Article ; Online: Basal forebrain cholinergic neurons have specific characteristics during the perinatal period.
2024
Abstract: Cholinergic neurons of the basal forebrain (BF) represent the main source of cholinergic innervation of large parts of the neocortex and are involved in adults in the modulation of attention, memory, and arousal. During the first postnatal days, they ... ...
Abstract | Cholinergic neurons of the basal forebrain (BF) represent the main source of cholinergic innervation of large parts of the neocortex and are involved in adults in the modulation of attention, memory, and arousal. During the first postnatal days, they play a crucial role in the development of cortical neurons and cortical cytoarchitecture. However, their characteristics, during this period have not been studied. To understand how they can fulfill this role, we investigated the morphological and electrophysiological maturation of cholinergic neurons of the substantia innominata-nucleus basalis of Meynert complex (SI/NBM) in the perinatal period in mice. We show that cholinergic neurons, whether or not they express γ-aminobutyric acid (GABA) as a co-transmitter, are already functional at embryonic day 18 (E18). Until the end of the first postnatal week, they constitute a single population of neurons with a well-developed dendritic tree, a spontaneous activity including bursting periods, and a short latency response to depolarizations (early-firing). They are excited by both their GABAergic and glutamatergic afferents. During the second postnatal week, a second, less excitable, neuronal population emerges, with a longer delay response to depolarizations (late-firing), together with the hyperpolarizing action of GABA |
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Language | English |
Publishing date | 2024-05-16 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 2800598-3 |
ISSN | 2373-2822 ; 2373-2822 |
ISSN (online) | 2373-2822 |
ISSN | 2373-2822 |
DOI | 10.1523/ENEURO.0538-23.2024 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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