LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 3 of total 3

Search options

  1. Article ; Online: Flavonols as potential antiviral drugs targeting SARS-CoV-2 proteases (3CL

    Mouffouk, Chaima / Mouffouk, Soumia / Mouffouk, Sara / Hambaba, Leila / Haba, Hamada

    European journal of pharmacology

    2020  Volume 891, Page(s) 173759

    Abstract: The novel coronavirus outbreak (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents the actual greatest global public health crisis. The lack of efficacious drugs and vaccines against this viral infection created a ...

    Abstract The novel coronavirus outbreak (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents the actual greatest global public health crisis. The lack of efficacious drugs and vaccines against this viral infection created a challenge for scientific researchers in order to find effective solutions. One of the promising therapeutic approaches is the search for bioactive molecules with few side effects that display antiviral properties in natural sources like medicinal plants and vegetables. Several computational and experimental studies indicated that flavonoids especially flavonols and their derivatives constitute effective viral enzyme inhibitors and possess interesting antiviral activities. In this context, the present study reviews the efficacy of many dietary flavonols as potential antiviral drugs targeting the SARS-CoV-2 enzymes and proteins including Chymotrypsin-Like Protease (3CL
    MeSH term(s) Angiotensin-Converting Enzyme 2/metabolism ; Antiviral Agents/pharmacology ; COVID-19/metabolism ; Coronavirus 3C Proteases/metabolism ; Coronavirus RNA-Dependent RNA Polymerase/metabolism ; Drug Development ; Flavonols/pharmacology ; Humans ; Phytochemicals/pharmacology ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus/metabolism ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents ; Flavonols ; Phytochemicals ; Spike Glycoprotein, Coronavirus ; Coronavirus RNA-Dependent RNA Polymerase (EC 2.7.7.48) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; 3C-like protease, SARS coronavirus (EC 3.4.22.-) ; 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Coronavirus 3C Proteases (EC 3.4.22.28)
    Language English
    Publishing date 2020-11-27
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2020.173759
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 522: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: In vitro photoprotective, hemostatic, anti-inflammatory and antioxidant activities of the species Linaria scariosa Desf

    Mouffouk, Chaima / Mouffouk, Soumia / Oulmi, Kafia / Mouffouk, Sara / Haba, Hamada

    SAAB South African journal of botany. 2020 May, v. 130

    2020  

    Abstract: Recently, plant-derived extracts gained considerable attention as skincare agents, because of their capacity to exert a broad spectrum of biological activities, including their power to absorb ultraviolet radiation, their antioxidant, anti-inflammatory ... ...

    Abstract Recently, plant-derived extracts gained considerable attention as skincare agents, because of their capacity to exert a broad spectrum of biological activities, including their power to absorb ultraviolet radiation, their antioxidant, anti-inflammatory and hemostatic properties. In this context, the study focused on the evaluation of in vitro pharmacological activities of the methanolic extract obtained from the species Linaria scariosa. The plant is used by the local populations of Aures region (Algeria) for wound healing and its traditional applications will be validated. The quantification of the total phenolic and flavonoid content was performed spectrophotometrically using Folin-Ciocalteu and trichloroaluminum methods. The antioxidant activity was determined by four different assays including ferric reducing antioxidant power, total antioxidant capacity, ferric thiocyanate assay and the antioxidant activity by potentiometric method. Furthemore, the in vitro anti-inflammatory activity was assessed by albumin denaturation method, the photoprotective effect was evaluated by the measurment of sun protection factor (SPF) and the hemostatic activity was carried out by the determination of plasma re-calcification time (PRT). Result of the phytochemical screening from the methanolic extract was found to contain several secondary metabolites known for their biological properties. Moderate contents of polyphenols and flavonoids were estimated. The MeOH extract possessed moderate antioxidant activity for various tested assays and had the ability to inhibit thermally-induced protein denaturation in a dose-dependent manner with a percentage of 40.98% at 500 μg/ml. Moreover, this plant extract significantly shortened the clotting time compared to the control group and had a higher capacity to absorb UV radiations with a sun protection factor estimated at 38.46 ± 0.22. The methanolic extract from L. scariosa could be used in cosmetic formulations and as a skincare agent.
    Keywords Linaria ; albumins ; anti-inflammatory activity ; antioxidant activity ; antioxidants ; chemical constituents of plants ; denaturation ; dose response ; flavonoids ; methanol ; plant extracts ; polyphenols ; protein denaturation ; radiation resistance ; screening ; secondary metabolites ; thiocyanates ; tissue repair ; ultraviolet radiation ; Algeria
    Language English
    Dates of publication 2020-05
    Size p. 383-388.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2126918-X
    ISSN 0254-6299
    ISSN 0254-6299
    DOI 10.1016/j.sajb.2020.01.003
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Phytochemicals, Antihemolytic, Anti-inflammatory, Antioxidant, and Antibacterial Activities from Thymus Algeriensis

    Mokhtari, Mouna / Chabani, Sonia / Mouffouk, Soumia / Aberkane, Mohamed-Cherif / Dibi, Ammar / Benkhaled, Mohammed / Haba, Hamada

    Journal of herbs, spices & medicinal plants. 2021 July 03, v. 27, no. 3

    2021  

    Abstract: The chemical composition and anti-inflammatory, antihemolytic, antioxidant, and antibacterial activities of solvent extracts of Thymus algeriensis in petroleum ether, chloroform, and n-butanol were evaluated. Ten compounds including four flavonoids, four ...

    Abstract The chemical composition and anti-inflammatory, antihemolytic, antioxidant, and antibacterial activities of solvent extracts of Thymus algeriensis in petroleum ether, chloroform, and n-butanol were evaluated. Ten compounds including four flavonoids, four phenolics, and two triterpenoids were isolated and identified by chromatography and spectroscopy. The n-butanol extract had the greatest antioxidant activity and inhibited hemolysis with a value of IC₅₀ at 322.85 ± 0.87 µg mL⁻¹. The chloroform extract exhibited the highest anti-inflammatory effect with 45.27% inhibition. The extracts demonstrated antibacterial activity against the tested strains.
    Keywords Thymus algeriensis ; anti-inflammatory activity ; antibacterial properties ; antioxidant activity ; antioxidants ; butanol ; chemical composition ; chloroform ; chromatography ; flavonoids ; hemolysis ; petroleum ; phenolic compounds ; solvents ; spectroscopy ; triterpenoids
    Language English
    Dates of publication 2021-0703
    Size p. 253-266.
    Publishing place Taylor & Francis
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1122804-0
    ISSN 1540-3580 ; 1049-6475
    ISSN (online) 1540-3580
    ISSN 1049-6475
    DOI 10.1080/10496475.2021.1891174
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3868: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top