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Article ; Online: Updated Perspectives on Lifestyle Interventions as Secondary Stroke Prevention Measures: A Narrative Review.

Govori, Valbona / Budinčević, Hrvoje / Morović, Sandra / Đerke, Filip / Demarin, Vida

2024 Volume 60, Issue 3

Abstract: Despite being highly preventable, stroke is the second-most common cause of death and disability in the world. Secondary prevention is critical as the stroke recurrence risk is 6- to 15-fold higher than the risk of stroke in the general population. ... ...

Abstract	Despite being highly preventable, stroke is the second-most common cause of death and disability in the world. Secondary prevention is critical as the stroke recurrence risk is 6- to 15-fold higher than the risk of stroke in the general population. Stroke recurrence is associated with higher mortality rates and increased disability levels. Lifestyle modifications should address not single but multiple cardiovascular risk factors to effectively reduce the risk of stroke. Lifestyle modifications on a personal level should include adequate physical activity, a healthy diet, the cessation of smoking and alcohol consumption, and stress reduction. Physical activities should be performed in a healthy environment without air pollution. According to recent studies, up to 90% of strokes might be prevented by addressing and treating ten modifiable stroke risk factors, half of which are related to lifestyle modifications. These lifestyle modifications, which are behavioral interventions, could impact other modifiable risk factors such as arterial hypertension, hyperlipidemia, obesity, diabetes, and atrial fibrillation. The most common obstacles to effective secondary stroke prevention are motor impairment, post-stroke cognitive impairment, post-stroke depression, and stroke subtype. Long-term lifestyle modifications are difficult to sustain and require comprehensive, individualized interventions. This review underlines the benefits of adhering to lifestyle modifications as the most effective secondary stroke prevention measure.
MeSH term(s)	Humans ; Secondary Prevention ; Stroke/etiology ; Stroke/prevention & control ; Risk Factors ; Life Style ; Diabetes Mellitus/epidemiology
Language	English
Publishing date	2024-03-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina60030504
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Zs.A 6270: Show issues

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Article: Alternative to Conventional Solutions in the Development of Membranes and Hydrogen Evolution Electrocatalysts for Application in Proton Exchange Membrane Water Electrolysis: A Review.

Perović, Klara / Morović, Silvia / Jukić, Ante / Košutić, Krešimir

Materials (Basel, Switzerland)

2023 Volume 16, Issue 18

Abstract: Proton exchange membrane water electrolysis (PEMWE) represents promising technology for the generation of high-purity hydrogen using electricity generated from renewable energy sources (solar and wind). Currently, benchmark catalysts for hydrogen ... ...

Abstract	Proton exchange membrane water electrolysis (PEMWE) represents promising technology for the generation of high-purity hydrogen using electricity generated from renewable energy sources (solar and wind). Currently, benchmark catalysts for hydrogen evolution reactions in PEMWE are highly dispersed carbon-supported Pt-based materials. In order for this technology to be used on a large scale and be market competitive, it is highly desirable to better understand its performance and reduce the production costs associated with the use of expensive noble metal cathodes. The development of non-noble metal cathodes poses a major challenge for scientists, as their electrocatalytic activity still does not exceed the performance of the benchmark carbon-supported Pt. Therefore, many published works deal with the use of platinum group materials, but in reduced quantities (below 0.5 mg cm
Language	English
Publishing date	2023-09-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16186319
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Article: Comorbidity from a Neuropsychiatric Perspective.

Demarin, Vida / Morović, Sandra

Psychiatria Danubina

2021 Volume 33, Issue Suppl 4, Page(s) 445–450

Abstract: Comorbidity in neurology and psychiatry involves the onset of a mental illness with the simultaneous presence of a neurological disorder or other illness. The degree of comorbidity of mental and neurological disorders is unexpectedly high. In addition to ...

