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  1. AU="Morroni, Gianluca"
  2. AU="Choi, Kristal S."
  3. AU="Verma, Smita Rastogi" AU="Verma, Smita Rastogi"
  4. AU="Zhou, Bingfeng"
  5. AU="Kivala, Milan"
  6. AU="Salafia, O S"
  7. AU="Taghavi, Fouad J"
  8. AU="Xiao, Jun-Hua"
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  1. Article: Side effects of antibiotics and perturbations of mitochondria functions.

    D'Achille, Gloria / Morroni, Gianluca

    International review of cell and molecular biology

    2023  Volume 377, Page(s) 121–139

    Abstract: Antibiotics are one of the greatest discoveries of medicine of the past century. Despite their invaluable contribution to infectious disease, their administration could lead to side effects that in some cases are serious. The toxicity of some antibiotics ...

    Abstract Antibiotics are one of the greatest discoveries of medicine of the past century. Despite their invaluable contribution to infectious disease, their administration could lead to side effects that in some cases are serious. The toxicity of some antibiotics is in part due to their interaction with mitochondria: these organelles derive from a bacterial ancestor and possess specific translation machinery that shares similarities with the bacterial counterpart. In other cases, the antibiotics could interfere with mitochondrial functions even if their main bacterial targets are not shared with the eukaryotic cells. The purpose of this review is to summarize the effects of antibiotics administration on mitochondrial homeostasis and the opportunity that some of these molecules could represent in cancer treatment. The importance of antimicrobial therapy is unquestionable, but the identification of interaction with eukaryotic cells and in particular with mitochondria is crucial to reduce the toxicity of these drugs and to explore other useful medical applications.
    MeSH term(s) Anti-Bacterial Agents/adverse effects ; Mitochondria ; Bacteria
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-04-10
    Publishing country Netherlands
    Document type Review ; Journal Article
    ZDB-ID 2427220-6
    ISSN 1937-6448 ; 0074-7696
    ISSN 1937-6448 ; 0074-7696
    DOI 10.1016/bs.ircmb.2023.03.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.317: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Oxazolidinones: mechanisms of resistance and mobile genetic elements involved.

    Brenciani, Andrea / Morroni, Gianluca / Schwarz, Stefan / Giovanetti, Eleonora

    The Journal of antimicrobial chemotherapy

    2022  Volume 77, Issue 10, Page(s) 2596–2621

    Abstract: The oxazolidinones (linezolid and tedizolid) are last-resort antimicrobial agents used for the treatment of severe infections in humans caused by MDR Gram-positive bacteria. They bind to the peptidyl transferase centre of the bacterial ribosome ... ...

    Abstract The oxazolidinones (linezolid and tedizolid) are last-resort antimicrobial agents used for the treatment of severe infections in humans caused by MDR Gram-positive bacteria. They bind to the peptidyl transferase centre of the bacterial ribosome inhibiting protein synthesis. Even if the majority of Gram-positive bacteria remain susceptible to oxazolidinones, resistant isolates have been reported worldwide. Apart from mutations, affecting mostly the 23S rDNA genes and selected ribosomal proteins, acquisition of resistance genes (cfr and cfr-like, optrA and poxtA), often associated with mobile genetic elements [such as non-conjugative and conjugative plasmids, transposons, integrative and conjugative elements (ICEs), prophages and translocatable units], plays a critical role in oxazolidinone resistance. In this review, we briefly summarize the current knowledge on oxazolidinone resistance mechanisms and provide an overview on the diversity of the mobile genetic elements carrying oxazolidinone resistance genes in Gram-positive and Gram-negative bacteria.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/pharmacology ; DNA, Ribosomal ; Drug Resistance, Bacterial/genetics ; Gram-Negative Bacteria ; Gram-Positive Bacteria/genetics ; Gram-Positive Bacterial Infections/microbiology ; Interspersed Repetitive Sequences ; Linezolid ; Microbial Sensitivity Tests ; Oxazolidinones/pharmacology ; Peptidyl Transferases/genetics ; Ribosomal Proteins/genetics
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; DNA, Ribosomal ; Oxazolidinones ; Ribosomal Proteins ; Peptidyl Transferases (EC 2.3.2.12) ; Linezolid (ISQ9I6J12J)
    Language English
    Publishing date 2022-08-21
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkac263
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1197: Show issues Location:
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    Zs.MO 124: Show issues

