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Article ; Online: Transcatheter Leadless Pacemaker for the Treatment of Vasovagal Syncope.

Kadado, Anis John / Gobeil, Kyle / Motta, Jishu / Chalhoub, Fadi

2023 Volume 22, Issue 3, Page(s) 88–90

Abstract: Vasovagal syncope (VVS) is largely a benign condition focused on patient education, lifestyle modification, and avoidance of triggers. However, a subset of patients may benefit from permanent pacemaker placement. Commonly, patients with VVS are younger ... ...

Abstract	Vasovagal syncope (VVS) is largely a benign condition focused on patient education, lifestyle modification, and avoidance of triggers. However, a subset of patients may benefit from permanent pacemaker placement. Commonly, patients with VVS are younger and those requiring pacing have symptoms associated with severe cardioinhibitory syncope. With the advent of leadless pacemaker systems, a lot of the risks associated with traditional transvenous pacemaker systems are mitigated. In this article, we provide a comprehensive review of the data available for the treatment of cardioinhibitory vasovagal syncope using leadless pacemaker systems.
MeSH term(s)	Humans ; Syncope, Vasovagal/therapy ; Syncope, Vasovagal/diagnosis ; Cardiac Pacing, Artificial ; Pacemaker, Artificial
Language	English
Publishing date	2023-05-31
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2079676-6
ISSN	1535-2811 ; 1535-282X
ISSN (online)	1535-2811
ISSN	1535-282X
DOI	10.1097/HPC.0000000000000325
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Article ; Online: Flow-NMR as a Process-Monitoring Tool for mRNA IVT Reaction.

Sarkar, Aritra / Dong, Guogang / Quaglia-Motta, Jennifer / Sackett, Kelly

Journal of pharmaceutical sciences

2023 Volume 113, Issue 4, Page(s) 900–905

Abstract: Messenger RNA (mRNA) based vaccines were instrumental in accelerating the end of the SARS-CoV-2 pandemic and are being aggressively developed as prophylaxes for a range of viral diseases. The swift adoption of mRNA-based therapeutics has also left open ... ...

Abstract	Messenger RNA (mRNA) based vaccines were instrumental in accelerating the end of the SARS-CoV-2 pandemic and are being aggressively developed as prophylaxes for a range of viral diseases. The swift adoption of mRNA-based therapeutics has also left open vast areas of opportunity for improving the development of mRNA-based drugs. One such area with immense potential focuses on the mRNA drug substance production, where mRNA is generated by a cell-free reaction called in vitro transcription (IVT). Process analytical technologies (PAT) are integral to the pharmaceutical industry and are necessary to facilitate agile process optimization and enhance process quality, control, and understanding. Due to the complexity and novelty inherent to the IVT reaction, there is a need for effective PAT that would provide in-depth, real-time insight into the reaction process to allow delivery of novel mRNA vaccines to patients faster in a more cost-effective way. Herein, we showcase the development of flow-nuclear magnetic resonance (flow-NMR) as a highly effective process-analytical tool for monitoring mRNA IVT reactions to support process development, optimization, and production.
MeSH term(s)	Humans ; RNA, Messenger/genetics ; Pharmaceutical Preparations ; Drug Industry ; Magnetic Resonance Spectroscopy
Chemical Substances	RNA, Messenger ; Pharmaceutical Preparations
Language	English
Publishing date	2023-11-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	3151-3
ISSN	1520-6017 ; 0022-3549
ISSN (online)	1520-6017
ISSN	0022-3549
DOI	10.1016/j.xphs.2023.11.021
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Article: First hydrogen-bonded adduct of sterically hindered 2-

Rivera, Augusto / Ríos-Motta, Jaime / Bolte, Michael

Acta crystallographica. Section E, Crystallographic communications

2022 Volume 78, Issue Pt 6, Page(s) 599–602

Abstract: The title compound, ... ...

Abstract	The title compound, C
Language	English
Publishing date	2022-05-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2041947-8
ISSN	2056-9890 ; 1600-5368
ISSN	2056-9890 ; 1600-5368
DOI	10.1107/S2056989022004972
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Article: Synthesis and crystal structure of 2-(2-hy-droxy-phen-yl)-1,3-bis-(4-meth-oxy-benz-yl)-1,3-diazinan-5-ol.

Rivera, Augusto / Ríos-Motta, Jaime / Bolte, Michael

Acta crystallographica. Section E, Crystallographic communications

2022 Volume 78, Issue Pt 7, Page(s) 742–745

Abstract: The redetermined structure of 2-(2-hy-droxy-phen-yl)-1,3-bis-(4-meth-oxy-benz-yl)-1,3-diazinan-5-ol, ... ...

Abstract	The redetermined structure of 2-(2-hy-droxy-phen-yl)-1,3-bis-(4-meth-oxy-benz-yl)-1,3-diazinan-5-ol, C
Language	English
Publishing date	2022-06-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2041947-8
ISSN	2056-9890 ; 1600-5368
ISSN	2056-9890 ; 1600-5368
DOI	10.1107/S2056989022006508
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Article ; Online: Investigating changes in IQ scores over a decade in Brazil: factors at play.

