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  1. Article: Is hepatitis C virus a risk factor for thyroid autoimmunity?

    Floreani, A / Betterle, C / Carderi, I / Presotto, F / Pedini, B / Moscon, A / Andrea, O / Chiaramonte, M

    Journal of viral hepatitis

    2006  Volume 13, Issue 4, Page(s) 272–277

    Abstract: The role of hepatitis C virus (HCV) in inducing thyroid autoimmunity is still under discussion and to assess the prevalence of thyroid autoantibodies and thyroid disease in the general population and to analyse the role of HCV in inducing thyroid ... ...

    Abstract The role of hepatitis C virus (HCV) in inducing thyroid autoimmunity is still under discussion and to assess the prevalence of thyroid autoantibodies and thyroid disease in the general population and to analyse the role of HCV in inducing thyroid autoimmunity. We studied 697 subjects residing in Arsita (a small town in central Italy). Thyroid autoantibodies and nonorgan-specific autoantibodies (NOSAs) were tested in each subject, who were also screened for anti-HCV antibodies; all subjects found positive to HCV-RNA were considered as being HCV-infected. Thyroid function tests were performed in all subjects positive for thyroid autoantibody. Seventy-one subjects were found HCV-positive; four of these (5.6%) were positive for at least one thyroid autoantibody, as opposed to 7 (4.9%) of the 142 sex- and age-matched controls of the same population (P = n.s.). Thyroid dysfunction was found in 2/4 HCV-positive, and in 1/7 HCV-negative subjects with thyroid autoantibodies (P = n.s.). NOSAs were significantly more common in HCV-positive than in HCV-negative subjects (P < 0.0001). Hence HCV per se is not responsible for thyroid autoimmune dysfunction, whereas HCV does seem to induce NOSAs. It should be taken into account, however, that the phenotypic expression of autoimmune diseases is obviously influenced by a number of risk factors, including genetic predisposition, female sex and infectious agents, that could trigger the onset of the disease.
    MeSH term(s) Adult ; Age Factors ; Autoantibodies/blood ; Female ; Hepacivirus/immunology ; Hepatitis C Antibodies/blood ; Hepatitis C, Chronic/epidemiology ; Hepatitis C, Chronic/immunology ; Hepatitis C, Chronic/virology ; Humans ; Italy/epidemiology ; Male ; Middle Aged ; Risk Factors ; Seroepidemiologic Studies ; Sex Factors ; Statistics, Nonparametric ; Thyroid Diseases/epidemiology ; Thyroid Diseases/immunology ; Thyroid Diseases/virology
    Chemical Substances Autoantibodies ; Hepatitis C Antibodies ; thyroid microsomal antibodies
    Language English
    Publishing date 2006-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212497-7
    ISSN 1365-2893 ; 1352-0504
    ISSN (online) 1365-2893
    ISSN 1352-0504
    DOI 10.1111/j.1365-2893.2005.00699.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4119: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Pancreatic autoantibodies in Italian patients with newly diagnosed type 1 diabetes mellitus over the age of 20 years.

    Betterle, C / Lazzarotto, F / Fusari, A / Zanchetta, R / Benedini, S / Pedini, B / Moscon, A / Presotto, F

    Acta diabetologica

    2006  Volume 43, Issue 3, Page(s) 79–83

    Abstract: The aim was to estimate the prevalence of the serological markers of pancreatic autoimmunity in a cohort of Italian patients with type 1 diabetes mellitus occurring after 20 years of age in order to determine the prevalence of autoimmune diabetes and the ...

