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Article ; Online: Re: Transperineal Prostate Biopsies Using Local Anesthesia: Experience with 1,287 Patients. Prostate Cancer Detection Rate, Complications and Patient Tolerability.

Moro, Fabrizio Dal / Pizzolito, Stefano

2019 Volume 202, Issue 6, Page(s) 1272–1273

MeSH term(s)	Anesthesia, Local ; Biopsy ; Humans ; Male ; Prostatic Neoplasms
Language	English
Publishing date	2019-08-07
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1097/JU.0000000000000474
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Article ; Online: Identification of a gene signature for the prediction of recurrence and progression in non-muscle-invasive bladder cancer.

Dalla, Emiliano / Picco, Raffaella / Novara, Giacomo / Moro, Fabrizio Dal / Brancolini, Claudio

Molecular biomedicine

2022 Volume 3, Issue 1, Page(s) 9

Language	English
Publishing date	2022-03-15
Publishing country	Singapore
Document type	Letter
ISSN	2662-8651
ISSN (online)	2662-8651
DOI	10.1186/s43556-022-00069-0
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Article: Why should a "gasless" oncologic robotic procedure be performed?

Moro, Fabrizio Dal / Mangano, Angelo

Saudi journal of anaesthesia

2017 Volume 11, Issue 2, Page(s) 260–261

Language	English
Publishing date	2017-04-11
Publishing country	India
Document type	Journal Article
ZDB-ID	2562174-9
ISSN	0975-3125 ; 1658-354X
ISSN (online)	0975-3125
ISSN	1658-354X
DOI	10.4103/sja.SJA_53_17
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Article: The bladder-flap ureteral augmentation: An original solution in case of complex distal stricture.

Antonelli, Alessandro / Trabacchin, Nicolò / Monaco, Carmelo / Tafuri, Alessandro / Cerruto, Maria Angela / Moro, Fabrizio Dal

Urology case reports

2021 Volume 37, Page(s) 101636

Abstract: An original surgical solution for complex stenosis of the distal ureter is presented. A young, single-kidney male patient developed a stricture of the pelvic ureter after ureteroscopy and laser lithotripsy. Surgical repair was planned after the failure ... ...

Abstract	An original surgical solution for complex stenosis of the distal ureter is presented. A young, single-kidney male patient developed a stricture of the pelvic ureter after ureteroscopy and laser lithotripsy. Surgical repair was planned after the failure of conservative management. The ureter was sectioned prevesically and spatulated; a bladder flap with the same dimensions of the ureteral plate was taken from the anterior wall, and used to augment the ureter; finally an omental flap was wrapped around the reconstructed tract. Further radiological and ureteroscopic controls showed a largely patent reconstructed ureter, and follow up proved a regularly maintained kidney function.
Language	English
Publishing date	2021-03-10
Publishing country	United States
Document type	Case Reports
ZDB-ID	2745459-9
ISSN	2214-4420
ISSN	2214-4420
DOI	10.1016/j.eucr.2021.101636
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Article: Can anastomotic urinary leakage in robotic prostatectomy be considered as a marker of surgical skill?

Moro, Fabrizio Dal / Beltrami, Paolo / Zattoni, Filiberto

Central European journal of urology

2017 Volume 71, Issue 1, Page(s) 21–25

Abstract: Introduction: The study was conducted to analyze whether the anastomotic urinary leakage (AUL) rate in robot-assisted radical prostatectomy (RARP) can be considered as a marker of surgical skill.: Material and methods: Post-operative cystograms taken ...

