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  1. Article ; Online: Comparing Budesonide and Fluticasone Propionate in Children with Moderate to Severe Asthma: A Pilot Randomized Controlled Trial.

    Sadeghzadeh, Mansour / Khoshnevisasl, Parisa / Ahmadiafshar, Akefeh / Motamed, Nima / Pourmarjani, Azadeh

    Iranian journal of allergy, asthma, and immunology

    2023  Volume 22, Issue 6, Page(s) 527–535

    Abstract: The aim of asthma treatment is to reduce airway inflammation by avoiding environmental triggers and using daily anti-inflammatory medications. This study aimed to compare the effects of fluticasone propionate (FP) and budesonide (Bud) on the clinical ... ...

    Abstract The aim of asthma treatment is to reduce airway inflammation by avoiding environmental triggers and using daily anti-inflammatory medications. This study aimed to compare the effects of fluticasone propionate (FP) and budesonide (Bud) on the clinical symptoms and control of asthma in children with moderate to severe asthma. In this open-label study, children with moderate to severe asthma were randomly selected to receive either FP 250 mcg or Bud 400 mcg for 3 months. Asthma control test scores were measured in both groups monthly. The clinical symptoms, drug adherence, and rescue medication were also evaluated. A total of 50 patients with ages between 4 and 7 years old were included in the study (25 cases received Bud and 25 cases received FP). Asthma control test scores, daily and nocturnal symptoms, and cough rates were significantly improved in both groups. The average asthma control scores for the fluticasone group were 21.68±3.32 in the second month and 24.84±2.67 in the third month, whereas the budesonide group had scores of 18.52±3.32 and 22.48±4.12 during the same periods. These variances were statistically significant. Additionally, the requirement for salbutamol use was notably reduced in the fluticasone group compared to the budesonide group throughout all three months. The efficacy of fluticasone propionate in decreasing the need for rescue medication and enhancing asthma control test scores was markedly superior to that of budesonide.
    MeSH term(s) Child ; Humans ; Child, Preschool ; Fluticasone ; Budesonide ; Pilot Projects ; Asthma ; Albuterol
    Chemical Substances Fluticasone (CUT2W21N7U) ; Budesonide (51333-22-3) ; Albuterol (QF8SVZ843E)
    Language English
    Publishing date 2023-12-28
    Publishing country Iran
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2488724-9
    ISSN 1735-5249 ; 1735-1502
    ISSN (online) 1735-5249
    ISSN 1735-1502
    DOI 10.18502/ijaai.v22i6.14642
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  2. Article: Does Bleaching Affect the Microleakage of Class II Restoration with Bulk-Fill Composite?

    Zajkani, Elham / Rahbar, Mahdi / Motamed, Nima / Kordlou, Eissa

    International journal of dentistry

    2022  Volume 2022, Page(s) 9924553

    Abstract: Introduction: The use of technology in bulk-fill composites (BCs) has reduced the stresses caused by polymerization shrinkage, debonding, microleakage, or posttreatment sensitivity in them. This study was conducted to determine whether bleaching affects ...

    Abstract Introduction: The use of technology in bulk-fill composites (BCs) has reduced the stresses caused by polymerization shrinkage, debonding, microleakage, or posttreatment sensitivity in them. This study was conducted to determine whether bleaching affects the microleakage of class II restoration with bulk-fill material.
    Materials and methods: This laboratory study was performed on 40 normal human premolars in 4 groups (
    Results: Microleakage was determined in the CC group (0.97 ± 0.42), BC group (1.08 ± 0.54), CCB group (1.19 ± 0.37), and BCB group (0.30 ± 0.47). There were also no significant differences in the mean microleakage between the groups. No cases with zero microleakage (no microleakage) and grade 3 of microleakage (pigment penetration into the axial wall) were observed in the samples. Also, a two-by-two comparison of significant differences between CC and BC groups (
    Conclusion: Results showed no difference between microleakage of BC and CC with and without bleaching, and bleaching had the same effect on microleakage of these two types of composites.
    Language English
    Publishing date 2022-01-05
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2546524-7
    ISSN 1687-8736 ; 1687-8728
    ISSN (online) 1687-8736
    ISSN 1687-8728
    DOI 10.1155/2022/9924553
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  3. Article ; Online: The Effect of Magnesium Supplementation on Insulin Resistance and Metabolic Profiles in Women with Polycystic Ovary Syndrome: a Randomized Clinical Trial.

