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  1. Article: Interactions entre diabète et cancer.

    Mourey, Loïc

    Soins; la revue de reference infirmiere

    2011  , Issue 754 Suppl, Page(s) S8–9

    Abstract: Diabetes and cancer are two very common pathologies, all the more so as the population ages. There are many interactions between them, both on a physiopathological level as well as in daily clinical practice. Thanks to new therapies, cancer is ... ...

    Title translation Interactions between diabetes and cancer.
    Abstract Diabetes and cancer are two very common pathologies, all the more so as the population ages. There are many interactions between them, both on a physiopathological level as well as in daily clinical practice. Thanks to new therapies, cancer is increasingly being considered as a chronic disease, and oncology teams have a lot to learn in this area from the treatment of diabetic patients.
    MeSH term(s) Diabetes Complications/therapy ; Humans ; Neoplasms/complications ; Neoplasms/therapy
    Language French
    Publishing date 2011-04
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 604655-1
    ISSN 0038-0814
    ISSN 0038-0814
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  2. Article ; Online: Abiraterone acetate in combination with prednisone in the treatment of prostate cancer: safety and efficacy.

    Manceau, Cécile / Mourey, Loic / Pouessel, Damien / Ploussard, Guillaume

    Expert review of anticancer therapy

    2020  Volume 20, Issue 8, Page(s) 629–638

    Abstract: Introduction: Metastatic prostate cancer is a life-threatening disease and an important public health concern with prevalence rates varying drastically between high- and low-income countries. Androgen-deprivation therapy alone has been the first-line ... ...

    Abstract Introduction: Metastatic prostate cancer is a life-threatening disease and an important public health concern with prevalence rates varying drastically between high- and low-income countries. Androgen-deprivation therapy alone has been the first-line treatment option for decades, temporarily controlling disease until invariable tumor regression. At the castration-resistant stage, metastatic disease becomes lethal. In recent years several new treatments, including second-generation hormone therapies, have proven to be life-prolonging in metastatic castration-resistant prostate cancer, and at an earlier hormone-sensitive stage. Abiraterone acetate in combination with prednisone was the first approved hormone therapy demonstrating survival benefit, and represents, to date, an alternative, or a second-line treatment after taxane-based chemotherapy, in addition to androgen-deprivation therapy, in hormone sensitive, and metastatic castration-resistant prostate cancer.
    Area covered: We performed a literature review of papers from 2012 to 2020 using PubMed, Web of Science, and Embase searching for the safety and efficacy of abiraterone acetate in prostate cancer management. Search results were limited to phase III-IV trials and post hoc analysis of Phase III trials evaluated Abiraterone acetate in the English language.
    Expert opinion: This literature review confirms the role of abiraterone acetate in the therapeutic landscape with well-proven safety and efficacy, demonstrated in trials and post-approval studies.
    MeSH term(s) Abiraterone Acetate/administration & dosage ; Androgen Antagonists/administration & dosage ; Animals ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Humans ; Male ; Neoplasm Metastasis ; Prednisone/administration & dosage ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/pathology ; Survival Rate
    Chemical Substances Androgen Antagonists ; Abiraterone Acetate (EM5OCB9YJ6) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2020-06-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2112544-2
    ISSN 1744-8328 ; 1473-7140
    ISSN (online) 1744-8328
    ISSN 1473-7140
    DOI 10.1080/14737140.2020.1785289
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  3. Article: 5/7 Le cancer de la prostate chez l'homme âgé.

    Mourey, Loïc

    Soins. Gerontologie

    2010  , Issue 86, Page(s) 45–46

    Title translation 5/7 Prostate cancer in the elderly man.
    MeSH term(s) Age Distribution ; Aged ; Aged, 80 and over ; Androgen Antagonists/therapeutic use ; France/epidemiology ; Gonadotropin-Releasing Hormone/analogs & derivatives ; Gonadotropin-Releasing Hormone/antagonists & inhibitors ; Humans ; Male ; Mass Screening ; Orchiectomy ; Prostatectomy ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/therapy ; Radiotherapy, Adjuvant ; Risk Factors
    Chemical Substances Androgen Antagonists ; Gonadotropin-Releasing Hormone (33515-09-2)
    Language French
    Publishing date 2010-11
    Publishing country France
    Document type Journal Article
    ZDB-ID 2246755-5
    ISSN 1268-6034
    ISSN 1268-6034
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  4. Article ; Online: Surgery with or Without Darolutamide in High-risk and/or Locally Advanced Prostate Cancer: The SUGAR (CCAFU-PR2) Phase 2 Trial Rationale and Protocol.

