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Article ; Online: Mechanical Evaluation of Tracheal Grafts on Different Scales.

Aoki, Fabio Gava / Moriya, Henrique Takachi

2017 Volume 42, Issue 5, Page(s) 476–483

Abstract: Tissue engineered (or bioengineered) tracheas are alternative options under investigation when the resection with end-to-end anastomosis cannot be performed. One approach to develop bioengineered tracheas is a complex process that involves the use of ... ...

Abstract	Tissue engineered (or bioengineered) tracheas are alternative options under investigation when the resection with end-to-end anastomosis cannot be performed. One approach to develop bioengineered tracheas is a complex process that involves the use of decellularized tissue scaffolds, followed by recellularization in custom-made tracheal bioreactors. Tracheas withstand pressure variations and their biomechanics are of great importance so that they do not collapse during respiration, although there has been no preferred method of mechanical assay of tracheas among several laboratories over the years. These methods have been performed in segments or whole tracheas and in different species of mammals. This article aims to present some methods used by different research laboratories to evaluate the mechanics of tracheal grafts and presents the importance of the tracheal biomechanics in both macro and micro scales. If bioengineered tracheas become a reality in hospitals in the next few years, the standardization of biomechanical parameters will be necessary for greater consistency of results before transplantations.
MeSH term(s)	Animals ; Bioartificial Organs ; Bioengineering/methods ; Biomechanical Phenomena ; Humans ; Tissue Engineering/methods ; Tissue Scaffolds/chemistry ; Tissue Transplantation/methods ; Trachea/chemistry ; Trachea/cytology ; Trachea/physiology ; Trachea/transplantation ; Transplants/chemistry ; Transplants/cytology ; Transplants/physiology ; Transplants/transplantation
Language	English
Publishing date	2017-12-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	441812-8
ISSN	1525-1594 ; 0160-564X
ISSN (online)	1525-1594
ISSN	0160-564X
DOI	10.1111/aor.13063
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Article ; Online: Respiratory mechanics during methacholine bolus and continuous infusion protocols in asthma model.

Vitorasso, Renato Lima / Oliveira, Maria Aparecida / Tavares-de-Lima, Wothan / Moriya, Henrique Takachi

Respiratory physiology & neurobiology

2021 Volume 292, Page(s) 103705

Abstract: Balb/c mice respiratory mechanics was studied in two intravenous methacholine (MCh) protocols: bolus and continuous infusion. The Constant Phase Model (CPM) was used in this study. The harmonic distortion index ( ... ...

Abstract	Balb/c mice respiratory mechanics was studied in two intravenous methacholine (MCh) protocols: bolus and continuous infusion. The Constant Phase Model (CPM) was used in this study. The harmonic distortion index (k
MeSH term(s)	Animals ; Asthma/chemically induced ; Bronchoconstrictor Agents/administration & dosage ; Disease Models, Animal ; Male ; Methacholine Chloride/administration & dosage ; Mice ; Mice, Inbred BALB C ; Models, Theoretical ; Respiratory Mechanics/drug effects
Chemical Substances	Bronchoconstrictor Agents ; Methacholine Chloride (0W5ETF9M2K)
Language	English
Publishing date	2021-05-29
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2077867-3
ISSN	1878-1519 ; 1569-9048
ISSN (online)	1878-1519
ISSN	1569-9048
DOI	10.1016/j.resp.2021.103705
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Article: Assessment of Regional Ventilation During Recruitment Maneuver by Electrical Impedance Tomography in Dogs.

Ambrósio, Aline Magalhães / Sanchez, Ana Flávia / Pereira, Marco Aurélio Amador / Andrade, Felipe Silveira Rego Monteiro De / Rodrigues, Renata Ramos / Vitorasso, Renato de Lima / Moriya, Henrique Takachi / Fantoni, Denise Tabacchi

Frontiers in veterinary science

2022 Volume 8, Page(s) 815048

Abstract: Background: During protective mechanical ventilation, electrical impedance tomography (EIT) is used to monitor alveolar recruitment maneuvers as well as the distribution of regional ventilation. This technique can infer atelectasis and lung ... ...

