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  1. Article: Vitamin D receptor gene polymorphism in Egyptian multiple sclerosis patients.

    Abdelwahab, Nermin R / Mabrouk, Randa R / Zakaria, Nahla M / Abdel Nasser, Azza / Mostafa, Afaf A / Wahba, Nancy S

    The Egyptian journal of immunology

    2024  Volume 31, Issue 2, Page(s) 44–54

    Abstract: One of the most common neurological illnesses in the world is multiple sclerosis (MS), a chronic autoimmune demyelinating disease of the central nervous system (CNS). MS has both a genetic and an environmental origin. In terms of environmental factors, ... ...

    Abstract One of the most common neurological illnesses in the world is multiple sclerosis (MS), a chronic autoimmune demyelinating disease of the central nervous system (CNS). MS has both a genetic and an environmental origin. In terms of environmental factors, vitamin D deficiency is one of the most important risk factors and closely connected with gene polymorphisms involved in vitamin D metabolism, transport, or activity. Since vitamin D activity requires a receptor-mediated response, any changes to the vitamin D receptor (VDR) may have an effect on the pathophysiology of the disease. In this study, we aimed to identify the relationship between VDR gene polymorphisms, FokI A>G (rs2228570), ApaI A>C (rs7975232) and BsmI C>T (rs1544410) and MS. FokI, ApaI and BsmI genotypes were determined in 50 patients with relapsing remitting MS (RRMS) and in 50 control subjects. DNA was isolated from blood samples, and then FokI, ApaI and BsmI gene polymorphisms were identified using allelic discrimination real time polymerase chain reaction (PCR) assay. The distribution of FokI, ApaI and BsmI polymorphisms did not show any significant differences between MS patients and controls. Thus, we concluded that there is no association between the studied VDR gene polymorphisms and MS.
    MeSH term(s) Humans ; Egypt/epidemiology ; Multiple Sclerosis/genetics ; Polymorphism, Genetic ; Receptors, Calcitriol/genetics ; Vitamin D/metabolism ; North African People/genetics
    Chemical Substances Receptors, Calcitriol ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2024-04-13
    Publishing country Egypt
    Document type Journal Article
    ISSN 1110-4902
    ISSN 1110-4902
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Study of intercurrent infection pattern in hepatitis C seropositive renal transplant recipients, relationship with T-cell function.

    Ibrahim, Mohamed A / El Said, Heba W / Sany, Dawlat H / Mostafa, Afaf A

    Renal failure

    2016  Volume 38, Issue 8, Page(s) 1210–1217

    Abstract: Background: We assessed the effect of hepatitis C seropositivity on the percentage of various T-cells in living donor renal transplant recipients (LDRTRs) and their association with intercurrent infections post renal transplantation (post-Tx).: ... ...

    Abstract Background: We assessed the effect of hepatitis C seropositivity on the percentage of various T-cells in living donor renal transplant recipients (LDRTRs) and their association with intercurrent infections post renal transplantation (post-Tx).
    Methods: One hundred and thirty-three matching LDRTRs [A (seronegative) (68 patients) and B (seropositive) (65 patients) by ELISA] were studied prospectively 10 days, 6 months and 12 months post-Tx for intercurrent infections, acute rejection and T-cell% by flow cytometry.
    Results: CD4(+), CD8(+), CD4/CD8 were significantly higher 10 days post-Tx in Group B compared to Group A, p < 0.001. A significant increase in CD8% was seen 6-month post-Tx among Group B compared to Group A. No difference was detected between groups in (CD4(+), CD8(+), CD4/CD8, CD3-CD16/65(+)%), rate and severity of intercurrent infection, rate of acute rejection, 12 months post-Tx. A significantly higher rate of severe infections particularly urinary tract infections (UTI) was noted in Group B compared to Group A the first 3 months post-Tx particularly in those who received the combination of antithymocyte globulin (ATG) or basiliximab, tacrolimus, steroids, mycophenolate mofetil (MMF). CD4(+)% correlated negatively with intercurrent infections in Group B 6 months post-Tx.
    Conclusion: HCV(+) patients are more prone to intercurrent infections the first 3 months post-Tx. Infection rate correlates positively with pre-transplant HCV seropositivity and immunosuppressive regimen.
    MeSH term(s) Adolescent ; Adult ; Aged ; Antibodies, Monoclonal/therapeutic use ; CD4-CD8 Ratio ; Child ; Egypt ; Female ; Graft Rejection/epidemiology ; Graft Survival ; Hepatitis C/blood ; Hepatitis C/complications ; Humans ; Immunosuppressive Agents/therapeutic use ; Kidney Failure, Chronic/therapy ; Kidney Transplantation ; Male ; Middle Aged ; Mycophenolic Acid/therapeutic use ; Prospective Studies ; Recombinant Fusion Proteins/therapeutic use ; Regression Analysis ; T-Lymphocytes/cytology ; Tacrolimus/therapeutic use ; Urinary Tract Infections/epidemiology ; Young Adult
    Chemical Substances Antibodies, Monoclonal ; Immunosuppressive Agents ; Recombinant Fusion Proteins ; basiliximab (9927MT646M) ; Mycophenolic Acid (HU9DX48N0T) ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2016-09
    Publishing country England
    Document type Comparative Study ; Journal Article ; Observational Study
    ZDB-ID 632949-4
    ISSN 1525-6049 ; 0886-022X
    ISSN (online) 1525-6049
    ISSN 0886-022X
    DOI 10.1080/0886022X.2016.1209062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1331: Show issues Location:
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  3. Article ; Online: Study of peripheral blood natural killer cells, T-cell helper/T-cell suppressor ratio and intercurrent infection frequency in hepatitis C seropositive prevalent hemodialysis patients.