    Calleris, Giorgio / Filleron, Thomas / Kesch, Claudia / Roubaud, Guilhem / Pradère, Benjamin / Cabarrou, Bastien / Malavaud, Bernard / Roupret, Morgan / Mourey, Loic / Ploussard, Guillaume

    European urology oncology

    2023  

    Abstract: Background: High-risk prostate cancer (PCa) patients frequently experience recurrence and progression after radical prostatectomy (RP). Neoadjuvant androgen deprivation therapy (ADT) has not demonstrated a clear oncological benefit and is not currently ... ...

    Abstract Background: High-risk prostate cancer (PCa) patients frequently experience recurrence and progression after radical prostatectomy (RP). Neoadjuvant androgen deprivation therapy (ADT) has not demonstrated a clear oncological benefit and is not currently recommended.
    Objective: The SUGAR trial is the first phase 2, randomised, controlled, multicentre, noncommercial, open-label study investigating single-agent perioperative darolutamide compared with the standard of care (ie, upfront RP, without neoadjuvant ADT).
    Design, setting, and participants: SUGAR aims to randomise 240 men affected by nonmetastatic PCa, with the major eligibility criteria being International Society of Urological Pathology grade group ≥4, seminal vesicle invasion at magnetic resonance imaging and/or clinically node-positive disease. Patients in the experimental arm will undergo neoadjuvant darolutamide monotherapy, RP, and adjuvant darolutamide, completing 9 mo of treatment.
    Outcome measurements and statistical analysis: The primary endpoint is noncurable recurrence-free survival, an innovative and clinically meaningful measure; the secondary endpoints encompass safety; recurrence-free, metastasis-free, and overall survival; pathological response; and quality of life. A predictive biomarker analysis will also be performed.
    Results and limitations: Initial data suggest that intensified neoadjuvant treatment with androgen receptor signalling inhibitors (ARSIs) is associated with a sustained pathological response and may improve outcomes, via tumour downstaging and micrometastasis eradication. ARSI monotherapy could further enhance tolerability.
    Conclusions: SUGAR will provide efficacy and safety information on perioperative darolutamide monotherapy compared with upfront RP, in a contemporary high-risk PCa population undergoing surgery.
    Patient summary: The on-going SUGAR clinical trial evaluates 9 mo of darolutamide treatment in addition to radical prostatectomy, in men affected by prostate cancer with specific high-risk characteristics. It investigates whether this hormonal treatment can lower the rates of noncurable recurrences, maintaining a favourable tolerability profile.
    Language English
    Publishing date 2023-10-06
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2588-9311
    ISSN (online) 2588-9311
    DOI 10.1016/j.euo.2023.09.020
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  5. Article ; Online: Perspectives on geriatric oncology research presented at the 2018 European Society for Medical Oncology: Young international society of geriatric oncology report.

    Baldini, Capucine / Mourey, Loic / Liposits, Gabor

    Journal of geriatric oncology

    2018  Volume 10, Issue 2, Page(s) 183–185

    MeSH term(s) Aged ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents, Immunological/therapeutic use ; Biomarkers, Tumor/metabolism ; Biomedical Research ; Clinical Trials as Topic ; DNA Methylation ; Europe ; Geriatric Assessment ; Geriatrics ; Humans ; Medical Oncology ; Molecular Targeted Therapy ; Nanoparticles ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/therapy ; Prognosis ; Protein Kinase Inhibitors/therapeutic use ; Radiotherapy/methods
    Chemical Substances Antineoplastic Agents ; Antineoplastic Agents, Immunological ; Biomarkers, Tumor ; Protein Kinase Inhibitors
    Language English
    Publishing date 2018-12-28
    Publishing country Netherlands
    Document type Congress
    ZDB-ID 2556813-9
    ISSN 1879-4076 ; 1879-4068
    ISSN (online) 1879-4076
    ISSN 1879-4068
    DOI 10.1016/j.jgo.2018.12.007
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  6. Article ; Online: Outcomes of comprehensive geriatric assessment and surgical management in head and neck cancers of the elderly: an observational study.

