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  1. Article ; Online: MicroRNAs - small RNAs with a big influence on brain excitability.

    Morris, Gareth

    The Journal of physiology

    2023  Volume 601, Issue 10, Page(s) 1711–1718

    Abstract: MicroRNAs are non-coding RNAs, approximately 22 nt in length, which serve to negatively regulate gene expression through binding to complementary sequences in the 3' untranslated region (3'UTR) of target mRNA. The microRNA-target interaction does not ... ...

    Abstract MicroRNAs are non-coding RNAs, approximately 22 nt in length, which serve to negatively regulate gene expression through binding to complementary sequences in the 3' untranslated region (3'UTR) of target mRNA. The microRNA-target interaction does not require perfect complementarity, meaning that an individual microRNA often has a pool of hundreds of gene targets. Equally, one 3'UTR can contain target sites for many different microRNAs. This gives rise to a complex web of molecular interactions. An emerging concept is that microRNAs have a role as 'master' regulators of certain cellular properties, simultaneously mediating the subtle repression of multiple related genes within a pathway or system, thereby achieving a common phenotypic output. One such example is regulation of brain excitability. There are numerous examples of microRNAs which can target ion channels, ion transporters and genes associated with synaptic transmission. Often, the expression of the microRNA itself is regulated in an activity-dependent manner, thereby forming homeostatic loops. Limitations in our understanding arise from the sheer complexity of microRNA-target interactions, which are difficult to capture experimentally and computationally. Further, many microRNA studies rely on animal model systems, but many microRNAs (and mRNA targets) have sequences which are either not conserved or are entirely unique in the human brain. This leaves many exciting and challenging opportunities to further progress the field in an attempt to fully understand the roles of microRNAs in brain function.
    MeSH term(s) Animals ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; 3' Untranslated Regions ; Base Sequence ; RNA, Messenger/metabolism ; Brain/metabolism
    Chemical Substances MicroRNAs ; 3' Untranslated Regions ; RNA, Messenger
    Language English
    Publishing date 2023-03-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP283719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Investigating the employment motivation, job satisfaction, and dissatisfaction of international high school teachers in China: the impact of the COVID-19 pandemic.

    Mo, Junhua / Morris, Gareth

    Frontiers in psychology

    2024  Volume 15, Page(s) 1271604

    Abstract: International education has become increasingly challenging to manage in an unpredictable world beset by pandemics, regional disputes, and evolving market practices. The last few decades have seen a huge demand for international education in China, and ... ...

    Abstract International education has become increasingly challenging to manage in an unpredictable world beset by pandemics, regional disputes, and evolving market practices. The last few decades have seen a huge demand for international education in China, and numerous acclaimed international brand names set up operations in China's K12 schooling sector. However, the COVID-19 pandemic exerted a noticeably negative impact on international high schools and their staff in China, and exacerbated a difficult period of management for these institutions. Interestingly, but perhaps unsurprisingly, the actual operation of these educational workplaces remains under investigated in academic studies. This paper therefore attempts to examine international high schools in China by focusing on their teachers and their associated employment motivation, job satisfaction, and dissatisfaction which has been perceptibly influenced by the impact of the COVID-19 pandemic. Through a qualitative, case-study approach which adopted semi-structured interviews, an acclaimed British high school, now closed, was investigated. The study found that international high school teachers were driven by diverse work motives such as the school's reputation, values, salary, environment, and chances for career development. Their job satisfaction was also multi-faceted, and their dissatisfaction in certain areas concerning. That is, they derived an early satisfaction from a range of facets, such as the students, class sizes, initial workloads, autonomy and collegiality. However, these early feelings were replaced by a sense of dissatisfaction and noticeable unhappiness resulting from leadership changes and subsequent management practices, increased workload, unmet employment package expectations and obligations, as well as limited professional development opportunities. This study highlights the importance of recruiting well, generating the right starting and longer-term conditions, retaining key staff and managing astutely. The work will be of interest to policy makers, investors, leaders, managers and staff alike. It will also extend educational research in the areas of teacher motivation, satisfaction and dissatisfaction, and in particular in China in international K12 settings.
    Language English
    Publishing date 2024-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2024.1271604
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Spontaneous behaviour is shaped by dopamine in two ways.

    Khatib, Dorgham / Morris, Genela

    Nature

    2023  Volume 614, Issue 7946, Page(s) 36–37

    MeSH term(s) Animals ; Dopamine ; Motor Activity ; Behavior, Animal
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-023-00004-5
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  4. Article ; Online: Reviewing the reviewers.

