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  1. Article: Covidsomnia: is the sirtuin1-NAD + axis the clue of the matter?

    Mormile, Raffaella / Mormile, Cristina

    Sleep and biological rhythms

    2024  Volume 22, Issue 2, Page(s) 293–294

    Language English
    Publishing date 2024-03-02
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2185804-4
    ISSN 1479-8425 ; 1446-9235
    ISSN (online) 1479-8425
    ISSN 1446-9235
    DOI 10.1007/s41105-024-00518-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6051: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Enhanced Stability of Dopamine Delivery via Hydrogel with Integrated Graphene.

    Mormile, Cristina / Opriș, Ocsana / Bellucci, Stefano / Lung, Ildiko / Kacso, Irina / Turza, Alexandru / La Pietra, Matteo / Vacacela Gomez, Cristian / Stegarescu, Adina / Soran, Maria-Loredana

    Journal of functional biomaterials

    2023  Volume 14, Issue 12

    Abstract: The synthesis of graphene-based materials for drug delivery represents an area of active research, and the use of graphene in drug delivery systems is promising due to its unique properties. Thus, in the present work, we discuss the potential of few- ... ...

    Abstract The synthesis of graphene-based materials for drug delivery represents an area of active research, and the use of graphene in drug delivery systems is promising due to its unique properties. Thus, in the present work, we discuss the potential of few-layer graphene in a hydrogel system for dopamine release. The hydrogels are frequently used for these systems for their special physico-chemical properties, which can ensure that the drug is effectively released in time. However, the release from such structures is mostly determined by diffusion alone, and to overcome this restriction, the hydrogel can be "improved" with nanoscale fillers like graphene. The release kinetics of the composite obtained were analyzed to better understand how the use of graphene, instead of the more common graphene oxide (GO) and reduced graphene oxide (rGO), affects the characteristics of the system. Thus, the systems developed in this study consist of three main components: biopolymer, graphene, and dopamine. The hydrogels with graphene were prepared by combining two different solutions, one with polyacrylic acid and agarose and one with graphene prepared by the exfoliation method with microwave irradiation. The drug delivery systems were developed by adding dopamine to the obtained hydrogels. After 24 h of release, the presence of dopamine was observed, demonstrating that the system developed can slow down the drug's degradation because of the interactions with the graphene nanoplates and the polymer matrix.
    Language English
    Publishing date 2023-11-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2648525-4
    ISSN 2079-4983
    ISSN 2079-4983
    DOI 10.3390/jfb14120558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Oxidized Alginate Dopamine Conjugate: In Vitro Characterization for Nose-to-Brain Delivery Application.

    Trapani, Adriana / Corbo, Filomena / Agrimi, Gennaro / Ditaranto, Nicoletta / Cioffi, Nicola / Perna, Filippo / Quivelli, Andrea / Stefàno, Erika / Lunetti, Paola / Muscella, Antonella / Marsigliante, Santo / Cricenti, Antonio / Luce, Marco / Mormile, Cristina / Cataldo, Antonino / Bellucci, Stefano

    Materials (Basel, Switzerland)

    2021  Volume 14, Issue 13

    Abstract: Background: The blood-brain barrier (BBB) bypass of dopamine (DA) is still a challenge for supplying it to the neurons of : Methods: A Schiff base was designed to connect oxidized polymeric backbone to DA and both AlgOX and AlgOX-DA were ... ...

    Abstract Background: The blood-brain barrier (BBB) bypass of dopamine (DA) is still a challenge for supplying it to the neurons of
    Methods: A Schiff base was designed to connect oxidized polymeric backbone to DA and both AlgOX and AlgOX-DA were characterized in terms of Raman, XPS, FT-IR, and
    Results: Data demonstrated that AlgOX-DA was the most mucoadhesive material among the tested ones and it released the neurotransmitter in simulated nasal fluid and in low amounts in phosphate buffer saline. Results also demonstrated the capability of scanning near-field optical microscopy to study the structural and fluorescence properties of AlgOX, fluorescently labeled with fluorescein isothiocyanate microstructures. Interestingly, in SH-SY5Y neuroblastoma cell line up to 100 μg/mL, no toxic effect was derived from AlgOX and AlgOX-DA in 24 h.
    Conclusions: Overall, the in vitro performances of AlgOX and AlgOX-DA conjugates seem to encourage further ex vivo and in vivo studies in view of nose-to-brain administration.
    Language English
    Publishing date 2021-06-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma14133495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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