Article: A randomized, double-blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromyalgia.
1996 Volume 39, Issue 11, Page(s) 1852–1859
Abstract: Objective: To study the effect of fluoxetine (FL) and amitriptyline (AM), alone and in combination, in patients with fibromyalgia (FM).: Methods: Nineteen patients with FM completed a randomized, double-blind crossover study, which consisted of 4 6- ... ...
Abstract | Objective: To study the effect of fluoxetine (FL) and amitriptyline (AM), alone and in combination, in patients with fibromyalgia (FM). Methods: Nineteen patients with FM completed a randomized, double-blind crossover study, which consisted of 4 6-week trials of FL (20 mg), AM (25 mg), a combination of FL and AM, or placebo. Patients were evaluated on the first and last day of each trial period. Outcome measures included a tender point score, the Fibromyalgia Impact Questionnaire (FIQ), the Beck Depression Inventory (BDI) scale, and visual analog scales (VAS) for global well-being (1 completed by the physician and 1 by the patient), pain, sleep trouble, fatigue, and feeling refreshed upon awakening. Results: Both FL and AM were associated with significantly improved scores on the FIQ and on the VAS for pain, global well-being, and sleep disturbances. When combined, the 2 treatments worked better than either medication alone. Similar, but nonsignificant, improvement occurred in the BDI scale, the physician global VAS, and the VAS for fatigue and feeling refreshed upon awakening. Trends were less clear for the tender point score. Conclusion: Both FL and AM are effective treatments for FM, and they work better in combination than either medication alone. |
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MeSH term(s) | Adolescent ; Adult ; Amitriptyline/therapeutic use ; Analysis of Variance ; Double-Blind Method ; Drug Therapy, Combination ; Female ; Fibromyalgia/drug therapy ; Fluoxetine/therapeutic use ; Humans ; Male ; Middle Aged ; Serotonin Uptake Inhibitors/therapeutic use ; Treatment Outcome |
Chemical Substances | Serotonin Uptake Inhibitors ; Fluoxetine (01K63SUP8D) ; Amitriptyline (1806D8D52K) |
Language | English |
Publishing date | 1996-11 |
Publishing country | United States |
Document type | Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't |
ZDB-ID | 127294-9 |
ISSN | 1529-0131 ; 0004-3591 ; 2326-5191 |
ISSN (online) | 1529-0131 |
ISSN | 0004-3591 ; 2326-5191 |
DOI | 10.1002/art.1780391111 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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