    Shahmoradi, Shabnam / Chiti, Hossein / Tavakolizadeh, Mahdi / Hatami, Robabeh / Motamed, Nima / Ghaemi, Marjan

    Biological trace element research

    2023  Volume 202, Issue 3, Page(s) 941–946

    Abstract: Due to the definitive known effect of magnesium on insulin resistance and the fact that insulin resistance is a main etiology in polycystic ovary syndrome (PCOS), it is assumed the use of magnesium supplements can improve insulin resistance, lipid ... ...

    Abstract Due to the definitive known effect of magnesium on insulin resistance and the fact that insulin resistance is a main etiology in polycystic ovary syndrome (PCOS), it is assumed the use of magnesium supplements can improve insulin resistance, lipid profiles, and glucose and thus may also play a role in improving the clinical condition of patients with PCOS. We aimed to assess the effects of magnesium supplements on anthropometric, clinical, and metabolic parameters in women suffering from PCOS. This triple-blind randomized clinical trial study was conducted on women aged 15-35 years with PCOS. The patients were randomly assigned to receive a magnesium oxide supplement (250 mg/day for 2 months) or a placebo. The study parameters were evaluated and compared between two groups before as well as 2 months and 5 months after the initial assessment. In total, 40 cases (20 in each group) were recruited in the study. A significant reduction in the serum insulin level (P-value = 0.036) and insulin resistance (p-value = 0.032) was observed in the case group. Prescribing magnesium supplements could also lead to lowering total cholesterol, low-density lipoprotein, and fasting blood sugar along with increasing the level of high-density lipoprotein. We could not find any significant difference in anthropometric parameters as well as the mean systolic and diastolic blood pressures before and after intervention between the two groups. Although the rate of oligomenorrhea significantly decreased in the two study groups, it was no different across the two groups before and also after the intervention. The use of magnesium supplements in patients with PCO, regardless of the etiology or progression of the disease, can greatly improve the metabolic status of these patients by improving insulin resistance and modulating the level of lipid profile.
    MeSH term(s) Female ; Humans ; Blood Glucose ; Dietary Supplements ; Double-Blind Method ; Insulin/metabolism ; Insulin Resistance/physiology ; Lipids ; Magnesium ; Metabolome ; Polycystic Ovary Syndrome/drug therapy ; Adolescent ; Young Adult ; Adult
    Chemical Substances Blood Glucose ; Insulin ; Lipids ; Magnesium (I38ZP9992A)
    Language English
    Publishing date 2023-07-02
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 445336-0
    ISSN 1559-0720 ; 0163-4984
    ISSN (online) 1559-0720
    ISSN 0163-4984
    DOI 10.1007/s12011-023-03744-7
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  4. Article ; Online: Correction to: The Effect of Magnesium Supplementation on Insulin Resistance and Metabolic Profles in Women with Polycystic Ovary Syndrome: A Randomized Clinical Trial.

    Shahmoradi, Shabnam / Chiti, Hossein / Tavakolizadeh, Mahdi / Hatami, Robabeh / Motamed, Nima / Ghaemi, Marjan

    Biological trace element research

    2023  Volume 202, Issue 5, Page(s) 2402

    Language English
    Publishing date 2023-07-31
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 445336-0
    ISSN 1559-0720 ; 0163-4984
    ISSN (online) 1559-0720
    ISSN 0163-4984
    DOI 10.1007/s12011-023-03794-x
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  5. Article ; Online: Genetic variations in IKZF3, LET7-a2, and CDKN2B-AS1: Exploring associations with metabolic syndrome susceptibility and clinical manifestations.

    Paniri, Alireza / Hosseini, Mohammad Mahdi / Fattahi, Sadegh / Amiribozorgi, Galia / Asouri, Mohsen / Maadi, Mansooreh / Motamed, Nima / Zamani, Farhad / Akhavan-Niaki, Haleh

    Journal of clinical laboratory analysis

    2024  Volume 38, Issue 1-2, Page(s) e24999

    Abstract: Background and aim: Metabolic syndrome (MetS) increases the risk of atherosclerosis and diabetes, but there are no approved predictive markers. This study assessed the role of specific genetic variations in MetS susceptibility and their impact on ... ...

