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  1. Article: Effective Treatments of UTI-Is Intravesical Therapy the Future?

    Morris, Chris J / Rohn, Jennifer L / Glickman, Scott / Mansfield, Kylie J

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 3

    Abstract: Urinary tract infection (UTI) afflicts millions of patients globally each year. While the majority of UTIs are successfully treated with orally administered antibiotics, the impact of oral antibiotics on the host microbiota is under close research ... ...

    Abstract Urinary tract infection (UTI) afflicts millions of patients globally each year. While the majority of UTIs are successfully treated with orally administered antibiotics, the impact of oral antibiotics on the host microbiota is under close research scrutiny and the potential for dysbiosis is a cause for concern. Optimal treatment of UTI relies upon the selection of an agent which displays appropriate pharmacokinetic-pharmacodynamic (PK-PD) properties that will deliver appropriately high concentrations in the urinary tract after oral administration. Alternatively, high local concentrations of antibiotic at the urothelial surface can be achieved by direct instillation into the urinary tract. For antibiotics with the appropriate physicochemical properties, this can be of critical importance in cases for which an intracellular urothelial bacterial reservoir is suspected. In this review, we summarise the underpinning biopharmaceutical barriers to effective treatment of UTI and provide an overview of the evidence for the deployment of the intravesical administration route for antibiotics.
    Language English
    Publishing date 2023-03-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12030417
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  2. Article ; Online: PiMS: a data management system for structural proteomics.

    Morris, Chris

    Methods in molecular biology (Clifton, N.J.)

    2015  Volume 1261, Page(s) 21–34

    Abstract: PiMS (Protein Information Management System) is a laboratory information management system for protein scientists. It enables researchers to enter data, track samples, and report results during the production of recombinant proteins for structural and ... ...

    Abstract PiMS (Protein Information Management System) is a laboratory information management system for protein scientists. It enables researchers to enter data, track samples, and report results during the production of recombinant proteins for structural and functional applications. PiMS is the only custom LIMS for protein production, recording data from the selected target to the sample of soluble protein. The xtalPIMS extension supports crystallogenesis and has recently been extended to support crystal fishing and crystal treatment. PiMS can be configured to match local working methods by defining protocols. These are used to provide templates for recording details of the experiments. PiMS will continue to be developed in response to the needs of users to provide a unified and extensible set of software tools for protein sciences. The vision for PiMS is that it will become the laboratory standard for protein-related data management. The Science and Technology Facilities Council (STFC) distributes PiMS free to academic users under the Community Model.
    MeSH term(s) Database Management Systems ; Databases, Protein ; Information Management ; Internet ; Proteins/chemistry ; Proteins/genetics ; Proteins/metabolism ; Proteomics/methods ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; User-Computer Interface
    Chemical Substances Proteins ; Recombinant Proteins
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-2230-7_2
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  3. Article ; Online: Towards a structural biology work bench.

    Morris, Chris

    Acta crystallographica. Section D, Biological crystallography

    2013  Volume 69, Issue Pt 5, Page(s) 681–682

    Abstract: This is an introduction to four papers based on presentations given at a workshop entitled Integrated Software for Integrative Structural Biology. The use of hybrid techniques, and other trends in structural research, pose new challenges to software ... ...

    Abstract This is an introduction to four papers based on presentations given at a workshop entitled Integrated Software for Integrative Structural Biology. The use of hybrid techniques, and other trends in structural research, pose new challenges to software developers. A structural biology work bench that meets these needs would provide seamless data transfer between processing steps, and accumulate archival data and metadata without intruding into the scientist's work process.
    MeSH term(s) Algorithms ; Computational Biology/methods ; Internet ; Molecular Biology ; Software
    Language English
    Publishing date 2013-04-19
    Publishing country United States
    Document type Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020492-9
    ISSN 1399-0047 ; 0907-4449
    ISSN (online) 1399-0047
    ISSN 0907-4449
    DOI 10.1107/S090744491300276X
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  4. Article ; Online: Mind the gap: social sciences can reveal community needs.

    Morris, Chris

    Nature

    2010  Volume 463, Issue 7280, Page(s) 425

    MeSH term(s) Molecular Biology/methods ; Molecular Biology/trends ; Residence Characteristics ; Social Sciences/trends ; Software Design
    Language English
    Publishing date 2010-01-28
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/463425b
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  5. Article ; Online: Foreseeability and causation in clinical negligence cases.

    Morris, Chris / Francis, Tania / Chawla, Gautam

    British dental journal

    2019  Volume 226, Issue 11, Page(s) 831–832

    Abstract: This article summarises the law on foreseeability and causation in clinical negligence cases. It focuses on what a claimant needs to prove and the development of the law in these areas. ...

    Abstract This article summarises the law on foreseeability and causation in clinical negligence cases. It focuses on what a claimant needs to prove and the development of the law in these areas.
    MeSH term(s) Malpractice
    Language English
    Publishing date 2019-06-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-019-0414-4
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  6. Article ; Online: Clinical negligence: duty and breach.

    Morris, Chris / Chawla, Gautam / Francis, Tania

    British dental journal

    2019  Volume 226, Issue 9, Page(s) 647–648

    Abstract: This article summarises the first two of the basic ingredients for a clinical negligence claim: duty of care and breach of duty. The article focuses on breach of duty and explores what evidence is required to prove breach, as well as some of the relevant ...

    Abstract This article summarises the first two of the basic ingredients for a clinical negligence claim: duty of care and breach of duty. The article focuses on breach of duty and explores what evidence is required to prove breach, as well as some of the relevant legal case law.
    MeSH term(s) Malpractice
    Language English
    Publishing date 2019-05-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-019-0312-9
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  7. Article ; Online: The EQUATOR Network: promoting the transparent and accurate reporting of research.

