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  1. Book ; Thesis: Epidemiologie und Lebensqualität nach Hüft- oder Knieprotheseninfekt

    Morlock, Julia

    2013  

    Author's details vorgelegt von Julia Morlock
    Language German
    Size 64 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Freiburg i. Br., Univ., Diss., 2013
    HBZ-ID HT017640024
    Database Catalogue ZB MED Medicine, Health

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  2. Article: Individualized Decision Making in Transperineal Prostate Biopsy: Should All Men Undergo an Additional Systematic Biopsy?

    Sigle, August / Suarez-Ibarrola, Rodrigo / Benndorf, Matthias / Weishaar, Moritz / Morlock, Jonathan / Miernik, Arkadiusz / Gratzke, Christian / Jilg, Cordula A / Grabbert, Markus

    Cancers

    2022  Volume 14, Issue 21

    Abstract: Background: In prostate cancer (PC) diagnosis, additional systematic biopsy (SB) is recommended to complement MRI-targeted biopsy (TB) to address the limited sensitivity of TB alone. The combination of TB+SB is beneficial for diagnosing additional ... ...

    Abstract Background: In prostate cancer (PC) diagnosis, additional systematic biopsy (SB) is recommended to complement MRI-targeted biopsy (TB) to address the limited sensitivity of TB alone. The combination of TB+SB is beneficial for diagnosing additional significant PC (sPC) but harmful in terms of the additional diagnosis of indolent PC (iPC), morbidity, and resource expenditures. We aimed to investigate the benefit of additional SB and to identify predictors for this outcome. Methods: We analyzed the frequency of upgrading to sPC by additional SB in a retrospective single-center cohort of 1043 men. Regression analysis (RA) was performed to identify predictors for this outcome. Reclassification rates of ISUP grade groups between prostate biopsy and a subsequent radical prostatectomy were assessed. Results: Additional SB led to upgrading to sPC in 98/1043 men (9.4%) and to the additional diagnosis of iPC in 71/1043 (6.8%). In RA, men harboring a PI-RADS 2-4 lesion were more likely to have TB results upgraded by SB (p < 0.01) compared to PI-RADS 5 men. When analyzing reclassification rates, additional SB reduced the upgrading to sPC from 43/214 (20.1%) to 8/214 (3.7%). In the PI-RADS 5 subgroup, this difference decreased: 4/87 (4.7%) with TB only vs. 1/87 (1.2%) with TB+SB. Conclusion: Men with a PI-RADS 5 lesion may obviate additional SB.
    Language English
    Publishing date 2022-10-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14215230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Conference proceedings: Thoracic Endovascular Aortic Repair for the Treatment of Acute Aortic Rupture

    Kreibich, M. / Siepe, M. / Berger, T. / Morlock, J. / Kondov, S. / Pingpoh, C. / Schröfel, H. / Beyersdorf, F. / Rylski, B. / Czerny, M.

    The Thoracic and Cardiovascular Surgeon

    2021  Volume 69, Issue S 01

    Event/congress 50th Annual Meeting of the German Society for Thoracic and Cardiovascular Surgery (DGTHG), Online, 2021-02-26
    Language English
    Publishing date 2021-01-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 800050-5
    ISSN 1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
    ISSN (online) 1439-1902
    ISSN 0171-6425 ; 0946-4778 ; 0172-6137
    DOI 10.1055/s-0041-1725641
    Database Thieme publisher's database

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  4. Article ; Online: Downstream thoracic endovascular aortic repair following zone 2, 100-mm stent graft frozen elephant trunk implantation.

    Kreibich, Maximilian / Siepe, Matthias / Berger, Tim / Kondov, Stoyan / Morlock, Julia / Pingpoh, Clarence / Beyersdorf, Friedhelm / Rylski, Bartosz / Czerny, Martin

    Interactive cardiovascular and thoracic surgery

    2021  Volume 34, Issue 6, Page(s) 1141–1146

    Abstract: Objectives: The aim of this study was to analyse outcomes of downstream thoracic endovascular aortic repair (TEVAR) following the frozen elephant trunk (FET) procedure.: Methods: Sixty-six patients underwent downstream TEVAR following the FET ... ...