    Abstract Background and aim: Metabolic syndrome (MetS) increases the risk of atherosclerosis and diabetes, but there are no approved predictive markers. This study assessed the role of specific genetic variations in MetS susceptibility and their impact on clinical manifestations.
    Method: In this study, a genotype-phenotype assessment was performed for IKZF3 (rs907091), microRNA-let-7a-2 (rs1143770), and lncRNA-CDKN2B-AS1 (rs1333045).
    Results: Analyses indicate that while rs907091 and rs1143770 may have potential associations with MetS susceptibility and an increased risk of atherosclerosis and diabetes, there is an observed trend suggesting that the rs1333045 CC genotype may be associated with a decreased risk of MetS. The genotypes and allele frequencies of rs1333045 were significantly different between studied groups (OR = 0.56, 95% CI 0.38-0.81, p = 0.002, and OR = 0.71, 95% CI 0.55-0.92, p = 0.008), with the CC genotype displaying increased levels of HDL. Furthermore, the rs907091 TT genotype was associated with increased triglyceride, cholesterol, and HOMA index in MetS patients. Subjects with the CC genotype for rs1143770 had higher HbA1c and BMI. In silico analyses illustrated that rs907091 C remarkably influences the secondary structure and the target site of a broad spectrum of microRNAs, especially hsa-miR-4497. Moreover, rs1333045 creates a binding site for seven different microRNAs.
    Conclusion: Further studies on other populations may help confirm these SNPs as useful predictive markers in assessing the MetS risk.
    MeSH term(s) Humans ; Atherosclerosis ; Diabetes Mellitus ; Genetic Predisposition to Disease/genetics ; Genotype ; Ikaros Transcription Factor/genetics ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Polymorphism, Single Nucleotide/genetics ; RNA, Long Noncoding ; RNA, Antisense/genetics
    Chemical Substances CDKN2B protein, human ; Ikaros Transcription Factor (148971-36-2) ; IKZF3 protein, human ; MicroRNAs ; mirnlet7 microRNA, human ; RNA, Long Noncoding ; RNA, Antisense
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645095-7
    ISSN 1098-2825 ; 0887-8013
    ISSN (online) 1098-2825
    ISSN 0887-8013
    DOI 10.1002/jcla.24999
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  6. Article: Effect of Simvastatin and Low-Level Laser Therapy on Sutural Bone Formation After Expansion in Rats: Biomechanical, Computed Tomography and Immunohistochemical Assessment.

    Farzan, Arash / Moshiri, Ali / Andalib, Sina / Shamsi, Mostafa / Motamed, Nima

    Journal of lasers in medical sciences

    2022  Volume 13, Page(s) e21

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2022-05-10
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2658681-2
    ISSN 2228-6721 ; 2008-9783
    ISSN (online) 2228-6721
    ISSN 2008-9783
    DOI 10.34172/jlms.2022.21
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  7. Article ; Online: The association between dietary inflammatory index (DII) scores and c-reactive protein (CRP) and nonalcoholic fatty liver disease (NAFLD) in a general population cohort.

    Doustmohammadian, Azam / Amirkalali, Bahareh / Esfandyari, Saeed / Motamed, Nima / Maadi, Mansooreh / Shivappa, Nitin / Gholizadeh, Esmaeel / Hébert, James R / Zamani, Farhad

    Clinical nutrition ESPEN

    2024  Volume 60, Page(s) 156–164

    Abstract: Background and aims: Although there is extensive literature showing the ability of the dietary inflammation index (DII®) to predict concentrations of plasma inflammatory markers, few studies are testing the association between DII scores and ... ...

