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  1. Article ; Online: Chitosan coating silver nanoparticles as a promising feed additive in broilers chicken.

    Hassanen, Eman I / Hussien, Ahmed M / Mehanna, Sally / Morsy, Eman A

    BMC veterinary research

    2023  Volume 19, Issue 1, Page(s) 265

    Abstract: The present study aimed to evaluate the potential of chitosan coating silver nanoparticles to enhance the growth performance and immune status of broilers without inducing oxidative stress-related pathological lesions in any organs or leaving residues of ...

    Abstract The present study aimed to evaluate the potential of chitosan coating silver nanoparticles to enhance the growth performance and immune status of broilers without inducing oxidative stress-related pathological lesions in any organs or leaving residues of silver in the edible parts. Five clusters of Cobb one-day-old chicks (n = 10/group in each replication) were given oral therapy, once a week for 36 days as follows: (1) distilled water, (2, 3) 0.5- and 5 ppm silver nanoparticles (AgNPs), respectively, (4, 5) 0.5- and 5 ppm chitosan/silver nanoconjugates (CS/Ag-NCs), respectively. The results demonstrated a marked elevation in the body weight gain with a decline in the food conversion ratio and marked improvement in feeding and drinking behavior of all nanoparticles treated groups, but higher in CS/Ag-NCs groups than AgNPs groups and control group. In contrast to the 0.5 ppm AgNPs receiving group, the group receiving 5 ppm AgNPs noticed remarkable histological changes in some organs, including the liver, kidneys, spleen, and heart. Moreover, the administration of CS/Ag-NCs at two dosage levels didn't influence any histological changes. The AgNPs groups' antibody titers against the ND and AI viruses were almost identical to those of the control group. Otherwise, CS/Ag-NCs groups recorded the highest antibody titers. Additionally, there was a significant increase in silver content in most edible organs of AgNPs groups at a dosage level of 5 ppm. Otherwise, the coating of AgNPs by CSNPs could decrease the aggregation of silver in the biological organs. Thus, we recommend utilizing 0.5 ppm CS/Ag-NCs in broiler farms to promote their growth performance and strengthen their immune defense.
    MeSH term(s) Animals ; Silver/pharmacology ; Chickens ; Chitosan ; Metal Nanoparticles/therapeutic use ; Metal Nanoparticles/chemistry ; Oxidative Stress
    Chemical Substances Silver (3M4G523W1G) ; Chitosan (9012-76-4)
    Language English
    Publishing date 2023-12-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2191675-5
    ISSN 1746-6148 ; 1746-6148
    ISSN (online) 1746-6148
    ISSN 1746-6148
    DOI 10.1186/s12917-023-03826-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cytotoxicity and Genotoxicity of Copper oxide Nanoparticles in chickens.

    Morsy, Eman A / Hussien, Ahmed M / Ibrahim, Marwa A / Farroh, Khaled Y / Hassanen, Eman I

    Biological trace element research

    2021  Volume 199, Issue 12, Page(s) 4731–4745

    Abstract: Copper oxide nanoparticles (CuO-NPs) are consciously used to control the growth of bacteria, fungi, and algae. Several studies documented the beneficial and hazardous effects of CuO-NPs on human cells and different experimental animals but there are not ... ...

    Abstract Copper oxide nanoparticles (CuO-NPs) are consciously used to control the growth of bacteria, fungi, and algae. Several studies documented the beneficial and hazardous effects of CuO-NPs on human cells and different experimental animals but there are not many studies that report the effect of CuO-NPs in poultry. Therefore, the present study was performed to investigate the dose-dependent effects of copper oxide nanoparticles on the growth performance, immune status, oxidant/antioxidant capacity, DNA status, and histological structures of most edible parts of broiler chickens (muscle, heart, liver, spleen, and kidneys). The experiment was carried out on 90 1-day-old broiler chicks (Cobb 500) which were divided into three experimental groups (n = 30) in three replicates (n = 10). Group 1 was kept as a control group and did not receive copper oxide nanoparticles. Groups 2 and 3 received CuO-NPs by oral gavage at dose 5 mg/kg and 15 mg/kg bwt respectively at 1, 7, 14, 21, 28, and 35 days of the life of the chickens. An increase in the amount of feed intake and weight was recorded every week, and finally, the food conversion ratio (FCR) was calculated. Our results showed dose-dependent increases in malondialdehyde levels, copper contents, DNA fragmentation percent, and microscopic scoring in different examined organs of CuO-NPs-receiving groups associated with a remarkable reduction in weight gain, food conversion ratio, catalase activity, and antibody titer of both New Castle and Avian Influenza viruses. Histopathological alterations were observed in both groups receiving CuO-NPs with some variations in its severity. Our study concluded that CuO-NPs are considered cytotoxic and we recommend not adding them to poultry feed.
    MeSH term(s) Animals ; Chickens ; Copper/toxicity ; DNA Damage ; Humans ; Metal Nanoparticles/toxicity ; Nanoparticles/toxicity ; Oxides
    Chemical Substances Oxides ; Copper (789U1901C5)
    Language English
    Publishing date 2021-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 445336-0
    ISSN 1559-0720 ; 0163-4984
    ISSN (online) 1559-0720
    ISSN 0163-4984
    DOI 10.1007/s12011-021-02595-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2323: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Comparative assessment of the bactericidal effect of nanoparticles of copper oxide, silver, and chitosan-silver against Escherichia coli infection in broilers.

