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  1. Article ; Online: Autonomic nerves differentially control inflammation during endotoxaemia.

    Mota, Clarissa M D

    The Journal of physiology

    2022  

    Language English
    Publishing date 2022-10-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP283816
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  2. Article ; Online: Neural circuits of long-term thermoregulatory adaptations to cold temperatures and metabolic demands.

    Mota, Clarissa M D / Madden, Christopher J

    Nature reviews. Neuroscience

    2024  Volume 25, Issue 3, Page(s) 143–158

    Abstract: The mammalian brain controls heat generation and heat loss mechanisms that regulate body temperature and energy metabolism. Thermoeffectors include brown adipose tissue, cutaneous blood flow and skeletal muscle, and metabolic energy sources include white ...

    Abstract The mammalian brain controls heat generation and heat loss mechanisms that regulate body temperature and energy metabolism. Thermoeffectors include brown adipose tissue, cutaneous blood flow and skeletal muscle, and metabolic energy sources include white adipose tissue. Neural and metabolic pathways modulating the activity and functional plasticity of these mechanisms contribute not only to the optimization of function during acute challenges, such as ambient temperature changes, infection and stress, but also to longitudinal adaptations to environmental and internal changes. Exposure of humans to repeated and seasonal cold ambient conditions leads to adaptations in thermoeffectors such as habituation of cutaneous vasoconstriction and shivering. In animals that undergo hibernation and torpor, neurally regulated metabolic and thermoregulatory adaptations enable survival during periods of significant reduction in metabolic rate. In addition, changes in diet can activate accessory neural pathways that alter thermoeffector activity. This knowledge may be harnessed for therapeutic purposes, including treatments for obesity and improved means of therapeutic hypothermia.
    MeSH term(s) Humans ; Animals ; Cold Temperature ; Body Temperature Regulation/physiology ; Shivering/physiology ; Neural Pathways/physiology ; Muscle, Skeletal ; Mammals
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2034150-7
    ISSN 1471-0048 ; 1471-0048 ; 1471-003X
    ISSN (online) 1471-0048
    ISSN 1471-0048 ; 1471-003X
    DOI 10.1038/s41583-023-00785-8
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  3. Article ; Online: Melanin-concentrating hormone neurons affect adipose tissues and modulate weight gain.

    Mota, Clarissa M D

    The Journal of physiology

    2021  Volume 600, Issue 4, Page(s) 727–728

    MeSH term(s) Humans ; Hypothalamic Hormones ; Melanins ; Neurons/physiology ; Pituitary Hormones ; Weight Gain
    Chemical Substances Hypothalamic Hormones ; Melanins ; Pituitary Hormones ; melanin-concentrating hormone (67382-96-1)
    Language English
    Publishing date 2021-10-26
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP282373
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  4. Article: Mediobasal hypothalamic neurons contribute to the control of brown adipose tissue sympathetic nerve activity and cutaneous vasoconstriction.

    Mota, Clarissa M D / Madden, Christopher J

    Journal of thermal biology

    2023  Volume 114, Page(s) 103551

    Abstract: The mediobasal hypothalamus (MBH) contains heterogeneous neuronal populations that regulate food intake and energy expenditure. However, the role of MBH neurons in the neural control of thermoeffector activity for thermoregulation is not known. This ... ...

    Abstract The mediobasal hypothalamus (MBH) contains heterogeneous neuronal populations that regulate food intake and energy expenditure. However, the role of MBH neurons in the neural control of thermoeffector activity for thermoregulation is not known. This study sought to determine the effects of modulating the activity of MBH neurons on the sympathetic outflow to brown adipose tissue (BAT), BAT thermogenesis, and cutaneous vasomotion. Pharmacological inhibition of MBH neurons by local administration of muscimol, a GABA
    MeSH term(s) Rats ; Animals ; Rats, Sprague-Dawley ; Adipose Tissue, Brown/metabolism ; Carbon Dioxide/metabolism ; Vasoconstriction ; Neurons/physiology ; Thermogenesis/physiology ; gamma-Aminobutyric Acid/pharmacology
    Chemical Substances Carbon Dioxide (142M471B3J) ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2023-05-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1498364-3
    ISSN 1879-0992 ; 0306-4565
    ISSN (online) 1879-0992
    ISSN 0306-4565
    DOI 10.1016/j.jtherbio.2023.103551
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  5. Article ; Online: High Fat Diet Suppresses Energy Expenditure Via Neurons in the Brainstem.

