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  1. Article ; Online: Interaction of the antiphospholipid syndrome autoantigen beta-2 glycoprotein I with DNA and neutrophil extracellular traps.

    Kmeťová, Katarína / Lonina, Elena / Yalavarthi, Srilakshmi / Levine, Jerrold S / Hoy, Claire K / Sarosh, Cyrus / Gockman, Kelsey / Morris, Alexandra E / Tambralli, Ajay / Madison, Jacqueline A / Zuo, Yu / Subang, Rebecca / Rauch, Joyce / Knight, Jason S

    Clinical immunology (Orlando, Fla.)

    2023  Volume 255, Page(s) 109714

    Abstract: Beta-2 glycoprotein I ( ... ...

    Abstract Beta-2 glycoprotein I (β
    Language English
    Publishing date 2023-07-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2023.109714
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 880: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Release of neutrophil extracellular traps by neutrophils stimulated with antiphospholipid antibodies: a newly identified mechanism of thrombosis in the antiphospholipid syndrome.

    Yalavarthi, Srilakshmi / Gould, Travis J / Rao, Ashish N / Mazza, Levi F / Morris, Alexandra E / Núñez-Álvarez, Carlos / Hernández-Ramírez, Diego / Bockenstedt, Paula L / Liaw, Patricia C / Cabral, Antonio R / Knight, Jason S

    Arthritis & rheumatology (Hoboken, N.J.)

    2015  Volume 67, Issue 11, Page(s) 2990–3003

    Abstract: Objective: Antiphospholipid antibodies (aPL), especially those targeting β2 -glycoprotein I (β2 GPI), are well known to activate endothelial cells, monocytes, and platelets, with prothrombotic implications. In contrast, the interaction of aPL with ... ...

    Abstract Objective: Antiphospholipid antibodies (aPL), especially those targeting β2 -glycoprotein I (β2 GPI), are well known to activate endothelial cells, monocytes, and platelets, with prothrombotic implications. In contrast, the interaction of aPL with neutrophils has not been extensively studied. Neutrophil extracellular traps (NETs) have recently been recognized as an important activator of the coagulation cascade, as well as an integral component of arterial and venous thrombi. This study was undertaken to determine whether aPL activate neutrophils to release NETs, thereby predisposing to the arterial and venous thrombosis inherent in the antiphospholipid syndrome (APS).
    Methods: Neutrophils, sera, and plasma were prepared from patients with primary APS (n = 52) or from healthy volunteers and characterized. No patient had concomitant systemic lupus erythematosus.
    Results: Sera and plasma from patients with primary APS had elevated levels of both cell-free DNA and NETs, as compared to healthy volunteers. Freshly isolated neutrophils from patients with APS were predisposed to high levels of spontaneous NET release. Further, APS patient sera, as well as IgG purified from APS patients, stimulated NET release from control neutrophils. Human aPL monoclonal antibodies, especially those targeting β2 GPI, also enhanced NET release. The induction of APS NETs was abrogated with inhibitors of reactive oxygen species formation and Toll-like receptor 4 signaling. Highlighting the potential clinical relevance of these findings, APS NETs promoted thrombin generation.
    Conclusion: Our findings indicate that NET release warrants further investigation as a novel therapeutic target in APS.
    MeSH term(s) Antibodies, Antiphospholipid/immunology ; Antiphospholipid Syndrome/immunology ; Antiphospholipid Syndrome/metabolism ; Extracellular Traps ; Humans ; Immunoglobulin G/immunology ; Neutrophils/immunology ; Neutrophils/metabolism ; Reactive Oxygen Species/metabolism ; Signal Transduction/physiology ; Thrombosis/immunology ; Thrombosis/metabolism ; Toll-Like Receptor 4/metabolism
    Chemical Substances Antibodies, Antiphospholipid ; Immunoglobulin G ; Reactive Oxygen Species ; TLR4 protein, human ; Toll-Like Receptor 4
    Language English
    Publishing date 2015-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.39247
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 24: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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