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Artikel ; Online: Advancing Towards Personalized Prescription of Radiotherapy Dose.

Citrin, Deborah / Morris, Zachary S

2023 Band 33, Heft 3, Seite(n) 219–220

Mesh-Begriff(e)	Humans ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Prescriptions ; Radiotherapy, Intensity-Modulated
Sprache	Englisch
Erscheinungsdatum	2023-07-01
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ZDB-ID	1146999-7
ISSN	1532-9461 ; 1053-4296
ISSN (online)	1532-9461
ISSN	1053-4296
DOI	10.1016/j.semradonc.2023.03.008
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Examining the relevance of employment integration policies on disability benefit receipt: a multilevel analysis of older working age adults in 16 countries.

Morris, Zachary A

Disability and rehabilitation

2019 Band 42, Heft 23, Seite(n) 3339–3347

Abstract: Purpose: ...

Abstract	Purpose:
Mesh-Begriff(e)	Aged ; Disabled Persons ; Employment ; Europe ; Humans ; Longitudinal Studies ; Multilevel Analysis ; Policy
Sprache	Englisch
Erscheinungsdatum	2019-04-21
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1104775-6
ISSN	1464-5165 ; 0963-8288
ISSN (online)	1464-5165
ISSN	0963-8288
DOI	10.1080/09638288.2019.1593521
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Loneliness as a Predictor of Work Disability Onset Among Nondisabled, Working Older Adults in 14 Countries.

Morris, Zachary A

Journal of aging and health

2019 Band 32, Heft 7-8, Seite(n) 554–563

Abstract: Objective: ...

Abstract	Objective:
Mesh-Begriff(e)	Aged ; Depression/psychology ; Employment/psychology ; Europe ; Female ; Humans ; Loneliness/psychology ; Longitudinal Studies ; Male ; Mediation Analysis ; Middle Aged ; Sick Leave/statistics & numerical data
Sprache	Englisch
Erscheinungsdatum	2019-04-09
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1045392-1
ISSN	1552-6887 ; 0898-2643
ISSN (online)	1552-6887
ISSN	0898-2643
DOI	10.1177/0898264319836549
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The experience of persons with disabilities as beneficiaries of Ghana's District Assemblies Common Fund.

Abdul Karimu, Alimata Thelma Flora / Mont, Daniel M / Morris, Zachary A

PloS one

2024 Band 19, Heft 4, Seite(n) e0297845

Abstract: Ghana's Disability Fund aims to build the capacity of persons with disabilities, particularly those outside of formal employment, to engage in livelihood generation activities as a way to reduce poverty. The objective of this paper is to investigate the ... ...

Abstract	Ghana's Disability Fund aims to build the capacity of persons with disabilities, particularly those outside of formal employment, to engage in livelihood generation activities as a way to reduce poverty. The objective of this paper is to investigate the kind of knowledge that exists on the District Assemblies Common Fund program, understand the experience of beneficiaries when they access the program, and examine the benefits on beneficiaries' livelihoods. The research consisted of five focus group discussions with 35 beneficiaries, key informant interviews with six member organizations of Ghana Federation of Disability Organizations, and interviews with eleven Disability Fund Management Committees members. This research found the experiences of beneficiaries on the program are varied yet the program on the whole has had a positive outcomes on their livelihoods. Persons with disabilities who participated in this study demonstrated knowledge of the program. Beneficiaries further described issues relating to the quality of purchased items, the procurement process, as well as reductions and changes to requested items. Disability-specific issues in accessing the funds were also noted. These limited the effectiveness of the Fund to meet its stated goals. The findings of the study can inform the Common Fund Secretariat efforts to improve the performance of the fund as well as the advocacy of the disability movement. The findings are also relevant to the design and implementation of other social protection programmes in low-and middle-income countries.
Mesh-Begriff(e)	Humans ; Ghana ; Disabled Persons ; Poverty ; Focus Groups ; Employment
Sprache	Englisch
Erscheinungsdatum	2024-04-11
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0297845
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Predictors of food insecurity among older adults before and during COVID-19 in the United States.

