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  1. Article ; Online: Salvage transoral robotic surgery in recurrent oropharyngeal carcinoma: a single-center retrospective study.

    Ansarin, Mohssen / Pietrobon, Giacomo / Tagliabue, Marta / Mossinelli, Chiara / Ruju, Francesca / Maffini, Fausto / Rocca, Maria Cossu / Alterio, Daniela / Simon, Christian / Zorzi, Stefano Filippo

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2024  Volume 281, Issue 6, Page(s) 3167–3177

    Abstract: Purpose: Salvage surgery is still the best therapeutic option for resectable recurrent oropharyngeal squamous cell carcinoma (rOPSCC). Transoral robotic surgery may potentially reduce the morbidity of standard open approaches. The aim of the study is to ...

    Abstract Purpose: Salvage surgery is still the best therapeutic option for resectable recurrent oropharyngeal squamous cell carcinoma (rOPSCC). Transoral robotic surgery may potentially reduce the morbidity of standard open approaches. The aim of the study is to present oncological and functional outcomes of a monocentric experience in salvage transoral robotic surgery.
    Methods: We performed a single-center retrospective analysis of patients submitted to transoral robotic salvage surgery with or without neck dissection for cT1-3 rOPSCC. We investigated complication rate, survival outcomes (Overall Survival, Disease Specific Survival, Loco-Regional Recurrence Free Survival) and functional outcomes (tracheal tube and/or gastrostomy dependence).
    Results: Sixty-one patients were included in the analysis. No major complications or perioperative deaths were recorded. The estimated 2-year OS was 76.7%, DSS 81.8% and LRRFS 50.5%. In multivariable analysis rpT, PNI (perineural infiltration) and HPV-positivity were significantly associated with LRRFS (Hazard Ratios: T3 vs T1 6.43, PNI yes vs no 4.19, HPV+ yes vs no 2.63). At last follow up, 97% of patients were tracheal tube-free, while 93% were gastrostomy-free.
    Conclusion: Transoral robotic salvage surgery is a successful treatment in selected patients affected by rOPSCC because it grants good oncologic and functional outcomes.
    MeSH term(s) Humans ; Robotic Surgical Procedures/methods ; Retrospective Studies ; Male ; Salvage Therapy/methods ; Oropharyngeal Neoplasms/surgery ; Oropharyngeal Neoplasms/pathology ; Oropharyngeal Neoplasms/mortality ; Female ; Middle Aged ; Neoplasm Recurrence, Local/surgery ; Aged ; Carcinoma, Squamous Cell/surgery ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/mortality ; Neck Dissection/methods ; Adult ; Treatment Outcome ; Natural Orifice Endoscopic Surgery/methods ; Aged, 80 and over
    Language English
    Publishing date 2024-03-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-024-08590-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Outcomes of mini-invasive transoral surgery without neck dissection in supraglottic laryngeal cancer: Real world data from a tertiary cancer center.

    Zorzi, Stefano / Pietrobon, Giacomo / Mossinelli, Chiara / Bandi, Francesco / Chu, Francesco / Tagliabue, Marta / De Berardinis, Rita / Zocchi, Jacopo / Alterio, Daniela / Rocca, Maria Cossu / Ruju, Francesca / Ansarin, Mohssen

    American journal of otolaryngology

    2023  Volume 45, Issue 1, Page(s) 104113

    Abstract: Purpose: The neck management in early-stage cN0 supraglottic cancer represents an argument of debate. The aim of our study is to evaluate the oncological and functional outcomes in patients with early-stage cN0 supraglottic carcinoma treated with a wait- ...

