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  1. Article ; Online: Potential issues specific to cytotoxicity tests of cellulose nanofibrils.

    Moriyama, Akihiro / Ogura, Isamu / Fujita, Katsuhide

    Journal of applied toxicology : JAT

    2022  Volume 43, Issue 1, Page(s) 195–207

    Abstract: Cellulose nanofibrils (also called cellulose nanofibers or nanofibrillated cellulose [CNFs]) are novel polymers derived from biomass with excellent physicochemical properties and various potential applications. However, the introduction of such new ... ...

    Abstract Cellulose nanofibrils (also called cellulose nanofibers or nanofibrillated cellulose [CNFs]) are novel polymers derived from biomass with excellent physicochemical properties and various potential applications. However, the introduction of such new materials into the market requires thorough safety studies to be conducted. Recently, toxicity testing using cultured cells has attracted attention as a safety assessment that does not rely on experimental animals. This article reviews recent information regarding the cytotoxicity testing of CNFs and highlights the issues relevant to evaluating tests. In the literature, we found that a variety of cell lines and CNF exposure concentrations was evaluated. Furthermore, the results of cytotoxicity results tests differed and were not necessarily consistent. Numerous reports that we examined had not evaluated endotoxin/microbial contamination or the interaction of CNFs with the culture medium used in the tests. The following potential specific issues involved in CNF in vitro testing, were discussed: (1) endotoxin contamination, (2) microbial contamination, (3) adsorption of culture medium components to CNFs, and (4) changes in aggregation/agglomeration and dispersion states of CNFs resulting from culture medium components. In this review, the available measurement methods and solutions for these issues are also discussed. Addressing these points will lead to a better understanding of the cellular effects of CNFs and the development of safer CNFs.
    MeSH term(s) Animals ; Cellulose/toxicity ; Cellulose/chemistry ; Nanofibers/toxicity ; Nanofibers/chemistry ; Endotoxins/toxicity
    Chemical Substances Cellulose (9004-34-6) ; Endotoxins
    Language English
    Publishing date 2022-09-18
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 604625-3
    ISSN 1099-1263 ; 0260-437X
    ISSN (online) 1099-1263
    ISSN 0260-437X
    DOI 10.1002/jat.4390
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1661: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Contaminant microorganisms in the

    Horie, Masanori / Fujita, Katsuhide / Endoh, Shigehisa / Sugino, Sakiko / Maru, Junko / Moriyama, Akihiro / Ogura, Isamu

    Toxicology mechanisms and methods

    2023  Volume 33, Issue 9, Page(s) 741–754

    Abstract: Cellulose nanofibers (CNFs) are fibrous nanomaterials produced from plants. Since some nanomaterials are toxic, toxicity evaluation, ... ...

    Abstract Cellulose nanofibers (CNFs) are fibrous nanomaterials produced from plants. Since some nanomaterials are toxic, toxicity evaluation, including
    MeSH term(s) Humans ; Cellulose/toxicity ; Nanofibers/toxicity ; Caco-2 Cells ; Microbial Viability ; Lipopolysaccharides
    Chemical Substances Cellulose (9004-34-6) ; Lipopolysaccharides
    Language English
    Publishing date 2023-08-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2081252-8
    ISSN 1537-6524 ; 1537-6516 ; 1051-7235
    ISSN (online) 1537-6524
    ISSN 1537-6516 ; 1051-7235
    DOI 10.1080/15376516.2023.2238061
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3215: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Molecular networking-based lipid profiling and multi-omics approaches reveal new contributions of functional vanilloids to gut microbiota and lipometabolism changes.

    Hattori, Hiroyuki / Moriyama, Akihiro / Ohno, Tomoki / Shibata, Takahiro / Iwahashi, Hitoshi / Mitsunaga, Tohru

    Food chemistry. Molecular sciences

    2022  Volume 5, Page(s) 100123

    Abstract: Obesity is now recognized as an epidemic, requiring rapid intervention. We previously demonstrated that vanilloids from the African spice known as Grains of Paradise (GOP) exhibit strong anti-obesity effects. Here, the molecular mechanism behind the ... ...