    Abstract Background and aims: Although there is extensive literature showing the ability of the dietary inflammation index (DII®) to predict concentrations of plasma inflammatory markers, few studies are testing the association between DII scores and nonalcoholic fatty liver disease (NAFLD). Considering the high prevalence of NAFLD and its complications, we conducted a validation study of DII scores and examined its association with NAFLD in the general adult population of Iran.
    Methods: This cross-sectional study was conducted on 3110 adult participants in the Amol Cohort Study (AmolCS) who underwent abdominal ultrasonography to diagnose NAFLD. DII and energy-adjusted DII (E-DII™) scores were computed using data from a valid semi-quantitative 168-item food frequency questionnaire (FFQ). Multivariable logistic regression adjusting for socio-demographic, lifestyle, and health-related factors was used to assess association.
    Results: The EDII was associated with CRP inflammatory biomarker. Participants in the highest, i.e., most pro-inflammatory tertile had the highest odds of NAFLD by ultrasound in all models [fully adjusted model: OR (95 % CI)
    Conclusions: Our results suggest that diet plays a role in regulating inflammation. Additionally, we observed an inflammatory diet predicts the risk of NAFLD in Iranian adults. However, longitudinal studies are required in order to further substantiate the utility of the DII in the development of more effective dietary interventions among populations at risk of chronic disease.
    MeSH term(s) Male ; Adult ; Humans ; Female ; C-Reactive Protein/metabolism ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Cohort Studies ; Cross-Sectional Studies ; Iran/epidemiology ; Obesity, Abdominal ; Diet ; Inflammation ; Obesity
    Chemical Substances C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2405-4577
    ISSN (online) 2405-4577
    DOI 10.1016/j.clnesp.2024.01.017
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  8. Article: Prevalence of Occult Hepatitis B Virus Infection in Hemodialysis Patients Using Nested PCR.

    Samadi, Elham / Mirshahabi, Hessam / Motamed, Nima / Sadeghi, Hamid

    Reports of biochemistry & molecular biology

    2020  Volume 9, Issue 1, Page(s) 82–88

    Abstract: Background: Occult hepatitis B infection (OBI) is defined as the lack of detectable HBsAg in serum, despite the presence of intrahepatic viral DNA, and low levels of covalently closed circular DNA (cccDNA). Since the hemodialysis patients are at a ... ...

    Abstract Background: Occult hepatitis B infection (OBI) is defined as the lack of detectable HBsAg in serum, despite the presence of intrahepatic viral DNA, and low levels of covalently closed circular DNA (cccDNA). Since the hemodialysis patients are at a greater disadvantage if they are a carrier of Hep B, as it can lead to OBI this study was designed to determine the prevalence of OBI in hemodialysis patients residing in Zanjan, Iran.
    Methods: We conducted an anti-HBc test (ELISA) on 166 HBsAg negative hemodialysis patient samples. OBI was evaluated using seropositive (anti-HBc and/or anti-HBs) and seronegative (anti-HBc and anti-HBs) using nested PCR.
    Results: Out of the total hemodialysis patients sampled, the study consisted of 58.4% male and 41.6% female participants. The age of the study group ranged from 58.89±15.49, and had received approximately 28.27±27.43 years of dialysis. Additionally, 5.4% of patients had a history of blood transfusions, while 58.4% were vaccinated against the hepatitis B virus (HBV). Moreover, 23.5% patients were anti-HBc positive, while 76.5% patients tested negative. Lastly, 66.3% of the patients were positive for anti-HBs, whereas 33.7% were negative for anti-HBs. Overall, the study revealed that the prevalence of OBI was 6%, and HBV DNA was detected in 2.1% of individuals who were vaccinated against hepatitis B (p < 0.01).
    Conclusion: Though no significant difference between the prevalence of OBI to the patients' age, sex, duration of dialysis, or history of blood transfusion was identified, however, a strong correlation between the prevalence of OBI to HBV vaccination was found.
    Language English
    Publishing date 2020-08-13
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2743890-9
    ISSN 2322-3480
    ISSN 2322-3480
    DOI 10.29252/rbmb.9.1.82
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  9. Article ; Online: Clinical values of expression signature of circCDR1AS and circHIAT1 in prostate cancer: Two circRNAs with regulatory function in androgen receptor (AR) and PI3K/AKT signaling pathways.

    Aghajani Mir, Mahsa / Dinmohammadi, Hossein / Moudi, Emadoddin / Motamed, Nima / Daraei, Abdolreza

    Journal of clinical laboratory analysis

    2022  Volume 36, Issue 2, Page(s) e24220

    Abstract: Background: Prostate cancer (PCa) is a genetically heterogeneous disease with highly molecular aberrations. It has been revealed that a newly discovered class of non-coding RNAs called circular RNAs (circRNAs) play key roles in dictating tumor behaviors ...