Abstract	Introduction: The study was conducted to analyze whether the anastomotic urinary leakage (AUL) rate in robot-assisted radical prostatectomy (RARP) can be considered as a marker of surgical skill. Material and methods: Post-operative cystograms taken after RARP, performed between 2006 and 2016 at a third-level university urology center, were prospectively collected. Cystograms were scheduled for all patients on post-operative day 6, but were performed over a range from days 4 to 10 (median 6). In cases of mild, moderate or excessive AUL (according to Han's classification), catheters were maintained; in the other cases, they were removed. Results: Data from 1366 consecutive patients undergoing RARP were collected. The incidence of AUL at first check-up was 18.1%, with a descending trend when RARP were performed by the same surgeon. Evaluating the influence of differing technical modifications on leakage, the AUL rate was significantly lower after the introduction of posterior reconfigurations and a single posterior stitch. The introduction of barbed sutures was initially associated with an increase of leakage, but only in the first year. Conclusions: This study describes the effect of increasing experience and technical modifications in RARP on the AUL rate in a third-level university Italian center over a 10-year period; by stratifying data, we demonstrated a strong correlation between robotic surgical skill and AUL rate, which can therefore be used as an indicator of surgical proficiency.
Language	English
Publishing date	2017-02-12
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2672528-9
ISSN	2080-4873 ; 2080-4806
ISSN (online)	2080-4873
ISSN	2080-4806
DOI	10.5173/ceju.2018.1587
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Article ; Online: Role of targeted biopsy, perilesional biopsy, and random biopsy in prostate cancer diagnosis by mpMRI/transrectal ultrasonography fusion biopsy.

Novara, Giacomo / Zattoni, Fabio / Zecchini, Giovanni / Aceti, Alberto / Pellizzari, Anna / Ferraioli, Giordana / Carlesso, Maria / La Bombarda, Giulia / Morlacco, Alessandro / Lacognata, Carmelo Salvino / Lauro, Alberto / Gardiman, Marina / Betto, Giovanni / Zanovello, Nicola / Moro, Fabrizio Dal

World journal of urology

2023 Volume 41, Issue 11, Page(s) 3239–3247

Abstract: Purpose: It is still not clear the role of perilesional biopsy (PL) and the extension of the random biopsy (RB) scheme to be adopted during mpMRI-guided ultrasound fusion biopsy (FB). To evaluate the increase in diagnostic accuracy achieved by PL and ... ...

Abstract	Purpose: It is still not clear the role of perilesional biopsy (PL) and the extension of the random biopsy (RB) scheme to be adopted during mpMRI-guided ultrasound fusion biopsy (FB). To evaluate the increase in diagnostic accuracy achieved by PL and different RB schemes over target biopsy (TB). Methods: We collected prospectively 168 biopsy-naïve patients with positive mpMRI receiving FB and concurrent 24-core RB. The diagnostic yields of the different possible biopsy schemes (TB only; TB + 4 PL cores; TB + 12-core RB; TB + 24-core RB) were compared by the McNemar test. Clinically significant (CS) prostate cancer (PCA) was defined according to the definition of the PROMIS trial. Regression analyses were used to identify independent predictors of the presence of any cancer, csPCA. Results: The detection rate of CS cancers increased to 35%, 45%, and 49% by adding 4 PL cores, 12, and 24 RB cores, respectively (all p < 0.02). Notably, the largest scheme including 3 TB and 24 RB cores identified a small but statistically significant 4% increase in detection rate of CS cancer, as compared with the second largest scheme. TB alone identified only 62% of the CS cancers. Such figure increased to 72% by adding 4 PL cores, and to 91% by adding 14 RB cores. Conclusions: We found that PL biopsy increased the detection rate of CS cancers as compared with TB alone. However, the combination of those cores missed about 30% of the CS cancers identified with larger RB cores, notably including a considerable 15% of cases located contralaterally to the index tumor.
MeSH term(s)	Male ; Humans ; Multiparametric Magnetic Resonance Imaging ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Prostate/diagnostic imaging ; Prostate/pathology ; Image-Guided Biopsy ; Ultrasonography ; Magnetic Resonance Imaging ; Ultrasonography, Interventional
Language	English
Publishing date	2023-04-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	380333-8
ISSN	1433-8726 ; 0724-4983
ISSN (online)	1433-8726
ISSN	0724-4983
DOI	10.1007/s00345-023-04382-3
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Article ; Online: Impact of peritoneal reconfiguration on lymphocele formation after robot-assisted radical prostatectomy with pelvic lymph node dissection: a systematic review and meta-analysis of randomized controlled trials.

