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  1. Article ; Online: Cutis verticis gyrata due to a novel NPR2 variant.

    McKenna, J / Morrison, P J

    QJM : monthly journal of the Association of Physicians

    2023  Volume 116, Issue 8, Page(s) 709

    MeSH term(s) Humans ; Connective Tissue Diseases ; Biopsy
    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcad068
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    Ua VI Zs.131: Show issues Location:
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  2. Article ; Online: Chaotic saddles and interior crises in a dissipative nontwist system.

    Simile Baroni, R / de Carvalho, R Egydio / Caldas, I L / Viana, R L / Morrison, P J

    Physical review. E

    2023  Volume 107, Issue 2-1, Page(s) 24216

    Abstract: We consider a dissipative version of the standard nontwist map. Nontwist systems present a robust transport barrier, called the shearless curve, that becomes the shearless attractor when dissipation is introduced. This attractor can be regular or chaotic ...

    Abstract We consider a dissipative version of the standard nontwist map. Nontwist systems present a robust transport barrier, called the shearless curve, that becomes the shearless attractor when dissipation is introduced. This attractor can be regular or chaotic depending on the control parameters. Chaotic attractors can undergo sudden and qualitative changes as a parameter is varied. These changes are called crises, and at an interior crisis the attractor suddenly expands. Chaotic saddles are nonattracting chaotic sets that play a fundamental role in the dynamics of nonlinear systems; they are responsible for chaotic transients, fractal basin boundaries, and chaotic scattering, and they mediate interior crises. In this work we discuss the creation of chaotic saddles in a dissipative nontwist system and the interior crises they generate. We show how the presence of two saddles increases the transient times and we analyze the phenomenon of crisis induced intermittency.
    Language English
    Publishing date 2023-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.107.024216
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  3. Article ; Online: Huntington disease in 2013 - genetic choices across the life cycle.

    Morrison, P J

    Clinical genetics

    2014  Volume 85, Issue 1, Page(s) 76–77

    MeSH term(s) Female ; Humans ; Huntington Disease/diagnosis ; Huntington Disease/genetics ; Pregnancy ; Prenatal Diagnosis
    Language English
    Publishing date 2014-01
    Publishing country Denmark
    Document type Introductory Journal Article
    ZDB-ID 221209-2
    ISSN 1399-0004 ; 0009-9163
    ISSN (online) 1399-0004
    ISSN 0009-9163
    DOI 10.1111/cge.12093
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    Zs.A 413: Show issues Location:
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  4. Article ; Online: Aetiology of Eagle syndrome: ossification of the stylohyoid ligament.

    Morrison, R J / Morrison, P J

    QJM : monthly journal of the Association of Physicians

    2018  Volume 112, Issue 6, Page(s) 467

    Language English
    Publishing date 2018-07-29
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcy168
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  5. Article ; Online: Oral dimethyl fumarate induces changes within the peripheral neutrophil compartment of patients with psoriasis that are linked with skin improvement.

    Morrison, P J / Suhrkamp, I / Gerdes, S / Mrowietz, U

    The British journal of dermatology

    2021  Volume 185, Issue 3, Page(s) 605–615

    Abstract: Background: Dimethyl fumarate (DMF) is a treatment for moderate-to-severe psoriasis and multiple sclerosis. DMF therapy typically improves skin inflammation within the first 3 months of treatment. DMF is a prodrug that generates the hydroxycarboxylic ... ...

    Abstract Background: Dimethyl fumarate (DMF) is a treatment for moderate-to-severe psoriasis and multiple sclerosis. DMF therapy typically improves skin inflammation within the first 3 months of treatment. DMF is a prodrug that generates the hydroxycarboxylic acid receptor 2 (HCA2) agonist, monomethyl fumarate (MMF). Despite widespread clinical use, DMF's mechanism of action is not fully understood.
    Objectives: We wished to characterize the changes induced by DMF in peripheral neutrophils within the first 3 months of treatment to better understand its early antipsoriatic effects.
    Methods: Flow cytometry was used to assess T-cell and neutrophil frequencies, apoptosis and activation phenotype. In vitro culture of neutrophils with DMF and MMF was used to evaluate apoptosis and HCA2 internalization. Serum levels of neutrophil degranulation products were measured by enzyme-linked immunosorbent assay.
    Results: Patients with psoriasis had significantly higher leucocyte counts at baseline compared with controls, with a large population of pro-inflammatory CD62L
    Conclusions: Our results reveal a novel in vivo effect of DMF therapy on pro-inflammatory neutrophils that likely contributes to this treatment's antipsoriatic efficacy.
    Language English
    Publishing date 2021-06-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.19899
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  6. Article ; Online: Epi-Two-Dimensional Fluid Flow: A New Topological Paradigm for Dimensionality.

    Yoshida, Z / Morrison, P J

    Physical review letters

    2017  Volume 119, Issue 24, Page(s) 244501

    Abstract: While a variety of fundamental differences are known to separate two-dimensional (2D) and three-dimensional (3D) fluid flows, it is not well understood how they are related. Conventionally, dimensional reduction is justified by an a priori geometrical ... ...

    Abstract While a variety of fundamental differences are known to separate two-dimensional (2D) and three-dimensional (3D) fluid flows, it is not well understood how they are related. Conventionally, dimensional reduction is justified by an a priori geometrical framework; i.e., 2D flows occur under some geometrical constraint such as shallowness. However, deeper inquiry into 3D flow often finds the presence of local 2D-like structures without such a constraint, where 2D-like behavior may be identified by the integrability of vortex lines or vanishing local helicity. Here we propose a new paradigm of flow structure by introducing an intermediate class, termed epi-two-dimensional flow, and thereby build a topological bridge between 2D and 3D flows. The epi-2D property is local and is preserved in fluid elements obeying ideal (inviscid and barotropic) mechanics; a local epi-2D flow may be regarded as a "particle" carrying a generalized enstrophy as its charge. A finite viscosity may cause "fusion" of two epi-2D particles, generating helicity from their charges giving rise to 3D flow.
    Language English
    Publishing date 2017-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.119.244501
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  7. Article ; Online: How common is tuberous sclerosis complex?