    Abstract Obesity is now recognized as an epidemic, requiring rapid intervention. We previously demonstrated that vanilloids from the African spice known as Grains of Paradise (GOP) exhibit strong anti-obesity effects. Here, the molecular mechanism behind the obesity prevention property of the GOP extract was investigated by employing molecular networking-based lipid profiling and 16S rRNA sequencing. Administration of either GOP extract or two of its components, 6-paradol and 6-gingerol, reversed the unbalanced gut microbiota composition induced by a high-fat diet (HFD) with a decrease in Firmicutes / Bacteroidetes ratio and increase in genera
    Language English
    Publishing date 2022-07-18
    Publishing country England
    Document type Journal Article
    ISSN 2666-5662
    ISSN (online) 2666-5662
    DOI 10.1016/j.fochms.2022.100123
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  4. Article ; Online: The Effects of Endoplasmic Reticulum Stress via Intratracheal Instillation of Water-Soluble Acrylic Acid Polymer on the Lungs of Rats.

    Morimoto, Toshiki / Izumi, Hiroto / Tomonaga, Taisuke / Nishida, Chinatsu / Kawai, Naoki / Higashi, Yasuyuki / Wang, Ke-Yong / Ono, Ryohei / Sumiya, Kazuki / Sakurai, Kazuo / Moriyama, Akihiro / Takeshita, Jun-Ichi / Yamasaki, Kei / Yatera, Kazuhiro / Morimoto, Yasuo

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: Polyacrylic acid (PAA), an organic chemical, has been used as an intermediate in the manufacture of pharmaceuticals and cosmetics. It has been suggested recently that PAA has a high pulmonary inflammatory and fibrotic potential. Although endoplasmic ... ...

    Abstract Polyacrylic acid (PAA), an organic chemical, has been used as an intermediate in the manufacture of pharmaceuticals and cosmetics. It has been suggested recently that PAA has a high pulmonary inflammatory and fibrotic potential. Although endoplasmic reticulum stress is induced by various external and intracellular stimuli, there have been no reports examining the relationship between PAA-induced lung injury and endoplasmic reticulum stress. F344 rats were intratracheally instilled with dispersed PAA (molecular weight: 269,000) at low (0.5 mg/mL) and high (2.5 mg/mL) doses, and they were sacrificed at 3 days, 1 week, 1 month, 3 months and 6 months after exposure. PAA caused extensive inflammation and fibrotic changes in the lungs' histopathology over a month following instillation. Compared to the control group, the mRNA levels of endoplasmic reticulum stress markers Bip and Chop in BALF were significantly increased in the exposure group. In fluorescent immunostaining, both Bip and Chop exhibited co-localization with macrophages. Intratracheal instillation of PAA induced neutrophil inflammation and fibrosis in the rat lung, suggesting that PAA with molecular weight 269,000 may lead to pulmonary disorder. Furthermore, the presence of endoplasmic reticulum stress in macrophages was suggested to be involved in PAA-induced lung injury.
    MeSH term(s) Rats ; Animals ; Polymers ; Lung Injury ; Rats, Inbred F344 ; Endoplasmic Reticulum Stress ; Inflammation ; Lung ; Acrylates
    Chemical Substances Polymers ; acrylic acid (J94PBK7X8S) ; Acrylates
    Language English
    Publishing date 2024-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25073573
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  5. Article: Damage to adjacent organs during transvaginal surgery: A case complicated with sigmoid colon injury during uterine cervix conization.

    Shen, Jiao / Moriyama, Akihiro

    Gynecology and minimally invasive therapy

    2016  Volume 6, Issue 2, Page(s) 94–95

    Language English
    Publishing date 2016-06-27
    Publishing country India
    Document type Journal Article
    ISSN 2213-3070
    ISSN 2213-3070
    DOI 10.1016/j.gmit.2016.05.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Oxidative stress caused by TiO

    Moriyama, Akihiro / Yamada, Ikuho / Takahashi, Junko / Iwahashi, Hitoshi

    Chemico-biological interactions

    2018  Volume 294, Page(s) 144–150

    Abstract: Currently, nanoparticles are used in various commercial products. One of the most common nanoparticles is titanium dioxide ( ... ...