Ditonno, Francesco / Manfredi, Celeste / Franco, Antonio / Veccia, Alessandro / Moro, Fabrizio Dal / De Nunzio, Cosimo / De Sio, Marco / Antonelli, Alessandro / Autorino, Riccardo

Prostate cancer and prostatic diseases

2023

Abstract: Background: Different strategies have been proposed to prevent lymphocele (LC) formation after radical prostatectomy (RARP) with pelvic lymph node dissection (PLND). According to several recently published randomized control trials (RCTs) on the topic, ... ...

Abstract	Background: Different strategies have been proposed to prevent lymphocele (LC) formation after radical prostatectomy (RARP) with pelvic lymph node dissection (PLND). According to several recently published randomized control trials (RCTs) on the topic, peritoneal reconfiguration appears to be associated with promising results. This systematic review aimed to assess the impact of peritoneal reconfiguration on LC formation in patients undergoing RARP and PLND. Methods: A comprehensive bibliographic search was conducted in August 2023. Studies assessing patients with prostate cancer undergoing RARP with PLND (P) and concomitant peritoneal reconfiguration (I) compared or not with other techniques (C) to prevent LC formation (O) were included. Original prospective and retrospective studies (S) were selected. LC and symptomatic LC rates were chosen as co-primary outcomes. Only RCTs were included in the meta-analysis. Results: Eleven studies investigating 2991 patients were included in the systematic review, and five RCTs evaluating 1712 subjects were deemed eligible for meta-analysis. Peritoneal flap (PF) was the most common surgical technique used for LC prevention (9 studies). A significantly lower likelihood of LC was observed after PF (OR 0.82, 95% CI 0.27-1.37, I Conclusions: PF after RARP with PLND reduces LC formation, LC-related complications, and severe postoperative adverse events.
Language	English
Publishing date	2023-10-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1419277-9
ISSN	1476-5608 ; 1365-7852
ISSN (online)	1476-5608
ISSN	1365-7852
DOI	10.1038/s41391-023-00744-5
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Zs.A 5277: Show issues

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Article ; Online: The impact of COVID-19 pandemic on pornography habits: a global analysis of Google Trends.

Zattoni, Fabio / Gül, Murat / Soligo, Matteo / Morlacco, Alessandro / Motterle, Giovanni / Collavino, Jeanlou / Barneschi, Andrea Celeste / Moschini, Marco / Moro, Fabrizio Dal

International journal of impotence research

2020 Volume 33, Issue 8, Page(s) 824–831

Abstract: As the COVID-19 spread globally, social distancing, self-isolation/quarantine, and national lockdowns have become crucial to control the pandemic. However, these measures may also lead to increases in social isolation, loneliness, and stress, which can ... ...