    Mota, Clarissa M D / Madden, Christopher J

    Neuroscience

    2023  Volume 520, Page(s) 84–94

    Abstract: Oxidation of fat by brown adipose tissue (BAT) contributes to energy balance and heat production. During cold exposure, BAT thermogenesis produces heat to warm the body. Obese subjects and rodents, however, show impaired BAT thermogenesis to the cold. ... ...

    Abstract Oxidation of fat by brown adipose tissue (BAT) contributes to energy balance and heat production. During cold exposure, BAT thermogenesis produces heat to warm the body. Obese subjects and rodents, however, show impaired BAT thermogenesis to the cold. Our previous studies suggest that vagal afferents synapsing in the nucleus tractus solitarius (NTS), tonically inhibit BAT thermogenesis to the cold in obese rats. NTS neurons send projections to the dorsal aspect of the lateral parabrachial nucleus (LPBd), which is a major integrative center that receives warm afferent inputs from the periphery and promotes inhibition of BAT thermogenesis. This study investigated the contribution of LPBd neurons in the impairment of BAT thermogenesis in rats fed a high-fat diet (HFD). By using a targeted dual viral vector approach, we found that chemogenetic activation of an NTS-LPB pathway inhibited BAT thermogenesis to the cold. We also found that the number of Fos-labelled neurons in the LPBd was higher in rats fed a HFD than in chow diet-fed rats after exposure to a cold ambient temperature. Nanoinjections of a GABA
    MeSH term(s) Rats ; Animals ; Diet, High-Fat/adverse effects ; Rats, Sprague-Dawley ; Thermogenesis/physiology ; Obesity ; Neurons ; Energy Metabolism ; Solitary Nucleus
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2023.04.006
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  6. Article ; Online: A new role for serotonin: the 5-HT

    Mota, Clarissa M D

    The Journal of physiology

    2019  Volume 598, Issue 1, Page(s) 23–24

    MeSH term(s) Animals ; Mice ; Receptors, Serotonin, 5-HT3 ; Serotonin ; Urinary Bladder ; Visceral Pain
    Chemical Substances Receptors, Serotonin, 5-HT3 ; Serotonin (333DO1RDJY)
    Language English
    Publishing date 2019-12-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP279094
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  7. Article ; Online: Neural control of the spleen as an effector of immune responses to inflammation: mechanisms and treatments.

    Mota, Clarissa M D / Madden, Christopher J

    American journal of physiology. Regulatory, integrative and comparative physiology

    2022  Volume 323, Issue 4, Page(s) R375–R384

    Abstract: Immune system responses are a vital defense mechanism against pathogens. Inflammatory mediators finely regulate complex inflammatory responses from initiation to resolution. However, in certain conditions, the inflammation is initiated and amplified, but ...

    Abstract Immune system responses are a vital defense mechanism against pathogens. Inflammatory mediators finely regulate complex inflammatory responses from initiation to resolution. However, in certain conditions, the inflammation is initiated and amplified, but not resolved. Understanding the biological mechanisms underlying the regulation of the immune response is critical for developing therapeutic alternatives, including pharmaceuticals and bioelectronic tools. The spleen is an important immune effector organ since it orchestrates innate and adaptive immune responses such as pathogen clearance, cytokine production, and differentiation of cells, therefore playing a modulatory role that balances pro- and anti-inflammatory responses. However, modulation of splenic immune activity is a largely unexplored potential therapeutic tool that could be used for the treatment of inflammatory and life-threatening conditions. This review discusses some of the mechanisms controlling neuroimmune communication and the brain-spleen axis.
    MeSH term(s) Humans ; Immune System ; Immunity, Innate ; Inflammation ; Neuroimmunomodulation/physiology ; Spleen
    Language English
    Publishing date 2022-08-22
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 603839-6
    ISSN 1522-1490 ; 0363-6119
    ISSN (online) 1522-1490
    ISSN 0363-6119
    DOI 10.1152/ajpregu.00151.2022
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  8. Article ; Online: Neural circuits mediating circulating interleukin-1β-evoked fever in the absence of prostaglandin E2 production.

