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  1. Book ; Conference proceedings: Photoaging Research Symposium

    Morita, Akimichi

    Society of Japanese Photoaging Research 9th annual meeting, Kyoto, Japan, May 13th, 2008

    (Journal of investigative dermatology : Symposium proceedings ; 14,1)

    2009  

    Institution Society of Japanese Photoaging Research
    Event/congress Photoaging Research Symposium (2008, Kyōto)
    Author's details guest ed.: Akimichi Morita
    Series title Journal of investigative dermatology : Symposium proceedings ; 14,1
    The journal of investigative dermatology
    Journal of investigative dermatology ; Symposium proceedings
    Collection The journal of investigative dermatology
    Journal of investigative dermatology ; Symposium proceedings
    Language English
    Size S. 1 - 75 : Ill., graph. Darst.
    Publisher Nature Publ. Group
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT016050605
    Database Catalogue ZB MED Medicine, Health

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    Zs A 4510 -14- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: Farewell from the Editor-in-Chief of Photodermatology, Photoimmunology & Photomedicine.

    Morita, Akimichi

    Photodermatology, photoimmunology & photomedicine

    2021  Volume 37, Issue 6, Page(s) 481

    Language English
    Publishing date 2021-11-16
    Publishing country England
    Document type Editorial
    ZDB-ID 1028855-7
    ISSN 1600-0781 ; 0108-9684 ; 0905-4383
    ISSN (online) 1600-0781
    ISSN 0108-9684 ; 0905-4383
    DOI 10.1111/phpp.12739
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  3. Article ; Online: Celebrating 100 volumes of JDS: A huge achievement together with expansion of the JSID.

    Morita, Akimichi

    Journal of dermatological science

    2020  Volume 100, Issue 1, Page(s) 10–12

    MeSH term(s) Congresses as Topic ; Copyright/economics ; Copyright/history ; Copyright/legislation & jurisprudence ; Dermatology ; Governing Board ; History, 21st Century ; International Cooperation/history ; International Cooperation/legislation & jurisprudence ; Patents as Topic/history ; Patents as Topic/legislation & jurisprudence ; Publishing/ethics ; Publishing/history ; Publishing/legislation & jurisprudence ; Publishing/organization & administration ; Societies, Medical/history ; Societies, Medical/legislation & jurisprudence ; Societies, Medical/organization & administration
    Keywords covid19
    Language English
    Publishing date 2020-10-09
    Publishing country Netherlands
    Document type Editorial ; Historical Article
    ZDB-ID 1024446-3
    ISSN 1873-569X ; 0923-1811
    ISSN (online) 1873-569X
    ISSN 0923-1811
    DOI 10.1016/j.jdermsci.2020.10.006
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  4. Article ; Online: Resignation as JSID President.

    Morita, Akimichi

    Journal of dermatological science

    2020  Volume 101, Issue 1, Page(s) 2–3

    MeSH term(s) Dermatology/history ; Dermatology/organization & administration ; History, 21st Century ; Humans ; Japan ; Male ; Societies, Medical/history ; Societies, Medical/organization & administration
    Language English
    Publishing date 2020-12-03
    Publishing country Netherlands
    Document type Address ; Autobiography ; Editorial ; Historical Article ; Portrait
    ZDB-ID 1024446-3
    ISSN 1873-569X ; 0923-1811
    ISSN (online) 1873-569X
    ISSN 0923-1811
    DOI 10.1016/j.jdermsci.2020.12.001
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  5. Article ; Online: Pediatric psoriasis: Understanding pathological conditions and advances in treatment.

    Morita, Akimichi / Saeki, Hidehisa

    The Journal of dermatology

    2023  Volume 51, Issue 2, Page(s) 185–195

    Abstract: Psoriasis is a long-lasting skin disease that primarily affects the skin, nails, and joints and is characterized by inflammation. Genetic factors contribute to its development and environmental triggers can worsen symptoms. Pathologically, psoriasis is ... ...

    Abstract Psoriasis is a long-lasting skin disease that primarily affects the skin, nails, and joints and is characterized by inflammation. Genetic factors contribute to its development and environmental triggers can worsen symptoms. Pathologically, psoriasis is characterized by uncontrolled keratinocyte proliferation and abnormal differentiation, and histological features include acanthosis with inflammatory cell infiltration and neovascularization. Psoriasis often starts in childhood, with about one-third of cases beginning during this time. Its prevalence steadily increases from the ages of 1 to 18 years in a linear fashion. Young people with psoriasis often require treatment throughout their childhood and adolescence, and into adulthood. However, prolonged treatment may increase the risk of complications and adverse events, so it is important to adopt an effective treatment approach that minimizes this risk. In addition, psoriasis is often associated with various comorbidities that may place a great burden on the physical and mental health of the children beyond those due to psoriasis itself. To ensure good long-term health outcomes, individuals with psoriasis should undergo regular screening. Treatment should be provided not only for skin lesions, but also for any comorbidities; however, currently there is not enough evidence on the treatment of pediatric psoriasis and no globally agreed-on guidelines exist for treating psoriasis in children. This article describes the etiology, clinical symptoms, and disease burden of pediatric psoriasis, the pathological conditions and diagnosis of plaque psoriasis, psoriatic arthritis, and generalized pustular psoriasis, and the available treatments for these conditions in Japan.
    MeSH term(s) Humans ; Child ; Adolescent ; Psoriasis/diagnosis ; Psoriasis/epidemiology ; Psoriasis/etiology ; Arthritis, Psoriatic/drug therapy ; Skin/pathology ; Comorbidity ; Treatment Outcome
    Language English
    Publishing date 2023-12-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.17049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Treatment patterns and drug survival for generalized pustular psoriasis: A patient journey study using a Japanese claims database.

