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  1. Book: Peters' atlas of tropical medicine and parasitology

    Nabarro, Laura / Morris-Jones, Stephen / Moore, David A. J.

    2019  

    Title translation Atlas of tropical medicine and parasitology
    Author's details Laura Nabarro, Stephen Morris-Jones, David A.J. Moore
    Keywords Tropical medicine ; Medical parasitology
    Subject code 616.9883
    Language English
    Size viii, 357 Seiten, Illustrationen, 27 cm
    Edition Seventh edition
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    Note Zugang zur Online-Ausgabe über Code ; Includes bibliographical references and index
    HBZ-ID HT019929707
    ISBN 978-0-7020-4061-0 ; 9780702050404 ; 0-7020-4061-4 ; 0702050407
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2019 A 87 available for loan (reading room) Lesesaal EG
    Zugang zur Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Article ; Online: Leg ulceration due to cutaneous melioidosis in a returning traveller.

    Stavrou, Christiana / Veraitch, Ophelia / Morris-Jones, Stephen / Walker, Stephen L

    BMJ case reports

    2021  Volume 14, Issue 6

    Abstract: A 26-year-old man, returned to the UK having travelled extensively in Asia. He was referred with a 3-month history of distal leg ulceration following an insect bite while in Thailand. Despite multiple courses of oral antibiotics, he developed two ... ...

    Abstract A 26-year-old man, returned to the UK having travelled extensively in Asia. He was referred with a 3-month history of distal leg ulceration following an insect bite while in Thailand. Despite multiple courses of oral antibiotics, he developed two adjacent ulcers. A wound swab isolated an organism identified as
    MeSH term(s) Adult ; Asia, Southeastern ; Australia ; Burkholderia ; Burkholderia pseudomallei ; Humans ; Leg ; Male ; Melioidosis/complications ; Melioidosis/diagnosis ; Melioidosis/drug therapy ; Thailand ; Ulcer
    Language English
    Publishing date 2021-06-14
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-241490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: T2Candida assay: diagnostic performance and impact on antifungal prescribing.

    Patrocínio de Jesus, Rita / Houston, Hamish / Schutte, Annemiek H J / Morris-Jones, Stephen / Stone, Neil / Gorton, Rebecca / Pollara, Gabriele

    JAC-antimicrobial resistance

    2023  Volume 5, Issue 2, Page(s) dlad035

    Abstract: Objectives: To assess the performance of T2Candida for the diagnosis of invasive candidiasis (IC) against gold standards of candidaemia or consensus IC definitions, and to evaluate the impact of T2Candida on antifungal drug prescribing.: Methods: A ... ...

    Abstract Objectives: To assess the performance of T2Candida for the diagnosis of invasive candidiasis (IC) against gold standards of candidaemia or consensus IC definitions, and to evaluate the impact of T2Candida on antifungal drug prescribing.
    Methods: A retrospective review was undertaken of all T2Candida (T2MR technology, T2 Biosystems) performed from October 2020 to February 2022. T2Candida performance was evaluated against confirmed candidaemia or against proven/probable IC within 48 hours of T2Candida, and its impact on antifungal drug prescriptions.
    Results: T2Candida was performed in 61 patients, with 6 (9.8%) positive results. Diagnostic performance of T2Candida against candidaemia had a specificity of 85.7% and negative predictive value (NPV) of 96.8%. When comparing T2Candida results with consensus definitions of IC, the specificity and NPV of T2Candida was respectively 90% (54/60) and 98.2% (54/55) for proven IC, and 91.4% (53/58) and 96.4% (53/55) for proven/probable IC. Antifungals were initiated in three of six patients (50%) with a positive T2Candida result. Thirty-three patients were receiving empirical antifungals at the time of T2Candida testing, and a negative result prompted cessation of antifungals in 11 (33%) patients, compared with 6 (25%) antifungal prescriptions stopped following negative beta-d-glucan (BDG) testing in a control population (
    Conclusions: T2Candida shows high specificity and NPV compared with evidence of
    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Journal Article
    ISSN 2632-1823
    ISSN (online) 2632-1823
    DOI 10.1093/jacamr/dlad035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Management and Clinical Outcomes of 37 Patients with Necrotizing Otitis Externa: Retrospective Review of a Standardized 6-Week Treatment Pathway.