    Ibrahim, Mohamed A / Mostafa, Afaf A / El-Said, Heba W / Mohab, Amr M / Hebah, Hayam A

    Hemodialysis international. International Symposium on Home Hemodialysis

    2014  Volume 18 Suppl 1, Page(s) S23–31

    Abstract: Hemodialysis (HD) may adversely affect the immune system. It is established that intercurrent infection rate and severity may be increased in prevalent HD patients. Moreover, hepatitis C viral infection, a common infection in many HD centers, may further ...

    Abstract Hemodialysis (HD) may adversely affect the immune system. It is established that intercurrent infection rate and severity may be increased in prevalent HD patients. Moreover, hepatitis C viral infection, a common infection in many HD centers, may further inhibit the immune system. To our knowledge, no previous study in the literature has attempted to investigate the possible effects of hepatitis C seropositivity on rate and severity of intercurrent infection in prevalent HD patients. The aim of this study was to assess the peripheral blood CD16-natural killer cells, CD4/CD8 ratio, as well as rate of intercurrent infection in hepatitis C seropositive prevalent HD patients as compared with hepatitis C seronegative prevalent HD patients. Twenty hepatitis C seropositive stable prevalent HD patients (group A), as well as another twenty hepatitis C seronegative stable prevalent HD patients (group B), were randomly selected from our HD unit and enrolled in the study. Both groups were similar in age, sex, body mass index, and duration of HD. Diabetics, smokers, and cases with advanced liver disease (Child classification stages B and C) were excluded from the study. A third group (group C) of 10 apparently healthy subjects (of similar age, sex, and body mass index), was also enrolled in the study. All subjects were investigated by complete blood count, routine chemistry, assessment of peripheral lymphocytes CD3,CD16, CD4, CD8, CD4/CD8 ratio by flow cytometer, as well assessment of intercurrent infection frequency retrospectively (since the start of HD therapy and seroconversion in HD patients, and prospectively for a period of six months. Although we detected statistically significant higher frequency of intercurrent infection in both HD groups compared with the healthy group, we did not detect significant differences between hepatitis C seropositive and seronegative groups regarding frequency or severity of intercurrent infection. Moreover, we did not detect significant differences among the three studied groups regarding levels of CD16, CD3, CD4, CD8, CD4/CD8 ratio in peripheral lymphocytes. It may be concluded that hepatitis C seropositive prevalent HD patients are not at increased risk of intercurrent infection as compared with hepatitis C seronegative prevalent HD patients, contrary to what is reported in hepatitis C seroconverted organ transplant candidates.
    MeSH term(s) Female ; Hepatitis C, Chronic/blood ; Hepatitis C, Chronic/etiology ; Hepatitis C, Chronic/immunology ; Humans ; Killer Cells, Natural/cytology ; Killer Cells, Natural/immunology ; Male ; Middle Aged ; Prevalence ; Prospective Studies ; Renal Dialysis/adverse effects ; Renal Dialysis/methods ; Retrospective Studies ; T-Lymphocyte Subsets/immunology ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Helper-Inducer/pathology ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/pathology
    Language English
    Publishing date 2014-10
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2192458-2
    ISSN 1542-4758 ; 1492-7535
    ISSN (online) 1542-4758
    ISSN 1492-7535
    DOI 10.1111/hdi.12220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6091: Show issues Location:
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  4. Article: Plasma interleukin-1beta levels in children with febrile seizures.

    Tomoum, Hoda Y / Badawy, Nagya M / Mostafa, Afaf A / Harb, Manal Y

    Journal of child neurology

    2007  Volume 22, Issue 6, Page(s) 689–692

    Abstract: Proinflammatory and anti-inflammatory cytokines regulate the febrile response during infection. In this study, the role of cytokines in the pathogenesis of febrile seizures was investigated, through comparing levels of interleukin-1beta in the peripheral ...

