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Article ; Online: The kinetics of signaling through the common FcRγ chain determine cytokine profiles in dendritic cells.

Watanabe, Miyuki / Motooka, Daisuke / Yamasaki, Sho

2023 Volume 16, Issue 775, Page(s) eabn9909

Abstract: The common Fc receptor γ (FcRγ) chain is a signaling subunit common to several immune receptors, but cellular responses induced by FcRγ-coupled receptors are diverse. We investigated the mechanisms by which FcRγ generates divergent signals when coupled ... ...

Abstract	The common Fc receptor γ (FcRγ) chain is a signaling subunit common to several immune receptors, but cellular responses induced by FcRγ-coupled receptors are diverse. We investigated the mechanisms by which FcRγ generates divergent signals when coupled to Dectin-2 and Mincle, structurally similar C-type lectin receptors that induce the release of different cytokines from dendritic cells. Chronological tracing of transcriptomic and epigenetic changes upon stimulation revealed that Dectin-2 induced early and strong signaling, whereas Mincle-mediated signaling was delayed, which reflects their expression patterns. Generation of early and strong FcRγ-Syk signaling by engineered chimeric receptors was sufficient to recapitulate a Dectin-2-like gene expression profile. Early Syk signaling selectively stimulated the activity of the calcium ion-activated transcription factor NFAT, which rapidly altered the chromatin status and transcription of the
MeSH term(s)	Receptors, Fc ; Kinetics ; Signal Transduction ; Receptors, IgG/genetics ; Cytokines ; Dendritic Cells
Chemical Substances	Receptors, Fc ; Receptors, IgG ; Cytokines
Language	English
Publishing date	2023-03-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2417226-1
ISSN	1937-9145 ; 1945-0877
ISSN (online)	1937-9145
ISSN	1945-0877
DOI	10.1126/scisignal.abn9909
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Article ; Online: Genetic Landscape of Masticatory Muscle Tendon-Aponeurosis Hyperplasia.

Tajima, Rina / Okazaki, Atsuko / Sato, Tsuyoshi / Ozaki, Kokoro / Motooka, Daisuke / Okazaki, Yasushi / Yoda, Tetsuya

Genes

2023 Volume 14, Issue 9

Abstract: Limited mouth opening is a characteristic of masticatory muscle tendon-aponeurosis hyperplasia (MMTAH). Although genetic involvement is suspected where familial onset is frequently observed, the genetic background of MMTAH is yet to be elucidated. In ... ...

Abstract	Limited mouth opening is a characteristic of masticatory muscle tendon-aponeurosis hyperplasia (MMTAH). Although genetic involvement is suspected where familial onset is frequently observed, the genetic background of MMTAH is yet to be elucidated. In this study, we conducted whole genome sequencing of 10 patients with MMTAH and their family members when available. We also conducted RNA sequencing of normal temporal tendon (as disease region) and Achilles tendon (as control region) from commercially available pig samples. We identified 51 genes that had rare variants in patients with MMTAH and were highly expressed in the temporal tendons of pigs. Among the 51 genes, 37 genes have not been reported to be causative for human genetic diseases so far. As an implication of genetic involvement in the pathogenesis of MMTAH, 21 of these 37 genes were identified in two independent families. In particular,
Language	English
Publishing date	2023-08-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14091718
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Article ; Online: Carbapenem triggers dissemination of chromosomally integrated carbapenemase genes via conjugative plasmids in

Abe, Ryuichiro / Akeda, Yukihiro / Sugawara, Yo / Matsumoto, Yuki / Motooka, Daisuke / Iida, Tetsuya / Hamada, Shigeyuki

mSystems

2023 Volume 8, Issue 3, Page(s) e0127522

Abstract: Epidemiological surveys have shown that carbapenem resistance is mainly transmitted across species by carbapenemase genes located on conjugative plasmids. As chromosomal integration of carbapenemase genes has rarely been identified, only a few studies ... ...