    Dhariwal, Ankush / Manjaly, Joseph G / Patel, Bhavesh / Morris-Jones, Stephen / David, Kate / Khetarpal, Priya / Beale, Tim / Mehta, Nishchay / Logan, Sarah

    The journal of international advanced otology

    2023  Volume 19, Issue 3, Page(s) 223–227

    Abstract: Background: Necrotizing otitis externa is an invasive infection, affecting older patients, with significant associated morbidity. Despite this, there are no randomized controlled trials that address management, and therefore, treatment approaches may ... ...

    Abstract Background: Necrotizing otitis externa is an invasive infection, affecting older patients, with significant associated morbidity. Despite this, there are no randomized controlled trials that address management, and therefore, treatment approaches may vary considerably. We describe the management and outcomes of 37 patients managed using a multidisciplinary treatment pathway for necrotizing otitis externa over a 5-year period. The pathway is based on a standardized antibiotic regime of 3 weeks of intravenous ceftazidime plus oral ciprofloxacin, followed by a further 3 weeks of ciprofloxacin.
    Methods: This is a retrospective review of all patients diagnosed with necrotizing otitis externa since the introduction of our pathway in 2016. We include data on patient demographics, comorbidities, microbiology, length of stay, and length of antimicrobial treatment. Outcome data, including mortality, relapse and treatment failure, and adverse effects of treatment, are presented.
    Results: The median age of our patients was 82 years. About 54% of patients had diabetes mellitus or another cause of immunocompromise. Pseudomonas aeruginosa was isolated in 68%. The median duration of inpatient stay was 9 days, and median treatment duration was 6 weeks. Of 37 patients, 32 were cured (86%), and of the remaining 5 patients, there were 2 mortalities unrelated to necrotizing otitis externa and 3 patients with recurrent infections due to anatomical abnormalities.
    Conclusion: We note favorable treatment outcomes when using a standardized multidisciplinary pathway and a 6-week course of antibiotic therapy.
    MeSH term(s) Humans ; Aged, 80 and over ; Otitis Externa/drug therapy ; Otitis Externa/microbiology ; Retrospective Studies ; Ciprofloxacin/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Ceftazidime/therapeutic use ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/complications
    Chemical Substances Ciprofloxacin (5E8K9I0O4U) ; Anti-Bacterial Agents ; Ceftazidime (9M416Z9QNR)
    Language English
    Publishing date 2023-06-05
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2561231-1
    ISSN 2148-3817 ; 1308-7649 ; 2148-3817
    ISSN (online) 2148-3817
    ISSN 1308-7649 ; 2148-3817
    DOI 10.5152/iao.2023.22637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Acetic Acid Enables Molecular Enumeration of Mycobacterium tuberculosis from Sputum and Eliminates the Need for a Biosafety Level 3 Laboratory.

    Palekyte, Ana / Morkowska, Anna / Billington, Owen / Morris-Jones, Stephen / Millard, James / Marakalala, Mohlopheni J / Owolabi, Olumuyiwa / Sambou, Basil / Zumla, Alimuddin / Sutherland, Jayne S / McHugh, Timothy D / Honeyborne, Isobella

    Clinical chemistry

    2024  Volume 70, Issue 4, Page(s) 642–652

    Abstract: Background: Improved monitoring of Mycobacterium tuberculosis response to treatment is urgently required. We previously developed the molecular bacterial load assay (MBLA), but it is challenging to integrate into the clinical diagnostic laboratory due ... ...