Soares, Pedro San Martin / Wehrmeister, Fernando César / Menezes, Ana Maria / Gonçalves, Helen / Horta, Bernardo / Motta, Janaina / Hartwig, Fernando

Social psychiatry and psychiatric epidemiology

2024

Abstract: Purpose: This study aimed to determine whether the factors underlying potential differences between two birth cohorts, born in 1982 and 1993, influence the changes in IQ over time.: Methods: Data from two Brazilian birth cohorts were used (1993 and ... ...

Abstract	Purpose: This study aimed to determine whether the factors underlying potential differences between two birth cohorts, born in 1982 and 1993, influence the changes in IQ over time. Methods: Data from two Brazilian birth cohorts were used (1993 and 1982 Pelotas Birth Cohorts). The IQ scores were assessed using the WAIS-III test. Results: Results showed that women born in 1993 had a higher average IQ score than those born in 1982, but no difference was found among men. The increase in IQ scores was only limited to participants from families with an income ranging from 1.1 to 3 times the minimum wage at the time of birth. The mean IQ score of participants born to mothers below the age of 20 remained stable over time, but increase for participants whose mothers were 20 years of age or older at the time of birth. Conclusions: This study emphasizes the importance of considering socio-economic and demographic factors when examining differences in IQ scores over time. Further research is needed to understand the underlying mechanisms of these findings.
Language	English
Publishing date	2024-02-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	623071-4
ISSN	1433-9285 ; 0037-7813 ; 0933-7954
ISSN (online)	1433-9285
ISSN	0037-7813 ; 0933-7954
DOI	10.1007/s00127-024-02623-3
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Article ; Online: Experiencia con el Biofire FilmArray® para meningitis/encefalitis infecciosa en una institución de alta complejidad en Bogotá, Colombia.

Romero-Hernández, C A / Zuleta-Motta, J L / Zapa-Pérez, N M / Martínez-Lemus, J D

Revista de neurologia

2023 Volume 77, Issue 4, Page(s) 87–93

Abstract: Introduction: Infectious meningoencephalitis (IME) is a neurological emergency with a significant rate of morbidity and mortality. The Biofire FilmArray® meningitis/encephalitis (FAME) panel for testing in cerebrospinal fluid (CSF) has proven to be a ... ...

Title translation	Experience with the Biofire FilmArray® for infectious meningitis/encephalitis in a high complexity institution in Bogota, Colombia.
Abstract	Introduction: Infectious meningoencephalitis (IME) is a neurological emergency with a significant rate of morbidity and mortality. The Biofire FilmArray® meningitis/encephalitis (FAME) panel for testing in cerebrospinal fluid (CSF) has proven to be a valuable tool for the aetiological diagnosis of IME, facilitating targeted antimicrobial therapy. The aim is to determine the impact of the FAME panel on antimicrobial therapeutic decisions in patients with suspected IME in the first 24 hours of clinical assessment. Patients and methods: This is a descriptive observational study that comments on the clinical manifestations, the neuroimaging and paraclinical findings, and the antibiotic therapy of patients with suspected IME. An analysis was performed to determine the impact of FAME on antimicrobial therapy in the first 24 hours of the clinical assessment of patients. Results: Altogether 44 patients were included. The average time required to obtain the result of the FAME panel for testing in CSF was nine hours, with 20.4% (9/44) of tests yielding positive results. Within 24 hours of clinical assessment, their outcome had an impact on antimicrobial treatment decisions in 75% (33/44) of cases. In patients with a high clinical suspicion of IME, the result of FAME made it possible to change the initial empirical therapy to a targeted therapy in 15% (3/20) of cases and to discontinue the initial empirical therapy in 35% (7/20) of the subjects. In patients with low clinical suspicion of IME, their result allowed 25% (6/24) to have their suspicion confirmed and they were started on targeted antibiotic therapy; in contrast, 70.8% (17/24) had their diagnosis ruled out and were not started on treatment. Conclusions: The result of the FAME panel for testing in CSF has a high impact on antimicrobial therapeutic decisions within 24 hours of clinical assessment. However, it must be interpreted with the clinical context, local epidemiology and other diagnostic studies.
MeSH term(s)	Humans ; Colombia ; Encephalitis ; Infectious Encephalitis ; Meningitis ; Anti-Bacterial Agents
Chemical Substances	Anti-Bacterial Agents
Language	Spanish
Publishing date	2023-07-25
Publishing country	Spain
Document type	Observational Study ; English Abstract ; Journal Article
ZDB-ID	1468278-3
ISSN	1576-6578 ; 0210-0010
ISSN (online)	1576-6578
ISSN	0210-0010
DOI	10.33588/rn.7704.2023082
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Article ; Conference proceedings: Small intestinal villus vascularization is driven via an epithelial-to-endothelial PAR1 signaling axis

Mimmler, M. / Dremova, O. / Mann, A. / Malinarich, F. / Vergnolle, N. / Motta, J.-P. / Kalte, I. / Mammadova, K. / Pontarollo, G. / Reinhardt, C.