Nicklett, Emily Joy / Cheng, Greta Jianjia / Morris, Zachary A

Frontiers in public health

2023 Band 11, Seite(n) 1112575

Abstract: Background: The COVID-19 pandemic has strained the health and wellbeing of older adult populations through increased morbidity, mortality, and social exclusion. However, the impact of COVID-19 on the health of older adults through food security has ... ...

Abstract	Background: The COVID-19 pandemic has strained the health and wellbeing of older adult populations through increased morbidity, mortality, and social exclusion. However, the impact of COVID-19 on the health of older adults through food security has received relatively little attention, despite the strong impact of diet quality on the health and longevity of older adults. Objective: The objective of this study was to identify sociodemographic and socioeconomic predictors of self-reported food insecurity before and early in the COVID-19 pandemic among community-dwelling older adults in the United States. Methods: Using longitudinal data from the Health and Retirement Study, a nationally representative sample of middle-aged and older adults in the United States, we examined the associations between sociodemographic and socioeconomic predictors of self-reported food insecurity between 2018 ( Results: The prevalence of food insecurity doubled among participants from 2018 (4.83%) to June 2020 (9.54%). In 2018, non-Hispanic Black and rural residents were more likely to report food insecurity, while individuals with higher education and greater wealth were less likely to report food insecurity in adjusted models. In June 2020, those who were relatively younger, not working due to a disability, and renting were more likely to report food insecurity. Those with an increased number of functional limitations, a recent onset of a work-limiting disability, and those who were no longer homeowners experienced an elevated longitudinal risk for food insecurity. Conclusion: Future research should examine effective policies and interventions to address the disproportionate impacts of COVID-19 on populations at a heightened risk of experiencing food insecurity.
Mesh-Begriff(e)	Middle Aged ; Humans ; United States/epidemiology ; Aged ; COVID-19/epidemiology ; Pandemics ; Food Supply ; Diet ; Food Insecurity
Sprache	Englisch
Erscheinungsdatum	2023-05-12
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1112575
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Heading for higher ground: Developmental origins and evolutionary diversification of the amniote face.

Morris, Zachary S / Abzhanov, Arhat

Current topics in developmental biology

2021 Band 141, Seite(n) 241–277

Abstract: Amniotes, a clade of terrestrial vertebrates, which includes all of the descendants of the last common ancestor of the reptiles (including dinosaurs and birds) and mammals, is one of the most successful group of animals on our planet. In addition to ... ...

Abstract	Amniotes, a clade of terrestrial vertebrates, which includes all of the descendants of the last common ancestor of the reptiles (including dinosaurs and birds) and mammals, is one of the most successful group of animals on our planet. In addition to having an egg equipped with an amnion, an adaptation to lay eggs on land, amniotes possess a number of other major morphological characteristics. Chief among them is the amniote skull, which can be classified into several major types distinguished by the presence and number of temporal fenestrae (windows) in the posterior part. Amniotes evolved from ancestors who possessed a skull composed of a complex mosaic of small bones separated by sutures. Changes in skull composition underlie much of the large-scale evolution of amniotes with many lineages showing a trend in reduction of cranial elements known as the "Williston's Law." The skull of amniotes is also arranged into a set of modules of closely co-evolving bones as revealed by modularity and integration tests. One of the most consistently recovered and at the same time most versatile modules is the "face," anatomically defined as the anterior portion of the head. The faces of amniotes display extraordinary amount of variation, with many adaptive radiations showing parallel tendencies in facial scaling, e.g., changes in length or width. This review explores the natural history of the amniote face and discusses how a better understanding of its anatomy and developmental biology helps to explain the outstanding scale of adaptive facial diversity. We propose a model for facial evolution in the amniotes, based on the differential rate of cranial neural crest cell proliferation and the timing of their skeletal differentiation.
Mesh-Begriff(e)	Animals ; Biological Evolution ; Body Patterning ; Face/anatomy & histology ; Face/embryology ; Gene Expression Regulation, Developmental ; Neural Crest/cytology ; Skull/anatomy & histology ; Skull/embryology ; Vertebrates/anatomy & histology
Sprache	Englisch
Erscheinungsdatum	2021-01-25
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ISSN	1557-8933 ; 0070-2153
ISSN (online)	1557-8933
ISSN	0070-2153
DOI	10.1016/bs.ctdb.2020.12.003
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Discovering chromatin dysregulation induced by protein-coding perturbations at scale.