    Banh Chong, Thanaphone / Grosclaude, Pascale / Chabrillac, Emilien / Lozano, Stéphanie / Vergez, Sébastien / Mourey, Loïc / Dupret-Bories, Agnès

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2022  

    Abstract: Aim: The aims of this study were to assess the survival benefit of optimal vs suboptimal management in elderly patients presenting with upper aerodigestive tract (UADT) cancer for which surgery was the standard of care, and determine if comprehensive ... ...

    Abstract Aim: The aims of this study were to assess the survival benefit of optimal vs suboptimal management in elderly patients presenting with upper aerodigestive tract (UADT) cancer for which surgery was the standard of care, and determine if comprehensive geriatric assessment (CGA) was a prognostic factor for survival.
    Materials and methods: This single-center retrospective cohort study was conducted from January 2014 to December 2018. Included patients were aged 70 or older at the time of diagnosis, and presented with UADT cancer with a theoretical indication for curative-intent surgery according to international guidelines.
    Results: A total of 188 patients were included, with a median age of 78 years. Treatment included surgery in 67.6% of cases and was considered optimal in 60.6% of patients. The overall 3-year survival was 55.2%, and was significantly better in case of optimal vs suboptimal treatment (74.5% vs 25.8%, p < 0.001). In univariate analysis, factors associated with a significantly improved 3-year survival included surgery (p < 0.001), age < 80 years, performance status < 2 and G8 score > 14. In multivariate analysis, CGA was associated with a better survival.
    Conclusions: In patients aged over 70 presenting with UADT cancer for which the standard of care is surgery, an optimal management is associated with better overall survival. Receiving a CGA seems to provide a survival benefit in patients with a G8 score ≤ 14, through an optimization of the care pathway before and after the cancer treatment.
    Language English
    Publishing date 2022-07-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-022-07559-5
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  7. Article ; Online: Advances in geriatric oncology: a multidisciplinary perspective.

    Somasundar, Ponnandai / Mourey, Loïc / Lozza, Laura / Maggi, Stefania / Stepney, Rob

    Tumori

    2018  Volume 104, Issue 4, Page(s) 252–257

    Abstract: A growing majority of people with cancer is composed of older patients. For many such patients, independence and quality of life are as important as prolongation of survival, emphasizing the need for treatments that are not only effective but also well- ... ...

    Abstract A growing majority of people with cancer is composed of older patients. For many such patients, independence and quality of life are as important as prolongation of survival, emphasizing the need for treatments that are not only effective but also well-tolerated. Given age-related decline in organ function and the prevalence of comorbidities and polypharmacy, optimum management is complex and requires collaboration between oncologists and geriatricians. Advances in surgery now include preoperative assessment and, when indicated, prehabilitation of the patient, as well as the enhanced recovery after surgery approach. Medical treatment is benefiting from the advent of highly effective novel immunomodulatory agents that join the tumor-targeted small molecule tyrosine kinase inhibitors and monoclonal antibodies in modifying the tolerability of therapy. Improved tolerability is evident with radiotherapy (RT). The adoption of stereotactic body RT in community oncology practice is increasing the proportion of elderly patients with comorbidities who can receive curative treatment. A further aspect of precision medicine as it relates to the older cancer patient is the tailoring of intervention to the robustness or frailty and life expectancy of the individual. Quantitative and validated tools for comprehensive geriatric assessment are playing an important role in this process.
    MeSH term(s) Aged ; Aged, 80 and over ; Comorbidity ; Female ; Geriatric Assessment ; Geriatrics/trends ; Humans ; Life Expectancy ; Male ; Medical Oncology/trends ; Neoplasms/epidemiology ; Neoplasms/pathology ; Neoplasms/radiotherapy ; Quality of Life ; Radiosurgery
    Language English
    Publishing date 2018-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 280962-x
    ISSN 2038-2529 ; 0300-8916
    ISSN (online) 2038-2529
    ISSN 0300-8916
    DOI 10.5301/tj.5000661
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  8. Article ; Online: Création et évaluation d’un MOOC sur le syndrome confusionnel en oncogériatrie.

