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  1. Article ; Online: Dealing with a mucosal viral pandemic: lessons from COVID-19 vaccines.

    Mouro, Violette / Fischer, Alain

    Mucosal immunology

    2022  Volume 15, Issue 4, Page(s) 584–594

    Abstract: The development and deployment of vaccines against COVID-19 demonstrated major successes in providing immunity and preventing severe disease and death. Yet SARS-CoV-2 evolves and vaccine-induced protection wanes, meaning progress in vaccination ... ...

    Abstract The development and deployment of vaccines against COVID-19 demonstrated major successes in providing immunity and preventing severe disease and death. Yet SARS-CoV-2 evolves and vaccine-induced protection wanes, meaning progress in vaccination strategies is of upmost importance. New vaccines directed at emerging viral strains are being developed while vaccination schemes with booster doses and combinations of different platform-based vaccines are being tested in trials and real-world settings. Despite these diverse approaches, COVID-19 vaccines are only delivered intramuscularly, whereas the nasal mucosa is the primary site of infection with SARS-CoV-2. Preclinical mucosal vaccines with intranasal or oral administration demonstrate promising results regarding mucosal IgA generation and tissue-resident lymphocyte responses against SARS-CoV-2. By mounting an improved local humoral and cell-mediated response, mucosal vaccination could be a safe and effective way to prevent infection, block transmission and contribute to reduce SARS-CoV-2 spread. However, questions and limitations remain: how effectively and reproducibly will vaccines penetrate mucosal barriers? Will vaccine-induced mucosal IgA responses provide sustained protection against infection?
    MeSH term(s) Antibodies, Viral ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Immunoglobulin A ; Pandemics ; SARS-CoV-2 ; Viral Vaccines
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines ; Immunoglobulin A ; Viral Vaccines
    Language English
    Publishing date 2022-05-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2411370-0
    ISSN 1935-3456 ; 1933-0219
    ISSN (online) 1935-3456
    ISSN 1933-0219
    DOI 10.1038/s41385-022-00517-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6796: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: PD-1 inhibits T cell actin remodeling at the immunological synapse independently of its signaling motifs.

    Paillon, Noémie / Mouro, Violette / Dogniaux, Stéphanie / Maurin, Mathieu / Saez Pons, Juan-José / Ferran, Hermine / Bataille, Laurence / Zucchetti, Andrés Ernesto / Hivroz, Claire

    Science signaling

    2023  Volume 16, Issue 813, Page(s) eadh2456

    Abstract: Engagement of the receptor programmed cell death molecule 1 (PD-1) by its ligands PD-L1 and PD-L2 inhibits T cell-mediated immune responses. Blocking such signaling provides the clinical effects of PD-1-targeted immunotherapy. Here, we investigated the ... ...

    Abstract Engagement of the receptor programmed cell death molecule 1 (PD-1) by its ligands PD-L1 and PD-L2 inhibits T cell-mediated immune responses. Blocking such signaling provides the clinical effects of PD-1-targeted immunotherapy. Here, we investigated the mechanisms underlying PD-1-mediated inhibition. Because dynamic actin remodeling is crucial for T cell functions, we characterized the effects of PD-1 engagement on actin remodeling at the immunological synapse, the interface between a T cell and an antigen-presenting cell (APC) or target cell. We used microscopy to analyze the formation of immunological synapses between PD-1
    MeSH term(s) Humans ; Actins/metabolism ; Immunological Synapses ; B7-H1 Antigen/metabolism ; Programmed Cell Death 1 Receptor/metabolism ; Signal Transduction ; Lymphocyte Activation
    Chemical Substances Actins ; B7-H1 Antigen ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2023-11-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2417226-1
    ISSN 1937-9145 ; 1945-0877
    ISSN (online) 1937-9145
    ISSN 1945-0877
    DOI 10.1126/scisignal.adh2456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Education and mental health: good reasons to vaccinate children.

    Cauchemez, Simon / Bosetti, Paolo / Kiem, Cécile Tran / Mouro, Violette / Consoli, Angèle / Fontanet, Arnaud

    Lancet (London, England)

    2021  Volume 398, Issue 10298, Page(s) 387

    MeSH term(s) COVID-19 Vaccines ; Child ; Education ; Humans ; Mental Health ; Patient Acceptance of Health Care ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-07-15
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)01453-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 94: Show issues

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  4. Article ; Online: Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination.

    Fumagalli, Valeria / Ravà, Micol / Marotta, Davide / Di Lucia, Pietro / Bono, Elisa B / Giustini, Leonardo / De Leo, Federica / Casalgrandi, Maura / Monteleone, Emanuele / Mouro, Violette / Malpighi, Chiara / Perucchini, Chiara / Grillo, Marta / De Palma, Sara / Donnici, Lorena / Marchese, Silvia / Conti, Matteo / Muramatsu, Hiromi / Perlman, Stanley /
    Pardi, Norbert / Kuka, Mirela / De Francesco, Raffaele / Bianchi, Marco E / Guidotti, Luca G / Iannacone, Matteo

    Nature immunology

    2024  Volume 25, Issue 4, Page(s) 633–643

    Abstract: Vaccines have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) morbidity and mortality, yet emerging variants challenge their effectiveness. The prevailing approach to updating vaccines targets the antibody response, operating under ... ...

    Abstract Vaccines have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) morbidity and mortality, yet emerging variants challenge their effectiveness. The prevailing approach to updating vaccines targets the antibody response, operating under the presumption that it is the primary defense mechanism following vaccination or infection. This perspective, however, can overlook the role of T cells, particularly when antibody levels are low or absent. Here we show, through studies in mouse models lacking antibodies but maintaining functional B cells and lymphoid organs, that immunity conferred by prior infection or mRNA vaccination can protect against SARS-CoV-2 challenge independently of antibodies. Our findings, using three distinct models inclusive of a novel human/mouse ACE2 hybrid, highlight that CD8
    MeSH term(s) Humans ; Animals ; Mice ; SARS-CoV-2 ; CD8-Positive T-Lymphocytes ; COVID-19/prevention & control ; Antibodies ; Vaccination ; Vaccines ; Antibodies, Viral ; Antibodies, Neutralizing
    Chemical Substances Antibodies ; Vaccines ; Antibodies, Viral ; Antibodies, Neutralizing
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-024-01787-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5294: Show issues Location:
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    Zs.MG 42: Show issues

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  5. Article ; Online: Tackling corruption in global health.

    Bah, Maimouna / Charlier, Ludmilla / Davila, Camilla / Descousse, Sophie / Frimon-Richard, Benoît / Hashem, Sameh / Leroy, Clara / Minault, Marie / Mouro, Violette / Nillameyom, Rajiv / Schlüter, Louise / Wailly, Manon

    Lancet (London, England)

    2020  Volume 396, Issue 10245, Page(s) 161

    MeSH term(s) Fraud ; Global Health ; Government Programs
    Language English
    Publishing date 2020-07-18
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)30310-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.5: Show issues Location:
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