Frenkel, Max / Hujoel, Margaux L A / Morris, Zachary / Raman, Srivatsan

bioRxiv : the preprint server for biology

2023

Abstract: Although population-scale databases have expanded to millions of protein-coding variants, insight into variant mechanisms has not kept pace. We present PROD-ATAC, a high-throughput method for discovering the effects of protein-coding variants on ... ...

Abstract	Although population-scale databases have expanded to millions of protein-coding variants, insight into variant mechanisms has not kept pace. We present PROD-ATAC, a high-throughput method for discovering the effects of protein-coding variants on chromatin. A pooled library of variants is expressed in a disease-agnostic cell line, and single-cell ATAC resolves each variant's effect on chromatin. Using PROD-ATAC, we characterized the effects of >100 oncofusions (a class of cancer-causing chimeric proteins) and controls and revealed that pioneer activity is a common feature of fusions spanning an enormous range of fusion frequencies. Further, fusion-induced dysregulation can be context-agnostic as observed mechanisms often overlapped with cancer and cell-type specific prior knowledge. We also showed that gain-of-function pioneering is common among oncofusions. This work provides a global view of fusion-induced chromatin. We uncovered convergent mechanisms among disparate oncofusions and shared modes of dysregulation across different cancers. PROD-ATAC is generalizable to any set of protein-coding variants.
Sprache	Englisch
Erscheinungsdatum	2023-09-21
Erscheinungsland	United States
Dokumenttyp	Preprint
DOI	10.1101/2023.09.20.555752
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Radiation-associated secondary malignancies: a novel opportunity for applying immunotherapies.

Atajanova, Tavus / Rahman, Md Mahfuzur / Konieczkowski, David J / Morris, Zachary S

Cancer immunology, immunotherapy : CII

2023 Band 72, Heft 11, Seite(n) 3445–3452

Abstract: Radiation is commonly used as a treatment intended to cure or palliate cancer patients. Despite remarkable advances in the precision of radiotherapy delivery, even the most advanced forms inevitably expose some healthy tissues surrounding the target site ...

Abstract	Radiation is commonly used as a treatment intended to cure or palliate cancer patients. Despite remarkable advances in the precision of radiotherapy delivery, even the most advanced forms inevitably expose some healthy tissues surrounding the target site to radiation. On rare occasions, this results in the development of radiation-associated secondary malignancies (RASM). RASM are typically high-grade and carry a poorer prognosis than their non-radiated counterparts. RASM are characterized by a high mutation burden, increased T cell infiltration, and a microenvironment that bears unique inflammatory signatures of prior radiation, including increased expression of various cytokines (e.g., TGF-β, TNF-α, IL4, and IL10). Interestingly, these cytokines have been shown to up-regulate the expression of PD-1 and/or PD-L1-an immune checkpoint receptor/ligand pair that is commonly targeted by immune checkpoint blocking immunotherapies. Here, we review the current understanding of the tumor-immune interactions in RASM, highlight the distinct clinical and molecular characteristics of RASM that may render them immunologically "hot," and propose a rationale for the formal testing of immune checkpoint blockade as a treatment approach for patients with RASM.
Mesh-Begriff(e)	Humans ; Immunotherapy/methods ; Neoplasms/radiotherapy ; T-Lymphocytes/metabolism ; Cytokines ; Tumor Microenvironment ; B7-H1 Antigen/metabolism
Chemische Substanzen	Cytokines ; B7-H1 Antigen
Sprache	Englisch
Erscheinungsdatum	2023-09-02
Erscheinungsland	Germany
Dokumenttyp	Journal Article ; Review
ZDB-ID	195342-4
ISSN	1432-0851 ; 0340-7004
ISSN (online)	1432-0851
ISSN	0340-7004
DOI	10.1007/s00262-023-03532-1
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: The Role of MRI-Guided Radiotherapy for Soft Tissue Sarcomas.