    Abstract Objectives: The aim of this study was to analyse outcomes of downstream thoracic endovascular aortic repair (TEVAR) following the frozen elephant trunk (FET) procedure.
    Methods: Sixty-six patients underwent downstream TEVAR following the FET procedure to treat thoracic aortic dissections (n = 42, 64%), aneurysms (n = 19, 29%) or penetrating aortic ulcers involving the aortic arch (n = 5, 8%). Patient and outcome characteristics were analysed.
    Results: Downstream TEVAR was performed 7 [interquartile range: 2-18] months after the FET procedure in 39 male (59%) and 27 female (41%) patients aged 68 [interquartile range: 56, 75] years, including 11 patients (17%) with a connective tissue disease. Before TEVAR, cerebrospinal fluid drainage was put in place in 61 patients (92%). Patients were treated with 1 stent graft (n = 28, 42%), 2 stent grafts (n = 37, 56%) or 3 stent grafts (n = 1, 2%). The femoral artery was accessed through surgical cut-down (n = 15, 23%) or percutaneously (n = 49, 74%). One patient (2%) developed a temporary spinal cord injury that resolved spontaneously. No case of permanent spinal cord injury, stroke or death was observed. After 12 [interquartile range: 2-23] months, 15 patients required an additional aortic reintervention (endovascular: n = 6; surgical: n = 9).
    Conclusions: Downstream TEVAR following the FET procedure is associated with excellent clinical outcomes. We thus maintain that staging thoracic aortic repair-FET and secondary TEVAR-is a very successful and safe strategy. Certain patients might need a tertiary procedure to fix their entire aortic pathology; therefore, they will require long-term continuous follow-up, ideally in a dedicated aortic clinic.
    MeSH term(s) Aneurysm, Dissecting/diagnostic imaging ; Aneurysm, Dissecting/etiology ; Aneurysm, Dissecting/surgery ; Aorta, Thoracic/diagnostic imaging ; Aorta, Thoracic/pathology ; Aorta, Thoracic/surgery ; Aortic Aneurysm, Thoracic/diagnostic imaging ; Aortic Aneurysm, Thoracic/etiology ; Aortic Aneurysm, Thoracic/surgery ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation/adverse effects ; Blood Vessel Prosthesis Implantation/methods ; Endovascular Procedures/adverse effects ; Endovascular Procedures/methods ; Female ; Humans ; Male ; Retrospective Studies ; Spinal Cord Injuries/etiology ; Stents/adverse effects ; Treatment Outcome ; Ulcer/surgery
    Language English
    Publishing date 2021-11-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2095298-3
    ISSN 1569-9285 ; 1569-9293
    ISSN (online) 1569-9285
    ISSN 1569-9293
    DOI 10.1093/icvts/ivab338
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Conference proceedings: Semi-Controlled Aortic Stent Graft Deployment in the Distal Landing Zone: Incidence, Reasons and Consequences

    Berezowski, M. / Morlock, J. / Beyersdorf, F. / Plonek, T. / Siepe, M. / Czerny, M. / Rylski, B.

    The Thoracic and Cardiovascular Surgeon

    2017  Volume 65, Issue S 01

    Event/congress 46th Annual Meeting of the German Society for Thoracic and Cardiovascular Surgery (DGTHG), Leipzig, 2017-02-11
    Language English
    Publishing date 2017-01-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 800050-5
    ISSN 1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
    ISSN (online) 1439-1902
    ISSN 0171-6425 ; 0946-4778 ; 0172-6137
    DOI 10.1055/s-0037-1598826
    Database Thieme publisher's database

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  6. Article ; Online: The Frozen Elephant Trunk Technique for the Treatment of Type B and Type Non-A Non-B Aortic Dissection.

    Kreibich, Maximilian / Siepe, Matthias / Berger, Tim / Kondov, Stoyan / Morlock, Julia / Pingpoh, Clarence / Beyersdorf, Friedhelm / Rylski, Bartosz / Czerny, Martin

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2020  Volume 61, Issue 1, Page(s) 107–113

    Abstract: Objective: To evaluate outcomes of patients with acute complicated or chronic Type B or non-A non-B aortic dissection who underwent the frozen elephant trunk (FET) technique.: Methods: Between April 2013 and July 2019, 41 patients presenting with ... ...