Abstract	Epidemiological surveys have shown that carbapenem resistance is mainly transmitted across species by carbapenemase genes located on conjugative plasmids. As chromosomal integration of carbapenemase genes has rarely been identified, only a few studies have investigated their advantages to the carbapenem-resistant bacterial community. Here, we confirmed the increased stability of
MeSH term(s)	Carbapenems/pharmacology ; Escherichia coli/genetics ; Meropenem/pharmacology ; Anti-Bacterial Agents/pharmacology ; Plasmids/genetics
Chemical Substances	Carbapenems ; carbapenemase (EC 3.5.2.6) ; Meropenem (FV9J3JU8B1) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-06-05
Publishing country	United States
Document type	Journal Article
ISSN	2379-5077
ISSN (online)	2379-5077
DOI	10.1128/msystems.01275-22
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Article ; Online: Fungal dysbiosis and decreased tear mucin at the conjunctiva in patients with conjunctival mucosa-associated lymphoid tissue lymphoma.

Asao, Kazunobu / Hashida, Noriyasu / Motooka, Daisuke / Tsukamoto, Teruhisa / Nakamura, Shota / Maruyama, Kazuichi / Nishida, Kohji

BMJ open ophthalmology

2023 Volume 8, Issue 1

Abstract: Objective: This study aimed to examine the differences in the fungal microbiome between patients with conjunctival mucosa-associated lymphoid tissue (MALT) and healthy controls using metagenomic analysis.: Methods and analysis: This case-control ... ...

Abstract	Objective: This study aimed to examine the differences in the fungal microbiome between patients with conjunctival mucosa-associated lymphoid tissue (MALT) and healthy controls using metagenomic analysis. Methods and analysis: This case-control study was conducted at Osaka University Hospital in Osaka, Japan, from April 2015 to March 2022. Twenty-five consecutive patients with conjunctival MALT lymphoma and 25 healthy volunteers were included. Metagenomic analysis using Internal Transcribed Spacer (ITS)1 deep sequencing and hierarchical clustering was performed to investigate differences in the fungal microbiome. To assess tear environmental change, we measured tear mucin concentrations using ELISA. Results: Detailed analyses showed fungal dysbiosis and changes in β-diversity within the conjunctiva of patients with conjunctival MALT lymphoma. Hierarchical clustering revealed that the participants could be divided into three clusters according to the Conclusion: The metagenomic analysis using ITS1 deep sequencing was useful for identifying the differences in commensal fungi between patients with MALT lymphoma and healthy individuals. The increased prevalence of the
MeSH term(s)	Humans ; Lymphoma, B-Cell, Marginal Zone/microbiology ; Case-Control Studies ; Mucins ; Dysbiosis/pathology ; Conjunctiva/pathology ; Conjunctival Neoplasms/microbiology ; Lacerations/pathology ; Neoplasms, Connective Tissue/pathology ; Skin Neoplasms/pathology
Chemical Substances	Mucins
Language	English
Publishing date	2023-09-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2397-3269
ISSN (online)	2397-3269
DOI	10.1136/bmjophth-2023-001360
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Article: Identification of invasive subpopulations using spatial transcriptome analysis in thyroid follicular tumors.

Suzuki, Ayana / Nojima, Satoshi / Tahara, Shinichiro / Motooka, Daisuke / Kohara, Masaharu / Okuzaki, Daisuke / Hirokawa, Mitsuyoshi / Morii, Eiichi

Journal of pathology and translational medicine

2024 Volume 58, Issue 1, Page(s) 22–28

Abstract: Background: Follicular tumors include follicular thyroid adenomas and carcinomas; however, it is difficult to distinguish between the two when the cytology or biopsy material is obtained from a portion of the tumor. The presence or absence of invasion ... ...