    Abstract Purpose: The neck management in early-stage cN0 supraglottic cancer represents an argument of debate. The aim of our study is to evaluate the oncological and functional outcomes in patients with early-stage cN0 supraglottic carcinoma treated with a wait-and-see policy for the neck.
    Materials and methods: Retrospective monocentric cohort study in a referral cancer care center. We collected a consecutive sample of patients from 2000 to 2020 with Squamous Cell Carcinoma of the supraglottis without clinical evidence of nodal metastases (cN0), surgically treated with Transoral Surgery (Laser or Robotic) without neck dissection. From 316 supraglottic cancer we finally selected 66 eligible participants that met all inclusion criteria.
    Results: Sixty-six patients (M 75.8 % vs F 24.2 %), median age 65.8 years (IQR 60.9, 70.5). The most common subsite was the epiglottis (62.1 %). Tumor stage distribution was as follows: 35 % cT1, 53 % cT2, 15.2 % cT3. Neither deaths nor major treatment-related complications were reported after surgery. The median follow-up was 62 months. For oncological outcomes, we evaluated 56 patients (10 excluded for adjuvant radiotherapy): 5-year overall survival rate 87 % (CI 95 %: 73.1-94), disease- specific survival rate 95.3 % (CI 95 %: 82-98.8) and neck recurrence-free survival rate 87 % (CI 95 %: 73.1-94). Six patients developed neck recurrence, with a median time of 13 months.
    Conclusions: Supraglottic carcinoma has been historically associated to a considerable risk of occult metastasis. However, in early-stage cases data are still inconclusive. Our results suggest that in such patients a wait-and-see policy does not impact negatively on survival outcomes, while granting the reduced morbidity associated to a minimally invasive surgical approach.
    MeSH term(s) Humans ; Aged ; Laryngeal Neoplasms/pathology ; Neck Dissection/methods ; Retrospective Studies ; Cohort Studies ; Neoplasm Staging ; Carcinoma, Squamous Cell/pathology
    Language English
    Publishing date 2023-11-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2023.104113
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    Zs.A 1637: Show issues Location:
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  3. Article ; Online: Modified transcervical lipofilling of the base of the tongue under local anaesthesia: Case series.

    Chu, Francesco / De Benedetto, Luigi / Zurlo, Valeria / Mossinelli, Chiara / Zorzi, Stefano / Tagliabue, Marta / De Berardinis, Rita / Bandi, Francesco / Pietrobon, Giacomo / Ansarin, Mohssen

    Ear, nose, & throat journal

    2022  , Page(s) 1455613221097201

    Abstract: Laryngeal carcinoma represents one-third of all head and neck cancers and is burdened by significant morbidity and mortality for advanced-stage disease. Surgical treatments, including Open Partial Horizontal Laryngectomy (OPHL), are often followed by ... ...

    Abstract Laryngeal carcinoma represents one-third of all head and neck cancers and is burdened by significant morbidity and mortality for advanced-stage disease. Surgical treatments, including Open Partial Horizontal Laryngectomy (OPHL), are often followed by long-lasting swallowing rehabilitation and more rarely, persistent dysphagia. Some authors reported single cases, successfully treated with fat injection of the base of tongue, but nowadays, a standardized technique has never been described so far. We provide a step-by-step technique description of the trans-cervical lipofilling of the base of the tongue (BOT) under local anaesthesia in a case series of three patients. The functional results have been evaluated with a videofluoroscopic study of deglutition and Penetration-Aspiration Score. The procedure was well tolerated; all patients were discharged after 24 hours without any majorcomplications. After six months, all patients had a steady improvement in swallowing. During follow-up, the videofluoroscopic study of deglutition confirmed a sensitive amelioration of the Penetration-Aspiration Score and an empowered base of tongue retropulsion. Finally, the lipofilling of the BOT under local anaesthesia showed to be a feasible, and reproducible procedure, for dysphagia after OPHLs.
    Language English
    Publishing date 2022-04-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    DOI 10.1177/01455613221097201
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  4. Article ; Online: Challenging neck mass: non-functional giant parathyroid adenoma.

