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  1. Article ; Online: Patient-therapist congruence and incongruence of process expectations during psychotherapy.

    Tzur Bitan, Dana / Ben David, Tzviel / Moshe-Cohen, Rotem / Kivity, Yogev

    Psychotherapy (Chicago, Ill.)

    2021  Volume 58, Issue 4, Page(s) 493–498

    Abstract: Recent studies suggest that patient-therapist congruence of expectations affects psychotherapy outcome. Nonetheless, most studies assessing expectations in their dyadic context have focused on outcome expectations. This study was aimed to assess whether ... ...

    Abstract Recent studies suggest that patient-therapist congruence of expectations affects psychotherapy outcome. Nonetheless, most studies assessing expectations in their dyadic context have focused on outcome expectations. This study was aimed to assess whether patients and therapists view expected processes similarly, and whether these beliefs change over time to become more congruent or more dissimilar. Patients (N = 75) were assessed for process expectations at baseline and at 3 months into treatment, and their therapists (N = 17) reported on their general expectations only once, prior to the initiation of treatment. Multilevel models were fitted to assess differences between patients' and therapists' process expectations at baseline and after 3 months and changes in level of congruence. The results indicated that at baseline, therapists perceived the processing of therapist-patient relations as the expected therapeutic process, whereas patients viewed the provision of tools of cognitive control as such. No significant changes in patients' expectations after 3 months of treatment were detected; however, therapists' higher expectations of the provision of tools for cognitive control predicted increases in patients' rankings of this process. These results suggest that patients and therapists are incongruent in their views of the expected therapeutic process, and that therapists' initial views of the therapeutic process affect patients' beliefs. These findings highlight the importance of investigating process expectations in the dyadic context and set the stage for subsequent process-outcome demonstrations, focusing on the effect of patient-therapist congruence of process expectations as a potential predictor or mediator of psychotherapy outcomes. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
    MeSH term(s) Humans ; Motivation ; Professional-Patient Relations ; Psychotherapy ; Treatment Outcome
    Language English
    Publishing date 2021-12-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 281564-3
    ISSN 1939-1536 ; 0033-3204
    ISSN (online) 1939-1536
    ISSN 0033-3204
    DOI 10.1037/pst0000410
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Agreement in patient-therapist alliance ratings and its relation to dropout and outcome in a large sample of cognitive behavioral therapy for panic disorder.

    Moshe-Cohen, Rotem / Kivity, Yogev / Huppert, Jonathan D / Barlow, David H / Gorman, Jack M / Shear, Katherine / Woods, Scott W

    Psychotherapy research : journal of the Society for Psychotherapy Research

    2022  Volume 34, Issue 1, Page(s) 28–40

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Humans ; Panic Disorder/therapy ; Therapeutic Alliance ; Professional-Patient Relations ; Cognitive Behavioral Therapy ; Treatment Outcome
    Language English
    Publishing date 2022-09-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1080323-3
    ISSN 1468-4381 ; 1050-3307
    ISSN (online) 1468-4381
    ISSN 1050-3307
    DOI 10.1080/10503307.2022.2124131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Dunaliella salina Extract Counteracts Skin Aging under Intense Solar Irradiation Thanks to Its Antiglycation and Anti-Inflammatory Properties

    Fabien Havas / Shlomo Krispin / Moshe Cohen / Estelle Loing / Morgane Farge / Thierry Suere / Joan Attia-Vigneau

    Marine Drugs, Vol 20, Iss 104, p

    2022  Volume 104

    Abstract: Glycation, and the resulting buildup of advanced glycation end products (AGEs), is recognized as a key driver of cumulative skin damage and skin aging. Dunaliella salina is a halophile microalga adapted to intense solar radiation through the production ... ...

    Abstract Glycation, and the resulting buildup of advanced glycation end products (AGEs), is recognized as a key driver of cumulative skin damage and skin aging. Dunaliella salina is a halophile microalga adapted to intense solar radiation through the production of carotenoids. We present a natural supercritical CO 2 extract of Dunaliella salina rich in the colorless carotenoids phytoene and phytofluene. The extract exhibited antiglycation and anti-inflammatory activities in ex vivo testing, showing strongly reduced formation of N-ε-carboxy-methyl-lysine with exposure to methylglyoxal, reduced AGE receptor levels, and significantly reduced interleukins 6 and 8. In a placebo-controlled clinical study under intense solar exposure, the extract significantly reduced the skin’s glycation scores and its sensitivity to histamine; key skin aging parameters were also significantly improved vs. placebo, including wrinkle counts and spots. These results demonstrate the value of this Dunaliella salina extract, rich in colorless carotenoids, as an antiglycative, anti-inflammatory, and antiaging active ingredient, including in high-irradiation contexts.
    Keywords algae ; skin aging ; glycation ; inflammation ; antiaging ; sun care ; Biology (General) ; QH301-705.5
    Subject code 571
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: OMN6 a novel bioengineered peptide for the treatment of multidrug resistant Gram negative bacteria

    Shira Mandel / Janna Michaeli / Noa Nur / Isabelle Erbetti / Jonathan Zazoun / Livia Ferrari / Antonio Felici / Moshe Cohen-Kutner / Niv Bachnoff

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 12

    Abstract: Abstract New antimicrobial agents are urgently needed, especially to eliminate multidrug resistant Gram-negative bacteria that stand for most antibiotic-resistant threats. In the following study, we present superior properties of an engineered ... ...