    Abstract Objective: To evaluate outcomes of patients with acute complicated or chronic Type B or non-A non-B aortic dissection who underwent the frozen elephant trunk (FET) technique.
    Methods: Between April 2013 and July 2019, 41 patients presenting with acute complicated (n = 29) or chronic (n = 12) descending thoracic aortic dissection were treated by the FET technique, which was the treatment of choice when supra-aortic vessel transposition would not suffice to create a satisfactory proximal landing zone for endovascular aortic repair, when a concomitant ascending or arch aneurysm was present, or in patients with connective tissue diseases.
    Results: One patient (2%) died intra-operatively secondary to an aortic rupture in dwnstream aortic segments. No post-operative deaths occurred. Four patients (10%) suffered a non-disabling posto-operative stroke and were discharged with no clinical symptoms (modified Rankin Scale [mRS] 0, n = 1), no significant disability (mRS 1, n = 2), or with slight disability (mRS 2, n = 1). No spinal cord ischaemia was observed. The primary entry tear was either surgically resected or excluded from circulation in all patients. During follow up, one patient (2%) died after two years (not aorta related) and 16 patients (39%) underwent an aortic re-intervention after 7.7 [interquartile range 0.7, 15.8] months (endovascular aortic repair: n = 14; open thoraco-abdominal aortic replacement: n = 1, hybrid approach: n = 1).
    Conclusion: The FET technique is an effective treatment option for acute complicated and chronic Type B or non-A non-B aortic dissection in patients in whom primary endovascular aortic repair is non-feasible. While the post-operative outcome is acceptable with a relatively low incidence of non-disabling strokes, this study also underlines the considerable need for aortic re-interventions. Continuous follow up of all patients undergoing the FET procedure is essential.
    MeSH term(s) Aged ; Aneurysm, Dissecting/mortality ; Aneurysm, Dissecting/pathology ; Aneurysm, Dissecting/surgery ; Aorta, Thoracic/pathology ; Aorta, Thoracic/surgery ; Aortic Aneurysm, Thoracic/mortality ; Aortic Aneurysm, Thoracic/pathology ; Aortic Aneurysm, Thoracic/surgery ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Reoperation/statistics & numerical data ; Survival Analysis ; Vascular Grafting/methods
    Keywords covid19
    Language English
    Publishing date 2020-09-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2020.08.040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Generalized Malperfusion Due to Systemic Embolization From a Large Thrombosed Pulmonary Vein Aneurysm.

    Kreibich, Maximilian / Rylski, Bartosz / Morlock, Julia / Beyersdorf, Friedhelm / Czerny, Martin

    The Annals of thoracic surgery

    2016  Volume 102, Issue 2, Page(s) e123–4

    Abstract: We report the case of a 61-year-old patient who presented with generalized malperfusion due to systemic embolization from a large, partially thrombosed aneurysm of the left upper pulmonary vein. When the patient arrived at our center, large thrombus ... ...

    Abstract We report the case of a 61-year-old patient who presented with generalized malperfusion due to systemic embolization from a large, partially thrombosed aneurysm of the left upper pulmonary vein. When the patient arrived at our center, large thrombus formations were detected in the left atrium and the abdominal aorta, as well as the renal, iliac, and femoral arteries. Renal, splenic, and mesenteric ischemia was diagnosed with computed tomography. The patient was in shock, acute kidney failure, and in high vasopressor need. The case highlights the risk of intraluminal thrombus formation in pulmonary vein aneurysms and underlines the need for systemic anticoagulation therapy and surgical therapy, if diagnosed in time.
    MeSH term(s) Aneurysm/complications ; Aneurysm/diagnostic imaging ; Aneurysm/surgery ; Aorta, Abdominal/diagnostic imaging ; Aorta, Abdominal/pathology ; Computed Tomography Angiography/methods ; Critical Illness ; Disease Progression ; Fatal Outcome ; Female ; Femoral Artery/diagnostic imaging ; Femoral Artery/pathology ; Humans ; Iliac Artery/diagnostic imaging ; Iliac Artery/pathology ; Middle Aged ; Palliative Care/methods ; Pulmonary Veins/diagnostic imaging ; Pulmonary Veins/pathology ; Renal Artery/diagnostic imaging ; Renal Artery/pathology ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/drug therapy ; Venous Thrombosis/physiopathology
    Language English
    Publishing date 2016-08
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2015.12.054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Leitlinien Aortenerkrankungen der European Society of Cardiology. Zusammenfassung und Kommentar

    Rylski, B. / Siepe, M. / Kari, F. A. / Kondov, S. / Morlock, J. / Scheumann, J. / Beyersdorf, F. / Czerny, M.