    Mossinelli, Chiara / Saibene, Alberto Maria / De Pasquale, Loredana / Maccari, Alberto

    BMJ case reports

    2016  Volume 2016

    Abstract: A 46-year-old man was referred to our ear, nose and throat department after the accidental discovery of a large retrotracheal mass. In order to obtain the diagnosis and to plan treatment he underwent a full battery of tests (CT, MRI, blood tests, ... ...

    Abstract A 46-year-old man was referred to our ear, nose and throat department after the accidental discovery of a large retrotracheal mass. In order to obtain the diagnosis and to plan treatment he underwent a full battery of tests (CT, MRI, blood tests, hormonal assays, ultrasounds, thyroid scintigraphy, urine tests and fine-needle aspiration of the mass), but none of these was able to define the true nature of such cervical mass. Only after surgical excision and histological evaluation, it was diagnosed as an exceptional case of giant non-functional parathyroid adenoma.
    MeSH term(s) Adenoma/diagnosis ; Adenoma/surgery ; Diagnosis, Differential ; Humans ; Incidental Findings ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Multimodal Imaging ; Neck ; Parathyroid Neoplasms/diagnosis ; Parathyroid Neoplasms/surgery ; Physical Examination ; Tomography, X-Ray Computed ; Treatment Outcome
    Language English
    Publishing date 2016-08-17
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2016-215973
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  5. Article ; Online: The role of radiomics in tongue cancer: A new tool for prognosis prediction.

    Mossinelli, Chiara / Tagliabue, Marta / Ruju, Francesca / Cammarata, Giulio / Volpe, Stefania / Raimondi, Sara / Zaffaroni, Mattia / Isaksson, Johannes Lars / Garibaldi, Cristina / Cremonesi, Marta / Corso, Federica / Gaeta, Aurora / Emili, Ilaria / Zorzi, Stefano / Alterio, Daniela / Marvaso, Giulia / Pepa, Matteo / De Fiori, Elvio / Maffini, Fausto /
    Preda, Lorenzo / Benazzo, Marco / Jereczek-Fossa, Barbara Alicja / Ansarin, Mohssen

    Head & neck

    2023  Volume 45, Issue 4, Page(s) 849–861

    Abstract: Background: Radiomics represents an emerging field of precision-medicine. Its application in head and neck is still at the beginning.: Methods: Retrospective study about magnetic resonance imaging (MRI) based radiomics in oral tongue squamous cell ... ...

    Abstract Background: Radiomics represents an emerging field of precision-medicine. Its application in head and neck is still at the beginning.
    Methods: Retrospective study about magnetic resonance imaging (MRI) based radiomics in oral tongue squamous cell carcinoma (OTSCC) surgically treated (2010-2019; 79 patients). All preoperative MRIs include different sequences (T1, T2, DWI, ADC). Tumor volume was manually segmented and exported to radiomic-software, to perform feature extraction. Statistically significant variables were included in multivariable analysis and related to survival endpoints. Predictive models were elaborated (clinical, radiomic, clinical-radiomic models) and compared using C-index.
    Results: In almost all clinical-radiomic models radiomic-score maintained statistical significance. In all cases C-index was higher in clinical-radiomic models than in clinical ones. ADC provided the best fit to the models (C-index 0.98, 0.86, 0.84 in loco-regional recurrence, cause-specific mortality, overall survival, respectively).
    Conclusion: MRI-based radiomics in OTSCC represents a promising noninvasive method of precision medicine, improving prognosis prediction before surgery.
    MeSH term(s) Humans ; Retrospective Studies ; Tongue Neoplasms/diagnostic imaging ; Carcinoma, Squamous Cell/diagnostic imaging ; Carcinoma, Squamous Cell/therapy ; Prognosis ; Magnetic Resonance Imaging/methods ; Squamous Cell Carcinoma of Head and Neck ; Head and Neck Neoplasms
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Upfront surgical organ-preservation strategy in advanced-stage laryngeal cancer.

