758-5082
    DOI 10.1088/1758-5090/ace2ec
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Microfluidic Device to Manipulate 3D Human Epithelial Cell-Derived Intestinal Organoids.

    Matsumoto, Miki / Morimoto, Yuya / Sato, Toshiro / Takeuchi, Shoji

    Micromachines

    2022  Volume 13, Issue 12

    Abstract: In this study, we propose a microfluidic organoid-trapping device used to immobilize human intestinal organoids and apply fluidic stimuli to them. The proposed device has a microchannel with a trapping region with wall gaps between the channel walls and ... ...

    Abstract In this study, we propose a microfluidic organoid-trapping device used to immobilize human intestinal organoids and apply fluidic stimuli to them. The proposed device has a microchannel with a trapping region with wall gaps between the channel walls and the bottom surface, and a constriction to clog the organoids in the channel. Since the introduced culture medium escapes from the gap, organoids can be cultured without excessive deformation by hydrostatic pressure. Owing to the characteristics of the organoid-trapping device, we succeeded in trapping human intestinal organoids in the channel. Furthermore, to demonstrate the applicability of the device for culturing intestinal organoids, we induced organoid fusion to form large organoids by aligning the organoids in the channel and applying fluidic shear stress to the organoids to regulate their surface structures. Therefore, we believe that organoid-trapping devices will be useful for investigating organoids aligned or loaded with fluidic stimulation.
    Language English
    Publishing date 2022-11-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi13122082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: 3D printed microfluidic devices for lipid bilayer recordings.

    Ogishi, Kazuto / Osaki, Toshihisa / Morimoto, Yuya / Takeuchi, Shoji

    Lab on a chip

    2022  Volume 22, Issue 5, Page(s) 890–898

    Abstract: This paper verifies the single-step and monolithic fabrication of 3D structural lipid bilayer devices using stereolithography. Lipid bilayer devices are utilized to host membrane ... ...

    Abstract This paper verifies the single-step and monolithic fabrication of 3D structural lipid bilayer devices using stereolithography. Lipid bilayer devices are utilized to host membrane proteins
    MeSH term(s) Lab-On-A-Chip Devices ; Lipid Bilayers ; Microfluidics/methods ; Printing, Three-Dimensional ; Stereolithography
    Chemical Substances Lipid Bilayers
    Language English
    Publishing date 2022-03-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2056646-3
    ISSN 1473-0189 ; 1473-0197
    ISSN (online) 1473-0189
    ISSN 1473-0197
    DOI 10.1039/d1lc01077h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Functional analysis of human brain endothelium using a microfluidic device integrating a cell culture insert.

    Miura, Shigenori / Morimoto, Yuya / Furihata, Tomomi / Takeuchi, Shoji

    APL bioengineering

    2022  Volume 6, Issue 1, Page(s) 16103

    Abstract: The blood-brain barrier (BBB) is a specialized brain endothelial barrier structure that regulates the highly selective transport of molecules under continuous blood flow. Recently, various types of BBB-on-chip models have been developed to mimic the ... ...

    Abstract The blood-brain barrier (BBB) is a specialized brain endothelial barrier structure that regulates the highly selective transport of molecules under continuous blood flow. Recently, various types of BBB-on-chip models have been developed to mimic the microenvironmental cues that regulate the human BBB drug transport. However, technical difficulties in complex microfluidic systems limit their accessibility. Here, we propose a simple and easy-to-handle microfluidic device integrated with a cell culture insert to investigate the functional regulation of the human BBB endothelium in response to fluid shear stress (FSS). Using currently established immortalized human brain microvascular endothelial cells (HBMEC/ci18), we formed a BBB endothelial barrier without the substantial loss of barrier tightness under the relatively low range of FSS (0.1-1 dyn/cm
    Language English
    Publishing date 2022-03-09
    Publishing country United States
    Document type Journal Article
    ISSN 2473-2877
    ISSN (online) 2473-2877
    DOI 10.1063/5.0085564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: 3D-Printed Centrifugal Pump Driven by Magnetic Force in Applications for Microfluidics in Biological Analysis.

    Jo, Byeongwook / Morimoto, Yuya / Takeuchi, Shoji

    Advanced healthcare materials

    2022  Volume 11, Issue 24, Page(s) e2200593

    Abstract: In recent years, microfluidic systems have been extensively utilized for biological analysis. The integration of pumps in microfluidic systems requires precise control of liquids and effort-intensive set-ups for multiplexed experiments. In this study, a ... ...

    Abstract In recent years, microfluidic systems have been extensively utilized for biological analysis. The integration of pumps in microfluidic systems requires precise control of liquids and effort-intensive set-ups for multiplexed experiments. In this study, a 3D-printed centrifugal pump driven by magnetic force is presented for microfluidics and biological analysis. The permanent magnets implemented in the centrifugal pump synchronized the rotation of the driving and operating parts. Precise control of the flow rate and a wide range and variety of flow profiles are achieved by controlling the rotational speed of the motor in the driving part. The compact size and contactless driving part allow simple set-ups within commercially available culture dishes and tubes. It is demonstrated that the fabricated 3D-printed centrifugal pump can induce laminar flow in a microfluidic device, perfusion culture of in vitro tissues, and alignment of cells under shear stress. This device has a high potential for applications in microfluidic devices and perfusion culture of cells.
    MeSH term(s) Microfluidics ; Lab-On-A-Chip Devices ; Printing, Three-Dimensional ; Magnetic Phenomena
    Language English
    Publishing date 2022-06-03
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202200593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6966: Show issues Location:
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