    Abstract Background: Prostate cancer (PCa) is a genetically heterogeneous disease with highly molecular aberrations. It has been revealed that a newly discovered class of non-coding RNAs called circular RNAs (circRNAs) play key roles in dictating tumor behaviors and phenotypes of the prostate tumors. In the current study, our aim was to determine the expression profiles of circHIAT1 and circCDR1AS in PCa compared with benign prostatic hyperplasia (BPH) tissues, as well as their clinicopathological relevance.
    Methods: The 50 prostate tissues including 25 PCa tissues and 25 BPH samples were collected for analyzing the expression levels of target circRNAs by quantitative real-time PCR (qRT-PCR).
    Results: The results revealed that expression of circCDR1AS was significantly elevated in PCa compared with the BPH (p < 0.05). We also observed that PCa patients over the age of 60 had a higher expression of the circCDR1AS than patients under the age of 60 (p = 0.017). Moreover, a lower expression level of circHIAT1 was found in the PCa than BPH tissues (p < 0.05), and finally, the findings indicated that the area under the curve (AUC) of circCDR1AS was 0.848, with 92% sensitivity and 76% specificity, as well as an AUC of 0.828, with the 80% sensitivity and 76% specificity for circHIAT1.
    Conclusion: These observations suggest that the abnormal expression of circCDR1AS and circHIAT1 can be regarded as two different types of molecular pathology with potential biomarker values for PCa, although further studies are needed.
    MeSH term(s) Area Under Curve ; Biomarkers, Tumor ; Humans ; Male ; Prostate/metabolism ; Prostatic Hyperplasia/genetics ; Prostatic Hyperplasia/metabolism ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; RNA, Circular/metabolism ; Real-Time Polymerase Chain Reaction ; Receptors, Androgen ; Signal Transduction
    Chemical Substances Biomarkers, Tumor ; RNA, Circular ; Receptors, Androgen ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2022-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645095-7
    ISSN 1098-2825 ; 0887-8013
    ISSN (online) 1098-2825
    ISSN 0887-8013
    DOI 10.1002/jcla.24220
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  10. Article ; Online: Association between Vitamin D Insufficiency and Respiratory Problems in Premature Neonates.

    Jafari, Nahid / Taslimi Taleghani, Naeeme / Kazemi, Sayed AliNaghi / Abouoasef, Shabnam / Motamed, Nima / Jalilvand, Ahmad

    Archives of Iranian medicine

    2022  Volume 25, Issue 1, Page(s) 32–36

    Abstract: Background: Few studies have been performed to investigate the association between vitamin D and respiratory problems in premature neonates.: Methods: In this cohort study, a low serum level of vitamin D was considered as exposure and respiratory ... ...

    Abstract Background: Few studies have been performed to investigate the association between vitamin D and respiratory problems in premature neonates.
    Methods: In this cohort study, a low serum level of vitamin D was considered as exposure and respiratory problems and associated interventions were considered as outcome. All patients were followed during their hospital stay. All preterm neonates admitted to the neonatal intensive care unit of a general hospital in Iran during one-year period from January 2018 were enrolled in this study. Serum vitamin D level was measured in the first 24 hours of life by liquid chromatography-spectrometry. Then, respiratory complications were compared between neonates with and without vitamin D insufficiency.
    Results: Among the 113 preterm newborns, 65 (58%) had a low and 48 (42%) had a normal level of vitamin D who were classified into two groups I and II, respectively. Respiratory distress syndrome (RDS) and requirement for surfactant administration was found in 40 cases (61.5%) in group I and in 20 cases (41.7%) in group II (
    Conclusion: The incidence of RDS, need for surfactants, and need for NIV in newborns with vitamin D insufficiency were higher than the neonates with normal levels.
    MeSH term(s) Cohort Studies ; Humans ; Infant, Newborn ; Infant, Premature ; Respiratory Distress Syndrome, Newborn/epidemiology ; Respiratory Distress Syndrome, Newborn/etiology ; Vitamin D ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2022-01-01
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2204979-4
    ISSN 1735-3947 ; 1029-2977
    ISSN (online) 1735-3947
    ISSN 1029-2977
    DOI 10.34172/aim.2022.06
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