Abstract	As the COVID-19 spread globally, social distancing, self-isolation/quarantine, and national lockdowns have become crucial to control the pandemic. However, these measures may also lead to increases in social isolation, loneliness, and stress, which can alter the consumption of pornography habits. The aim of the study was thus to explore the interest pattern in pornography and coronavirus-themed pornography during the COVID-19 outbreak. Google Trends® was employed to determine the most popular porn websites (Porn, XNXX, PornHub, xVideos, and xHamster), and coronavirus-themed pornography worldwide and in six nations with different COVID-19 outbreak and self-isolation recommendations. We analyzed every search trend on Google® from January 9, 2020 to May 25, 2020 using "joint point regression analysis". Comparisons of week relative search volume (WRSV) and temporal patterns were analyzed to assess the change of interest in search terms during nations lockdowns. Paired t-test was used to compare WRSV values among the porn websites during the national lockdowns and the equivalent timespan of the weeks in the previous 4 years. The research trend of almost every keyword increased with significant inflection points for those nations with a straight "stay at home orders" (China, Italy, Spain, and France). "PornHub" and "Porn" showed the highest increase of interest worldwide with an average weekend percentage change (AWPC) of 4.9 and 3.8, respectively. The mean WRSV for keywords in USA and Sweden did not show a similar increase as the other nations. The WRSV percentage change with the historical data had a peak during the straight nations' lockdowns (p < 0.01). All the nations had a significant increase in WRSV coronavirus-themed pornography for each keyword (p < 0.01) with an AWPC, ranging worldwide between 18.5 and 61.8 (p < 0.01), after the beginning of self-quarantine. As strengths this study uses a big data technology to collect worldwide trend of interest, however, data are anonymous and do not allow analysis of subpopulation groups. In conclusion, we demonstrated an increased interest in pornography and coronavirus-themed pornography after the outbreak of COVID-19 in nations with a straight "stay at home orders".
MeSH term(s)	COVID-19 ; Communicable Disease Control ; Erotica ; Habits ; Humans ; Pandemics ; SARS-CoV-2 ; Search Engine
Language	English
Publishing date	2020-11-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1034295-3
ISSN	1476-5489 ; 0955-9930
ISSN (online)	1476-5489
ISSN	0955-9930
DOI	10.1038/s41443-020-00380-w
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Article: Frailty and elderly in urology: Is there an impact on post-operative complications?

Moro, Fabrizio Dal / Morlacco, Alessandro / Motterle, Giovanni / Barbieri, Lisa / Zattoni, Filiberto

Central European journal of urology

2017 Volume 70, Issue 2, Page(s) 197–205

Abstract: Introduction: Frailty used as predictive tool is still not carried out in daily practice, although many studies confirm the great clinical importance of the frailty syndrome in surgical outcomes. There is no standardized method of measuring the ... ...

Abstract	Introduction: Frailty used as predictive tool is still not carried out in daily practice, although many studies confirm the great clinical importance of the frailty syndrome in surgical outcomes. There is no standardized method of measuring the physiological reserves of older surgical patients. The aim of this study was to analyze a cohort of older urological patients according to various frailty indices, in order to evaluate whether they are predictors of post-operative complications after urological procedures. Material and methods: This is a prospective observational study on 78 consecutive older (≥70 years) patients, subjected to major urological (both endoscopic and 'open surgical') procedures. Frailty was defined according to the Edmonton Frail Scale. Several risk models and biochemical parameters were evaluated. Post-operative outcomes were surgical and medical complications, mortality and rehospitalisation within 3 months. Results: An overall prevalence of frailty of 21.8% was found. Patients with complications were frailer than those without complications (univariate analysis), considering both total patients (p = 0.002) and endoscopic (p = 0.04) and 'open surgical' patients (p = 0.013). However, in multivariate analysis, a significant correlation was not found between all frailty indices tested and the risk of major complications. Limitation of the study: the small sample size (lack of statistical power), although this is a prospective study focused on older urological patients. Conclusions: New urology-tailored pre-operative assessment tools may prove beneficial when calculating the risks/benefits of urological procedures, so that objective data can guide surgical decision- making and patient counselling. Further large clinical studies specifically focusing on elderly in urology will be needed.
Language	English
Publishing date	2017-06-12
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2672528-9
ISSN	2080-4873 ; 2080-4806
ISSN (online)	2080-4873
ISSN	2080-4806
DOI	10.5173/ceju.2017.1321
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Article ; Online: The Prognostic Role of Preoperative PSMA PET/CT in cN0M0 pN+ Prostate Cancer: A Multicenter Study.