Abstract	Background: During protective mechanical ventilation, electrical impedance tomography (EIT) is used to monitor alveolar recruitment maneuvers as well as the distribution of regional ventilation. This technique can infer atelectasis and lung overdistention during mechanical ventilation in anesthetized patients or in the ICU. Changes in lung tissue stretching are evaluated by monitoring the electrical impedance of lung tissue with each respiratory cycle. Objective: This study aimed to evaluate the distribution of regional ventilation during recruitment maneuvers based on the variables obtained in pulmonary electrical impedance tomography during protective mechanical ventilation, focusing on better lung recruitment associated with less or no overdistention. Methods: Prospective clinical study using seven adult client-owned healthy dogs, weighing 25 ± 6 kg, undergoing elective ovariohysterectomy or orchiectomy. The animals were anesthetized and ventilated in volume-controlled mode (7 ml.kg Results: The results show that the regional compliance of the dependent lung significantly increased in the PEEP 10 cmH Conclusions: The regional ventilation distribution assessed by EIT showed that the best PEEP value for recruitment maintenance, capable of decreasing areas of pulmonary atelectasis in dependent regions promoting less overinflation in nondependent areas, was from 10 to 5 cmH
Language	English
Publishing date	2022-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2021.815048
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Article: Lung Mechanics Over the Century: From Bench to Bedside and Back to Bench.

Biselli, Paolo Jose Cesare / Degobbi Tenorio Quirino Dos Santos Lopes, Fernanda / Righetti, Renato Fraga / Moriya, Henrique Takachi / Tibério, Iolanda Fátima Lopes Calvo / Martins, Milton Arruda

Frontiers in physiology

2022 Volume 13, Page(s) 817263

Abstract: Lung physiology research advanced significantly over the last 100 years. Respiratory mechanics applied to animal models of lung disease extended the knowledge of the workings of respiratory system. In human research, a better understanding of respiratory ...

Abstract	Lung physiology research advanced significantly over the last 100 years. Respiratory mechanics applied to animal models of lung disease extended the knowledge of the workings of respiratory system. In human research, a better understanding of respiratory mechanics has contributed to development of mechanical ventilators. In this review, we explore the use of respiratory mechanics in basic science to investigate asthma and chronic obstructive pulmonary disease (COPD). We also discuss the use of lung mechanics in clinical care and its role on the development of modern mechanical ventilators. Additionally, we analyse some bench-developed technologies that are not in widespread use in the present but can become part of the clinical arsenal in the future. Finally, we explore some of the difficult questions that intensive care doctors still face when managing respiratory failure. Bringing back these questions to bench can help to solve them. Interaction between basic and translational science and human subject investigation can be very rewarding, as in the conceptualization of "Lung Protective Ventilation" principles. We expect this interaction to expand further generating new treatments and managing strategies for patients with respiratory disease.
Language	English
Publishing date	2022-07-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.817263
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Article ; Online: Challenges for the development of alternative low-cost ventilators during COVID-19 pandemic in Brazil.

Suzumura, Erica Aranha / Zazula, Ana Denise / Moriya, Henrique Takachi / Fais, Cristina Quemelo Adami / Alvarado, Alembert Lino / Cavalcanti, Alexandre Biasi / Rodrigues, Ricardo Goulart

Revista Brasileira de terapia intensiva

2020 Volume 32, Issue 3, Page(s) 444–457

Abstract: The COVID-19 pandemic has brought concerns to managers, healthcare professionals, and the general population related to the potential mechanical ventilators' shortage for severely ill patients. In Brazil, there are several initiatives aimed at producing ... ...