    Abstract Abstract New antimicrobial agents are urgently needed, especially to eliminate multidrug resistant Gram-negative bacteria that stand for most antibiotic-resistant threats. In the following study, we present superior properties of an engineered antimicrobial peptide, OMN6, a 40-amino acid cyclic peptide based on Cecropin A, that presents high efficacy against Gram-negative bacteria with a bactericidal mechanism of action. The target of OMN6 is assumed to be the bacterial membrane in contrast to small molecule-based agents which bind to a specific enzyme or bacterial site. Moreover, OMN6 mechanism of action is effective on Acinetobacter baumannii laboratory strains and clinical isolates, regardless of the bacteria genotype or resistance-phenotype, thus, is by orders-of-magnitude, less likely for mutation-driven development of resistance, recrudescence, or tolerance. OMN6 displays an increase in stability and a significant decrease in proteolytic degradation with full safety margin on erythrocytes and HEK293T cells. Taken together, these results strongly suggest that OMN6 is an efficient, stable, and non-toxic novel antimicrobial agent with the potential to become a therapy for humans.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The Involvement of Ser1898 of the Human L-Type Calcium Channel in Evoked Secretion

    Daphne Atlas / Moshe Cohen-Kutner / Niv Bachnoff

    International Journal of Endocrinology, Vol

    2011  Volume 2011

    Keywords Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2011-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells

    Yoav Elkis / Moshe Cohen / Etai Yaffe / Shirly Satmary-Tusk / Tal Feldman / Elad Hikri / Abraham Nyska / Ariel Feiglin / Yanay Ofran / Sally Shpungin / Uri Nir

    Nature Communications, Vol 8, Iss 1, Pp 1-

    2017  Volume 17

    Abstract: The tyrosine-kinases Fer/FerT associate with the mitochondrial electron transport chain in cancer cells supporting their metabolic reprogramming. Here the authors discover a compound that disrupts Fer /FerT activity and selectively induces cell death of ... ...

    Abstract The tyrosine-kinases Fer/FerT associate with the mitochondrial electron transport chain in cancer cells supporting their metabolic reprogramming. Here the authors discover a compound that disrupts Fer /FerT activity and selectively induces cell death of cancer cell lines displaying anti-tumor activity in vivo.
    Keywords Science ; Q
    Language English
    Publishing date 2017-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Thioredoxin-mimetic peptide CB3 lowers MAPKinase activity in the Zucker rat brain

    Moshe Cohen-Kutner / Lena Khomsky / Michael Trus / Hila Ben-Yehuda / James M. Lenhard / Yin Liang / Tonya Martin / Daphne Atlas

    Redox Biology, Vol 2, Iss C, Pp 447-

    2014  Volume 456

    Abstract: Diabetes is a high risk factor for dementia. High glucose may be a risk factor for dementia even among persons without diabetes, and in transgenic animals it has been shown to cause a potentiation of indices that are pre-symptomatic of Alzheimer′s ... ...

