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  1. Article ; Online: Role of elderberry (Sambucus nigra) on the modulation of stress and immune response of Nile tilapia, Oreochromis niloticus

    Khan, Mursalin / Mortuza, Asif / Blumenthal, Elliott / Mustafa, Ahmed

    Journal of Applied Aquaculture. 2023 July 03, v. 35, no. 3 p.765-787

    2023  

    Abstract: We assessed the role of elderberry extract as a nutraceutical in Nile tilapia to modulate their stress and immune responses under density stress. In the experiment, we maintained tilapia at low (5 g/L) and high population density (120 g/L). We fed half ... ...

    Abstract We assessed the role of elderberry extract as a nutraceutical in Nile tilapia to modulate their stress and immune responses under density stress. In the experiment, we maintained tilapia at low (5 g/L) and high population density (120 g/L). We fed half of the low and high-density fish with commercial feed, and the other half, with membrane-separated 13% anthocyanin standardized elderberry extract with maltodextrin excipient, incorporated into commercial feed. We assessed plasma cortisol, blood glucose, IL-2, lysozyme activity, and spleen cell numbers for acute and chronic stress. Among them, blood glucose levels indicated the stress-modulating capability of elderberry in both acute and chronic stress conditions. Plasma cortisol concentrations also demonstrated the potential of elderberry as a stress-modulating agent in chronic stress. Based on our findings, elderberry could potentially be used as a nutraceutical to modulate stress and immune response in vertebrates.
    Keywords Oreochromis niloticus ; Sambucus nigra ; anthocyanins ; aquaculture ; blood glucose ; cortisol ; dietary supplements ; elderberries ; fish ; immune response ; interleukin-2 ; lysozyme ; maltodextrins ; population density ; spleen ; Nile tilapia ; nutrition ; stress physiology ; immune function
    Language English
    Dates of publication 2023-0703
    Size p. 765-787.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 1089577-2
    ISSN 1545-0805 ; 1045-4438
    ISSN (online) 1545-0805
    ISSN 1045-4438
    DOI 10.1080/10454438.2022.2026269
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 5584: Show issues

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  2. Article ; Online: Effects of CBD (Cannabidiol) on the physiology of Nile tilapia (Oreochromisn niloticus) as a chronic stress mitigating agent In-vivo.

    Mortuza, Asif / Fahim, Nahian / Ahmed, Malaika / Mustafa, Ahmed

    PloS one

    2023  Volume 18, Issue 9, Page(s) e0290835

    Abstract: This study evaluates the effects of Cannabidiol (CBD) on the physiology of stressed and non-stressed Nile tilapia, reared in a recirculating aquaculture system. Tilapia were fed with and without CBD (0.001% of feed weight) and with and without ... ...

    Abstract This study evaluates the effects of Cannabidiol (CBD) on the physiology of stressed and non-stressed Nile tilapia, reared in a recirculating aquaculture system. Tilapia were fed with and without CBD (0.001% of feed weight) and with and without hydrocortisone stress hormone (0.01% of body weight) every day for four weeks. This experiment compared the plasma cortisol, blood glucose and protein levels, liver and spleen somatic indices (HSI and SSI, respectively), and lysozyme activity of the fish. Stress group (S) had a significantly higher value than the control group (C) in two of the parameters, glucose and lysozyme activity, this is an indication of stress. CBD had a stress reducing effect under stressed conditions in lysozyme activity. Although not significant, the stress reducing effect of CBD on stress biomarkers such as glucose and HSI also seemed promising. Further investigation into the matter may not just be useful in stress mediation in aquatic organisms but may also have implications in human medicine as well.
    MeSH term(s) Animals ; Humans ; Cichlids ; Cannabidiol/pharmacology ; Muramidase ; Tilapia ; Glucose
    Chemical Substances Cannabidiol (19GBJ60SN5) ; Muramidase (EC 3.2.1.17) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0290835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Role of elderberry (Sambucus nigra) on the modulation of stress and immune response of Nile tilapia, Oreochromis niloticus

    Khan, Mursalin / Mortuza, Asif / Blumenthal, Elliott / Mustafa, Ahmed

    Journal of applied aquaculture

    2023  Volume 35, Issue 3, Page(s) 765

    Language English
    Document type Article
    ZDB-ID 1089577-2
    ISSN 1045-4438
    Database Current Contents Nutrition, Environment, Agriculture

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  4. Article: Effects of CBD (Cannabidiol) on the haematological parameters of Nile tilapia (Oreochromis niloticus, Linnaeus) under acute stress in vivo

    Mortuza, Asif / Mason, Lindee / Mustafa, Ahmed

    Aquaculture research. 2021 Nov., v. 52, no. 11

    2021  

    Abstract: This study evaluates the effects of Cannabidiol (CBD) on the haematological parameters of acutely stressed and non‐stressed Nile tilapia (Oreochromis niloticus, Linnaeus), reared in a recirculating aquaculture system. O. niloticus were fed with and ... ...