Abstract	Comorbidity in neurology and psychiatry involves the onset of a mental illness with the simultaneous presence of a neurological disorder or other illness. The degree of comorbidity of mental and neurological disorders is unexpectedly high. In addition to the direct connection and simultaneous occurrence of mental and neurological illness, the indirect impact of mental illness on the occurrence of neurological problems is even more significant. This link is realized through the influence of mental illness on risk factors for the development of cerebrovascular and cardiovascular diseases. Their incidence is higher in the psychiatric population than in the general population. Numerous studies have confirmed that risk factors for cerebrovascular disease (hypertension, hyperlipidemia, diabetes mellitus, etc.) are more common among patients with mental disorders than in the general population. Also, research shows that patients with mental disorders are less frequently controlled, have less control over risk factors, and that numerous comorbidities are detected later or remain undetected. Given that cerebrovascular and cardiovascular diseases represent one of the most important public health and socioeconomic problems of today, both in the world and in Croatia, this problem should not remain in the shadow.
MeSH term(s)	Cardiovascular Diseases/epidemiology ; Comorbidity ; Diabetes Mellitus/epidemiology ; Humans ; Mental Disorders/epidemiology ; Psychiatry
Language	English
Publishing date	2021-10-31
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	1067580-2
ISSN	0353-5053
ISSN	0353-5053
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Zs.A 3158: Show issues

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Article ; Online: Impact of Polymer Chain Rearrangements in the PA Structure of RO Membranes on Water Permeability and

Morović, Silvia / Vezjak Fluksi, Alegra / Babić, Sandra / Košutić, Krešimir

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 16

Abstract: The use of solvents is overall recognized as an efficient method to improve the water permeability of polyamide thin film composite membranes (PA-TFC). The objective of this work was to test the performance of the membranes after exposing them ... ...

Abstract	The use of solvents is overall recognized as an efficient method to improve the water permeability of polyamide thin film composite membranes (PA-TFC). The objective of this work was to test the performance of the membranes after exposing them to
Language	English
Publishing date	2023-08-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28166124
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Zs.MO 81: Show issues

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Article ; Online: Ultrasound subclinical markers in assessing vascular changes in cognitive decline and dementia.

Demarin, Vida / Morovic, Sandra

Journal of Alzheimer's disease : JAD

2014 Volume 42 Suppl 3, Page(s) S259–66

Abstract: Aging is often associated with some cognitive impairment. Greater population life expectancy is one explanation for increased incidence of cognitive impairment cases. Large numbers of people with cognitive impairment and dementia is becoming one of the ... ...

Abstract	Aging is often associated with some cognitive impairment. Greater population life expectancy is one explanation for increased incidence of cognitive impairment cases. Large numbers of people with cognitive impairment and dementia is becoming one of the most important medical and social problems worldwide. Therefore, prevention of cognitive impairment is an imperative. Dementia includes a heterogeneous group of disorders, the most common being Alzheimer's disease and vascular dementia. Most cardiovascular risk factors, such as hypertension, diabetes mellitus, hypercholesterolemia, atrial fibrillation, and smoking, are not exclusively risk factors for vascular dementia, but also for Alzheimer's disease. Early changes in the blood vessel wall can be detected by early ultrasound screening methods which allow us to detect changes before the disease becomes clinically evident. Intracranial hemodynamics can be assessed by transcranial Doppler sonography (TCD), functional TCD with various functional tests, and TCD detection of cerebral emboli. Extracranial circulation (carotid and vertebral arteries) can be assessed by means of color Doppler flow imaging. Novel ultrasound technology enables non-invasive, portable, bedside detection of early vascular changes such as arterial stiffness, measurement of the intima-media thickness, pulse-wave velocity, flow-mediated dilation, or endothelial dysfunction in order to obtain information necessary to determine more closely the relation between vascular status and disease development, so that the evolution of cardiovascular disease can be prevented or at least postponed. Early disease detection enables in-time management, and studies have shown that careful control of vascular risk factors can postpone or even reverse disease progression.
MeSH term(s)	Cardiovascular Diseases/diagnostic imaging ; Cardiovascular Diseases/etiology ; Cognition Disorders/complications ; Cognition Disorders/diagnostic imaging ; Dementia/complications ; Dementia/diagnostic imaging ; Humans ; Ultrasonography, Doppler, Color
Language	English
Publishing date	2014
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-132507
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Zs.A 6084: Show issues

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Article ; Online: Possibilities of Dementia Prevention - It is Never Too Early to Start.