    Morrison, P J / Donnelly, D E

    The British journal of dermatology

    2016  Volume 174, Issue 6, Page(s) 1184–1185

    MeSH term(s) Humans ; Tuberous Sclerosis
    Language English
    Publishing date 2016-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.14592
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  8. Article ; Online: Development and preliminary evaluation of the Neurofibromatosis Type 1 Adult Quality of Life (NF1-AdQoL) questionnaire.

    Crawford, H / North, K / Wilson, M J / Berman, Y / McKelvey-Martin, V / Morrison, P J / Fleming, J / Barton, B

    Clinical and experimental dermatology

    2021  Volume 47, Issue 2, Page(s) 271–281

    Abstract: Background: Neurofibromatosis Type 1 (NF1) is a variable and unpredictable multisystem genetic disorder that predisposes to medical complications, cognitive impairment and disfigurement, of all which can impact negatively upon the health-related quality ...

    Abstract Background: Neurofibromatosis Type 1 (NF1) is a variable and unpredictable multisystem genetic disorder that predisposes to medical complications, cognitive impairment and disfigurement, of all which can impact negatively upon the health-related quality of life (HRQoL) of affected adults.
    Aims: To develop and validate a disease-specific HRQoL adult questionnaire to evaluate effects of NF1 from the patient's viewpoint.
    Methods: The Neurofibromatosis Type 1 Adult Health-related Quality of Life questionnaire (NF1-AdQoL) was based on patient interviews (n = 8), clinician survey and questionnaire pilot study. Adults with NF1 (n = 114, aged 18-40 years) were recruited from three Australian genetics clinics and completed the NF1-AdQoL, the 29-item Skindex (Skindex-29) and the 36-item Short Form, version 2 (SF-36v2) questionnaires. An exploratory factor analysis of the NF1-AdQoL was conducted to assess construct validity. Convergent and discriminant validity of the NF1-AdQoL was determined by using multitrait multimethod analysis with Skindex-29 and SF-36v2 scores.
    Results: Factor analysis indicated that 62.7% of the common variance between the questionnaires could be explained by three factors: 'emotions associated with cosmetic appearance' (12 items), 'functioning - social and learning' (11 items) and 'physical symptoms' (8 items). NF1-AdQoL had good internal consistency (Cronbach α = 0.96). Convergent validity was confirmed by moderate associations with similarly named scales of the Skindex-29 and SF-36v2. Results from all three HRQoL questionnaires indicated overall healthy HRQoL for young to early middle-aged adults with NF1.
    Conclusion: The NF1-AdQoL is a relatively valid, feasible and fairly easy to read tool to measure the HRQoL of adults with NF1. Further evaluation is required to determine the test-retest reliability, responsiveness and validity of the NF1-AdQoL in larger adult NF1 cohorts.
    MeSH term(s) Adult ; Factor Analysis, Statistical ; Female ; Humans ; Interviews as Topic ; Male ; Neurofibromatosis 1 ; Pilot Projects ; Quality of Life ; Reproducibility of Results ; Surveys and Questionnaires
    Language English
    Publishing date 2021-10-12
    Publishing country England
    Document type Journal Article ; Validation Study
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1111/ced.14867
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    Zs.A 1278: Show issues Location:
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  9. Article: Variational necessary and sufficient stability conditions for inviscid shear flow.

    Hirota, M / Morrison, P J / Hattori, Y

    Proceedings. Mathematical, physical, and engineering sciences

    2014  Volume 470, Issue 2172, Page(s) 20140322

    Abstract: A necessary and sufficient condition for linear stability of inviscid parallel shear flow is formulated by developing a novel variational principle, where the velocity profile is assumed to be monotonic and analytic. It is shown that unstable eigenvalues ...

    Abstract A necessary and sufficient condition for linear stability of inviscid parallel shear flow is formulated by developing a novel variational principle, where the velocity profile is assumed to be monotonic and analytic. It is shown that unstable eigenvalues of Rayleigh's equation (which is a non-self-adjoint eigenvalue problem) can be associated with positive eigenvalues of a certain self-adjoint operator. The stability is therefore determined by maximizing a quadratic form, which is theoretically and numerically more tractable than directly solving Rayleigh's equation. This variational stability criterion is based on the understanding of Kreĭn signature for continuous spectra and is applicable to other stability problems of infinite-dimensional Hamiltonian systems.
    Language English
    Publishing date 2014-11-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 209241-4
    ISSN 1471-2946 ; 1364-5021 ; 0962-8444 ; 0080-4630 ; 0950-1207
    ISSN (online) 1471-2946
    ISSN 1364-5021 ; 0962-8444 ; 0080-4630 ; 0950-1207
    DOI 10.1098/rspa.2014.0322
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  10. Article: Insurance, genetic testing and familial cancer: recent policy changes in the United Kingdom.

    Morrison, P J

    The Ulster medical journal

    2001  Volume 70, Issue 2, Page(s) 79–88

    MeSH term(s) Genetic Privacy ; Genetic Testing/legislation & jurisprudence ; Health Policy ; Humans ; Insurance, Health/legislation & jurisprudence ; Neoplasms/genetics ; United Kingdom
    Language English
    Publishing date 2001-11
    Publishing country Northern Ireland
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 603342-8
    ISSN 2046-4207 ; 0041-6193
    ISSN (online) 2046-4207
    ISSN 0041-6193
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