    Tada, Yayoi / Guan, Jia / Iwasaki, Ryoko / Morita, Akimichi

    The Journal of dermatology

    2024  Volume 51, Issue 3, Page(s) 391–402

    Abstract: Generalized pustular psoriasis (GPP) is a potentially life-threatening skin disease. Although several medications are approved for treating GPP in Japan, there are limited data on real-world treatment patterns or drug survival (the number of prescribed ... ...

    Abstract Generalized pustular psoriasis (GPP) is a potentially life-threatening skin disease. Although several medications are approved for treating GPP in Japan, there are limited data on real-world treatment patterns or drug survival (the number of prescribed days of treatment). This retrospective cohort study describes drug survival and treatment patterns of patients with newly diagnosed GPP (International Classification of Diseases, 10th Revision code L40.1), and ≥1 year of follow-up, using de-identified claims data (Medical Data Vision Co., Ltd.) from January 2016 to August 2021. Most (97.0%) of the 434 Japanese patients received first-line therapy of etretinate (26.4%), topical medications (14.7%), or cyclosporin (14.3%); 80.0% and 60.1% of patients received a second and third line of therapy (LOT), respectively. Use of etretinate (12.6%) and cyclosporin (5.9%) decreased in second-line therapies, whereas use of biologics (interleukin [IL]-17, 14.3%; IL-23 inhibitors, 7.6%) and topical medications (22.1%) increased or remained consistent. Approximately 50% of biologics were prescribed in combination with systemic medications or systemic corticosteroids. Median (range) time to next therapy (TTNT) was 2.8 (0.03-48.07) months for first-line therapy and 3.3 (0.03-52.97) months for all other LOTs. TTNT was longer for combination therapies (up to 16.5 months) compared with monotherapies (up to 7.5 months). Biologics exhibited longer drug survival with fewer treatment episodes compared with non-biologic systemic medications. Among frequently used therapies, the median (95% confidence interval) drug survival was 8.8 (5.8-11.8) months for etretinate, 4.3 (2.2-6.9) months for systemic corticosteroids, and 19.6 (16.1-26.7) months for secukinumab. Treatment patterns varied considerably, highlighting the need for treatment algorithms and effective, well-tolerated medications to support patients to help them remain on long-term therapy.
    MeSH term(s) Humans ; Etretinate/therapeutic use ; Japan ; Retrospective Studies ; Psoriasis/drug therapy ; Biological Products/therapeutic use ; Adrenal Cortex Hormones/therapeutic use ; Cyclosporins/therapeutic use
    Chemical Substances Etretinate (65M2UDR9AG) ; Biological Products ; Adrenal Cortex Hormones ; Cyclosporins
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.17097
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  7. Article ; Online: More manuscript submissions, higher quality science for Photodermatology, Photoimmunology & Photomedicine.

    Morita, Akimichi

    Photodermatology, photoimmunology & photomedicine

    2018  Volume 34, Issue 3, Page(s) 166

    MeSH term(s) Allergy and Immunology ; Dermatology ; Humans ; Manuscripts, Medical as Topic ; Periodicals as Topic ; Phototherapy
    Language English
    Publishing date 2018-08-14
    Publishing country England
    Document type Editorial
    ZDB-ID 1028855-7
    ISSN 1600-0781 ; 0108-9684 ; 0905-4383
    ISSN (online) 1600-0781
    ISSN 0108-9684 ; 0905-4383
    DOI 10.1111/phpp.12393
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  8. Article ; Online: Current developments in phototherapy for psoriasis.

    Morita, Akimichi

    The Journal of dermatology

    2018  Volume 45, Issue 3, Page(s) 287–292

    Abstract: Phototherapy utilizes the beneficial effects of ultraviolet (UV) wavelengths to affect immunoregulatory functions. UV light phototherapy using narrowband UV-B (NB-UVB) and bath-psoralen UV-A (bath-PUVA) therapy are well-established treatments for ... ...