    Abstract Currently, nanoparticles are used in various commercial products. One of the most common nanoparticles is titanium dioxide (TiO
    MeSH term(s) Down-Regulation/drug effects ; Down-Regulation/genetics ; Down-Regulation/radiation effects ; Energy Metabolism/genetics ; Metal Nanoparticles/chemistry ; Metal Nanoparticles/toxicity ; Oligonucleotide Array Sequence Analysis ; Open Reading Frames/genetics ; Oxidative Stress/drug effects ; Oxidative Stress/radiation effects ; Protein Biosynthesis/genetics ; Reactive Oxygen Species/metabolism ; Saccharomyces cerevisiae/drug effects ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae/radiation effects ; Titanium/chemistry ; Ultraviolet Rays ; Up-Regulation/drug effects ; Up-Regulation/genetics ; Up-Regulation/radiation effects
    Chemical Substances Reactive Oxygen Species ; titanium dioxide (15FIX9V2JP) ; Titanium (D1JT611TNE)
    Language English
    Publishing date 2018-08-18
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 218799-1
    ISSN 1872-7786 ; 0009-2797
    ISSN (online) 1872-7786
    ISSN 0009-2797
    DOI 10.1016/j.cbi.2018.08.017
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 686: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: DNA Strand Break Properties of Protoporphyrin IX by X-Ray Irradiation against Melanoma.

    Hasegawa, Takema / Takahashi, Junko / Nagasawa, Shinsuke / Doi, Motomichi / Moriyama, Akihiro / Iwahashi, Hitoshi

    International journal of molecular sciences

    2020  Volume 21, Issue 7

    Abstract: Recent reports have suggested that 5-aminolevulinic acid (5-ALA), which is a precursor to protoporphyrin IX (PpIX), leads to selective accumulation of PpIX in tumor cells and acts as a radiation sensitizer in vitro and in vivo in mouse models of melanoma, ...

    Abstract Recent reports have suggested that 5-aminolevulinic acid (5-ALA), which is a precursor to protoporphyrin IX (PpIX), leads to selective accumulation of PpIX in tumor cells and acts as a radiation sensitizer in vitro and in vivo in mouse models of melanoma, glioma, and colon cancer. In this study, we investigated the effect of PpIX under X-ray irradiation through ROS generation and DNA damage. ROS generation by the interaction between PpIX and X-ray was evaluated by two kinds of probes, 3'-(p-aminophenyl) fluorescein (APF) for hydroxyl radical (•OH) detection and dihydroethidium (DHE) for superoxide (O
    MeSH term(s) Aminolevulinic Acid/metabolism ; Animals ; Cell Line, Tumor ; DNA Breaks, Double-Stranded ; Melanoma/genetics ; Melanoma/metabolism ; Melanoma/radiotherapy ; Mice ; Protoporphyrins/metabolism ; Protoporphyrins/radiation effects ; Radiation-Sensitizing Agents/metabolism ; Radiation-Sensitizing Agents/radiation effects ; Reactive Oxygen Species/metabolism ; X-Ray Therapy/methods ; X-Rays
    Chemical Substances Protoporphyrins ; Radiation-Sensitizing Agents ; Reactive Oxygen Species ; Aminolevulinic Acid (88755TAZ87) ; protoporphyrin IX (C2K325S808)
    Language English
    Publishing date 2020-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21072302
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  8. Article ; Online: Screening of X-ray responsive substances for the next generation of radiosensitizers.

    Moriyama, Akihiro / Hasegawa, Takema / Jiang, Lei / Iwahashi, Hitoshi / Mori, Takashi / Takahashi, Junko

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 18163

    Abstract: X-ray responsivity resulting in the generation of reactive oxygen species (ROS) was investigated in 9600 organic compounds that were selected by considering their structural diversity. We focused on superoxides that were primarily detected using ... ...