    Abstract The aim was to estimate the prevalence of the serological markers of pancreatic autoimmunity in a cohort of Italian patients with type 1 diabetes mellitus occurring after 20 years of age in order to determine the prevalence of autoimmune diabetes and the most sensitive autoantibody combination to be employed for the diagnosis. We investigated 57 patients (31 males and 26 females) at clinical diagnosis of type 1 diabetes. 35 patients were 21-40 years and 22 were 41-72 years of age. Autoantibodies to islet-cells (ICA) were detected by indirect immunofluorescence, while those against glutamic acid decarboxylase (GADA), tyrosine-phosphatase (IA2A) and insulin (IAA) were detected by radiobinding assays. A positive test for at least one of the pancreatic autoantibodies was found in 45 of the 57 patients (78.9%). Coupling two antibody tests, GADA and/or IAA were found in 73.7%, ICA and/or GADA in 71.9%, while GADA and/or IA2A were found in 70.2% of the patients. The most frequently positive test was for GADA (66.7%). In general, the frequency of diabetes-related antibodies was higher in the 21-40-year-old group compared to the 41-72-year-old group and in females than males. Based on the detection of pancreatic autoantibodies determination, the great majority of the adult patients with recent onset type 1 diabetes were found to be autoimmune in nature. The best cost/benefit combination is provided by coupling the detection of GADA and ICA.
    MeSH term(s) Adult ; Aged ; Autoantibodies/blood ; Autoimmunity ; Diabetes Mellitus, Type 1/immunology ; Female ; Glutamate Decarboxylase/immunology ; Humans ; Insulin Antibodies/blood ; Islets of Langerhans/enzymology ; Islets of Langerhans/immunology ; Italy ; Male ; Middle Aged ; Pancreas/immunology ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Protein Tyrosine Phosphatases/immunology
    Chemical Substances Autoantibodies ; Insulin Antibodies ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 (EC 3.1.3.48) ; Protein Tyrosine Phosphatases (EC 3.1.3.48) ; Glutamate Decarboxylase (EC 4.1.1.15)
    Language English
    Publishing date 2006-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1097676-0
    ISSN 1432-5233 ; 0940-5429
    ISSN (online) 1432-5233
    ISSN 0940-5429
    DOI 10.1007/s00592-006-0217-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 611: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Inactivation of the p16 tumor suppressor gene in adrenocortical tumors.

    Pilon, C / Pistorello, M / Moscon, A / Altavilla, G / Pagotto, U / Boscaro, M / Fallo, F

    The Journal of clinical endocrinology and metabolism

    1999  Volume 84, Issue 8, Page(s) 2776–2779

    Abstract: The mechanisms of adrenocortical tumorigenesis are still unknown. Evidence that the majority of adrenocortical tumors are monoclonal in origin suggests that a progressive accumulation of genetic aberrations, due to activation of protooncogenes and/or ... ...

    Abstract The mechanisms of adrenocortical tumorigenesis are still unknown. Evidence that the majority of adrenocortical tumors are monoclonal in origin suggests that a progressive accumulation of genetic aberrations, due to activation of protooncogenes and/or inactivation of tumor suppressor genes, leads to abnormal cell proliferation through a multistep process. Inactivation of the p16 tumor suppressor gene (p16INK4A), which encodes the cell cycle protein p16, was investigated in a series of 14 adrenocortical tumors. Using 11 polymorphic microsatellite markers spanning the short arm of chromosome 9, we demonstrated that three of seven adrenocortical carcinomas and one of seven adrenocortical adenomas had loss of heterozygosity (LOH) within chromosome 9p21, the region containing p16NK4A. Immunohistochemistry showed the absence of p16 nuclear staining in all adrenocortical tumors with LOH within 9p21, and positive staining in all remaining tumors without LOH. In conclusion, LOH within 9p21 associated with lack of p16 expression occurs in a considerable proportion of adrenocortical malignant tumors, but is rare in adenomas. Inactivation of p16INK4A may contribute to the deregulation of cell proliferation in this neoplastic disease.
    MeSH term(s) Adrenal Cortex Neoplasms/genetics ; Adult ; Aged ; Carrier Proteins/genetics ; Cell Cycle Proteins ; Chromosomes, Human, Pair 9 ; Cyclin-Dependent Kinase Inhibitor p15 ; Cyclin-Dependent Kinase Inhibitor p16 ; Female ; Genes, p16 ; Humans ; Immunohistochemistry ; Loss of Heterozygosity ; Male ; Middle Aged ; Tumor Suppressor Proteins
    Chemical Substances CDKN2B protein, human ; Carrier Proteins ; Cell Cycle Proteins ; Cyclin-Dependent Kinase Inhibitor p15 ; Cyclin-Dependent Kinase Inhibitor p16 ; Tumor Suppressor Proteins
    Language English
    Publishing date 1999-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/jcem.84.8.5877
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.134: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Autoantibodies to steroidogenic enzymes in patients with premature ovarian failure with and without Addison's disease.