    Abstract Background: Improved monitoring of Mycobacterium tuberculosis response to treatment is urgently required. We previously developed the molecular bacterial load assay (MBLA), but it is challenging to integrate into the clinical diagnostic laboratory due to a labor-intensive protocol required at biosafety level 3 (BSL-3). A modified assay was needed.
    Methods: The rapid enumeration and diagnostic for tuberculosis (READ-TB) assay was developed. Acetic acid was tested and compared to 4 M guanidine thiocyanate to be simultaneously bactericidal and preserve mycobacterial RNA. The extraction was based on silica column technology and incorporated low-cost reagents: 3 M sodium acetate and ethanol for the RNA extraction to replace phenol-chloroform. READ-TB was fully validated and compared directly to the MBLA using sputa collected from individuals with tuberculosis.
    Results: Acetic acid was bactericidal to M. tuberculosis with no significant loss in 16S rRNA or an unprotected mRNA fragment when sputum was stored in acetic acid at 25°C for 2 weeks or -20°C for 1 year. This novel use of acetic acid allows processing of sputum for READ-TB at biosafety level 2 (BSL-2) on sample receipt. READ-TB is semiautomated and rapid. READ-TB correlated with the MBLA when 85 human sputum samples were directly compared (R2 = 0.74).
    Conclusions: READ-TB is an improved version of the MBLA and is available to be adopted by clinical microbiology laboratories as a tool for tuberculosis treatment monitoring. READ-TB will have a particular impact in low- and middle-income countries (LMICs) for laboratories with no BSL-3 laboratory and for clinical trials testing new combinations of anti-tuberculosis drugs.
    MeSH term(s) Humans ; Mycobacterium tuberculosis/genetics ; Acetic Acid ; Sputum ; Laboratories ; RNA, Ribosomal, 16S/genetics ; Containment of Biohazards ; Tuberculosis/diagnosis ; Tuberculosis/microbiology
    Chemical Substances Acetic Acid (Q40Q9N063P) ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvae013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.171: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Routine Outpatient Parenteral Antimicrobial Therapy Clinic Review Minimizes Inpatient Readmission.

    Marks, Michael / Morris-Jones, Stephen / Logan, Sarah / Pollara, Gabriele

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 71, Issue 10, Page(s) 2771–2773

    MeSH term(s) Anti-Infective Agents ; Follow-Up Studies ; Humans ; Inpatients ; Outpatients ; Patient Readmission
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2020-02-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1505: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 480: Show issues

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  7. Article ; Online: 4 Infections Acquired by Airborne Transmission

    Nabarro, Laura / Morris-Jones, Stephen / Moore, David A.J.

    Peter's Atlas of Tropical Medicine and Parasitology

    Keywords covid19
    Publisher Elsevier; PMC
    Document type Article ; Online
    DOI 10.1016/b978-0-7020-4061-0.00004-2
    Database COVID19

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  8. Article ; Online: Azithromycin susceptibility testing for Salmonella enterica isolates: discordances in results using MIC gradient strips.

    Goldblatt, Jennifer / Ward, Andrew / Yusuf, Mohammed / Day, Martin / Godbole, Gauri / Morris-Jones, Stephen

    The Journal of antimicrobial chemotherapy

    2020  Volume 75, Issue 7, Page(s) 1820–1823

    Abstract: Background: Azithromycin resistance is emerging in typhoidal Salmonella. Confirmation of azithromycin MIC is the most frequent antibiotic susceptibility request made to the Gastrointestinal Bacteria Reference Unit (GBRU) laboratory in England by local ... ...