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  3. Article: Control of host mitochondria by bacterial pathogens

    Marchi, Saverio / Morroni, Gianluca / Pinton, Paolo / Galluzzi, Lorenzo

    Trends in microbiology. 2021,

    2021  

    Abstract: Mitochondria control various processes that are integral to cellular and organismal homeostasis, including Ca²⁺ fluxes, bioenergetic metabolism, and cell death. Perhaps not surprisingly, multiple pathogenic bacteria have evolved strategies to subvert ... ...

    Abstract Mitochondria control various processes that are integral to cellular and organismal homeostasis, including Ca²⁺ fluxes, bioenergetic metabolism, and cell death. Perhaps not surprisingly, multiple pathogenic bacteria have evolved strategies to subvert mitochondrial functions in support of their survival and dissemination. Here, we discuss nonimmunological pathogenic mechanisms that converge on the ability of bacteria to control the mitochondrial compartment of host cells.
    Keywords calcium ; cell death ; homeostasis ; metabolism ; mitochondria
    Language English
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2021.09.010
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2005/714: Show issues

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  4. Article ; Online: Antifungal Combinations in Dermatophytes.

    Brescini, Lucia / Fioriti, Simona / Morroni, Gianluca / Barchiesi, Francesco

    Journal of fungi (Basel, Switzerland)

    2021  Volume 7, Issue 9

    Abstract: Dermatophytes are the most common cause of fungal infections worldwide, affecting millions of people annually. The emergence of resistance among dermatophytes along with the availability of antifungal susceptibility procedures suitable for testing ... ...

    Abstract Dermatophytes are the most common cause of fungal infections worldwide, affecting millions of people annually. The emergence of resistance among dermatophytes along with the availability of antifungal susceptibility procedures suitable for testing antifungal agents against this group of fungi make the combinatorial approach particularly interesting to be investigated. Therefore, we reviewed the scientific literature concerning the antifungal combinations against dermatophytes. A literature search on the subject performed in PubMed yielded 68 publications: 37 articles referring to in vitro studies and 31 articles referring to case reports or clinical studies. In vitro studies involved over 400 clinical isolates of dermatophytes (69%
    Language English
    Publishing date 2021-09-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof7090727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Control of host mitochondria by bacterial pathogens.

    Marchi, Saverio / Morroni, Gianluca / Pinton, Paolo / Galluzzi, Lorenzo

    Trends in microbiology

    2021  Volume 30, Issue 5, Page(s) 452–465

    Abstract: Mitochondria control various processes that are integral to cellular and organismal homeostasis, including ... ...

    Abstract Mitochondria control various processes that are integral to cellular and organismal homeostasis, including Ca
    MeSH term(s) Energy Metabolism ; Homeostasis ; Listeria monocytogenes ; Mitochondria
    Language English
    Publishing date 2021-10-13
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2021.09.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3738: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Detection of an

    Cinthi, Marzia / Coccitto, Sonia Nina / Morroni, Gianluca / D'Achille, Gloria / Brenciani, Andrea / Giovanetti, Eleonora

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 11

    Abstract: Oxazolidinones are valuable antimicrobials that are used to treat severe infections due to multidrug-resistant (MDR) Gram-positive bacteria. However, in recent years, a significant spread of clinically relevant linezolid-resistant human bacteria that is ... ...