    Zeitschrift für Herz-, Thorax- und Gefässchirurgie

    2018  Volume 32, Issue 2, Page(s) 127

    Language German
    Document type Article
    ZDB-ID 639111-4
    ISSN 0930-9225
    Database Current Contents Medicine

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  9. Article: Endovaskuläre Behandlung des Aortenbogenaneurysmas

    Rylski, B. / Schröfel, H. / Siepe, M. / Kondov, S. / Morlock, J. / Scheumann, J. / Kreibich, M. / Riesterer, T. / Czerny, M. / Beyersdorf, F.

    Zeitschrift für Herz-, Thorax- und Gefässchirurgie

    2018  Volume 32, Issue 4, Page(s) 258

    Language German
    Document type Article
    ZDB-ID 639111-4
    ISSN 0930-9225
    Database Current Contents Medicine

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  10. Article ; Online: Impact of Intermittent Functional Internal Iliac Artery Occlusion on Spinal Cord Blood Supply during TEVAR.

    Maier, Sven / Morlock, Julia / Benk, Christoph / Kari, Fabian Alexander / Siepe, Matthias / Beyersdorf, Friedhelm / Czerny, Martin / Rylski, Bartosz

    The Thoracic and cardiovascular surgeon

    2019  Volume 68, Issue 4, Page(s) 315–321

    Abstract: Background: Measuring transcranial motor evoked potentials (EPs) and somatosensory EPs is a well-established method to assess spinal cord function during thoracic endovascular aortic repair (TEVAR). Functional occlusion of one or both internal iliac ... ...

    Abstract Background: Measuring transcranial motor evoked potentials (EPs) and somatosensory EPs is a well-established method to assess spinal cord function during thoracic endovascular aortic repair (TEVAR). Functional occlusion of one or both internal iliac arteries by large bore sheaths during TEVAR can cause unilateral intermittently EP loss.
    Methods: Between 2006 and 2016, 194 patients underwent TEVAR entailing EP monitoring. The ISIS IOM System (Inomed Medizintechnik GmbH, Emmendingen, Germany) was employed in all patients. EPs were recorded after inducing anesthesia, during the procedure, and before discontinuing anesthesia.
    Results: We observed a unilateral intermittently EP decrease or loss in 12 (6.2%) patients. Most events were ipsilateral (9 of 12). The underlying pathologies were descending aortic aneurysm in six patients and type B dissection in six patients. An evoked-potential decrease or loss was always associated with the insertion of large bore stent-graft-introducing sheaths. The median duration of the unilaterally EP decrease or loss was 16 (10; 31) minutes (range, 2-77 minutes) with baseline values re-established at the end of the procedure after sheath removal in all cases. No patient developed irreversible symptomatic spinal cord ischemia.
    Conclusion: A functional occlusion of internal iliac arteries via large bore TEVAR-introducing sheaths is associated with a unilateral intermittent decrease in or loss of EPs returning to baseline after sheath removal. This observation highlights the importance of the internal iliac arteries as one of the major spinal cord's blood supply territories, and may serve as a stimulus to reduce the duration of sheath indwelling to a minimum.
    MeSH term(s) Aged ; Aneurysm, Dissecting/diagnostic imaging ; Aneurysm, Dissecting/physiopathology ; Aneurysm, Dissecting/surgery ; Aortic Aneurysm, Thoracic/diagnostic imaging ; Aortic Aneurysm, Thoracic/physiopathology ; Aortic Aneurysm, Thoracic/surgery ; Blood Vessel Prosthesis Implantation/adverse effects ; Endovascular Procedures/adverse effects ; Evoked Potentials, Motor ; Evoked Potentials, Somatosensory ; Female ; Humans ; Iliac Artery/diagnostic imaging ; Iliac Artery/physiopathology ; Iliac Artery/surgery ; Intraoperative Neurophysiological Monitoring ; Male ; Operative Time ; Regional Blood Flow ; Retrospective Studies ; Risk Factors ; Spinal Cord/blood supply ; Spinal Cord Ischemia/etiology ; Spinal Cord Ischemia/physiopathology ; Transcranial Direct Current Stimulation ; Treatment Outcome
    Language English
    Publishing date 2019-05-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 800050-5
    ISSN 1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
    ISSN (online) 1439-1902
    ISSN 0171-6425 ; 0946-4778 ; 0172-6137
    DOI 10.1055/s-0039-1688474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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