Abstract	Background: Follicular tumors include follicular thyroid adenomas and carcinomas; however, it is difficult to distinguish between the two when the cytology or biopsy material is obtained from a portion of the tumor. The presence or absence of invasion in the resected material is used to differentiate between adenomas and carcinomas, which often results in the unnecessary removal of the adenomas. If nodules that may be follicular thyroid carcinomas are identified preoperatively, active surveillance of other nodules as adenomas is possible, which reduces the risk of surgical complications and the expenses incurred during medical treatment. Therefore, we aimed to identify biomarkers in the invasive subpopulation of follicular tumor cells. Methods: We performed a spatial transcriptome analysis of a case of follicular thyroid carcinoma and examined the dynamics of CD74 expression in 36 cases. Results: We identified a subpopulation in a region close to the invasive area, and this subpopulation expressed high levels of CD74. Immunohistochemically, CD74 was highly expressed in the invasive and peripheral areas of the tumor. Conclusions: Although high CD74 expression has been reported in papillary and anaplastic thyroid carcinomas, it has not been analyzed in follicular thyroid carcinomas. Furthermore, the heterogeneity of CD74 expression in thyroid tumors has not yet been reported. The CD74-positive subpopulation identified in this study may be useful in predicting invasion of follicular thyroid carcinomas.
Language	English
Publishing date	2024-01-10
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	3022395-7
ISSN	2383-7845 ; 2383-7837
ISSN (online)	2383-7845
ISSN	2383-7837
DOI	10.4132/jptm.2023.11.21
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Article ; Online: Clostridium butyricum Bacteremia Associated with Probiotic Use, Japan.

Sada, Ryuichi Minoda / Matsuo, Hiroo / Motooka, Daisuke / Kutsuna, Satoshi / Hamaguchi, Shigeto / Yamamoto, Go / Ueda, Akiko

Emerging infectious diseases

2024 Volume 30, Issue 4, Page(s) 665–671

Abstract: Clostridium butyricum, a probiotic commonly prescribed in Asia, most notably as MIYA-BM (Miyarisan Pharmaceutical Co., Ltd.; https://www.miyarisan.com), occasionally leads to bacteremia. The prevalence and characteristics of C. butyricum bacteremia and ... ...

Abstract	Clostridium butyricum, a probiotic commonly prescribed in Asia, most notably as MIYA-BM (Miyarisan Pharmaceutical Co., Ltd.; https://www.miyarisan.com), occasionally leads to bacteremia. The prevalence and characteristics of C. butyricum bacteremia and its bacteriologic and genetic underpinnings remain unknown. We retrospectively investigated patients admitted to Osaka University Hospital during September 2011-February 2023. Whole-genome sequencing revealed 5 (0.08%) cases of C. butyricum bacteremia among 6,576 case-patients who had blood cultures positive for any bacteria. Four patients consumed MIYA-BM, and 1 patient consumed a different C. butyricum-containing probiotic. Most patients had compromised immune systems, and common symptoms included fever and abdominal distress. One patient died of nonocclusive mesenteric ischemia. Sequencing results confirmed that all identified C. butyricum bacteremia strains were probiotic derivatives. Our findings underscore the risk for bacteremia resulting from probiotic use, especially in hospitalized patients, necessitating judicious prescription practices.
MeSH term(s)	Humans ; Clostridium butyricum/genetics ; Japan/epidemiology ; Retrospective Studies ; Probiotics/adverse effects ; Bacteremia/epidemiology
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid3004.231633
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Zs.A 4778: Show issues

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Article ; Online: RN7SL1 may be translated under oncogenic conditions.

Hara, Tomoaki / Meng, Sikun / Tsuji, Yoshiko / Arao, Yasuko / Saito, Yoshiko / Sato, Hiromichi / Motooka, Daisuke / Uchida, Shizuka / Ishii, Hideshi

Proceedings of the National Academy of Sciences of the United States of America

2024 Volume 121, Issue 12, Page(s) e2312322121

Abstract: RN7SL1 (RNA component of signal recognition particle 7SL1), a component of the signal recognition particle, is a non-coding RNA possessing a small ORF (smORF). However, whether it is translated into peptides is unknown. Here, we generated the RN7SL1- ... ...