    Abstract Phototherapy utilizes the beneficial effects of ultraviolet (UV) wavelengths to affect immunoregulatory functions. UV light phototherapy using narrowband UV-B (NB-UVB) and bath-psoralen UV-A (bath-PUVA) therapy are well-established treatments for psoriasis. Dual-action mechanisms of UV phototherapy have been identified: apoptosis and immune suppression. NB-UVB depletes pathogenic T cells by inducing apoptosis and regulatory T cells. Other wavelengths are also utilized for phototherapy, namely 308-nm excimer light and 312-nm flat-typed NB-UVB. Excimer light (308-nm) therapy effectively targets the affected skin without unduly exposing other areas and increases the levels of regulatory T cells. Phototherapy improves impaired resting regulatory T cells and increases activated regulatory T cells in patients with psoriasis. Intensive studies of phototherapy effects have led to several improvements in the design, protocols, and light sources, such as UV light-emitting diodes, thereby providing several options for patients with refractory skin disease, such as psoriasis.
    MeSH term(s) Apoptosis/radiation effects ; Dermatologic Agents/therapeutic use ; Humans ; Photosensitizing Agents/therapeutic use ; Psoriasis/immunology ; Psoriasis/therapy ; Skin/cytology ; Skin/immunology ; Skin/radiation effects ; T-Lymphocytes/immunology ; T-Lymphocytes/radiation effects ; Treatment Outcome ; Ultraviolet Therapy/instrumentation ; Ultraviolet Therapy/methods
    Chemical Substances Dermatologic Agents ; Photosensitizing Agents
    Language English
    Publishing date 2018-01-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.14213
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  9. Article ; Online: Generalized pustular psoriasis: current management status and unmet medical needs in Japan.

    Komine, Mayumi / Morita, Akimichi

    Expert review of clinical immunology

    2021  Volume 17, Issue 9, Page(s) 1015–1027

    Abstract: Introduction: Generalized pustular psoriasis (GPP) is a rare, inflammatory skin disease characterized by recurrent flares of pustulation accompanied by systemic symptoms that can be life-threatening. The clinical and humanistic burden of GPP in Japan is ...

    Abstract Introduction: Generalized pustular psoriasis (GPP) is a rare, inflammatory skin disease characterized by recurrent flares of pustulation accompanied by systemic symptoms that can be life-threatening. The clinical and humanistic burden of GPP in Japan is high, and it is a designated intractable disease. We reviewed clinical evidence and guidelines for GPP treatment in Japan to identify unmet needs and assess data supporting the development and use of new targeted therapies.
    Areas covered: Using specific search terms in PubMed and Embase, with additional back-referencing, we retrieved literature related to GPP in Japan focusing on clinical and pathogenic characteristics, diagnosis, and treatment.
    Expert opinion: Although there are approved systemic therapies for GPP in Japan, all present uncertainties in terms of safety and efficacy. Clinical evidence supporting their use comes mostly from studies in patients with mild or moderate disease, and their effectiveness in treating acute phase GPP is unknown. The interleukin-36 pathway appears to be central to GPP pathogenesis. New therapies targeting this pathway show promise in patients presenting with acute phase GPP. The rarity and intermittent course of GPP make it challenging to recruit sufficient patients for trials and robustly investigate the efficacy and safety of these agents to treat GPP.
    MeSH term(s) Acute Disease ; Humans ; Immunotherapy ; Interleukins ; Japan ; Psoriasis/diagnosis ; Psoriasis/drug therapy
    Chemical Substances Interleukins
    Language English
    Publishing date 2021-08-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2021.1961580
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    Zs.A 6661: Show issues Location:
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  10. Article ; Online: Immune activity in Merkel cell carcinoma.

    Nakamura, Motoki / Morita, Akimichi

    The Journal of dermatology

    2021  Volume 49, Issue 1, Page(s) 68–74

    Abstract: Merkel cell carcinoma (MCC) is widely known as a highly malignant skin cancer. The pathogenesis of MCC, however, remains mysterious due to the extremely small number of cases and its prevalence in the elderly. Despite its high-grade malignancy, ... ...

    Abstract Merkel cell carcinoma (MCC) is widely known as a highly malignant skin cancer. The pathogenesis of MCC, however, remains mysterious due to the extremely small number of cases and its prevalence in the elderly. Despite its high-grade malignancy, spontaneous regression occurs with some frequency. The immune activity of the tumor underlies this peculiar behavior. In recent years, immune checkpoint blockade therapies, including the anti-programmed death ligand 1 antibody, have provided successful results. These therapies, however, are ineffective in approximately half the patients with advanced MCC and few treatments are available for those patients. In this review, we summarize the increasing body of evidence relating to the immune activity of MCC and immunological biomarkers. The interesting and sometimes peculiar behavior of MCC, such as their spontaneous regression, is largely due to their high immunosensitivity. Understanding the tumor immunokinetics of MCC should provide critical insight for understanding cancer immunotherapy. Here, we introduce a new classification for MCC according to its immune activity. Combined application of programmed death ligand 1 (a prognostic factor and predictor of the efficacy of immune checkpoint inhibitors in various cancers) with glucose-6-phosphate dehydrogenase (a new promising biomarker for MCC) may enable classification of MCC based on its immune status. Whether the new classification can be used to predict the efficacy of immune checkpoint blockade therapies remains to be evaluated in future studies, but the classification may facilitate future treatment selection.
    MeSH term(s) Aged ; Carcinoma, Merkel Cell/therapy ; Humans ; Immunotherapy ; Skin Neoplasms/therapy
    Language English
    Publishing date 2021-11-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.16232
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