    Abstract This study evaluates the effects of Cannabidiol (CBD) on the haematological parameters of acutely stressed and non‐stressed Nile tilapia (Oreochromis niloticus, Linnaeus), reared in a recirculating aquaculture system. O. niloticus were fed with and without CBD (0, 0.001, 0.002 and 0.003% of feed weight) and with and without hydrocortisone (0 or 0.01% of body weight) for 72 hours. This experiment compared blood glucose, haematocrit and protein levels of the plasma of the fish. Among the non‐stressed groups, fish fed with the highest concentration of CBD showed to have less stress in terms of the stress parameters, while the highest stress was detected in the stressed group supplemented with no CBD. No significant difference in stress was observed between the different concentrations of CBD supplementation of fish in a 72‐hour period.
    Keywords Oreochromis niloticus ; blood glucose ; body weight ; cannabidiol ; cortisol ; fish ; hematocrit ; research
    Language English
    Dates of publication 2021-11
    Size p. 5375-5382.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 1227359-4
    ISSN 1355-557X
    ISSN 1355-557X
    DOI 10.1111/are.15407
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    Z 4230: Show issues

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  5. Article ; Online: Effects of cannabidiol (CBD) on the inhibition of melanoma cells

    Burch, Rosemary / Mortuza, Asif / Blumenthal, Elliott / Mustafa, Ahmed

    Journal of immunoassay & immunochemistry

    2021  Volume 42, Issue 3, Page(s) 285–291

    Abstract: Cannabidiol (CBD) is one of the most popular emerging plant extracts that is being investigated for its wide range of potential health benefits. This experiment tests how B16 mice melanoma cells, are affected by four different concentrations (0.2 mg/mL, ... ...

    Abstract Cannabidiol (CBD) is one of the most popular emerging plant extracts that is being investigated for its wide range of potential health benefits. This experiment tests how B16 mice melanoma cells, are affected by four different concentrations (0.2 mg/mL, 0.04 mg/mL, 0.008 mg/mL and 0.0016 mg/mL) of 99% CBD oil. The results of this experiment demonstrate that CBD significantly inhibited melanoma cell growth
    MeSH term(s) Animals ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Cannabidiol/chemistry ; Cannabidiol/pharmacology ; Cannabis/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Melanoma/drug therapy ; Melanoma/pathology ; Mice ; Plant Extracts/chemistry ; Plant Extracts/pharmacology
    Chemical Substances Antineoplastic Agents, Phytogenic ; Plant Extracts ; Cannabidiol (19GBJ60SN5)
    Language English
    Publishing date 2021-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050610-7
    ISSN 1532-4230 ; 1532-1819
    ISSN (online) 1532-4230
    ISSN 1532-1819
    DOI 10.1080/15321819.2020.1862863
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1606: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Stimulatory effect of Holy basil and Thai basil on mouse spleen cell proliferation.

    Biswas, Aparna / Mason, Lindee / Mortuza, Asif / Blumenthal, Elliott / Mustafa, Ahmed

    Journal of immunoassay & immunochemistry

    2020  Volume 42, Issue 3, Page(s) 292–299

    Abstract: Study was conducted on mouse spleen cells, cultured and ... ...

    Abstract Study was conducted on mouse spleen cells, cultured and incubated
    MeSH term(s) Animals ; B-Lymphocytes/drug effects ; B-Lymphocytes/immunology ; Cell Proliferation/drug effects ; Cells, Cultured ; Concanavalin A/pharmacology ; Macrophages/drug effects ; Macrophages/immunology ; Mice ; Mice, Inbred BALB C ; Ocimum/chemistry ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Spleen/drug effects ; Spleen/immunology ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; Thailand
    Chemical Substances Plant Extracts ; Concanavalin A (11028-71-0)
    Language English
    Publishing date 2020-12-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050610-7
    ISSN 1532-4230 ; 1532-1819
    ISSN (online) 1532-4230
    ISSN 1532-1819
    DOI 10.1080/15321819.2020.1862864
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1606: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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