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  1. Article ; Online: The geometry of predication: a configurational derivation of the defining property of clause structure.

    Moro, Andrea

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2019  Volume 375, Issue 1791, Page(s) 20190310

    Abstract: Predication is the fundamental grammatical relation defining clausal structures in all (and only) human languages. This notion is by definition compositional, since it consists of a link between a subject and a predicate. The central question addressed ... ...

    Abstract Predication is the fundamental grammatical relation defining clausal structures in all (and only) human languages. This notion is by definition compositional, since it consists of a link between a subject and a predicate. The central question addressed here is whether this traditional notion, which has never been dismissed ever since the canonical models of Ancient Greek linguistics, can be derived at a formal level from more abstract compositional algorithms. Capitalizing on predication in copular sentences, which allow factoring out non-essential aspects of this phenomenon, such as the morphological asymmetry between verbs and nouns, I propose a configurational approach to predication. This new approach is based on the notion of symmetry as derived by purely compositional mechanisms. Finally, I address some theoretical and empirical consequences of this generalization including those pertaining to neurolinguistics. This article is part of the theme issue 'Towards mechanistic models of meaning composition'.
    MeSH term(s) Comprehension ; Electrophysiological Phenomena ; Greece, Ancient ; Humans ; Language ; Linguistics ; Mental Processes ; Neurosciences ; Semantics ; Vocabulary
    Language English
    Publishing date 2019-12-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2019.0310
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  2. Article ; Online: Three reasons why AI doesn't model human language.

    Bolhuis, Johan J / Crain, Stephen / Fong, Sandiway / Moro, Andrea

    Nature

    2024  Volume 627, Issue 8004, Page(s) 489

    MeSH term(s) Humans ; Language ; Natural Language Processing ; Language Development
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Comparative Study ; Letter
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-024-00824-z
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  3. Article ; Online: Novel strategy for multi-material 3D bioprinting of human stem cell based corneal stroma with heterogenous design.

    Puistola, Paula / Miettinen, Susanna / Skottman, Heli / Mörö, Anni

    Materials today. Bio

    2023  Volume 24, Page(s) 100924

    Abstract: Three-dimensional (3D) bioprinting offers an automated, customizable solution to manufacture highly detailed 3D tissue constructs and holds great promise for regenerative medicine to solve the severe global shortage of donor tissues and organs. However, ... ...

    Abstract Three-dimensional (3D) bioprinting offers an automated, customizable solution to manufacture highly detailed 3D tissue constructs and holds great promise for regenerative medicine to solve the severe global shortage of donor tissues and organs. However, uni-material 3D bioprinting is not sufficient for manufacturing heterogenous 3D constructs with native-like microstructures and thus, innovative multi-material solutions are required. Here, we developed a novel multi-material 3D bioprinting strategy for bioprinting human corneal stroma. The human cornea is the transparent outer layer of your eye, and vision loss due to corneal blindness has serious effects on the quality of life of individuals. One of the main reasons for corneal blindness is the damage in the detailed organization of the corneal stroma where collagen fibrils are arranged in layers perpendicular to each other and the corneal stromal cells grow along the fibrils. Donor corneas for treating corneal blindness are scarce, and the current tissue engineering (TE) technologies cannot produce artificial corneas with the complex microstructure of native corneal stroma. To address this, we developed a novel multi-material 3D bioprinting strategy to mimic detailed organization of corneal stroma. These multi-material 3D structures with heterogenous design were bioprinted by using human adipose tissue -derived stem cells (hASCs) and hyaluronic acid (HA) -based bioinks with varying stiffnesses. In our novel design of 3D models, acellular stiffer HA-bioink and cell-laden softer HA-bioink were printed in alternating filaments, and the filaments were printed perpendicularly in alternating layers. The multi-material bioprinting strategy was applied for the first time in corneal stroma 3D bioprinting to mimic the native microstructure. As a result, the soft bioink promoted cellular growth and tissue formation of hASCs in the multi-material 3D bioprinted composites, whereas the stiff bioink provided mechanical support as well as guidance of cellular organization upon culture. Interestingly, cellular growth and tissue formation altered the mechanical properties of the bioprinted composite constructs significantly. Importantly, the bioprinted composite structures showed good integration to the host tissue in
    Language English
    Publishing date 2023-12-22
    Publishing country England
    Document type Journal Article
    ISSN 2590-0064
    ISSN (online) 2590-0064
    DOI 10.1016/j.mtbio.2023.100924
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  4. Article: Exploring a Potential Avenue for Beekeeping in Ireland: Safeguarding Locally Adapted Honeybees for Breeding Varroa-Resistant Lines.

    Smith, Stephen / Moro, Arrigo / McCormack, Grace P

    Insects

    2023  Volume 14, Issue 10

    Abstract: Beekeeping in Ireland has been strongly impacted by the parasitic ... ...