    Morris, Grace / Hamilton, Amber

    Bipolar disorders

    2023  Volume 25, Issue 1, Page(s) 83

    MeSH term(s) Humans ; Bipolar Disorder ; Surveys and Questionnaires
    Language English
    Publishing date 2023-02-12
    Publishing country Denmark
    Document type Letter
    ZDB-ID 1472242-2
    ISSN 1399-5618 ; 1398-5647
    ISSN (online) 1399-5618
    ISSN 1398-5647
    DOI 10.1111/bdi.13307
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  5. Book: Mental health issues and the media

    Morris, Gary

    an introduction for health professionals

    2006  

    Author's details Gary Morris
    Keywords Mental Health ; Communications Media ; Health Knowledge, Attitudes, Practice ; Mental health ; Mass media in mental health education ; Health in mass media
    Subject code 362.2
    Language English
    Size 259 S. : graph. Darst.
    Publisher Routledge
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT014741019
    ISBN 0-415-32530-7 ; 0-415-32531-5 ; 978-0-415-32530-1 ; 978-0-415-32531-8 ; 0203358228 ; 9780203358221
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2009 A 1066 order for loan Magazin

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  6. Article: A Bayesian probabilistic analysis of the use of English modal verbs in L2 writing: Focusing on L1 influence and topic effects.

    Bozdağ, Fatih Ünal / Morris, Gareth / Mo, Junhua

    Heliyon

    2024  Volume 10, Issue 7, Page(s) e28701

    Abstract: Modal verbs, with their multifaceted semantic nuances and varied grammatical configurations, present notable challenges for L2 learners and regularly intrigue L2 researchers. This study attempts to investigate and compare how English modal verbs are used ...

    Abstract Modal verbs, with their multifaceted semantic nuances and varied grammatical configurations, present notable challenges for L2 learners and regularly intrigue L2 researchers. This study attempts to investigate and compare how English modal verbs are used by L2 learners from different L1 backgrounds. By exploring the Turkish and Chinese learners' subcorpora of the International Corpus of Learner English (ICLE), this work scrutizes the overall frequencies of nine core English modal verbs as grouped into three major semantic classes along with the influential lexico-syntatic variables that are semantic classes of collocated verbs, grammatical patterns and subject pronominality. The results of a Bayesian probabilistic analysis show that both the Turkish and Chinese learners primed similar modal verbs and constructional preferences without topic as the normalizing factor. While the broader analysis reveals no statistically significant divergences between these two learner groups in English modal verb preferences, a pronounced contextual influence is evident when the dataset narrows to essays on a unified theme. This nuanced shift underscores the intricate relationship between essay topics and linguistic structures, thus emphasizing the pivotal role of context in modal verb usage.
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e28701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Notes on a Case of Labour with Exomphalos of the Fœtus.

    Morris, Glanville

    Transactions. Edinburgh Obstetrical Society

    2018  Volume 19, Page(s) 102–105

    Language English
    Publishing date 2018-04-03
    Publishing country Scotland
    Document type Journal Article
    ISSN 0269-3402
    ISSN 0269-3402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Rebuttal from Amy Richardson and Gareth Morris.

    Richardson, Amy / Morris, Gareth

    The Journal of physiology

    2022  Volume 600, Issue 21, Page(s) 4581–4582

    MeSH term(s) Electroencephalography ; Brain Mapping
    Language English
    Publishing date 2022-09-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP283577
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  9. Article ; Online: Cross Talk opposing view: Animal models of epilepsy are more useful than human tissue-based approaches.

    Richardson, Amy / Morris, Gareth

    The Journal of physiology

    2022  Volume 600, Issue 21, Page(s) 4575–4578

    MeSH term(s) Animals ; Humans ; Epilepsy ; Brain ; Models, Animal ; Disease Models, Animal
    Language English
    Publishing date 2022-09-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP282186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The chicken and egg problem of grid cells and place cells.

    Morris, Genela / Derdikman, Dori

    Trends in cognitive sciences

    2022  Volume 27, Issue 2, Page(s) 125–138

    Abstract: Place cells and grid cells are major building blocks of the hippocampal cognitive map. The prominent forward model postulates that grid-cell modules are generated by a continuous attractor network; that a velocity signal evoked during locomotion moves ... ...

    Abstract Place cells and grid cells are major building blocks of the hippocampal cognitive map. The prominent forward model postulates that grid-cell modules are generated by a continuous attractor network; that a velocity signal evoked during locomotion moves entorhinal activity bumps; and that place-cell activity constitutes summation of entorhinal grid-cell modules. Experimental data support the first postulate, but not the latter two. Several families of solutions that depart from these postulates have been put forward. We suggest a modified model (spatial modulation continuous attractor network; SCAN), whereby place cells are generated from spatially selective nongrid cells. Locomotion causes these cells to move the hippocampal activity bump, leading to movement of the entorhinal manifolds. Such inversion accords with the shift of hippocampal thought from navigation to more abstract functions.
    MeSH term(s) Grid Cells/physiology ; Entorhinal Cortex/physiology ; Place Cells/physiology ; Models, Neurological ; Hippocampus/physiology
    Language English
    Publishing date 2022-11-24
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2010989-1
    ISSN 1879-307X ; 1364-6613
    ISSN (online) 1879-307X
    ISSN 1364-6613
    DOI 10.1016/j.tics.2022.11.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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