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Book: Hämatologie Essentials

Hoffbrand, A. V. / Moss, Paul A. H. / Umlauf-Beck, Sabine / Manz, Markus G.

Grundlagen, Labordiagnostik und molekulare Therapieansätze

2020

Title translation	Hoffbrand's essential haematology
Author's details	A. Victor Hoffbrand, Paul A.H. Moss ; aus dem Amerikanischen von Sabine Umlauf-Beck ; deutschsprachige Ausgabe herausgegeben von Markus G. Manz ; unter Mitarbeit von Urs Schanz, Jan-Dirk Studt und Alexandre Theocharides
Keywords	Hämatologie
Subject code	610
Language	German
Size	462 Seiten, Illustrationen, Diagramme, 27 cm x 19 cm
Edition	1. Auflage
Publisher	Hogrefe
Publishing place	Bern
Publishing country	Switzerland
Document type	Book
HBZ-ID	HT019949773
ISBN	978-3-456-85921-7 ; 3-456-85921-X ; 9783456959214 ; 9783456759210 ; 3456959214 ; 3456759215
Database	Catalogue ZB MED Medicine, Health

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2020 A 262	available for loan (reading room)	Lesesaal EG

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Article ; Online: Systematic analysis of infectious disease outcomes by age shows lowest severity in school-age children.

Glynn, Judith R / Moss, Paul A H

Scientific data

2020 Volume 7, Issue 1, Page(s) 329

Abstract: The COVID-19 pandemic has ignited interest in age-specific manifestations of infection but surprisingly little is known about relative severity of infectious disease between the extremes of age. In a systematic analysis we identified 142 datasets with ... ...

Abstract	The COVID-19 pandemic has ignited interest in age-specific manifestations of infection but surprisingly little is known about relative severity of infectious disease between the extremes of age. In a systematic analysis we identified 142 datasets with information on severity of disease by age for 32 different infectious diseases, 19 viral and 13 bacterial. For almost all infections, school-age children have the least severe disease, and severity starts to rise long before old age. Indeed, for many infections even young adults have more severe disease than children, and dengue was the only infection that was most severe in school-age children. Together with data on vaccine response in children and young adults, the findings suggest peak immune function is reached around 5-14 years of age. Relative immune senescence may begin much earlier than assumed, before accelerating in older age groups. This has major implications for understanding resilience to infection, optimal vaccine scheduling, and appropriate health protection policies across the life course.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Betacoronavirus ; COVID-19 ; Child ; Child, Preschool ; Communicable Diseases/immunology ; Communicable Diseases/mortality ; Coronavirus Infections ; Datasets as Topic ; Humans ; Immunosenescence ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Severity of Illness Index ; Young Adult
Keywords	covid19
Language	English
Publishing date	2020-10-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-020-00668-y
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Article: Systematic analysis of infectious disease outcomes by age shows lowest severity in school-age children

Glynn, Judith R / Moss, Paul A H

Sci Data

Abstract	The COVID-19 pandemic has ignited interest in age-specific manifestations of infection but surprisingly little is known about relative severity of infectious disease between the extremes of age. In a systematic analysis we identified 142 datasets with information on severity of disease by age for 32 different infectious diseases, 19 viral and 13 bacterial. For almost all infections, school-age children have the least severe disease, and severity starts to rise long before old age. Indeed, for many infections even young adults have more severe disease than children, and dengue was the only infection that was most severe in school-age children. Together with data on vaccine response in children and young adults, the findings suggest peak immune function is reached around 5-14 years of age. Relative immune senescence may begin much earlier than assumed, before accelerating in older age groups. This has major implications for understanding resilience to infection, optimal vaccine scheduling, and appropriate health protection policies across the life course.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #872718
Database	COVID19

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Article ; Online: The Cellular Localization of Human Cytomegalovirus Glycoprotein Expression Greatly Influences the Frequency and Functional Phenotype of Specific CD4+ T Cell Responses.

Pachnio, Annette / Zuo, Jianmin / Ryan, Gordon B / Begum, Jusnara / Moss, Paul A H

Journal of immunology (Baltimore, Md. : 1950)

2015 Volume 195, Issue 8, Page(s) 3803–3815

Abstract: CMV infection is a significant cause of morbidity and mortality in immunocompromised individuals, and the development of a vaccine is of high priority. Glycoprotein B (gB) is a leading vaccine candidate but the glycoprotein H (gH) pentameric complex is ... ...