Morovic, Sandra / Budincevic, Hrvoje / Govori, Valbona / Demarin, Vida

Journal of medicine and life

2017 Volume 12, Issue 4, Page(s) 332–337

Abstract: Dementia represents one of the greatest global challenges for health and social care in this century. More than 50 million people worldwide suffer from dementia, and this number is predicted to triple by 2050. Ageing is often associated with cognitive ... ...

Abstract	Dementia represents one of the greatest global challenges for health and social care in this century. More than 50 million people worldwide suffer from dementia, and this number is predicted to triple by 2050. Ageing is often associated with cognitive impairment. Therefore, prevention of cognitive impairment is an imperative. Dementia includes a heterogeneous group of disorders, the most common being Alzheimer's disease and vascular dementia. Most cardiovascular risk factors such as hypertension, diabetes mellitus, hypercholesterolemia, atrial fibrillation and smoking are not exclusive risk factors for vascular dementia but also for Alzheimer's disease. The ApoE4 allele is the single non-modifiable risk factor for Alzheimer's disease. Today we know that an important, modifiable risk factor is education. Better education means better protection against dementia. A large number of dementia cases are potentially preventable by early intervention. Early changes in the blood vessel wall can be detected by early ultrasound methods or early biomarkers. These methods allow us to detect changes before the disease becomes clinically evident. Early disease detection enables timely management, and studies have shown that careful control of vascular risk factors can postpone the onset or even reverse disease progression.
MeSH term(s)	Alzheimer Disease/complications ; Biomarkers/metabolism ; Cognitive Dysfunction/complications ; Dementia, Vascular/pathology ; Dementia, Vascular/prevention & control ; Disease Progression ; Humans ; Risk Factors
Chemical Substances	Biomarkers
Language	English
Publishing date	2017-07-05
Publishing country	Romania
Document type	Journal Article ; Review
ZDB-ID	2559353-5
ISSN	1844-3117 ; 1844-3117 ; 1844-3109
ISSN (online)	1844-3117
ISSN	1844-3117 ; 1844-3109
DOI	10.25122/jml-2019-0088
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Article ; Online: CCSVI is associated with multiple sclerosis.

Morovic, Sandra / Zamboni, Paolo

Neurological research

2012 Volume 34, Issue 8, Page(s) 770–779

Abstract: Objectives: To analyze all the arguments against chronic cerebrospinal venous insufficiency (CCSVI) as a medical entity, and its association with multiple sclerosis (MS) and to revise all the findings suggesting a possible connection between these two ... ...

Abstract	Objectives: To analyze all the arguments against chronic cerebrospinal venous insufficiency (CCSVI) as a medical entity, and its association with multiple sclerosis (MS) and to revise all the findings suggesting a possible connection between these two entities. Methods: We revised the methodology and results of all fourteen published studies on prevalence of CCSVI in MS patients. Furthermore, we take into consideration other work dealing with possible causes and explanations of venous, as well as vascular dysfunctions linked with MS. Results: Studies of prevalence show a great variability in prevalence of CCSVI in MS patients. However, a recent meta-analysis assessed an over 13 times increased prevalence in MS. Global hypoperfusion of the brain, and reduced cerebral spinal fluid dynamics in MS was shown to be related to CCSVI. Post-mortem studies show a higher prevalence of intraluminal defects in the main extracranial vein in MS patients in respect to controls. Discussion: Taking into account the current epidemiological data, the autoptic findings, and the relationship between CCSVI and both hypoperfusion and cerebrospinal fluid flow, CCSVI can be inserted in the list of multiple factors involved in MS pathogenesis. Our careful data analysis may conclude that great variability in prevalence of CCSVI in MS patients can be a result of different methodologies used in venous ultrasound assessment. Finally, it has been proven that CCSVI share the three main risk factors with MS. On the other hand, smoking is the most important risk factor for endothelial cell damage, vitamin D has a protective role and Epstein-Barr virus passes the blood-brain barrier by invading the endothelial cells, therefore, epidemiologically, linking the imbalance of these three factors to MS through autoimmunity.
MeSH term(s)	Brain/blood supply ; Cerebrospinal Fluid/physiology ; Cerebrovascular Circulation/physiology ; Hemodynamics/physiology ; Humans ; Multiple Sclerosis/etiology ; Multiple Sclerosis/genetics ; Multiple Sclerosis/physiopathology ; Prevalence ; Risk Factors ; Spinal Cord/blood supply ; Venous Insufficiency/complications ; Venous Insufficiency/epidemiology ; Venous Insufficiency/genetics ; Venous Insufficiency/physiopathology
Language	English
Publishing date	2012-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	424428-x
ISSN	1743-1328 ; 0161-6412
ISSN (online)	1743-1328
ISSN	0161-6412
DOI	10.1179/1743132812Y.0000000035
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Zs.A 1491: Show issues