    Antoine, Valery / Nicolas, Charlotte / Albarède, Julie / Azria, David / Cristol, Laurence / Jeandel, Claude / Ferreira, Ernestine / Morel, Charlotte / Mourey, Loïc / Balardy, Laurent

    Bulletin du cancer

    2021  Volume 108, Issue 12, Page(s) 1101–1111

    Abstract: Introduction: Among the themes to be addressed by a Massive Open Online Course (MOOC) on geriatric oncology, one of the priorities was delirium, due to its frequency, complications and difficulties encountered by healthcare professionals in diagnosing ... ...

    Title translation Development and assessment of a MOOC about delirium in geriatric oncology.
    Abstract Introduction: Among the themes to be addressed by a Massive Open Online Course (MOOC) on geriatric oncology, one of the priorities was delirium, due to its frequency, complications and difficulties encountered by healthcare professionals in diagnosing and managing delirium. Our study aims to evaluate professional practices in the area of education, regarding the evaluation of the content of a MOOC module about delirium syndrome in geriatric oncology.
    Methods: We created a multidisciplinary group to define the scientific content, the pedagogical objectives, the scriptwriting and the development of a training module. The quality of instructional design was then evaluated according to eleven MOOC design principles to promote learning. Participants were studied.
    Results: Seven of the eleven criteria for evaluating pedagogical quality were documented. Among the 1020 participants, 455 (44.6%) completed the final test concerning delirium: 417 (40.8%) passed the final test; 406 documented their profession and the region of France where they worked: 146 (32%) nurses (confirming the participation of the targeted audience), 103 (22.6%) doctors/pharmacists (illustrating the multi-professional interest of the thematic), with a wide distribution of the participants over the national territory.
    Discussion: The multidisciplinary team's investment in developing these teaching materials strengthened the group's cohesion and valuated its professional skills. All teaching resources developed for access via the internet must be accompanied by an evaluation of the quality of the scientific content, objectives and teaching methods, before being able to appreciate its use in the field and assess its real impact on the participants' learning and practice.
    MeSH term(s) Aged ; Clinical Competence/statistics & numerical data ; Curriculum ; Delirium/diagnosis ; Delirium/etiology ; Delirium/therapy ; Education, Distance/organization & administration ; Educational Measurement/statistics & numerical data ; Female ; France ; Geriatrics/education ; Humans ; Male ; Medical Oncology/education ; Nurses/statistics & numerical data ; Pharmacists/statistics & numerical data ; Physicians/statistics & numerical data ; Program Development/methods ; Risk Factors ; Students, Health Occupations/statistics & numerical data ; Syndrome ; Teaching
    Language French
    Publishing date 2021-10-21
    Publishing country France
    Document type Journal Article
    ZDB-ID 213270-9
    ISSN 1769-6917 ; 0007-4551
    ISSN (online) 1769-6917
    ISSN 0007-4551
    DOI 10.1016/j.bulcan.2021.05.014
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  9. Article ; Online: A Signal-finding Study of Abemaciclib in Heavily Pretreated Patients with Metastatic Castration-Resistant Prostate Cancer: Results from CYCLONE 1.

    Agarwal, Neeraj / Castellano, Daniel / Alonso-Gordoa, Teresa / Arranz Arija, Jose Angel / Colomba, Emeline / Gravis, Gwenaelle / Mourey, Loic / Oudard, Stephane / Fléchon, Aude / Gonzalez, Macarena / Maroto, Pablo M / Schweizer, Michael T / Gallardo, Enrique / Johnston, Erica / Balar, Arjun / Haddad, Nadine / Appiah, Adams K / Nacerddine, Karim / Piulats, Josep M

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2024  

    Abstract: Background: Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors radically changed the treatment paradigm for breast cancer. Similar to estrogen receptor in breast cancer, androgen receptor signaling activates cyclin D-CDK4/6, driving proliferation and ... ...