Abstract	CMV infection is a significant cause of morbidity and mortality in immunocompromised individuals, and the development of a vaccine is of high priority. Glycoprotein B (gB) is a leading vaccine candidate but the glycoprotein H (gH) pentameric complex is now recognized as the major target for neutralizing Abs. However, little is known about the T cell immune response against gH and glycoprotein L (gL) and this is likely to be an important attribute for vaccine immunogenicity. In this study, we examine and contrast the magnitude and phenotype of the T cell immune response against gB, gH, and gL within healthy donors. gB-specific CD4(+) T cells were found in 95% of donors, and 29 epitopes were defined with gB-specific response sizes ranging from 0.02 to 2.88% of the CD4(+) T cell pool. In contrast, only 20% of donors exhibited a T cell response against gH or gL. Additionally, gB-specific CD4(+) T cells exhibited a more cytotoxic phenotype, with high levels of granzyme B expression. Glycoproteins were effectively presented following delivery to APCs but only gB-derived epitopes were presented following endogenous synthesis. gB expression was observed exclusively within vesicular structures colocalizing with HLA-DM whereas gH was distributed evenly throughout the cytoplasm. Grafting of the C-terminal domain from gB onto gH could not transfer this pattern of presentation. These results reveal that gB is a uniquely immunogenic CMV glycoprotein and this is likely to reflect its unique pattern of endogenous Ag presentation. Consideration may be required toward mechanisms that boost cellular immunity to gH and gL within future subunit vaccines.
MeSH term(s)	Adult ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/pathology ; Cytomegalovirus/genetics ; Cytomegalovirus/immunology ; Cytomegalovirus Infections/genetics ; Cytomegalovirus Infections/immunology ; Cytomegalovirus Infections/pathology ; Cytomegalovirus Vaccines/genetics ; Cytomegalovirus Vaccines/immunology ; Epitopes, T-Lymphocyte/genetics ; Epitopes, T-Lymphocyte/immunology ; Female ; Granzymes ; Humans ; Immunity, Cellular ; Male ; Middle Aged ; Viral Envelope Proteins/genetics ; Viral Envelope Proteins/immunology
Chemical Substances	Cytomegalovirus Vaccines ; Epitopes, T-Lymphocyte ; Viral Envelope Proteins ; GZMB protein, human (EC 3.4.21.-) ; Granzymes (EC 3.4.21.-)
Language	English
Publishing date	2015-09-11
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1500696
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Article ; Online: Profile of maternal CD4 T-cell effector function during normal pregnancy and in women with a history of recurrent miscarriage.

Lissauer, David / Goodyear, Oliver / Khanum, Rahela / Moss, Paul A H / Kilby, Mark D

Clinical science (London, England : 1979)

2014 Volume 126, Issue 5, Page(s) 347–354

Abstract: The traditional paradigm suggests that during normal pregnancy maternal immunological tolerance of the allogenic fetus is association with a maternal T-lymphocyte shift from a Th1 to a Th2 phenotype, with the opposite effect reported in patients with ... ...

Abstract	The traditional paradigm suggests that during normal pregnancy maternal immunological tolerance of the allogenic fetus is association with a maternal T-lymphocyte shift from a Th1 to a Th2 phenotype, with the opposite effect reported in patients with recurrent miscarriage. However, studies on maternal peripheral blood are conflicting. In the present study, we characterized the maternal CD4 T-cell effector subsets, including the recently described Th17 subset, during normal pregnancy (cross-sectional cohort, n=71; longitudinal cohort, n=17) and contrasted this with women with recurrent miscarriage (n=24). Longitudinal analysis of peripheral blood from normal pregnancy demonstrated a fall in the percentage of Th17 cells between the first and second trimester (P≤0.05), but no significant changes were observed across gestation or the post-natal period in Th1 or Th2 subsets. In contrast, in women with a history of recurrent miscarriage, an elevated proportion of Th17 (0.314% compared with 0.097%; P=0.0009) and Th1 (12.4% compared with 5.3%; P=0.0002) cells was detected. The suggestion that Th17 cells may have a role in the normal events of implantation and early pregnancy requires further evaluation and mechanistic studies. The results of the present study, by conducting a careful longitudinal analysis, demonstrate that a peripheral Th1/Th2 shift is not a requirement for normal pregnancy. By contrast, the profound increase in Th1 and Th17 cells in women with recurrent miscarriage indicates that peripheral immunological dysfunction may be important in this group specifically, and these assays may be important in guiding therapeutic interventions in this group and warrant further investigation to determine whether they are predictive of outcome or responses to immunomodulatory therapy.
MeSH term(s)	Abortion, Habitual ; Adolescent ; Adult ; CD4-Positive T-Lymphocytes/immunology ; Cohort Studies ; Cytokines/metabolism ; Female ; Humans ; Pregnancy/immunology ; Pregnancy Trimester, First ; Receptors, Chemokine/metabolism ; Young Adult
Chemical Substances	Cytokines ; Receptors, Chemokine
Language	English
Publishing date	2014-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	206835-7
ISSN	1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
ISSN (online)	1470-8736
ISSN	0301-0538 ; 0009-0360 ; 0143-5221
DOI	10.1042/CS20130247
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Article ; Online: Sociodemographic factors associated with IgG and IgM seroprevalence for human cytomegalovirus infection in adult populations of Pakistan: a seroprevalence survey.