    Mota, Clarissa M D / Madden, Christopher J

    Brain, behavior, and immunity

    2022  Volume 103, Page(s) 109–121

    Abstract: Infectious diseases and inflammatory conditions recruit the immune system to mount an appropriate acute response that includes the production of cytokines. Cytokines evoke neurally-mediated responses to fight pathogens, such as the recruitment of ... ...

    Abstract Infectious diseases and inflammatory conditions recruit the immune system to mount an appropriate acute response that includes the production of cytokines. Cytokines evoke neurally-mediated responses to fight pathogens, such as the recruitment of thermoeffectors, thereby increasing body temperature and leading to fever. Studies suggest that the cytokine interleukin-1β (IL-1β) depends upon cyclooxygenase (COX)-mediated prostaglandin E
    MeSH term(s) Adipose Tissue, Brown/physiology ; Animals ; Dinoprostone/metabolism ; Fever/chemically induced ; Hypothalamus/physiology ; Indomethacin ; Interleukin-1beta/blood ; Interleukin-1beta/pharmacology ; Rats ; Rats, Sprague-Dawley ; Sympathetic Nervous System ; Thermogenesis
    Chemical Substances Interleukin-1beta ; Dinoprostone (K7Q1JQR04M) ; Indomethacin (XXE1CET956)
    Language English
    Publishing date 2022-04-14
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2022.04.008
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  9. Article ; Online: A blood-to-brain delivery system to treat obesity.

    Mota, Clarissa M D / Madden, Christopher J

    Nature metabolism

    2021  Volume 3, Issue 10, Page(s) 1288–1289

    Language English
    Publishing date 2021-10-21
    Publishing country Germany
    Document type Journal Article
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-021-00463-y
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  10. Article ; Online: Acute deep brain stimulation of the paraventricular nucleus of the hypothalamus increases brown adipose tissue thermogenesis in rats.

    Mota, Clarissa M D / Siler, Dominic A / Burchiel, Kim J / Madden, Christopher J

    Neuroscience letters

    2023  Volume 799, Page(s) 137130

    Abstract: Brown adipose tissue (BAT) activity is controlled by the sympathetic nervous system. Activation of BAT has shown significant promise in preclinical studies to elicit weight loss. Since the hypothalamic paraventricular nucleus (PVN) contributes to the ... ...

    Abstract Brown adipose tissue (BAT) activity is controlled by the sympathetic nervous system. Activation of BAT has shown significant promise in preclinical studies to elicit weight loss. Since the hypothalamic paraventricular nucleus (PVN) contributes to the regulation of BAT thermogenic activity, we sought to determine the effects of electrical stimulation of the PVN as a model of deep brain stimulation (DBS) for increasing BAT sympathetic nerve activity (SNA). The rostral raphe pallidus area (rRPa) was also chosen as a target for DBS since it contains the sympathetic premotor neurons for BAT. Electrical stimulation (100 µA, 100 µs, 100 Hz, for 5 min at a 50 % duty cycle) of the PVN increased BAT SNA and BAT thermogenesis. These effects were prevented by a local nanoinjection of bicuculline, a GABA
    MeSH term(s) Rats ; Animals ; Paraventricular Hypothalamic Nucleus ; Rats, Sprague-Dawley ; Bicuculline/pharmacology ; Adipose Tissue, Brown/innervation ; Deep Brain Stimulation ; Thermogenesis ; Hypothalamus ; gamma-Aminobutyric Acid/metabolism ; Sympathetic Nervous System/metabolism
    Chemical Substances Bicuculline (Y37615DVKC) ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2023-02-14
    Publishing country Ireland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2023.137130
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