Blitzer, Grace C / Yadav, Poonam / Morris, Zachary S

Journal of clinical medicine

2022 Band 11, Heft 4

Abstract: Soft tissue sarcomas (STS) are a rare class of tumors that originate from mesenchymal tissues and occur most frequently in the extremities, trunk, and retroperitoneum. Surgical resection with R0 margins is the primary curative treatment for most ... ...

Abstract	Soft tissue sarcomas (STS) are a rare class of tumors that originate from mesenchymal tissues and occur most frequently in the extremities, trunk, and retroperitoneum. Surgical resection with R0 margins is the primary curative treatment for most localized STS. In this setting, radiation therapy is used either pre-operatively or post-operatively to reduce the rate of local recurrence. Modern pre- or post-operative radiation therapy rely on the use of MRI sequences to guide target delineation during treatment planning. MRI-guided radiotherapy also offers unique advantages over CT-guided approaches in differentiating STS from surrounding normal soft tissues and enabling better identification of target volumes on daily imaging. For patients with unresectable STS, radiation therapy may offer the best chance for local tumor control. However, most STS are relatively radioresistant with modest rates of local control achieved using conventionally fractionated radiation. Specialized techniques such as hypofractionated radiation may allow for dose intensification and may increase rates of local control for STS. In these settings, MRI becomes even more critical for the delineation of targets and organs at risk and management of tumor and organ at risk motion during and between radiotherapy treatment fractions.
Sprache	Englisch
Erscheinungsdatum	2022-02-17
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11041042
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Estimating Households' Expenditures on Disability in Africa: The Uses and Limitations of the Standard of Living Method.

Mont, Daniel / Morris, Zachary / Nasiir, Mercoledi / Goodman, Nanette

International journal of environmental research and public health

2022 Band 19, Heft 23

Abstract: People with disabilities face extra costs of living to participate in the social and economic lives of their communities on an equal basis with people without disabilities. If these extra costs are not accounted for, then their economic wellbeing will be ...

Abstract	People with disabilities face extra costs of living to participate in the social and economic lives of their communities on an equal basis with people without disabilities. If these extra costs are not accounted for, then their economic wellbeing will be overestimated. The Standard of Living (SOL) method is a way of generating these estimates and is thus useful for determining the economic impact of those costs in the current environment. However, previous studies have used different indicators for disability and different measures of the standard of living, so it is hard to compare estimates across different countries. This study applies a consistent set of indicators across seven African countries to produce comparable estimates. Our estimates of the extra costs of living in these lower-income countries are much lower than the results produced for higher-income countries in prior work. We argue that this finding highlights the limitations of the SOL method as a useful source of information for developing inclusive systems of social protection in lower-income countries because it captures what households spend but not what the person with a disability needs to fully participate in the social and economic lives of their community. In lower-income countries, people with disabilities are likely to have fewer opportunities to spend on needed items thus resulting in substantial unmet need for disability-related goods and services. Failing to account for these unmet needs can lead to inadequate systems of social protection if they are based solely on SOL estimates.
Sprache	Englisch
Erscheinungsdatum	2022-12-01
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192316069
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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