    Abstract Oxazolidinones are valuable antimicrobials that are used to treat severe infections due to multidrug-resistant (MDR) Gram-positive bacteria. However, in recent years, a significant spread of clinically relevant linezolid-resistant human bacteria that is also present in animal and environmental settings has been detected and is a cause for concern. This study aimed to investigate the presence, genetic environments, and transferability of oxazolidinone resistance genes in enterococci from freshwater samples. A total of 10 samples were collected from a river in Central Italy. Florfenicol-resistant enterococci were screened for the presence of oxazolidinone resistance genes by PCR.
    Language English
    Publishing date 2022-11-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11111618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Antifungal Combinations against

    Fioriti, Simona / Brescini, Lucia / Pallotta, Francesco / Canovari, Benedetta / Morroni, Gianluca / Barchiesi, Francesco

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 10

    Abstract: Candida spp. is the major causative agent of fungal infections in hospitalized patients and the fourth most common cause of nosocomial bloodstream infection (BSI). The availability of standardized methods for testing the in vitro activity of antifungals ... ...

    Abstract Candida spp. is the major causative agent of fungal infections in hospitalized patients and the fourth most common cause of nosocomial bloodstream infection (BSI). The availability of standardized methods for testing the in vitro activity of antifungals along with the expanding of antifungal armamentarium, the rising of drug-resistance and the persistence of a high mortality rate in systemic candidiasis have led to an increased interest in combination therapy. Therefore, we aimed to review the scientific literature concerning the antifungal combinations against Candida. A literature search performed in PubMed yielded 92 studies published from 2000 to 2021: 29 articles referring to in vitro studies, six articles referring to either in vitro and in vivo (i.e., animal models) studies and 57 clinical articles. Pre-clinical studies involved 735 isolates of Candida species and 12 unique types of antifungal combination approaches including azoles plus echinocandins (19%), polyenes plus echinocandins (16%), polyenes plus azoles (13%), polyenes plus 5-flucytosine ([5-FC], 13%), azoles plus 5-FC (11%) and other types of combinations (28%). Results varied greatly, often being species-, drug- and methodology-dependent. Some combinatorial regimens exerted a synergistic effect against difficult-to-treat Candida species (i.e., azoles plus echinocandins; polyenes plus 5-FC) or they were more effective than monotherapy in prevent or reducing biofilm formation and in speeding the clearance of infected tissues (i.e., polyenes plus echinocandins). In 283 patients with documented Candida infections (>90% systemic candidiasis/BSI), an antifungal combination approach could be evaluated. Combinations included: azoles plus echinocandins (36%), 5-FC-combination therapies (24%), polyenes plus azoles (18%), polyenes plus echinocandins (16%) and other types of combination therapy (6%). Case reports describing combination therapies yielded favorable response in most cases, including difficult-to-treat fungal infections (i.e., endocarditis, osteoarticular infections, CNS infections) or difficult-to-treat fungal pathogens. The only randomized trial comparing amphotericin-B deoxycholate (AMB) plus FLU vs. AMB alone for treatment of BSI in nonneutropenic patients showed that the combination trended toward improved success and more-rapid clearance from the bloodstream. In summary, antifungal combinations against Candida have produced great interest in the past two decades. To establish whether this approach can become a reliable treatment option, additional in vitro and clinical data are warranted.
    Language English
    Publishing date 2022-10-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8101077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: New insight into old and new antimicrobial molecules targeting quorum sensing for MRSA wound infection.

    Simonetti, Oriana / Rizzetto, Giulio / Cirioni, Oscar / Molinelli, Elisa / Morroni, Gianluca / Giacometti, Andrea / Offidani, Annamaria

    Future microbiology

    2022  Volume 17, Page(s) 177–183

    Abstract: MRSA represents one of the largest problems in wound healing as a result of its increasing incidence and the complex therapeutic approach required to treat it. The need for new solutions to overcome antibiotic resistance led to the development of ... ...