Abstract	RN7SL1 (RNA component of signal recognition particle 7SL1), a component of the signal recognition particle, is a non-coding RNA possessing a small ORF (smORF). However, whether it is translated into peptides is unknown. Here, we generated the RN7SL1-Green Fluorescent Protein (GFP) gene, in which the smORF of RN7SL1 was replaced by GFP, introduced it into 293T cells, and observed cells emitting GFP fluorescence. Furthermore, RNA-seq of GFP-positive cells revealed that they were in an oncogenic state, suggesting that RN7SL1 smORF may be translated under special conditions.
MeSH term(s)	Signal Recognition Particle/metabolism ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Peptides/metabolism
Chemical Substances	Signal Recognition Particle ; Green Fluorescent Proteins (147336-22-9) ; Peptides
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2312322121
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Zs.A 1148: Show issues

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Article ; Online: Development of transgenic mice overexpressing mouse carbonyl reductase 1

Yokoyama, Minako / Fujita, Toshitsugu / Kadonosawa, Yuka / Tatara, Yota / Motooka, Daisuke / Ikawa, Masahito / Fujii, Hodaka / Yokoayama, Yoshihito

Mol Biol Rep. 2023 Jan., v. 50, no. 1 p.531-540

2023

Abstract: BACKGROUND: Carbonyl reductase 1 (CBR1) is a nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reductase with broad substrate specificity. CBR1 catalyzes the reduction of numerous carbonyl compounds, including quinones, prostaglandins, ... ...

Abstract	BACKGROUND: Carbonyl reductase 1 (CBR1) is a nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reductase with broad substrate specificity. CBR1 catalyzes the reduction of numerous carbonyl compounds, including quinones, prostaglandins, menadione, and multiple xenobiotics, while also participating in various cellular processes, such as carcinogenesis, apoptosis, signal transduction, and drug resistance. In this study, we aimed to generate transgenic mice overexpressing mouse Cbr1 (mCbr1), characterize the mCbr1 expression in different organs, and identify changes in protein expression patterns. METHODS AND RESULTS: To facilitate a deeper understanding of the functions of CBR1, we generated transgenic mice overexpressing CBR1 throughout the body. These transgenic mice overexpress 3xFLAG-tagged mCbr1 (3xFLAG-mCbr1) under the CAG promoter. Two lines of transgenic mice were generated, one with 3xFLAG-mCbr1 expression in multiple tissues, and the other, with specific expression of 3xFLAG-mCbr1 in the heart. Pathway and network analysis using transgenic mouse hearts identified 73 proteins with levels of expression correlating with mCbr1 overexpression. The expression of voltage-gated anion channels, which may be directly related to calcium ion-related myocardial contraction, was also upregulated. CONCLUSION: mCbr1 transgenic mice may be useful for further in vivo analyses of the molecular mechanisms regulated by Cbr1; such analyses will provide a better understanding of its effects on carcinogenesis and cardiotoxicity of certain cancer drugs.
Keywords	NADP (coenzyme) ; apoptosis ; calcium ; carcinogenesis ; cardiotoxicity ; drug resistance ; genetically modified organisms ; heart ; menadione ; mice ; myocardial contraction ; oxidoreductases ; prostaglandins ; protein synthesis ; signal transduction ; substrate specificity ; xenobiotics
Language	English
Dates of publication	2023-01
Size	p. 531-540.
Publishing place	Springer Netherlands
Document type	Article ; Online
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-022-07994-x
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Genetic and phenotypic analyses of mcr-harboring extended-spectrum β-lactamase-producing Escherichia coli isolates from companion dogs and cats in Japan

Yasugi, Mayo / Hatoya, Shingo / Motooka, Daisuke / Kondo, Daisuke / Akiyoshi, Hideo / Horie, Masayuki / Nakamura, Shota / Shimada, Terumasa

Veterinary Microbiology. 2023 May, v. 280 p.109695-

2023

Abstract: The emergence of mcr plasmid-mediated colistin-resistant extended-spectrum β-lactamase (ESBL)-producing Enterobacterales among companion dogs and cats poses a risk of the animals acting as reservoirs for cross-species transmission. However, current ... ...