    Abstract Beekeeping in Ireland has been strongly impacted by the parasitic mite
    Language English
    Publishing date 2023-10-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662247-6
    ISSN 2075-4450
    ISSN 2075-4450
    DOI 10.3390/insects14100827
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  5. Article ; Online: Large languages, impossible languages and human brains.

    Moro, Andrea / Greco, Matteo / Cappa, Stefano F

    Cortex; a journal devoted to the study of the nervous system and behavior

    2023  Volume 167, Page(s) 82–85

    Abstract: We aim at offering a contribution to highlight the essential differences between Large Language Models (LLM) and the human language faculty. More explicitly, we claim that the existence of impossible languages for humans does not have any equivalent for ... ...

    Abstract We aim at offering a contribution to highlight the essential differences between Large Language Models (LLM) and the human language faculty. More explicitly, we claim that the existence of impossible languages for humans does not have any equivalent for LLM making them unsuitable models of the human language faculty, especially for a neurobiological point of view. The core part is preceded by two premises bearing on the distinction between machines and humans and the distinction between competence and performance.
    Language English
    Publishing date 2023-07-17
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 280622-8
    ISSN 1973-8102 ; 0010-9452
    ISSN (online) 1973-8102
    ISSN 0010-9452
    DOI 10.1016/j.cortex.2023.07.003
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  6. Article ; Online: Rare Presentation of Umbilical Condyloma.

    Ward, Caroline C / Moro, Amika / Bennett, Robert D

    The American surgeon

    2023  Volume 89, Issue 7, Page(s) 3207–3208

    Abstract: Syphilis is associated with 3 stages of infection-primary, secondary, and tertiary-each with their own associated clinical findings. Secondary syphilis manifests with condyloma lata and other cutaneous findings, and typically occurs several months after ... ...

    Abstract Syphilis is associated with 3 stages of infection-primary, secondary, and tertiary-each with their own associated clinical findings. Secondary syphilis manifests with condyloma lata and other cutaneous findings, and typically occurs several months after the initial infection. Condyloma lata are primarily found in the genital area, but may also be found in other locations such as the umbilicus, axilla, and neck. This brief report describes an umbilical condyloma lata discovered in a patient with secondary syphilis and HIV co-infection and discusses surgical excision and fulguration as an option for definitive management.
    MeSH term(s) Humans ; Umbilicus/surgery ; Syphilis/complications ; Syphilis, Cutaneous/complications ; HIV Infections/complications
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    DOI 10.1177/00031348231157886
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  7. Article ; Online: Understanding the Dynamics of Violent Political Revolutions in an Agent-Based Framework.

    Moro, Alessandro

    PloS one

    2016  Volume 11, Issue 4, Page(s) e0154175

    Abstract: This paper develops an agent-based computational model of violent political revolutions in which a subjugated population of citizens and an armed revolutionary organisation attempt to overthrow a central authority and its loyal forces. The model ... ...

    Abstract This paper develops an agent-based computational model of violent political revolutions in which a subjugated population of citizens and an armed revolutionary organisation attempt to overthrow a central authority and its loyal forces. The model replicates several patterns of rebellion consistent with major historical revolutions, and provides an explanation for the multiplicity of outcomes that can arise from an uprising. The relevance of the heterogeneity of scenarios predicted by the model can be understood by considering the recent experience of the Arab Spring involving several rebellions that arose in an apparently similar way, but resulted in completely different political outcomes: the successful revolution in Tunisia, the failed protests in Saudi Arabia and Bahrain, and civil war in Syria and Libya.
    MeSH term(s) Algorithms ; Bahrain ; Civil Disorders ; Computer Simulation ; Humans ; Libya ; Models, Theoretical ; Politics ; Population Dynamics ; Saudi Arabia ; Syria ; Tunisia ; Violence ; Warfare and Armed Conflicts
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0154175
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  8. Article: The dataset of the CLU lichen herbarium (Calabria, Italy).

    Conti, Matteo / Martellos, Stefano / Moro, Andrea / Nimis, Pier Luigi / Puntillo, Domenico

    Biodiversity data journal

    2024  Volume 12, Page(s) e116965

    Abstract: Background: Calabria, the southernmost tip of the Italian Peninsula, is a biogeographically very interesting region for lichenologists, characterised by the abundance of oceanic and suboceanic species with subtropical affinities, but also by the ... ...