Ibrahim, Saira / Siddiqui, Anwar A / Siddiqui, Amna R / Ahmed, Waquaruddin / Moss, Paul A H / Lalani, El-Nasir M A

BMC public health

2016 Volume 16, Issue 1, Page(s) 1112

Abstract: Background: The seroprevalence of human cytomegalovirus (HCMV) infection ranges from 30 to 90 % in developed countries. Reliable estimates of HCMV seroprevalence are not available for Pakistan. This study determined the seroprevalence and ... ...

Abstract	Background: The seroprevalence of human cytomegalovirus (HCMV) infection ranges from 30 to 90 % in developed countries. Reliable estimates of HCMV seroprevalence are not available for Pakistan. This study determined the seroprevalence and sociodemographic factors associated with HCMV infection in adult populations of Karachi, Pakistan. Methods: A seroprevalence survey was conducted on 1000 adults, including residents of two semi-urban communities, and visitors to a government and a private hospital. Questionnaire-based interviews were conducted. Sera were analysed for HCMV-specific IgG and IgM. Chi-square or Fisher's exact test was used for comparing sociodemographic variables against seropositivity of HCMV-IgG or IgM. Multiple logistic regression modeling was performed for IgG seroprevalence and adjusted odds ratios were computed. Results: The seroprevalence of HCMV-IgG and IgM was 93.2 and 4.3 % respectively. 95.3 % of individuals who were IgM seropositive were also seropositive for IgG. Around 6 % (15/250) of women of childbearing age remained uninfected and were therefore susceptible to primary infection. HCMV-IgG seroprevalence was associated with being female (p = 0.001), increasing age (p = 0.002) and crowding index (p = 0.003) and also with lower levels of both education (p < 0.001) and income (p = 0.008). Seroprevalence also differed significantly by marital status (p = 0.008) and sampling location (p < 0.001). A logistic regression model for HCMV-IgG seroprevalence showed associations with being female (OR = 1.89; 95 % CI: 1.10-3.25), increasing age (OR = 3.95; 95 % CI: 1.79-8.71) and decreasing income (OR = 0.72; 95 % CI: 0.54-0.96). A strong association was observed between increased seroprevalence of HCMV-IgM and decreasing household size (p = 0.008). Conclusions: Seroprevalence of HCMV is very high in Pakistan, although 6 % of women of childbearing age remain at risk of primary infection. The IgM seropositivity observed in some individuals living in small household size (1-3 individuals) with persistent HCMV infection could have resulted from a recurrent HCMV infection. Future longitudinal research in pregnant women and neonates is required to study the trends in HCMV seroprevalence over time in Pakistan for the development of a potential HCMV prevention and vaccination programme.
MeSH term(s)	Adult ; Age Factors ; Antibodies, Viral/blood ; Cytomegalovirus/immunology ; Cytomegalovirus Infections/epidemiology ; Cytomegalovirus Infections/immunology ; Educational Status ; Family Characteristics ; Female ; Humans ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Income ; Logistic Models ; Male ; Marital Status ; Middle Aged ; Pakistan/epidemiology ; Prevalence ; Seroepidemiologic Studies ; Sex Factors ; Surveys and Questionnaires ; Young Adult
Chemical Substances	Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin M
Language	English
Publishing date	2016-10-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-016-3772-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Persistent viral infection in humans can drive high frequency low-affinity T-cell expansions.

Khan, Naeem / Cobbold, Mark / Cummerson, Joanne / Moss, Paul A H

Immunology

2010 Volume 131, Issue 4, Page(s) 537–548

Abstract: CD8 T cells that recognize cytomegalovirus (CMV) -encoded peptides can be readily detected by staining with human leucocyte antigen (HLA) -peptide tetramers. These cells are invariably highly differentiated effector memory cells with high avidity T-cell ... ...