    Dal Pra, C / Chen, S / Furmaniak, J / Smith, B Rees / Pedini, B / Moscon, A / Zanchetta, R / Betterle, C

    European journal of endocrinology

    2003  Volume 148, Issue 5, Page(s) 565–570

    Abstract: Design: Adrenal cortex autoantibodies (ACA), steroid-producing cell autoantibodies (StCA) and autoantibodies (Abs) to steroidogenic enzymes in three groups of patients with premature ovarian failure (POF), 15 with autoimmune Addison's disease (AD), 26 ... ...

    Abstract Design: Adrenal cortex autoantibodies (ACA), steroid-producing cell autoantibodies (StCA) and autoantibodies (Abs) to steroidogenic enzymes in three groups of patients with premature ovarian failure (POF), 15 with autoimmune Addison's disease (AD), 26 with non-adrenal autoimmune diseases and 31 with isolated POF, have been assessed.
    Methods: ACA and StCA were measured using an immunofluorescence technique. Abs to 21-hydroxylase (21-OH), to 17alpha-hydroxylase (17alpha-OH) and to cytochrome P450 side-chain cleavage (P450scc) were measured using an immunoprecipitation assay.
    Results: Seventy-three percent of patients with POF and AD were positive for StCA, 93% for 17alpha-OH and/or P450scc Abs, 93% for ACA and 100% for 21-OH Abs. Among patients with POF and non-adrenal autoimmune diseases, 8% were positive for StCA, 12% for 17alpha-OH and/or P450scc Abs, and 8% and 12% for ACA and 21-OH Abs respectively. StCA, 17alpha-OH and/or P450scc Abs were all found in 10% of patients with isolated POF, and 13% had ACA and 21-OH Abs. All StCA-, 17alpha-OH- and/or P450scc Abs-positive patients were also positive for ACA and 21-OH Abs. Two patients with isolated POF who were ACA and 21-OH Ab positive developed AD 3 and 5 Years after the onset of POF.
    Conclusion: This study has shown that, when POF is associated with AD, StCA, 17alpha-OH and/or P450scc Abs are present in the majority of patients, while in the other two groups these Abs are detectable in a much lower proportion of patients. Measurement of ACA/21-OH Abs in some patients with POF may be important in identifying patients at risk of developing overt AD.
    MeSH term(s) Addison Disease/complications ; Addison Disease/immunology ; Adrenal Cortex/immunology ; Adult ; Autoantibodies/analysis ; Autoimmune Diseases/immunology ; Cholesterol Side-Chain Cleavage Enzyme/immunology ; Enzymes/immunology ; Enzymes/metabolism ; Female ; Humans ; Primary Ovarian Insufficiency/complications ; Primary Ovarian Insufficiency/immunology ; Steroid 17-alpha-Hydroxylase/immunology ; Steroids/biosynthesis
    Chemical Substances Autoantibodies ; Enzymes ; Steroids ; Steroid 17-alpha-Hydroxylase (EC 1.14.14.19) ; Cholesterol Side-Chain Cleavage Enzyme (EC 1.14.15.6)
    Language English
    Publishing date 2003-04-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1183856-5
    ISSN 1479-683X ; 0804-4643
    ISSN (online) 1479-683X
    ISSN 0804-4643
    DOI 10.1530/eje.0.1480565
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.147: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Celiac disease and type 1 diabetes.

    Lazzarotto, Francesca / Basso, Daniela / Plebani, Mario / Moscon, Alessandro / Zanchetta, Renato / Betterle, Corrado

    Diabetes care

    2002  Volume 26, Issue 1, Page(s) 248–249

    MeSH term(s) Adult ; Aged ; Celiac Disease/complications ; Celiac Disease/epidemiology ; Celiac Disease/therapy ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/epidemiology ; Diabetes Mellitus, Type 1/therapy ; Female ; Humans ; Male ; Middle Aged ; Prevalence
    Language English
    Publishing date 2002-12-13
    Publishing country United States
    Document type Letter
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/diacare.26.1.248
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1434: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 365: Show issues

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