    Abstract MRSA represents one of the largest problems in wound healing as a result of its increasing incidence and the complex therapeutic approach required to treat it. The need for new solutions to overcome antibiotic resistance led to the development of antimicrobial molecules that are effective at blocking quorum sensing. This special report provides an up-to-date review, based on the latest evidence in the literature, of old and new molecules that can positively influence the process of wound healing via their action on MRSA quorum sensing. Quorum sensing-inhibiting molecules, applied topically or injected
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/pharmacology ; Humans ; Methicillin-Resistant Staphylococcus aureus ; Quorum Sensing ; Wound Infection/drug therapy
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents
    Language English
    Publishing date 2022-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2254620-0
    ISSN 1746-0921 ; 1746-0913
    ISSN (online) 1746-0921
    ISSN 1746-0913
    DOI 10.2217/fmb-2021-0120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Genetic analysis of vancomycin-variable Enterococcus faecium clinical isolates in Italy.

    Coccitto, Sonia Nina / Cinthi, Marzia / Simoni, Serena / Pocognoli, Antonella / Zeni, Guido / Mazzariol, Annarita / Morroni, Gianluca / Mingoia, Marina / Giovanetti, Eleonora / Brenciani, Andrea / Vignaroli, Carla

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2024  Volume 43, Issue 4, Page(s) 673–682

    Abstract: Purpose: To investigate the occurrence of vancomycin-variable enterococci (VVE) in a hospital in central Italy.: Methods: vanA positive but vancomycin-susceptible Enterococcus faecium isolates (VVE-S) were characterized by antibiotic susceptibility ... ...

    Abstract Purpose: To investigate the occurrence of vancomycin-variable enterococci (VVE) in a hospital in central Italy.
    Methods: vanA positive but vancomycin-susceptible Enterococcus faecium isolates (VVE-S) were characterized by antibiotic susceptibility tests, molecular typing (PFGE and MLST), and WGS approach. The reversion of VVE-S to a resistant phenotype was assessed by exposure to increasing vancomycin concentrations, and the revertant isolates were used in filter mating experiments. qPCR was used to analyze the plasmid copy number.
    Results: Eleven putative VVE-S were selected. WGS revealed two categories of vanA cluster plasmid located: the first type showed the lack of vanR, the deletion of vanS, and an intact vanH/vanA/vanX cluster; the second type was devoid of both vanR and vanS and showed a deletion of 544-bp at the 5'-end of the vanH. Strains (n = 7) carrying the first type of vanA cluster were considered VVE-S and were able to regain a resistance phenotype (VVE-R) in the presence of vancomycin, due to a 44-bp deletion in the promoter region of vanH/vanA/vanX, causing its constitutive expression. VVE-R strains were not able to transfer resistance by conjugation, and the resistance phenotype was unstable: after 11 days of growth without selective pressure, the revertants were still resistant but showed a lower vancomycin MIC. A higher plasmid copy number in the revertant strains was probably related to the resistance phenotype.
    Conclusion: We highlight the importance of VVE transition to VRE under vancomycin therapy resulting in a potential failure treatment. We also report the first-time identification of VVE-S isolates pstS-null belonging to ST1478.
    MeSH term(s) Humans ; Vancomycin/pharmacology ; Vancomycin/therapeutic use ; Enterococcus faecium ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Multilocus Sequence Typing ; Vancomycin Resistance/genetics ; Microbial Sensitivity Tests ; Enterococcus ; Bacterial Proteins/genetics ; Gram-Positive Bacterial Infections/microbiology
    Chemical Substances Vancomycin (6Q205EH1VU) ; Anti-Bacterial Agents ; Bacterial Proteins
    Language English
    Publishing date 2024-01-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-024-04768-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1732: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article: Candidemia: Evolution of Drug Resistance and Novel Therapeutic Approaches.

    Tortorano, Anna Maria / Prigitano, Anna / Morroni, Gianluca / Brescini, Lucia / Barchiesi, Francesco

    Infection and drug resistance

    2021  Volume 14, Page(s) 5543–5553

    Abstract: Candidemia and invasive candidiasis are the most common healthcare-associated invasive fungal infections, with a crude mortality rate of 25-50%. ...

    Abstract Candidemia and invasive candidiasis are the most common healthcare-associated invasive fungal infections, with a crude mortality rate of 25-50%.
    Language English
    Publishing date 2021-12-19
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S274872
    Database MEDical Literature Analysis and Retrieval System OnLINE

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