    Abstract Proinflammatory and anti-inflammatory cytokines regulate the febrile response during infection. In this study, the role of cytokines in the pathogenesis of febrile seizures was investigated, through comparing levels of interleukin-1beta in the peripheral blood of children with febrile seizures and in a matched control group of children with febrile illnesses without seizures. The study included 33 children with febrile seizures (mean +/- SD, 29.94 +/- 14.9 months) and 38 controls with comparable age, sex, and type of infection. A laboratory workup for the diagnosis of infection was performed, and interleukin-1beta levels were assessed by enzyme-linked immunosorbent assay for the patients and the control groups immediately on arrival at the hospital. The plasma levels of interleukin-1beta were comparable in the patients and the control group (mean +/- SD, 7.321 +/- 3.123 and 8.087 +/- 4.8 pg/mL, respectively). Furthermore, there was no significant difference when comparing the plasma levels of interleukin-1beta in patients with simple and complex types of febrile seizures. Plasma interleukin-1beta levels did not show a significant correlation to either the duration of the last seizure, the number of the previous attacks of febrile convulsion, or the degree of temperature. However, interleukin-1beta levels were negatively correlated to the duration from the last seizure attack (r = -.8). Thus, the results of the present study do not support the hypothesis that increased production of interleukin-1beta is involved in the pathogenesis of febrile seizures in children.
    MeSH term(s) Child, Preschool ; Female ; Humans ; Infant ; Interleukin-1beta/blood ; Male ; Retrospective Studies ; Seizures, Febrile/blood ; Statistics, Nonparametric
    Chemical Substances Interleukin-1beta
    Language English
    Publishing date 2007-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639288-x
    ISSN 1708-8283 ; 0883-0738
    ISSN (online) 1708-8283
    ISSN 0883-0738
    DOI 10.1177/0883073807304007
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    Zs.A 2301: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article: Keratinocyte and lymphocyte apoptosis: relation to disease outcome in systemic lupus erythematosus patients with and without cutaneous manifestations.

    Salem, Samar Abdallah M / Farouk, Hanan Mohamed / Mostafa, Afaf A / Hassan, Iman M Aly / Osman, Wesam M / Al-Shamy, Hebat-Allah Ahmed / Assaf, Naglaa Youssef M

    European journal of dermatology : EJD

    2010  Volume 20, Issue 1, Page(s) 35–41

    Abstract: Our aim was to assess the relationship of keratinocyte and lymphocyte apoptosis and macrophage function to disease outcome in systemic lupus erythematosus patients with and without cutaneous manifestations. 50 systemic lupus erythematosus patients [25 ... ...

    Abstract Our aim was to assess the relationship of keratinocyte and lymphocyte apoptosis and macrophage function to disease outcome in systemic lupus erythematosus patients with and without cutaneous manifestations. 50 systemic lupus erythematosus patients [25 with cutaneous manifestations (group I), 25 without cutaneous manifestations (group II)] and 20 normal controls (group III) were studied. Assessments of disease activity, peripheral lymphocyte apoptosis, macrophage function and apoptotic cells in skin and renal biopsies were carried out. The mean systemic lupus erythematosus disease activity index score was significantly higher in group I than II (18.6 +/- 6, 8.8 +/- 2.7 respectively, p < 0.001). The mean percentage of peripheral apoptotic lymphocytes was significantly higher in group I than groups II, III (55.3 +/- 21.4, 25.6 +/- 8.7 & 19.4 +/- 3.2 respectively, P < 0.001), so was serum neopterin level (27.5 +/- 7.3, 14.9 +/- 2.7, 9.4 +/- 1.1 respectively, p < 0.001), and the mean number of protein53 positive apoptotic keratinocytes in skin (20.6 +/- 5.4, 1.6 +/- 0.5, 1.7 +/- 0.4 respectively, p < 0.001). A higher percentage of class IV, V glomerulonephritis was found in group I (47%, 26%, respectively) compared to group II (11% both) (p < 0.001). The mean number of protein53 positive apoptotic skin keratinocytes showed a significant positive correlation to disease activity, percentage of peripheral apoptotic lymphocytes and serum neopterin (P < 0.001). In conclusion, an accumulation of apoptotic keratinocytes and lymphocytes in systemic lupus erythematosus with cutaneous manifestations is associated with a worse disease outcome.
    MeSH term(s) Adult ; Apoptosis ; Complement C4/analysis ; Female ; Humans ; Immunohistochemistry ; Keratinocytes/immunology ; Keratinocytes/pathology ; Lupus Erythematosus, Cutaneous/immunology ; Lupus Erythematosus, Cutaneous/pathology ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/pathology ; Lymphocytes/pathology ; Male ; Middle Aged ; Neopterin/blood ; Skin/pathology ; Tumor Suppressor Protein p53/analysis ; Young Adult
    Chemical Substances Complement C4 ; Tumor Suppressor Protein p53 ; Neopterin (670-65-5)
    Language English
    Publishing date 2010-01
    Publishing country France
    Document type Journal Article
    ZDB-ID 1128666-0
    ISSN 1952-4013 ; 1167-1122
    ISSN (online) 1952-4013
    ISSN 1167-1122
    DOI 10.1684/ejd.2010.0812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3484: Show issues Location:
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