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Article: Effects of Gap 26, a Connexin 43 Inhibitor, on Cirrhotic Cardiomyopathy in Rats.

Mohammed, Dlshad / Tavangar, Seyed Mohammad / Khodadoostan, Arash / Mousavi, Seyyedeh Elaheh / Dehpour, Ahmad-Reza / Jazaeri, Farahnaz

Cureus

2024 Volume 16, Issue 4, Page(s) e59053

Abstract: Introduction Cirrhotic cardiomyopathy (CCM) is recognized by impaired cardiac responsiveness to stress, prolonged QT interval, and systolic and diastolic dysfunctions. Connexins are a family of transmembrane proteins that play a key role in cardiac ... ...

Abstract	Introduction Cirrhotic cardiomyopathy (CCM) is recognized by impaired cardiac responsiveness to stress, prolonged QT interval, and systolic and diastolic dysfunctions. Connexins are a family of transmembrane proteins that play a key role in cardiac physiology. Connexin 43 (Cx43) inhibition showed cardio-protective effects. Peptide drug Cx43 inhibitor, Gap 26, could inhibit gap junction 43. This study was designed to evaluate the effects of a connexin mimetic peptide, Gap 26, in the CCM model in rats. Methods The cirrhosis was induced through carbon tetrachloride (CCl4). On day 56, electrocardiography (ECG) was recorded, spleen weight was measured, and tissue and serum samples were collected. Further, Cx43 mRNA expression in heart tissue was checked. Results The chronotropic responses decreased in the CCl4/saline and increased in the CCl4/Gap. The spleen weight, QTc interval, and brain natriuretic peptide (BNP), tumor necrosis factor-alpha (TNF-α), aspartate aminotransferase (AST), alanine transaminase (ALT), and malondialdehyde (MDA) levels elevated in the CCl4/saline, and the spleen weight, QTc interval, and MDA and ALT levels were reduced by Gap 26 treatment. The level of nuclear factor (erythroid-derived 2) factor 2 (Nrf2) decreased in the CCl4/saline. The Cx43 expression was downregulated in the CCl4/saline and upregulated with the Gap 26 treatment. Conclusion Gap 26 not only alleviated the chronotropic hyporesponsiveness and the severity of liver damage and upregulated the atrial Cx43 expression, but it also had an antioxidant effect on the heart.
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.59053
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Article ; Online: Investigation of Antioxidant and Anti-inflammatory Properties of Berberine Nanomicelles: In vitro and In vivo Studies.

Heidarzadeh, Marjan / Amininasab, Mehriar / Rezayat, Seyed Mahdi / Mousavi, Seyyedeh Elaheh

Current drug delivery

2023

Abstract: Introduction: In the present study, neuroprotective effects of berberine (BBR) and berberine nanomicelle (BBR-NM) against lipopolysaccharides (LPS)-induced stress oxidative were investigated, and compared by evaluating their antioxidant and anti- ... ...

Abstract	Introduction: In the present study, neuroprotective effects of berberine (BBR) and berberine nanomicelle (BBR-NM) against lipopolysaccharides (LPS)-induced stress oxidative were investigated, and compared by evaluating their antioxidant and anti-inflammatory activities in PC12 cells, and rat brains. A fast, green, and simple synthesis method was used to prepare BBR-NMs. Method: The prepared BBR-NMs were then characterized using dynamic light scattering (DLS), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). In vitro experiments were carried out on the LPS-treated PC12 cell lines to investigate the anti-cytotoxic and antioxidant properties of BBR-NM and BBR. The results showed that BBR-NMs with a diameter of ~100 nm had higher protective effects against ROS production and cytotoxicity induced by LPS in PC12 cells in comparison with free BBR. Results: Moreover, in vivo experiments indicated that the activity levels of antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), increased in the brain of LPS-treated rats administrated with BBR-NM at the optimum dose of 100 mg.kg-1 . BBR-NM administration also resulted in decreased concentration of lipid peroxidation (MDA) and pro-inflammatory cytokines, such as Serum interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α). Conclusion: Overall, BBR-NM demonstrated higher neuroprotective effects than free BBR, making it a promising treatment for improving many diseases caused by oxidative stress and inflammation.
Language	English
Publishing date	2023-10-06
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2185284-4
ISSN	1875-5704 ; 1567-2018
ISSN (online)	1875-5704
ISSN	1567-2018
DOI	10.2174/0115672018258030230920035222
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Article ; Online: Synergistic effects of citicoline and silymarin nanomicelles in restraint stress-exposed mice.