Abstract	CD8 T cells that recognize cytomegalovirus (CMV) -encoded peptides can be readily detected by staining with human leucocyte antigen (HLA) -peptide tetramers. These cells are invariably highly differentiated effector memory cells with high avidity T-cell receptors (TCR). In this report we demonstrate an HLA-A*0201 restricted CMV-specific CD8 T-cell response (designated YVL) that represents several percent of the CD8 T-cell subset, yet fails to bind tetrameric major histocompatibility complex (MHC) ligands. However, these tetramer-negative cells are both phenotypically and functionally similar to other CMV-specific CD8 T cells. YVL peptide-specific CD8 T-cell clones were generated and found to be of high avidity in both cytotoxicity and interferon-γ (IFN-γ) assays, and comparable with other CMV peptide-specific CD8 T-cell clones. However, under conditions of CD8 blockade, the response was almost nullified even at very high ligand concentrations. This was also the case in IFN-γ experiments using peripheral blood mononuclear cells stimulated with peptide ex vivo. In contrast, all other CMV specificities (tetramer-positive) displayed minimal or only partial CD8 dependence. This suggests that YVL-specific responses depict a low-affinity TCR-MHC-peptide interaction, that is compensated by substantial CD8 involvement for functional purposes, yet cannot engage multivalent soluble ligands for ex vivo analysis. It is interesting that such a phenomenon is apparent in the face of a persistent virus infection such as CMV, where the responding cells represent an immunodominant response in that individual and may present a highly differentiated effector phenotype.
MeSH term(s)	CD8-Positive T-Lymphocytes/immunology ; Cytomegalovirus/immunology ; Cytomegalovirus Infections/immunology ; HLA-A Antigens/immunology ; HLA-A2 Antigen ; Humans ; Interferon-gamma/immunology ; Peptides/immunology ; Peptides/pharmacology ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocyte Subsets/immunology ; Viral Proteins/immunology ; Viral Proteins/pharmacology
Chemical Substances	HLA-A Antigens ; HLA-A*02:01 antigen ; HLA-A2 Antigen ; Peptides ; Receptors, Antigen, T-Cell ; Viral Proteins ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2010-08-16
Publishing country	England
Document type	Journal Article
ZDB-ID	80124-0
ISSN	1365-2567 ; 0019-2805 ; 0953-4954
ISSN (online)	1365-2567
ISSN	0019-2805 ; 0953-4954
DOI	10.1111/j.1365-2567.2010.03326.x
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Article ; Online: Progesterone promotes maternal-fetal tolerance by reducing human maternal T-cell polyfunctionality and inducing a specific cytokine profile.

Lissauer, David / Eldershaw, Suzy A / Inman, Charlotte F / Coomarasamy, Aravinthan / Moss, Paul A H / Kilby, Mark D

European journal of immunology

2015 Volume 45, Issue 10, Page(s) 2858–2872

Abstract: Progesterone is a steroid hormone essential for the maintenance of human pregnancy, and its actions are thought to include promoting maternal immune tolerance of the semiallogenic fetus. We report that exposure of maternal T cells to progesterone at ... ...

Abstract	Progesterone is a steroid hormone essential for the maintenance of human pregnancy, and its actions are thought to include promoting maternal immune tolerance of the semiallogenic fetus. We report that exposure of maternal T cells to progesterone at physiological doses induced a unique skewing of the cytokine production profile of CD4(+) and CD8(+) T cells, with reductions not only in potentially deleterious IFN-γ and TNF-α production but also in IL-10 and IL-5. Conversely, production of IL-4 was increased. Maternal T cells also became less polyfunctional, focussing cytokine production toward profiles including IL-4. This was accompanied by reduced T-cell proliferation. Using fetal and viral antigen-specific CD8(+) T-cell clones, we confirmed that this as a direct, nonantigen-specific effect. Yet human T cells lacked conventional nuclear progesterone receptors, implicating a membrane progesterone receptor. CD4(+) and CD8(+) T cells responded to progesterone in a dose-dependent manner, with subtle effects at concentrations comparable to those in maternal blood, but profound effects at concentrations similar to those at the maternal-fetal interface. This characterization of how progesterone modulates T-cell function is important in understanding the normal biology of pregnancy and informing the rational use of progesterone therapy in pregnancies at risk of fetal loss.
MeSH term(s)	Adult ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Cytokines/blood ; Cytokines/immunology ; Female ; Fetus/immunology ; Fetus/metabolism ; Humans ; Immune Tolerance/physiology ; Pregnancy/blood ; Pregnancy/immunology ; Progesterone/blood ; Progesterone/immunology
Chemical Substances	Cytokines ; Progesterone (4G7DS2Q64Y)
Language	English
Publishing date	2015-10
Publishing country	Germany
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.201445404
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Article ; Online: Health state utilities for chronic lymphocytic leukemia: importance of prolonging progression-free survival.