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Article ; Online: Fusion imaging technology of the intracranial veins.

Zamboni, P / Menegatti, E / Viselner, G / Morovic, S / Bastianello, S

Phlebology

2012 Volume 27, Issue 7, Page(s) 360–367

Abstract: Objectives: Fusion imaging technology (FIT) combines different imaging techniques by means of properly designed software. The aim of this study was to validate the ultrasonographic representation of intracranial vein anatomy by combining transcranial ... ...

Abstract	Objectives: Fusion imaging technology (FIT) combines different imaging techniques by means of properly designed software. The aim of this study was to validate the ultrasonographic representation of intracranial vein anatomy by combining transcranial echo-colour Doppler (TECD) with conventional magnetic resonance imaging (MRI). In addition, we investigated the possibility of insonating the veins of the base of the skull through the novel condylar window. Methods: We examined venous brain circulation in five healthy subjects by means of FIT, using a 1.5 T MR scanner and an ultrasound TECD equipped with Virtual Navigator technology. Results and conclusions Insonation of the Rosenthal and other intracranial veins through the classical transtemporal window, based on anatomical assumption, but never before validated by means of FIT study, was confirmed. Moreover, in all five subjects, FIT demonstrated the possibility of insonating the petrosal sinuses and the cavernous sinus area through the novel transcondylar approach. In conclusion, the feasibility of FIT of the intracranial veins potentially permits to study subjects in different postures and/or at the bed of non-transportable patients, after the initial MRI acquisition. Finally, the novel transcondylar approach allows obtaining haemodynamic information from the cavernous and the petrosal sinuses usually not investigated by TECD alone.
MeSH term(s)	Adolescent ; Adult ; Cavernous Sinus/pathology ; Cerebral Veins/diagnostic imaging ; Cerebral Veins/pathology ; Cranial Sinuses/pathology ; Female ; Hemodynamics ; Humans ; Image Processing, Computer-Assisted/methods ; Imaging, Three-Dimensional/methods ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Software ; Ultrasonography, Doppler/methods ; Veins/anatomy & histology ; Veins/pathology ; Young Adult
Language	English
Publishing date	2012-10
Publishing country	England
Document type	Journal Article ; Validation Studies
ZDB-ID	645172-x
ISSN	1758-1125 ; 0268-3555
ISSN (online)	1758-1125
ISSN	0268-3555
DOI	10.1258/phleb.2011.011069
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Zs.A 2538: Show issues

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Article: Boron nutritional status in Croatia

Momcilovic, Berislav / Morovic, Sandra / Mimica, Ninoslav

Trace elements and electrolytes

2018 Volume 35, Issue 3, Page(s) 142

Language	German
Document type	Article
ZDB-ID	1181166-3
ISSN	0174-7371 ; 0946-2104
Database	Current Contents Medicine

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Zs.A 1976: Show issues

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Article ; Online: Prevalence, sensitivity, and specificity of chronic cerebrospinal venous insufficiency in MS.

Morovic, Sandra / Menegatti, Erica

Neurology

2011 Volume 77, Issue 21, Page(s) e124; author reply e124

MeSH term(s)	Female ; Humans ; Male ; Multiple Sclerosis/epidemiology ; Venous Insufficiency/epidemiology
Language	English
Publishing date	2011-11-22
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0b013e31823c130c
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