    Abstract Background: Azithromycin resistance is emerging in typhoidal Salmonella. Confirmation of azithromycin MIC is the most frequent antibiotic susceptibility request made to the Gastrointestinal Bacteria Reference Unit (GBRU) laboratory in England by local diagnostic laboratories.
    Objectives: (i) Determine concordance between local diagnostic and reference laboratory estimations of azithromycin MIC by gradient strip in Salmonella enterica serovars Typhi and Paratyphi. (ii) Consider causes of variation.
    Methods: Isolates from patients with enteric fever attending a central London hospital between May 2011 and April 2019 were tested for azithromycin susceptibility using gradient strips, according to EUCAST methodology. Matched local diagnostic and reference laboratory estimations of azithromycin and ciprofloxacin (as a comparator) MICs were included; concordance in estimations was examined.
    Results: Local diagnostic laboratory readings overestimated azithromycin MIC values compared with the reference laboratory, resulting in poor concordance in susceptibility/resistance attribution (concordant susceptibility interpretation in 8/19, κ = 0). In contrast, ciprofloxacin MIC estimation demonstrated superior concordance (concordant susceptibility interpretation in 16/17, κ = 0.85). None of the isolates was resistant to azithromycin at the reference laboratory and no known genes associated with azithromycin resistance were detected in any isolate using WGS.
    Conclusions: Overestimation of azithromycin resistance is likely to be due to difficulty in interpreting the point of intersection of the 'trailing edge' with the gradient strip, used to determine MIC. We advise local diagnostic laboratories to review their experience and consider adopting a 'second reader' system to mitigate this.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Azithromycin/pharmacology ; Ciprofloxacin/pharmacology ; Drug Resistance, Bacterial ; England ; Humans ; London ; Microbial Sensitivity Tests ; Salmonella enterica/genetics ; Salmonella typhi
    Chemical Substances Anti-Bacterial Agents ; Ciprofloxacin (5E8K9I0O4U) ; Azithromycin (83905-01-5)
    Language English
    Publishing date 2020-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkaa097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1197: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 124: Show issues

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  9. Article ; Online: Response to Author Comments on "Clinical, microbiological characteristics and predictors of mortality in patients with carbapenemase-producing Enterobacterales blood stream infections".

    Anton-Vazquez, Vanesa / Evans, Terry John / Fernando, Samitha / Somasunderam, Donald / David, Kate / Melzer, Mark / Hawkins, Lois / Morris-Jones, Stephen / Arias, Mauricio / Drazho, Borana / Dall'Antonia, Martino / Planche, Timothy

    Infection prevention in practice

    2023  Volume 5, Issue 4, Page(s) 100327

    Language English
    Publishing date 2023-11-17
    Publishing country England
    Document type Journal Article
    ISSN 2590-0889
    ISSN (online) 2590-0889
    DOI 10.1016/j.infpip.2023.100327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Clinical, microbiological characteristics and predictors of mortality in patients with carbapenemase-producing Enterobacterales bloodstream infections: a multicentre study.

    Anton-Vazquez, Vanesa / Evans, Terry John / Fernando, Samitha / Somasunderam, Donald / David, Kate / Melzer, Mark / Hawkins, Lois / Morris-Jones, Stephen / Arias, Mauricio / Drazho, Borana / Dall'Antonia, Martino / Planche, Timothy

    Infection prevention in practice

    2023  Volume 5, Issue 3, Page(s) 100298

    Abstract: Objectives: To investigate the clinical, microbiological characteristics and outcomes of patients with bloodstream infections (BSI) due to carbapenemase-producing Enterobacterales (CPE).: Methods: A multicentre retrospective observational study of ... ...

    Abstract Objectives: To investigate the clinical, microbiological characteristics and outcomes of patients with bloodstream infections (BSI) due to carbapenemase-producing Enterobacterales (CPE).
    Methods: A multicentre retrospective observational study of patients with BSIs due to CPE admitted to six UK hospitals was conducted between 2011 and 2021. Multivariate analysis was used to identify factors predicting 30-day case fatality rate (CFR).
    Results: There were 84 episodes of CPE-BSIs, 37 (44%) due to OXA-48, 35 (42%) to metallo-betalactamases (MBL) and 12 (14%) to KPC. 63% of patients were male with a median age of 64 years. Common organisms included
    Conclusion: Strategies targeting high-risk patients and adherence to infection prevention bundles for urinary devices and central venous catheters can reduce OXA-48 and KPC-BSIs. Early recognition and management of severe sepsis, prompt initiation of appropriate antimicrobial therapy and development of novel antimicrobials are crucial to mitigate the high CFR associated with CPE-BSIs
    Language English
    Publishing date 2023-07-08
    Publishing country England
    Document type Journal Article
    ISSN 2590-0889
    ISSN (online) 2590-0889
    DOI 10.1016/j.infpip.2023.100298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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