    Zorzi, Stefano Filippo / Lazio, Maria Silvia / Pietrobon, Giacomo / Chu, Francesco / Zurlo, Valeria / Bibiano, Debora / De Benedetto, Luigi / Cattaneo, Augusto / De Berardinis, Rita / Mossinelli, Chiara / Alterio, Daniela / Rocca, Maria Cossu / Gandini, Sara / Gallo, Oreste / Chiocca, Susanna / Tagliabue, Marta / Ansarin, Mohssen

    American journal of otolaryngology

    2021  Volume 43, Issue 1, Page(s) 103272

    Abstract: Purpose: Advanced-stage laryngeal cancer is a challenging disease that needs multimodal treatment. Medical and surgical organ-preservation strategies have been developing in the last decades to spare these functions while granting cancer cure. The ... ...

    Abstract Purpose: Advanced-stage laryngeal cancer is a challenging disease that needs multimodal treatment. Medical and surgical organ-preservation strategies have been developing in the last decades to spare these functions while granting cancer cure. The current work presents the experience of a tertiary-care center in conservative surgery for advanced-stage laryngeal cancer.
    Materials and methods: We collected clinical data of patients submitted to open partial horizontal laryngectomies (OPHLs) and any possible adjuvant treatment from 2005 to 2018. Outcomes were also compared to the most recent studies reporting on both medical and surgical organ-preservation strategies.
    Results: One hundred ten patients were included in the analysis. Adjuvant therapy was employed in 51% of cases. The local control rate was 96.4%, while overall survival (OS) was 67%, and laryngo-esophageal dysfunction free survival (LEDFS) was 66%. Stage IV and vascular invasion were associated with a statistically-significant worse survival.
    Conclusions: OPHLs are valid as upfront treatment in fit patients affected by advanced-stage laryngeal cancer. Disease control and function preservation are granted in a significant percentage of cases, even when followed by adjuvant therapy.
    MeSH term(s) Combined Modality Therapy ; Female ; Humans ; Laryngeal Neoplasms/mortality ; Laryngeal Neoplasms/pathology ; Laryngeal Neoplasms/surgery ; Laryngectomy/methods ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Organ Sparing Treatments/methods ; Survival Rate ; Treatment Outcome
    Language English
    Publishing date 2021-10-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2021.103272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Smart flap of sternocleidomastoid muscle in anterior cervical spine surgery: Surgical anatomical dissection technique.

    Cuzzocrea, Fabrizio / Ghiara, Matteo / Vanelli, Roberto / Medetti, Marta / Lombardini, Ambrogio Alberto / Benazzo, Francesco / Mauramati, Simone / Mossinelli, Chiara / Herman, Irene / Benazzo, Marco

    Head & neck

    2019  Volume 42, Issue 3, Page(s) 587–589

    Abstract: The use of sternocleidomastoid muscle flap has firstly been described in 1909. In spine surgery, it is usually reserved in the cases of revision after anterior cervical spine procedures. The aim of this article is to introduce its usage as prophylactic ... ...

    Abstract The use of sternocleidomastoid muscle flap has firstly been described in 1909. In spine surgery, it is usually reserved in the cases of revision after anterior cervical spine procedures. The aim of this article is to introduce its usage as prophylactic measure in cases at high risk of iatrogenic fistula formation. The procedure consists of three main steps: sternocleidomastoid isolation, flap design and harvesting, and flap fixation. The use of a surgical anchor allows a better adherence to the plate preventing hematoma formation. The use of SCM smart flap in primary anterior cervical spine surgery as a prophylactic method could be considered a safe and feasible procedure in patients with a high risk of iatrogenic fistulas.
    MeSH term(s) Cervical Vertebrae/diagnostic imaging ; Cervical Vertebrae/surgery ; Dissection ; Humans ; Neck Muscles ; Reconstructive Surgical Procedures ; Surgical Flaps
    Language English
    Publishing date 2019-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.25976
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