    Hassanen, Eman I / Morsy, Eman A / Hussien, Ahmed M / Farroh, Khaled Y / Ali, Merhan E

    Bioscience reports

    2021  Volume 41, Issue 4

    Abstract: Escherichia coli infection is considered one of the most economically important multi-systemic diseases in poultry farms. Several nanoparticles such as silver, chitosan, and copper oxide are known to be highly toxic to several microbes. However, there ... ...

    Abstract Escherichia coli infection is considered one of the most economically important multi-systemic diseases in poultry farms. Several nanoparticles such as silver, chitosan, and copper oxide are known to be highly toxic to several microbes. However, there are no data concerning their success against in vivo experimental E. coli infection in broilers. Therefore, the present study was designed to investigate the bactericidal effect of low doses of CuO-NPs (5 mg/kg bwt), Ag-NPs (0.5 mg/kg bwt), and Ch-Ag NPs (0.5 mg/kg bwt) against E. coli experimental infection in broilers. One hundred chicks were divided into five groups as follows: (1) control; (2) E. coli (4 × 108 CFU/ml) challenged; (3) E. coli +CuO-NPs; (4) E. coli +Ag-NPs; (5) E. coli +Ch-Ag NPs. The challenged untreated group, not NPs treated groups, recorded the lowest weight gain as well as the highest bacterial count and lesion score in all examined organs. The highest liver content of silver was observed in Ag-NPs treated group compared with the Ch-Ag NPs treated group. Our results concluded that Ch-Ag NPs not only had the best antibacterial effects but also acted as a growth promoter in broilers without leaving any residues in edible organs. We recommend using Ch-Ag NPs in broiler farms instead of antibiotics or probiotics.
    MeSH term(s) Animals ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/therapeutic use ; Chickens ; Chitosan/analogs & derivatives ; Copper/chemistry ; Escherichia coli Infections/drug therapy ; Escherichia coli Infections/veterinary ; Liver/metabolism ; Metal Nanoparticles/administration & dosage ; Metal Nanoparticles/chemistry ; Metal Nanoparticles/therapeutic use ; Poultry Diseases/drug therapy ; Silver/chemistry
    Chemical Substances Anti-Bacterial Agents ; Silver (3M4G523W1G) ; Copper (789U1901C5) ; Chitosan (9012-76-4)
    Language English
    Publishing date 2021-03-30
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 764946-0
    ISSN 1573-4935 ; 0144-8463
    ISSN (online) 1573-4935
    ISSN 0144-8463
    DOI 10.1042/BSR20204091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1676: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Cytotoxicity and Genotoxicity of Copper oxide Nanoparticles in chickens

    Morsy, Eman A. / Hussien, Ahmed M. / Ibrahim, Marwa A. / Farroh, Khaled Y. / Hassanen, Eman I.

    Biological trace element research. 2021 Dec., v. 199, no. 12

    2021  

    Abstract: Copper oxide nanoparticles (CuO-NPs) are consciously used to control the growth of bacteria, fungi, and algae. Several studies documented the beneficial and hazardous effects of CuO-NPs on human cells and different experimental animals but there are not ... ...