Title translation	Desafios para o desenvolvimento de ventiladores alternativos de baixo custo durante a pandemia de COVID-19 no Brasil.
Abstract	The COVID-19 pandemic has brought concerns to managers, healthcare professionals, and the general population related to the potential mechanical ventilators' shortage for severely ill patients. In Brazil, there are several initiatives aimed at producing alternative ventilators to cover this gap. To assist the teams that work in these initiatives, we provide a discussion of some basic concepts on physiology and respiratory mechanics, commonly used mechanical ventilation terms, the differences between triggering and cycling, the basic ventilation modes and other relevant aspects, such as mechanisms of ventilator-induced lung injury, respiratory drive, airway heating and humidification, cross-contamination risks, and aerosol dissemination. After the prototype development phase, preclinical bench-tests and animal model trials are needed to determine the safety and performance of the ventilator, following the minimum technical requirements. Next, it is mandatory going through the regulatory procedures as required by the Brazilian Health Regulatory Agency (Agência Nacional de Vigilância Sanitária - ANVISA). The manufacturing company should be appropriately registered by ANVISA, which also must be notified about the conduction of clinical trials, following the research protocol approval by the Research Ethics Committee. The registration requisition of the ventilator with ANVISA should include a dossier containing the information described in this paper, which is not intended to cover all related matters but to provide guidance on the required procedures.
MeSH term(s)	Animals ; Brazil/epidemiology ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Equipment Design ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Respiration, Artificial/instrumentation ; Respiratory Mechanics ; Ventilator-Induced Lung Injury/prevention & control ; Ventilators, Mechanical
Keywords	covid19
Language	English
Publishing date	2020-10-07
Publishing country	Brazil
Document type	Journal Article ; Review
ZDB-ID	2732162-9
ISSN	1982-4335 ; 0103-507X
ISSN (online)	1982-4335
ISSN	0103-507X
DOI	10.5935/0103-507X.20200075
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Desafios para o desenvolvimento de ventiladores alternativos de baixo custo durante a pandemia de COVID-19 no Brasil

Suzumura, Erica Aranha / Zazula, Ana Denise / Moriya, Henrique Takachi / Fais, Cristina Quemelo Adami / Alvarado, Alembert Lino / Cavalcanti, Alexandre Biasi / Rodrigues, Ricardo Goulart

Revista Brasileira de Terapia Intensiva v.32 n.3 2020

2020

Abstract: RESUMO A pandemia por COVID-19 tem deixado os gestores, os profissionais de saúde e a população preocupados com a potencial escassez de ventiladores pulmonares para suporte de pacientes graves. No Brasil, há diversas iniciativas com o intuito de produzir ...

Abstract	RESUMO A pandemia por COVID-19 tem deixado os gestores, os profissionais de saúde e a população preocupados com a potencial escassez de ventiladores pulmonares para suporte de pacientes graves. No Brasil, há diversas iniciativas com o intuito de produzir ventiladores alternativos para ajudar a suprir essa demanda. Para auxiliar as equipes que atuam nessas iniciativas, são expostos alguns conceitos básicos sobre fisiologia e mecânica respiratória, os termos comumente utilizados no contexto da ventilação mecânica, as fases do ciclo ventilatório, as diferenças entre disparo e ciclagem, os modos ventilatórios básicos e outros aspectos relevantes, como mecanismos de lesão pulmonar induzida pela ventilação mecânica, pacientes com drive respiratório, necessidade de umidificação de vias aéreas, risco de contaminação cruzada e disseminação de aerossóis. Após a fase de desenvolvimento de protótipo, são necessários testes pré-clínicos de bancada e em modelos animais, a fim de determinar a segurança e o desempenho dos equipamentos, seguindo requisitos técnicos mínimos exigidos. Então, é imprescindível passar pelo processo regulatório exigido pela Agência Nacional de Vigilância Sanitária (ANVISA). A empresa responsável pela fabricação do equipamento deve estar regularizada junto à ANVISA, que também deve ser notificada da condução dos testes clínicos em humanos, seguindo protocolo de pesquisa aprovado pelo Comitê de Ética em Pesquisa. O registro do ventilador junto à ANVISA deve ser acompanhado de um dossiê, composto por documentos e informações detalhadas neste artigo, que não tem o propósito de esgotar o assunto, mas de nortear os procedimentos necessários.
Keywords	Ventiladores mecânicos ; Respiração artificial ; Respiração com pressão positiva ; COVID-19 ; Síndrome respiratória aguda grave ; Engenharia biomédica ; Brasil ; covid19
Language	Portuguese
Publishing date	2020-09-01
Publisher	Associação de Medicina Intensiva Brasileira - AMIB
Publishing country	br
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Desaturation-Distance Ratio During Submaximal and Maximal Exercise Tests and Its Association With Lung Function Parameters in Patients With Lymphangioleiomyomatosis.