Abstract	The emergence of mcr plasmid-mediated colistin-resistant extended-spectrum β-lactamase (ESBL)-producing Enterobacterales among companion dogs and cats poses a risk of the animals acting as reservoirs for cross-species transmission. However, current knowledge of mcr-harboring ESBL-producing Enterobacterales in companion dogs and cats is still limited; thus, the genetic and phenotypic characteristics of the bacterial isolates and plasmids, in companion dogs and cats, remain to be elucidated. Here, we identified mcr gene-harboring ESBL-producing Escherichia coli isolates during whole-genome sequencing of ESBL-producing E. coli isolates from a dog and a cat in Osaka, Japan. Colistin-resistant MY732 isolate from a dog carried two plasmids: mcr-1.1-harboring IncI2 plasmid and blaCTX₋M₋₁₄-harboring IncFIB plasmid. Conjugation assays revealed that both plasmids can be co-transferred even though the IncFIB plasmid lacked a conjugal transfer gene cassette. The other isolate MY504 from a cat harbored two bla genes and mcr-9 on the identical IncHI2 plasmid. This isolate was not resistant to colistin, which is likely to be due to deletion of the regulatory two-component QseBC system associated with the mcr-9 expression. To the best of our knowledge, this is the first report of a colistin-resistant ESBL-producing E. coli isolate harboring mcr-1 from a companion dog in Japan. Given that the mcr gene-harboring IncI2 and IncHI2 plasmids in this study shared high homology with plasmids from human or animal-derived Enterobacterales, companion dogs and cats may act as important reservoirs for cross-species transmission of the mcr gene in the community, in Japan.
Keywords	Escherichia coli ; Japan ; beta-lactamase bacteria ; colistin ; dogs ; genes ; humans ; phenotype ; plasmids ; risk ; mcr ; ESBL ; Dog ; Cat
Language	English
Dates of publication	2023-05
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2023.109695
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 2917: Show issues

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Article: Possible biological processes controlled by the circatidal clock in the mangrove cricket inferred from transcriptome analysis

Takekata, Hiroki / Tachibana, Shin-Ichiro / Motooka, Daisuke / Nakamura, Shota / Goto, Shin G.

Biological rhythm research. 2022 June 03, v. 53, no. 6

2022

Abstract: Intertidal dwellers exhibit a circatidal rhythm corresponding to the tidal cycles, but its molecular mechanism remains largely unknown. The mangrove cricket Apteronemobius asahinai simultaneously exhibits circatidal and circadian rhythms in its locomotor ...

Abstract	Intertidal dwellers exhibit a circatidal rhythm corresponding to the tidal cycles, but its molecular mechanism remains largely unknown. The mangrove cricket Apteronemobius asahinai simultaneously exhibits circatidal and circadian rhythms in its locomotor activity. In A. asahinai, it is considered that the circatidal rhythm is generated by the circatidal clock, and its molecular mechanism appears to differ from that of the circadian clock. For the molecular dissection, it is necessary to investigate the effects of a candidate gene disruption in several circatidal rhythms. However, the circatidal rhythms other than locomotor activity have not been examined in this species. Here, to identify biological processes related to the circatidal rhythm, we performed whole-transcriptome analysis using RNA sequencing with RNA samples extracted from whole crickets. Under a light-dark cycle without tidal stimuli, more contigs showed a diel expression pattern than a tidal expression pattern. Gene ontology (GO) enrichment analysis revealed that most GO terms overrepresented in contigs related to the tidal cycle were also overrepresented in contigs related to the diel cycle. GO terms specific to tide-related contigs were related to cuticle development, melanization, and sclerotization. These results suggest that physiological events in the cuticle may be controlled by the circatidal clock.
Keywords	Orthoptera ; RNA ; circadian clocks ; dissection ; gene ontology ; gene targeting ; littoral zone ; locomotion ; melanization ; photoperiod ; research ; sclerotization ; transcriptomics
Language	English
Dates of publication	2022-0603
Size	p. 908-920.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	1185065-6
ISSN	1744-4179 ; 0929-1016
ISSN (online)	1744-4179
ISSN	0929-1016
DOI	10.1080/09291016.2020.1838747
Database	NAL-Catalogue (AGRICOLA)

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Zs.B 856: Show issues

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