    Abstract Diabetes is a high risk factor for dementia. High glucose may be a risk factor for dementia even among persons without diabetes, and in transgenic animals it has been shown to cause a potentiation of indices that are pre-symptomatic of Alzheimer′s disease. To further elucidate the underlying mechanisms linking inflammatory events elicited in the brain during oxidative stress and diabetes, we monitored the activation of mitogen-activated kinsase (MAPKs), c-jun NH2-terminal kinase (JNK), p38 MAP kinases (p38MAPK), and extracellular activating kinsae1/2 (ERK1/2) and the anti-inflammatory effects of the thioredoxin mimetic (TxM) peptides, Ac-Cys-Pro-Cys-amide (CB3) and Ac-Cys-Gly-Pro-Cys-amide (CB4) in the brain of male leptin-receptor-deficient Zucker diabetic fatty (ZDF) rats and human neuroblastoma SH-SY5Y cells. Daily i.p. injection of CB3 to ZDF rats inhibited the phosphorylation of JNK and p38MAPK, and prevented the expression of thioredoxin-interacting-protein (TXNIP/TBP-2) in ZDF rat brain. Although plasma glucose/insulin remained high, CB3 also increased the phosphorylation of AMP-ribose activating kinase (AMPK) and inhibited p70S6K kinase in the brain. Both CB3 and CB4 reversed apoptosis induced by inhibiting thioredoxin reductase as monitored by decreasing caspase 3 cleavage and PARP dissociation in SH-SY5Y cells. The decrease in JNK and p38MAPK activity in the absence of a change in plasma glucose implies a decrease in oxidative or neuroinflammatory stress in the ZDF rat brain. CB3 not only attenuated MAPK phosphorylation and activated AMPK in the brain, but it also diminished apoptotic markers, most likely acting via the MAPK–AMPK–mTOR pathway. These results were correlated with CB3 and CB4 inhibiting inflammation progression and protection from oxidative stress induced apoptosis in human neuronal cells. We suggest that by attenuating neuro-inflammatory processes in the brain Trx1 mimetic peptides could become beneficial for preventing neurological disorders associated with diabetes.
    Keywords Diabetes type 2 ; Inflammation ; Thioredoxin mimetics ; ZDF rat-model ; MAPK ; AMPK ; TXNIP/TBP-2 ; CB3 ; Oxidative stress ; Redox ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Subject code 571
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells

    Yoav Elkis / Moshe Cohen / Etai Yaffe / Shirly Satmary-Tusk / Tal Feldman / Elad Hikri / Abraham Nyska / Ariel Feiglin / Yanay Ofran / Sally Shpungin / Uri Nir

    Nature Communications, Vol 8, Iss 1, Pp 1-

    2017  Volume 17

    Abstract: The tyrosine-kinases Fer/FerT associate with the mitochondrial electron transport chain in cancer cells supporting their metabolic reprogramming. Here the authors discover a compound that disrupts Fer /FerT activity and selectively induces cell death of ... ...

    Abstract The tyrosine-kinases Fer/FerT associate with the mitochondrial electron transport chain in cancer cells supporting their metabolic reprogramming. Here the authors discover a compound that disrupts Fer /FerT activity and selectively induces cell death of cancer cell lines displaying anti-tumor activity in vivo.
    Keywords Science ; Q
    Language English
    Publishing date 2017-10-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Continuous trunk diameter recording can reveal water stress in peach trees

    Elias Fereres / David Goldhamer / Moshe Cohen / Joan Girona / Merce Mata

    California Agriculture, Vol 53, Iss 4, Pp 21-

    1999  Volume 25

    Abstract: The water status of a peach tree is traditionally monitored by measuring its predawn or midday leaf water potential or midday stem water potential. A study conducted on ‘O'Henry’ peach trees at the Kearney Agricultural Center showed that continuous ... ...

    Abstract The water status of a peach tree is traditionally monitored by measuring its predawn or midday leaf water potential or midday stem water potential. A study conducted on ‘O'Henry’ peach trees at the Kearney Agricultural Center showed that continuous monitoring of trunk diameter can also be an accurate technique of detecting water stress. The trees were evaluated during 21 days of underirrigation followed by 17 days of full irrigation. Trunk-based measurements were generally more sensitive than discrete measurements to both the onset of water stress and the magnitude of tree water deficits. Parameters based on trunk diameter monitoring correlated well with established physiological parameters of plant water status. These trunk diameter oscillations, which are only available from continuous monitoring, hold promise for improving the precision of irrigation decision making.
    Keywords Agriculture ; S ; Agriculture (General) ; S1-972
    Language English
    Publishing date 1999-07-01T00:00:00Z
    Publisher University of California Agriculture and Natural Resources
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Water relations of lysimeter-grown peach trees are sensitive to deficit irrigation

    Merce Mata / Joan Girona / David Goldhamer / Elias Fereres / Moshe Cohen / Scott Johnson

    California Agriculture, Vol 53, Iss 4, Pp 17-

    1999  Volume 20

    Abstract: To compare peach tree water use with soil and plant water status measurements, two trees in a large weighing lysimeter were deficit irrigated with insufficient amounts of water for 3 weeks. Transpiration decreased soon after the deficit irrigation began ... ...

    Abstract To compare peach tree water use with soil and plant water status measurements, two trees in a large weighing lysimeter were deficit irrigated with insufficient amounts of water for 3 weeks. Transpiration decreased soon after the deficit irrigation began and evaporation from the soil became relatively more important. Due to shallow, sparse rooting, high-frequency drip irrigation and high evaporative demand, allowable depletion in the wetted soil zone of the lysimeter was only 15% to 20% of available soil water. This indicates the small margin for error in managing irrigation of trees in this situation.
    Keywords Agriculture ; S ; Agriculture (General) ; S1-972
    Language English
    Publishing date 1999-07-01T00:00:00Z
    Publisher University of California Agriculture and Natural Resources
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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