    Abstract Background: Calabria, the southernmost tip of the Italian Peninsula, is a biogeographically very interesting region for lichenologists, characterised by the abundance of oceanic and suboceanic species with subtropical affinities, but also by the presence of the southernmost outposts of several boreal species on the highest peaks. The lichen biota of Calabria, which began to be intensively studied only from the 1980s, hosts more than 1000 infrageneric taxa. The lichen herbarium of the Botanical Garden of the University of Calabria (CLU) is the most relevant lichen collection from this region. It was established in 1985 and it presently includes 16926 specimens, most of which were collected in Calabria, although there are also several specimens from other parts of Italy and from abroad.
    New information: This dataset contains 16926 records of lichens for a total of 1316 species. Of the 15219 georeferenced specimens, 10254 were collected in Calabria, while 4965 in other administrative regions of Italy. The dataset is available through GBIF, as well as in ITALIC, the Information System of Italian Lichens.
    Language English
    Publishing date 2024-03-08
    Publishing country Bulgaria
    Document type Journal Article
    ZDB-ID 2736709-5
    ISSN 1314-2828
    ISSN 1314-2828
    DOI 10.3897/BDJ.12.e116965
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  9. Article: Orbital Exenteration in Recurrence Cancer: 5 Years Experience.

    Barbera, Giorgio / Todaro, Mattia / Saponaro, Gianmarco / Gasparini, Giulio / Moro, Alessandro

    Journal of clinical medicine

    2023  Volume 12, Issue 19

    Abstract: Introduction: The purpose of this study was to assess the overall survival (OS) and disease-free survival (DFS) of patients who underwent orbital exenteration for periorbital, conjunctival, and primary intraorbital carcinomas. Additionally, we assessed ... ...

    Abstract Introduction: The purpose of this study was to assess the overall survival (OS) and disease-free survival (DFS) of patients who underwent orbital exenteration for periorbital, conjunctival, and primary intraorbital carcinomas. Additionally, we assessed the outcomes of anterior retrograde temporalis muscle flap restoration.
    Methods: For all patients who had orbital exenteration in the previous five years, a non-comparative retrospective assessment of their medical records, histology, and radiographic imaging was carried out. We investigated the relationships between the various qualitative factors using Cramer's V Kaplan-Meier (KM) analysis. For each of the patient's categorical factors that were of relevance, estimates of the survival distribution were displayed, and log-rank tests were used to determine whether the survival distributions were equal.
    Results: This study looks at 19 participants. The sample is made up of 13 men (68%) and 6 women (32%). The degree of relationship (Cramer's V index) between lymph node metastases (N) and the existence of distant metastases (M) is high, at 64%, and is statistically significant because the
    Conclusion: Our findings show how crucial it is to identify any lymph node involvement that orbital neoplasms may have. In patients who have received many treatments, sentinel lymph node biopsy (SLNB) may be used to determine the stage and spread of the cancer. To determine whether additional tumor characteristics may be explored, more expertise in the SLNB field for patients with orbital cancer who have received many treatments may be helpful. To prevent additional scarring and to be comparable to previous techniques for facial nerve lesions, the anterior retrograde approach and the transorbital procedure for temporal muscle flap in-setting are both effective methods.
    Language English
    Publishing date 2023-09-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12196180
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  10. Article ; Online: Maximal Fusion Capacity and Efficient Replenishment of the Dense Core Vesicle Pool in Hippocampal Neurons.

    Baginska, Urszula / Moro, Alessandro / Toonen, Ruud F / Verhage, Matthijs

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2023  Volume 43, Issue 45, Page(s) 7616–7625

    Abstract: Neuropeptides and neurotrophins, stored in dense core vesicles (DCVs), are together the largest currently known group of chemical signals in the brain. Exocytosis of DCVs requires high-frequency or patterned stimulation, but the determinants to reach ... ...

    Abstract Neuropeptides and neurotrophins, stored in dense core vesicles (DCVs), are together the largest currently known group of chemical signals in the brain. Exocytosis of DCVs requires high-frequency or patterned stimulation, but the determinants to reach maximal fusion capacity and for efficient replenishment of released DCVs are unknown. Here, we systematically studied fusion of DCV with single vesicle resolution on different stimulation patterns in mammalian CNS neurons. We show that tetanic stimulation trains of 50-Hz action potential (AP) bursts maximized DCV fusion, with significantly fewer fusion event during later bursts of the train. This difference was omitted by introduction of interburst intervals but did not increase total DCV fusion. Interburst intervals as short as 5 s were sufficient to restore the fusion capacity. Theta burst stimulation (TBS) triggered less DCV fusion than tetanic stimulation, but a similar fusion efficiency per AP. Prepulse stimulation did not alter this. However, low-frequency stimulation (4 Hz) intermitted with fast ripple stimulation (200 APs at 200 Hz) produced substantial DCV fusion, albeit not as much as tetanic stimulation. Finally, individual fusion events had longer durations with more intense stimulation. These data indicate that trains of 50-Hz AP stimulation patterns triggered DCV exocytosis most efficiently and more intense stimulation promotes longer DCV fusion pore openings.
    MeSH term(s) Animals ; Humans ; Dense Core Vesicles ; Secretory Vesicles/metabolism ; Neurons/physiology ; Hippocampus/physiology ; Neuropeptides/metabolism ; Nerve Growth Factors/metabolism ; Mammals
    Chemical Substances Neuropeptides ; Nerve Growth Factors
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.2251-22.2023
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