    Abstract Background: Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors radically changed the treatment paradigm for breast cancer. Similar to estrogen receptor in breast cancer, androgen receptor signaling activates cyclin D-CDK4/6, driving proliferation and resistance to hormonal manipulation in prostate cancer. This study was designed to detect signals of clinical activity for abemaciclib in treatment-refractory metastatic castration-resistant prostate cancer (mCRPC).
    Methods: Eligible patients had progressive mCRPC, measurable disease, and previously received ≥1 novel hormonal agent(s) and 2 lines of taxane chemotherapy. Abemaciclib 200 mg BID was administered on a continuous dosing schedule. Primary endpoint was objective response rate (ORR) without concurrent bone progression. This study was designed to detect a minimum ORR of 12.5%.
    Results: At trial entry, forty (90.9%) of 44 patients had objective radiographic disease progression, four (9.1%) had prostate-specific antigen (PSA)-only progression, and 20 (46.5%) had visceral metastases (of these, 60% had liver metastases). Efficacy analyses are as follows: ORR without concurrent bone progression: 6.8%; disease control rate: 45.5%; median time to PSA progression: 6.5 months (95% CI: 3.2, NA); median radiographic PFS; 2.7 months (95% CI: 1.9, 3.7); and median OS: 8.4 months (95% CI: 5.6, 12.7). Most frequent grade ≥3 TEAEs were neutropenia (25.0%), anemia, and fatigue (11.4% each). No grade 4 or 5 AEs were related to abemaciclib.
    Conclusion: Abemaciclib monotherapy was well tolerated and showed clinical activity in this heavily pretreated population, nearly half with visceral metastases. This study is considered preliminary proof-of-concept and designates CDK4/6 as a valid therapeutic target in prostate cancer.
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-23-3436
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  10. Article ; Online: Use of comprehensive geriatric assessment (CGA) to define frailty in geriatric oncology: Searching for the best threshold. Cross-sectional study of 418 old patients with cancer evaluated in the Geriatric Frailty Clinic (G.F.C.) of Toulouse (France).

    Bréchemier, Delphine / Sourdet, Sandrine / Girard, Philippe / Steinmeyer, Zara / Mourey, Loic / Gérard, Stéphane / Balardy, Laurent

    Journal of geriatric oncology

    2019  Volume 10, Issue 6, Page(s) 944–950

    Abstract: Objectives: A consensual and operational definition of frailty is necessary in geriatric oncology. While many studies have focused on geriatric syndromes evaluated in the comprehensive geriatric assessment (CGA) to select patients at higher risk of poor ...

    Abstract Objectives: A consensual and operational definition of frailty is necessary in geriatric oncology. While many studies have focused on geriatric syndromes evaluated in the comprehensive geriatric assessment (CGA) to select patients at higher risk of poor outcomes, few have compared CGA data with Fried's phenotype of frailty, the most consensual measurement of frailty in geriatrics. Our objective was to determine a threshold of impaired domains evaluated in CGA associated with Frailty status.
    Methods: A cross-sectional study including all patients with cancer, evaluated from January 2011 to February 2016 at the Geriatric Frailty Clinic, Toulouse. A CGA was performed evaluating seven geriatric domains. Frailty was measured by Fried's phenotype to classify patients into three groups (robust/pre-frail/frail). We plotted a ROC curve to determine the threshold of impaired domains associated with frailty according to Fried.
    Results: We included 418 patients aged 82.8 years (range 66-100 years). Thirty-three patients (7.9%) were robust, 155 (37.1%) pre-frail and 230 (55%) frail. There was a significant difference in ADL, IADL, nutrition, cognition and polypharmacy between the three groups (p < .001 for each domain). Frail patients had more impaired geriatric domains on CGA than pre-frail and robust patients (respectively 4.5 ± 1.5, 2.8 ± 1.6 and 2.1 ± 1.2; p < .001). The threshold of 4 impaired geriatric domains associated with Fried's Frailty status was identified (Se 77.39%, Sp 67.55%). Area under the curve was 79.6%.
    Conclusion: The phenotype of frailty is associated with more impaired geriatric domains and a threshold of 4 altered domains could be used to detect frailty from CGA data.
    MeSH term(s) Activities of Daily Living ; Aged ; Aged, 80 and over ; Clinical Decision-Making ; Cross-Sectional Studies ; Disease Progression ; Female ; Frailty/classification ; Frailty/diagnosis ; Frailty/epidemiology ; Geriatric Assessment/methods ; Geriatrics/methods ; Humans ; Male ; Medical Oncology/methods ; Neoplasms/epidemiology ; Neoplasms/physiopathology ; Severity of Illness Index
    Language English
    Publishing date 2019-04-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2556813-9
    ISSN 1879-4076 ; 1879-4068
    ISSN (online) 1879-4076
    ISSN 1879-4068
    DOI 10.1016/j.jgo.2019.03.011
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