Marra, Giancarlo / Rajwa, Pawel / Filippini, Claudia / Ploussard, Guillaume / Montefusco, Gabriele / Puche-Sanz, Ignacio / Olivier, Jonathan / Zattoni, Fabio / Moro, Fabrizio Dal / Magli, Alessandro / Dariane, Charles / Affentranger, Andres / Grogg, Josias Bastian / Hermanns, Thomas / Chiu, Peter K / Malkiewicz, Bartosz / Kowalczyk, Kamil / Van den Bergh, Roderick C N / Shariat, Shahrokh F /

Bianchi, Alberto / Antonelli, Alessandro / Gallina, Sebastian / Berchiche, William / Sanchez-Salas, Rafael / Cathelineau, Xavier / Afferi, Luca / Fankhauser, Christian Daniel / Mattei, Agostino / Karnes, Robert Jeffrey / Scuderi, Simone / Montorsi, Francesco / Briganti, Alberto / Deandreis, Désirée / Gontero, Paolo / Gandaglia, Giorgio

Clinical genitourinary cancer

2023 Volume 22, Issue 2, Page(s) 244–251

Abstract: Context: Despite negative preoperative conventional imaging, up to 10% of patients with prostate cancer (PCa) harbor lymph-node involvement (LNI) at radical prostatectomy (RP). The advent of more accurate imaging modalities such as PET/CT improved the ... ...

Abstract	Context: Despite negative preoperative conventional imaging, up to 10% of patients with prostate cancer (PCa) harbor lymph-node involvement (LNI) at radical prostatectomy (RP). The advent of more accurate imaging modalities such as PET/CT improved the detection of LNI. However, their clinical impact and prognostic value are still unclear. We aimed to investigate the prognostic value of preoperative PET/CT in patients node positive (pN+) at RP. Evidence synthesis: We retrospectively identified cN0M0 patients at conventional imaging (CT and/or MRI, and bone scan) who had pN+ PCa at RP at 17 referral centers. Patients with cN+ at PSMA/Choline PET/CT but cN0M0 at conventional imaging were also included. Systemic progression/recurrence was the primary outcome; Cox proportional hazards models were used for multivariate analysis. Evidence acquisition: We included 1163 pN+ men out of whom 95 and 100 had preoperative PSMA and/or Choline PET/CT, respectively. ISUP grade ≥4 was detected in 66.6%. Overall, 42% of patients had postoperative PSA persistence (≥0.1 ng/mL). Postoperative management included initial observation (34%), ADT (22.7%) and adjuvant RT+/-ADT (42.8%). Median follow-up was 42 months. Patients with cN+ on PSMA PET/CT had an increased risk of systemic progression (52.9% vs. 13.6% cN0 PSMA PET/CT vs. 21.5% cN0 at conventional imaging; P < .01). This held true at multivariable analysis: (HR 6.184, 95% CI: 3.386-11-295; P < .001) whilst no significant results were highlighted for Choline PET/CT. No significant associations for both PET types were found for local progression, BCR, and overall mortality (all P > .05). Observation as an initial management strategy instead of adjuvant treatments was related with an increased risk of metastases (HR 1.808; 95% CI: 1.069-3.058; P < .05). Conclusions: PSMA PET/CT cN+ patients with negative conventional imaging have an increased risk of systemic progression after RP compared to their counterparts with cN0M0 disease both at conventional and/or molecular imaging.
MeSH term(s)	Male ; Humans ; Positron Emission Tomography Computed Tomography/methods ; Prognosis ; Retrospective Studies ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/surgery ; Prostatic Neoplasms/pathology ; Prostatectomy ; Choline ; Gallium Radioisotopes
Chemical Substances	Choline (N91BDP6H0X) ; Gallium Radioisotopes
Language	English
Publishing date	2023-11-17
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	2225121-2
ISSN	1938-0682 ; 1558-7673
ISSN (online)	1938-0682
ISSN	1558-7673
DOI	10.1016/j.clgc.2023.11.006
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