Kosmas, Charlotte E / Shingler, Sarah L / Samanta, Kunal / Wiesner, Christof / Moss, Paul A H / Becker, Ursula / Lloyd, Andrew J

Leukemia & lymphoma

2015 Volume 56, Issue 5, Page(s) 1320–1326

Abstract: Chronic lymphocytic leukemia (CLL) is a largely incurable disease which affects patients' health related quality of life (HRQL). Treatment is often initiated when symptoms affect HRQL, and patients can experience many rounds of treatment throughout their ...

Abstract	Chronic lymphocytic leukemia (CLL) is a largely incurable disease which affects patients' health related quality of life (HRQL). Treatment is often initiated when symptoms affect HRQL, and patients can experience many rounds of treatment throughout their life. Therefore, the economic burden of CLL can be high. Utility or preference weights for health states reflect the value of HRQL of a given health state and range from 1 (full health) to 0 (dead) and below (negative values possible). Nine health states were developed representing different CLL treatment lines or disease stages. One hundred members of the UK general public valued each health state using the time trade-off methodology. Progression-free survival (PFS) without therapy (mean utility = 0.82) was the least burdensome, with relapsed lines of treatment (mean utility = 0.42) representing the greatest burden. The results underline the value in maintaining a state of PFS for as long as possible.
MeSH term(s)	Adult ; Disease-Free Survival ; Female ; Health Status ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/epidemiology ; Leukemia, Lymphocytic, Chronic, B-Cell/mortality ; Male ; Middle Aged ; Quality of Life ; Surveys and Questionnaires ; Young Adult
Language	English
Publishing date	2015-01-14
Publishing country	United States
Document type	Journal Article ; Meta-Analysis
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.3109/10428194.2014.961012
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Article ; Online: Fetal-specific CD8+ cytotoxic T cell responses develop during normal human pregnancy and exhibit broad functional capacity.

Lissauer, David / Piper, Karen / Goodyear, Oliver / Kilby, Mark D / Moss, Paul A H

Journal of immunology (Baltimore, Md. : 1950)

2012 Volume 189, Issue 2, Page(s) 1072–1080

Abstract: Tolerance of the semiallogeneic fetus presents a significant challenge to the maternal immune system during human pregnancy. T cells with specificity for fetal epitopes have been detected in women with a history of previous pregnancy, but it has been ... ...

Abstract	Tolerance of the semiallogeneic fetus presents a significant challenge to the maternal immune system during human pregnancy. T cells with specificity for fetal epitopes have been detected in women with a history of previous pregnancy, but it has been thought that such fetal-specific cells were generally deleted during pregnancy as a mechanism to maintain maternal tolerance of the fetus. We used MHC-peptide dextramer multimers containing an immunodominant peptide derived from HY to identify fetal-specific T cells in women who were pregnant with a male fetus. Fetal-specific CD8(+) T lymphocytes were observed in half of all pregnancies and often became detectable from the first trimester. The fetal-specific immune response increased during pregnancy and persisted in the postnatal period. Fetal-specific cells demonstrated an effector memory phenotype and were broadly functional. They retained their ability to proliferate, secrete IFN-γ, and lyse target cells following recognition of naturally processed peptide on male cells. These data show that the development of a fetal-specific adaptive cellular immune response is a normal consequence of human pregnancy and that unlike reports from some murine models, fetal-specific T cells are not deleted during human pregnancy. This has broad implications for study of the natural physiology of pregnancy and for the understanding of pregnancy-related complications.
MeSH term(s)	Adaptive Immunity/immunology ; Clone Cells ; Cytotoxicity Tests, Immunologic/methods ; Embryonic Stem Cells/cytology ; Embryonic Stem Cells/immunology ; Embryonic Stem Cells/metabolism ; Epitopes, T-Lymphocyte/blood ; Epitopes, T-Lymphocyte/immunology ; Female ; Fetus/cytology ; Fetus/immunology ; H-Y Antigen/blood ; H-Y Antigen/immunology ; HLA-A2 Antigen/blood ; HLA-A2 Antigen/immunology ; Humans ; Immunophenotyping ; Male ; Minor Histocompatibility Antigens/blood ; Minor Histocompatibility Antigens/immunology ; Pregnancy ; Protein Multimerization/immunology ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/metabolism
Chemical Substances	Epitopes, T-Lymphocyte ; H-Y Antigen ; HLA-A*02:01 antigen ; HLA-A2 Antigen ; Minor Histocompatibility Antigens
Language	English
Publishing date	2012-07-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1200544
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