Article ; Online: Single-nucleotide polymorphisms related to vitamin D metabolism and severity or mortality of COVID-19: A systematic review and meta-analysis.
2024 Volume 906, Page(s) 148236
Abstract: This systematic review and meta-analysis aimed to verify the association between single-nucleotide polymorphisms (SNPs) in vitamin D-related genes and the severity or mortality of coronavirus disease 19 (COVID-19). We systematically searched PubMed, BVS/ ... ...
| Abstract | This systematic review and meta-analysis aimed to verify the association between single-nucleotide polymorphisms (SNPs) in vitamin D-related genes and the severity or mortality of coronavirus disease 19 (COVID-19). We systematically searched PubMed, BVS/Bireme, Scopus, Embase, and Web of Science for relevant studies published until November 24, 2023. Twelve studies were included. Thirty-one SNPs related to four genes were studied (VDR, 13 SNPs; GC, 6 SNPs; DHCR7/NADSYN1, 6 SNPs; CYP2R1, 6 SNPs). Eight SNPs were examined in two or more studies (VDR rs731236, rs2228570, rs1544410, rs7975232, rs739837, rs757343, rs11568820, and rs4516035). Meta-analysis showed a significant association between the VDR rs1544410 Bb + bb genotype and b allele and an increased odds of developing severe/critical COVID-19 (Bb + bb vs. BB = 2 studies, OR = 1.73, 95% confidence interval (CI): 1.16-2.57, P = 0.007, I |
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| MeSH term(s) | Humans ; Polymorphism, Single Nucleotide ; Genetic Predisposition to Disease ; Receptors, Calcitriol/genetics ; COVID-19/genetics ; Genotype ; Vitamin D/genetics | |||||
| Chemical Substances | Receptors, Calcitriol ; Vitamin D (1406-16-2) | |||||
| Language | English | |||||
| Publishing date | 2024-02-03 | |||||
| Publishing country | Netherlands | |||||
| Document type | Meta-Analysis ; Systematic Review ; Journal Article ; Review | |||||
| ZDB-ID | 391792-7 | |||||
| ISSN | 1879-0038 ; 0378-1119 | |||||
| ISSN (online) | 1879-0038 | |||||
| ISSN | 0378-1119 | |||||
| DOI | 10.1016/j.gene.2024.148236 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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