Queiroz, Douglas Silva / da Silva, Cibele Cristine Berto Marques / Amaral, Alexandre Franco / Oliveira, Martina Rodrigues / Moriya, Henrique Takachi / Carvalho, Carlos Roberto Ribeiro / Baldi, Bruno Guedes / Carvalho, Celso R F

Frontiers in medicine

2021 Volume 8, Page(s) 659416

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-07-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2021.659416
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Article ; Online: An in vivo image acquisition system for the evaluation of tracheal mechanics in rats.

Valenga, Marcelo Henrique / Vitorasso, Renato de Lima / Rodrigues, Thiago Guimarães / Pazetti, Rogério / Cardoso, Paulo Francisco Guerreiro / Moriya, Henrique Takachi / Aoki, Fabio Gava

Artificial organs

2019 Volume 44, Issue 5, Page(s) 504–512

Abstract: Mechanical evaluation of tracheal grafts is of great relevance for transplant research. Although there are some publications demonstrating different techniques of tracheal mechanical evaluation, there is still no definitive or preferred protocol ... ...

Abstract	Mechanical evaluation of tracheal grafts is of great relevance for transplant research. Although there are some publications demonstrating different techniques of tracheal mechanical evaluation, there is still no definitive or preferred protocol available. Here, we present a simple image processing acquisition system that can be used for in vivo experiments. Six male Wistar rats were submitted to orotracheal intubation and a longitudinal incision was made to expose the trachea. Images of tracheae were acquired from a video camera in different scenarios of bronchoconstriction using methacholine (MCh) (Basal, PBS, MCh 30 μg/kg, MCh 300 μg/kg, and postmetabolized) during imposed-inspiration and imposed-expiration. The area variation ratio (the ratio between areas during expiration vs. inspiration) was 1.1× for the Basal group, while the ratio for MCh 300 µg/kg was 6.5×. The area variation of imaged tracheae was statistically significant at the dose of MCh 300 µg/kg for imposed-inspiration versus imposed-expiration (P = .002). Likewise, elastance data of respiratory mechanics indicated a statistically significant difference at the dose of MCh 300 µg/kg for imposed-inspiration versus imposed-expiration (P = .026). Our image processing analysis protocol presented corresponding behavior when compared to mechanical parameters of the respiratory system. In addition, our image acquisition system was able to highlight the differences between imposed-inspiration and imposed-expiration. Image analysis of the tracheal area variation seems to be in agreement with the elastance of the respiratory system. Taken together, these observations may help future studies of tracheal transplantation for in situ assessment of graft patency.
MeSH term(s)	Animals ; Bronchoconstriction ; Image Processing, Computer-Assisted ; Male ; Rats, Wistar ; Trachea/diagnostic imaging ; Trachea/physiology
Language	English
Publishing date	2019-12-15
Publishing country	United States
Document type	Evaluation Study ; Journal Article
ZDB-ID	441812-8
ISSN	1525-1594 ; 0160-564X
ISSN (online)	1525-1594
ISSN	0160-564X
DOI	10.1111/aor.13604
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Article: Desafios para o desenvolvimento de ventiladores alternativos de baixo custo durante a pandemia de COVID-19 no Brasil./ Desafios para o desenvolvimento de ventiladores alternativos de baixo custo durante a pandemia de COVID-19 no Brasil./ Challenges for the development of alternative low-cost ventilators during COVID-19 pandemic in Brazil