    Morris, Chris

    Developmental medicine and child neurology

    2008  Volume 50, Issue 10, Page(s) 723

    MeSH term(s) Editorial Policies ; Guidelines as Topic ; Health Services Research/methods ; Health Services Research/standards ; Publishing/standards ; Quality Control ; Research/standards ; Research Design/standards ; Writing/standards
    Language English
    Publishing date 2008-10
    Publishing country England
    Document type Editorial
    ZDB-ID 80369-8
    ISSN 1469-8749 ; 0012-1622
    ISSN (online) 1469-8749
    ISSN 0012-1622
    DOI 10.1111/j.1469-8749.2008.03107.x
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  8. Article ; Online: Radiotherapy biobanking: current landscape, opportunities, challenges, and future aspirations.

    Ward, Tim H / Gilbert, Duncan C / Higginbotham, George / Morris, Chris M / Speirs, Valerie / Curtin, Nicola J

    The journal of pathology. Clinical research

    2021  Volume 8, Issue 1, Page(s) 3–13

    Abstract: Half of all cancer patients receive radiotherapy, which makes a substantial contribution to their long-term disease control/cure. There are significant inter-patient differences in response, both in terms of efficacy and toxicity (frequently delayed ... ...

    Abstract Half of all cancer patients receive radiotherapy, which makes a substantial contribution to their long-term disease control/cure. There are significant inter-patient differences in response, both in terms of efficacy and toxicity (frequently delayed onset) which are difficult to predict. With the introduction of technological improvements (e.g. stereotactic body radiotherapy and proton therapy) and development of combination therapies (e.g. radiotherapy and immune checkpoint inhibition), predictive biomarkers are needed even more. Whilst genomic studies have contributed significantly to predictions of response to anticancer therapy, there is no doubt that more information can be gathered from patient tissue samples. Patients are willing to donate their tissues to biobanks and wish them to be used as widely as possible for high-quality research. We report here a survey of the current practices in the UK from several groups collecting material from patients in radiotherapy trials and have identified barriers to collecting and sharing data and samples. We believe the current situation represents a significant missed opportunity to improve the personalisation of radiotherapy. We propose a greater involvement of patients and/or their advocates, a standardisation of the patient information leaflet, consent form content and data set, with easy linkage to clinical data, which would facilitate widespread sample and data discovery and availability to other researchers. The greater sharing of data and samples, nationally and internationally, would facilitate robust multicentre studies and avoid duplication of effort.
    MeSH term(s) Biological Specimen Banks ; Humans ; Neoplasms/radiotherapy ; Research Personnel
    Language English
    Publishing date 2021-10-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2814357-7
    ISSN 2056-4538 ; 2056-4538
    ISSN (online) 2056-4538
    ISSN 2056-4538
    DOI 10.1002/cjp2.246
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  9. Article: Measuring children's participation.

    Morris, Chris

    Developmental medicine and child neurology

    2007  Volume 49, Issue 9, Page(s) 645

    MeSH term(s) Activities of Daily Living ; Child ; Congresses as Topic ; Disabled Persons ; Europe ; Humans ; Motor Skills Disorders/physiopathology ; Psychomotor Performance ; Quality of Life ; Recreation ; Surveys and Questionnaires
    Language English
    Publishing date 2007-09
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 80369-8
    ISSN 1469-8749 ; 0012-1622
    ISSN (online) 1469-8749
    ISSN 0012-1622
    DOI 10.1111/j.1469-8749.2007.00645.x
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  10. Article ; Online ; Research data: (with research data) A Major Gene for Bovine Ovulation Rate.

    Kirkpatrick, Brian W / Morris, Chris A

    PloS one

    2015  Volume 10, Issue 6, Page(s) e0129025

    Abstract: Half-sib daughters sired by a bull believed to be a carrier of a major gene for high ovulation rate were evaluated for ovulation rate and genotyped in an effort to both test the hypothesis of segregation of a major gene and to map the gene's location. A ... ...

    Abstract Half-sib daughters sired by a bull believed to be a carrier of a major gene for high ovulation rate were evaluated for ovulation rate and genotyped in an effort to both test the hypothesis of segregation of a major gene and to map the gene's location. A total of 131 daughters were produced over four consecutive years at a University of Wisconsin-Madison research farm. All were evaluated for ovulation rate over an average of four estrous cycles using transrectal ultrasonography. The sire and all daughters were genotyped using a 3K SNP chip and the genotype and phenotype data were used in a linkage analysis. Subsequently, daughters recombinant within the QTL region and the sire were genotyped successively with 50K and 777K SNP chips to refine the location of the causative polymorphism. Positional candidate genes within the fine-mapped region were examined for polymorphism by Sanger sequencing of PCR amplicons encompassing coding and 5' and 3' flanking regions of the genes. Sire DNA was used as template in the PCR reactions. Strong evidence of a major gene for ovulation rate was observed (p < 1 x 10(-28)) with the gene localized to bovine chromosome 10. Fine-mapping subsequently reduced the location to a 1.2 Mb region between 13.6 and 14.8 Mb on chromosome 10. The location identified does not correspond to that for any previously identified major gene for ovulation rate. This region contains three candidate genes, SMAD3, SMAD6 and IQCH. While candidate gene screening failed to identify the causative polymorphism, three polymorphisms were identified that can be used as a haplotype to track inheritance of the high ovulation rate allele in descendants of the carrier sire.
    MeSH term(s) Animals ; Cattle/genetics ; Female ; Gene Frequency ; Genotype ; Linkage Disequilibrium ; Ovulation/genetics ; Phenotype ; Polymorphism, Single Nucleotide ; Smad3 Protein/genetics ; Smad6 Protein/genetics
    Chemical Substances Smad3 Protein ; Smad6 Protein
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0129025
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