    Abstract X-ray responsivity resulting in the generation of reactive oxygen species (ROS) was investigated in 9600 organic compounds that were selected by considering their structural diversity. We focused on superoxides that were primarily detected using dihydroethidium (DHE) and hydroxyl radicals, that were identified fluorometrically using 3'-(p-aminophenyl) Fluorescein (APF). Many organic compounds were discovered that responded to the DHE and/or APF assay using X-ray irradiation. These results suggest that some of these organic compounds emit either superoxides or hydroxyl radicals whereas others emit both under the influence of X-ray irradiation. The response of the derivatives of a hit compound with a partial change in the structure was also investigated. The products produced from DHE by X-ray irradiation were identified by HPLC to confirm the integrity of the process. Although, the reactions were suppressed by the superoxide dismutase (SOD), not only 2-hydroxyethidium (2-OH-E
    Language English
    Publishing date 2019-12-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-54649-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Truth of Toxicity Caused by Yttrium Oxide Nanoparticles to Yeast Cells.

    Moriyama, Akihiro / Takahashi, Ukyo / Mizuno, Youta / Takahashi, Junko / Horie, Masanori / Iwahashi, Hitoshi

    Journal of nanoscience and nanotechnology

    2019  Volume 19, Issue 9, Page(s) 5418–5425

    Abstract: Yttrium oxide (Y₂O₃) nanoparticles have widespread applications; however, toxicity due to these nanoparticles has also been reported. In this study, we evaluated ... ...

    Abstract Yttrium oxide (Y₂O₃) nanoparticles have widespread applications; however, toxicity due to these nanoparticles has also been reported. In this study, we evaluated the
    MeSH term(s) Metal Nanoparticles/toxicity ; Nanoparticles ; Oxidative Stress ; Saccharomyces cerevisiae/genetics ; Yttrium/toxicity
    Chemical Substances Yttrium (58784XQC3Y) ; yttria (X8071685XT)
    Language English
    Publishing date 2019-04-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1533-4880
    ISSN 1533-4880
    DOI 10.1166/jnn.2019.16544
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  10. Article: Thrombophlebitis of the Right Renal Capsular Vein during the Early Postpartum Period.

    Nakamura, Koji / Nakanishi, Kensuke / Kubota, Satoshi / Takahashi, Ryoko / Tomiie, Mari / Moriyama, Akihiro

    Case reports in obstetrics and gynecology

    2018  Volume 2018, Page(s) 3096468

    Abstract: Venous thrombophlebitis is an uncommon cause of fever and lower abdominal pain during the early postpartum period. It mostly occurs in the right ovarian vein, and computed tomography (CT) is useful for diagnosis. We present a case of thrombophlebitis of ... ...

    Abstract Venous thrombophlebitis is an uncommon cause of fever and lower abdominal pain during the early postpartum period. It mostly occurs in the right ovarian vein, and computed tomography (CT) is useful for diagnosis. We present a case of thrombophlebitis of the renal capsular vein. A 27-year-old postpartum woman presented with right lower abdominal pain and fever unresponsive to antibiotics. Contrast CT showed a ring-enhancing mass in the right retroperitoneum, which was distinct from the right ovarian vein. Exploratory laparoscopy revealed a retroperitoneal hematoma and normal appendix. Reconstruction of CT images revealed that the mass was connected to the right renal capsular vein. Anticoagulation therapy improved the patient's symptoms. Postpartum thrombophlebitis can occur at locations other than the ovarian vein, such as the renal capsular vein. If a retroperitoneal mass is discovered during puerperium, a thorough investigation of the mass's continuity with surrounding vessels is essential to avoid unnecessary surgery.
    Language English
    Publishing date 2018-10-09
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627654-9
    ISSN 2090-6692 ; 2090-6684
    ISSN (online) 2090-6692
    ISSN 2090-6684
    DOI 10.1155/2018/3096468
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