Suzumura, Erica Aranha / Zazula, Ana Denise / Moriya, Henrique Takachi / Fais, Cristina Quemelo Adami / Alvarado, Alembert Lino / Cavalcanti, Alexandre Biasi / Rodrigues, Ricardo Goulart

Rev Bras Ter Intensiva

Abstract	The COVID-19 pandemic has brought concerns to managers, healthcare professionals, and the general population related to the potential mechanical ventilators' shortage for severely ill patients. In Brazil, there are several initiatives aimed at producing alternative ventilators to cover this gap. To assist the teams that work in these initiatives, we provide a discussion of some basic concepts on physiology and respiratory mechanics, commonly used mechanical ventilation terms, the differences between triggering and cycling, the basic ventilation modes and other relevant aspects, such as mechanisms of ventilator-induced lung injury, respiratory drive, airway heating and humidification, cross-contamination risks, and aerosol dissemination. After the prototype development phase, preclinical bench-tests and animal model trials are needed to determine the safety and performance of the ventilator, following the minimum technical requirements. Next, it is mandatory going through the regulatory procedures as required by the Brazilian Health Regulatory Agency (Agência Nacional de Vigilância Sanitária - ANVISA). The manufacturing company should be appropriately registered by ANVISA, which also must be notified about the conduction of clinical trials, following the research protocol approval by the Research Ethics Committee. The registration requisition of the ventilator with ANVISA should include a dossier containing the information described in this paper, which is not intended to cover all related matters but to provide guidance on the required procedures.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #869258
Database	COVID19

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Article ; Online: Respiratory inductive plethysmography: a comparative study between isovolume maneuver calibration and qualitative diagnostic calibration in healthy volunteers assessed in different positions.

Barbosa, Renata Cléia Claudino / Carvalho, Celso Ricardo Fernandes de / Moriya, Henrique Takachi

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

2012 Volume 38, Issue 2, Page(s) 194–201

Abstract: Objective: To compare two methods of respiratory inductive plethysmography (RIP) calibration in three different positions.: Methods: We evaluated 28 healthy subjects (18 women and 10 men), with a mean age of 25.4 ± 3.9 years. For all of the subjects, ...

Abstract	Objective: To compare two methods of respiratory inductive plethysmography (RIP) calibration in three different positions. Methods: We evaluated 28 healthy subjects (18 women and 10 men), with a mean age of 25.4 ± 3.9 years. For all of the subjects, isovolume maneuver calibration (ISOCAL) and qualitative diagnostic calibration (QDC) were used in the orthostatic, sitting, and supine positions. In order to evaluate the concordance between the two calibration methods, we used ANOVA and Bland-Altman plots. Results: The values of the constant of proportionality (K) were significantly different between ISOCAL and QDC in the three positions evaluated: 1.6 ± 0.5 vs. 2.0 ± 1.2, in the supine position, 2.5 ± 0.8 vs. 0.6 ± 0.3 in the sitting position, and 2.0 ± 0.8 vs. 0.6 ± 0.3 in the orthostatic position (p < 0.05 for all). Conclusions: Our results suggest that QDC is an inaccurate method for the calibration of RIP. The K values obtained with ISOCAL reveal that RIP should be calibrated for each position evaluated.
MeSH term(s)	Adolescent ; Adult ; Aged ; Calibration ; Female ; Humans ; Male ; Middle Aged ; Plethysmography/methods ; Posture/physiology ; Respiration ; Respiratory Function Tests/methods ; Tidal Volume ; Young Adult
Language	Portuguese
Publishing date	2012-04-27
Publishing country	Brazil
Document type	Comparative Study ; Journal Article
ZDB-ID	2223157-2
ISSN	1806-3756 ; 1806-3713
ISSN (online)	1806-3756
ISSN	1806-3713
DOI	10.1590/s1806-37132012000200008
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