Hämostaseologie

2024 Volume 44, Issue S 01

Event/congress	GTH Congress 2024 - 68th Annual Meeting of the Society of Thrombosis and Haemostasis Research - Building Bridges in Coagulation, Vienna, Austria, 2024-03-27
Language	English
Publishing date	2024-02-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	801512-0
ISSN	2567-5761 ; 0720-9355
ISSN (online)	2567-5761
ISSN	0720-9355
DOI	10.1055/s-0044-1779238
Database	Thieme publisher's database

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Article ; Online: A novel simple and safe approach to frozen pacemaker leads.

Gobeil, Kyle / Kadado, Anis John / Gardner, Michael / Motta, Jishu / Chalhoub, Fadi

Heart rhythm

2022 Volume 20, Issue 2, Page(s) 311–312

MeSH term(s)	Pacemaker, Artificial/adverse effects ; Equipment Failure ; Cardiac Pacing, Artificial/adverse effects
Language	English
Publishing date	2022-09-16
Publishing country	United States
Document type	Letter
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2022.09.010
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Article: 171 Blood sample type and storage conditions affect circulating anti-Müllerian hormone concentrations in cattle.

Saade-Rampolla, D I / Motta, J C L / Crist, A E / Garcia-Guerra, A

Reproduction, fertility, and development

2022 Volume 34, Issue 2, Page(s) 324

Language	English
Publishing date	2022-02-26
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1019913-5
ISSN	1448-5990 ; 1031-3613
ISSN (online)	1448-5990
ISSN	1031-3613
DOI	10.1071/RDv34n2Ab171
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Article ; Online: Diabetes mellitus, its prevalence, awareness, and control in Panama: Data from ENSPA 2019, a national cross-sectional study.

Quintana, Hedley Knewjen / Moreno Velásquez, Ilais / Montenegro Mendoza, Roger / Niño Hall, Cecilio / Motta, Jorge / Roa, Reina

Medicine

2023 Volume 102, Issue 32, Page(s) e34600

Abstract: Diabetes mellitus (DM) represents an important global burden of disease. In Panama, DM was investigated in 1 study utilizing questionnaires and in another using biomarkers, but at subnational level. Using data from a recent cross-sectional country-wide ... ...

Abstract	Diabetes mellitus (DM) represents an important global burden of disease. In Panama, DM was investigated in 1 study utilizing questionnaires and in another using biomarkers, but at subnational level. Using data from a recent cross-sectional country-wide population-based study that included biomarkers, we estimated the prevalence of DM, its awareness, and control; evaluating possible risk factors. We used data from 4400 participants aged 18 years or older from the National Health Study of Panama (ENSPA) study conducted in 2019 at a national level. Weighted prevalence and 95% confidence intervals for DM, awareness, and control were estimated by sociodemographic factors, family history of DM, tobacco and alcohol use, nutritional status, and hypertension. Odds ratios (ORs) and 95% confidence intervals were calculated using logistic regression models to assess the possible risk factors associated with DM prevalence and awareness. We generated OR estimates by pooling ENSPA data with a previous regional study, prevalence of cardiovascular risk factors. The prevalence of DM was estimated to be 12.4% (10.9%-14.05%). In both men and women, age, family history of diabetes (OR in men: 4.0 ([2.4-6.7]; OR in women 3.5 [2.5-4.8]), and obesity (OR in men: 2.6 [1.4-5.1]; OR in women: 2.0 [0.9-4.5]) were associated with DM. Diagnosed and controlled hypertension was associated with DM only in women (OR: 2.1 [1.2-3.6]). DM awareness was estimated to be 62.6% (56.3%-68.9%). In both men and women, DM awareness was associated with age and a family history of diabetes (OR in men: 6.6 [2.4-18.4]; OR in women 1.9 ([1.1-3.6]). In women, having secondary education (OR: 1.9 [0.9-3.9]) and being diagnosed with uncontrolled hypertension (OR: 3.3 [1.2-9.5]) was also associated to DM awareness. Men in the ENSPA study were less likely to be aware of DM than those in the prevalence of cardiovascular risk factors (OR: 0.2 [0.0-0.7]). Less than half of the individuals diagnosed with DM had their condition controlled (39.6% [31.4%-47.8%]). This study revealed that the prevalence, awareness, and control of DM were similar to recent estimates reported in other Latin American countries. It also provides a baseline regarding DM and associated risk factors in Panama at a country-level knowledge that is essential for health policy development and useful in clinical practice.
MeSH term(s)	Male ; Humans ; Female ; Cross-Sectional Studies ; Prevalence ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/etiology ; Risk Factors ; Hypertension/epidemiology ; Hypertension/complications ; Panama/epidemiology
Language	English
Publishing date	2023-07-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000034600
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