    Abstract Copper oxide nanoparticles (CuO-NPs) are consciously used to control the growth of bacteria, fungi, and algae. Several studies documented the beneficial and hazardous effects of CuO-NPs on human cells and different experimental animals but there are not many studies that report the effect of CuO-NPs in poultry. Therefore, the present study was performed to investigate the dose-dependent effects of copper oxide nanoparticles on the growth performance, immune status, oxidant/antioxidant capacity, DNA status, and histological structures of most edible parts of broiler chickens (muscle, heart, liver, spleen, and kidneys). The experiment was carried out on 90 1-day-old broiler chicks (Cobb 500) which were divided into three experimental groups (n = 30) in three replicates (n = 10). Group 1 was kept as a control group and did not receive copper oxide nanoparticles. Groups 2 and 3 received CuO-NPs by oral gavage at dose 5 mg/kg and 15 mg/kg bwt respectively at 1, 7, 14, 21, 28, and 35 days of the life of the chickens. An increase in the amount of feed intake and weight was recorded every week, and finally, the food conversion ratio (FCR) was calculated. Our results showed dose-dependent increases in malondialdehyde levels, copper contents, DNA fragmentation percent, and microscopic scoring in different examined organs of CuO-NPs-receiving groups associated with a remarkable reduction in weight gain, food conversion ratio, catalase activity, and antibody titer of both New Castle and Avian Influenza viruses. Histopathological alterations were observed in both groups receiving CuO-NPs with some variations in its severity. Our study concluded that CuO-NPs are considered cytotoxic and we recommend not adding them to poultry feed.
    Keywords DNA ; DNA fragmentation ; antibodies ; antioxidant activity ; avian influenza ; catalase ; cupric oxide ; cytotoxicity ; dose response ; feed intake ; food conversion ; genotoxicity ; growth performance ; heart ; histology ; histopathology ; humans ; liver ; malondialdehyde ; muscles ; oxidants ; poultry feed ; research ; spleen ; weight gain
    Language English
    Dates of publication 2021-12
    Size p. 4731-4745.
    Publishing place Springer US
    Document type Article
    ZDB-ID 445336-0
    ISSN 1559-0720 ; 0163-4984
    ISSN (online) 1559-0720
    ISSN 0163-4984
    DOI 10.1007/s12011-021-02595-4
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2323: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: The effect of different concentrations of gold nanoparticles on growth performance, toxicopathological and immunological parameters of broiler chickens.

    Hassanen, Eman I / Morsy, Eman A / Hussien, Ahmed M / Ibrahim, Marwa A / Farroh, Khaled Y

    Bioscience reports

    2020  Volume 40, Issue 3

    Abstract: The present study aimed to evaluate what dosage of gold nanoparticles (GNPs) would improve growth performance, antioxidant levels and immune defense in broiler chickens. The experiment was carried out on 90 one-day-old mixbred Cobb chicks. The birds were ...

    Abstract The present study aimed to evaluate what dosage of gold nanoparticles (GNPs) would improve growth performance, antioxidant levels and immune defense in broiler chickens. The experiment was carried out on 90 one-day-old mixbred Cobb chicks. The birds were allocated into three groups with three replicates. Group (1) kept as a negative control. Groups (2) and (3) received 5, 15 ppm GNPs via drinking water weekly for 35 days of chicks' life. Blood samples were collected at 8, 15, 22 and 36 days for oxidative stress evaluations and immunological studies. The birds were slaughtered at the ages of 36 days and thymus, spleen, busa of Fabricius and liver were collected for histopathological description, RT-PCR analysis and DNA fragmentation assay. Our results confirmed that adding of 15ppm GNPs in drinking water were induced remarkable blood oxidative stress damage, histopathological alterations, up-regulation of IL-6, Nrf2 gene expression, and DNA fragmentation in the examined immune organs of the broiler chickens as well as a significant reduction in the antibody titer against Newcastle (ND) and avian influenza (AI) viruses were noticed. On the other hand, the group received 5 ppm GNPs noticed better growth performance with the enhancement of the final food conversion ratio (FCR) without any significant difference in the previous toxicological and immunological parameters compared with the control groups. We suggest that feeding of 5ppm GNPs could improve the antioxidant capacity, immunity and performance in poultry but further food quality assurance tests are required in the future to confirm its safety for people.
    MeSH term(s) Animal Feed/analysis ; Animals ; Chickens/growth & development ; Chickens/immunology ; Diet/methods ; Female ; Gold/chemistry ; Male ; Metal Nanoparticles/chemistry ; Metal Nanoparticles/therapeutic use ; Weight Gain/drug effects
    Chemical Substances Gold (7440-57-5)
    Language English
    Publishing date 2020-03-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 764946-0
    ISSN 1573-4935 ; 0144-8463
    ISSN (online) 1573-4935
    ISSN 0144-8463
    DOI 10.1042/BSR20194296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1676: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Ecoepidemiology and Potential Transmission of

    Ismail, Eman M / Kadry, Mona / Elshafiee, Esraa A / Ragab, Eman / Morsy, Eman A / Rizk, Omar / Zaki, Manal M

    Pathogens (Basel, Switzerland)

    2021  Volume 10, Issue 2

    Abstract: Cholera is a negative public health event caused ... ...

    Abstract Cholera is a negative public health event caused by
    Language English
    Publishing date 2021-02-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens10020190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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