Shayan, Elham / Maheri, Fatemeh / Aflaki, Fatemeh / Mousavi, Seyyedeh-Elaheh / Zarrindast, Mohammad-Reza / Fakhraei, Nahid / Rezayat Sorkhabadi, Seyyed-Mahdi / Shushtarian, Seyed-Mohammad-Masoud

Behavioural brain research

2024 Volume 464, Page(s) 114929

Abstract: This study evaluated the effects of citicoline and silymarin nanomicelles (SMnm) in repeated restraint stress (RRS).: Method: Mice were exposed to RRS for four consecutive days, 2 hrs. daily. On day 5 of the study, SMnm (25 and 50 mg/kg, i.p.) and ... ...

Abstract	This study evaluated the effects of citicoline and silymarin nanomicelles (SMnm) in repeated restraint stress (RRS). Method: Mice were exposed to RRS for four consecutive days, 2 hrs. daily. On day 5 of the study, SMnm (25 and 50 mg/kg, i.p.) and citicoline (25 and 75 mg/kg), and a combination of them (25 mg/kg, i.p.) were initiated. On day 18, anxiety-like behavior, behavioral despair, and exploratory behavior were evaluated. The prefrontal cortex (PFC) and the hippocampus were dissected measuring brain-derived neurotrophic factor (BDNF), cAMP response element-binding protein (CREB), and tumor necrosis factor-alpha (TNF-α) through Western Blot and ELISA, respectively. Results: In RR-exposed mice, anxiety-like behavior in the elevated plus maze (EPM) was enhanced by reductions in open arm time (OAT%) P < 0.001, and open arm entry (OAE%) P < 0.001. In the forced swimming test (FST), the immobility increased P < 0.001 while the swimming and climbing reduced P < 0.001. In the open field test (OFT), general motor activity was raised P < 0.05. Further, body weights reduced P < 0.001, and tissue BDNF and pCREB expressions decreased P < 0.001 while TNF-α increased P < 0.001. Conversely, SMnm, citicoline and their combination could reduce anxiety-like behavior P < 0.001. The combination group reduced the depressive-like behaviors P < 0.001. Moreover, body weights were restored P < 0.001. Besides, BDNF and pCREB expressions increased while TNF-α reduced, P < 0.001. Conclusion: The combination synergistically improved emotion-like behaviors, alleviating the inflammation and upregulating the hippocampal BDNF-mediated CREB signaling pathway.
MeSH term(s)	Mice ; Animals ; Antidepressive Agents/pharmacology ; Brain-Derived Neurotrophic Factor/metabolism ; Cytidine Diphosphate Choline/metabolism ; Cytidine Diphosphate Choline/pharmacology ; Silymarin/pharmacology ; Silymarin/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Hippocampus/metabolism ; Body Weight ; Depression/metabolism
Chemical Substances	Antidepressive Agents ; Brain-Derived Neurotrophic Factor ; Cytidine Diphosphate Choline (536BQ2JVC7) ; Silymarin ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2024-02-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	449927-x
ISSN	1872-7549 ; 0166-4328
ISSN (online)	1872-7549
ISSN	0166-4328
DOI	10.1016/j.bbr.2024.114929
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Article ; Online: Anti-rheumatic activity of topical nanoemulsion containing bee venom in rats.

Yousefpoor, Yaser / Amani, Amir / Divsalar, Adeleh / Mousavi, Seyyedeh Elaheh / Shakeri, Abbas / Sabzevari, Javad Torkamannejad

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

2022 Volume 172, Page(s) 168–176

Abstract: Purpose: Bee Venom (BV) has been used to treat rheumatoid arthritis (RA) for many centuries. However, its clinical use is limited by pain and fear of bee stings/injection. Nanoemulsions (NEs) are nanocarriers that are able to help their content(s) ... ...

Abstract	Purpose: Bee Venom (BV) has been used to treat rheumatoid arthritis (RA) for many centuries. However, its clinical use is limited by pain and fear of bee stings/injection. Nanoemulsions (NEs) are nanocarriers that are able to help their content(s) penetrate through the skin. They also act as drug reservoirs on the skin to provide an efficient, sustained-release vehicle. Methods: In this paper, we present the development of a stable water-in-oil NE to help passing BV through the animal skin when used topically. Results: Particle size of NE was 12.7 to 29.8 nm for NEs containing 0 to 150 µg/ml BV. Also, its anti-inflammatory effects were evaluated in rat models of type II collagen-induced arthritis. Topical administration of NEs containing 18.75 or 9.37 μg/ml BV were able to significantly (p < 0.05) reduce inflammation in the rat paws compared to the blank and control groups. Conclusion: Our findings demonstrated the efficacy of NEs containing BV to reduce inflammation caused by RA animal model.
MeSH term(s)	Animals ; Arthritis, Experimental/drug therapy ; Arthritis, Rheumatoid/drug therapy ; Bee Venoms/pharmacology ; Bee Venoms/therapeutic use ; Insect Bites and Stings/drug therapy ; Pain/drug therapy ; Rats
Chemical Substances	Bee Venoms
Language	English
Publishing date	2022-02-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1065368-5
ISSN	1873-3441 ; 0939-6411
ISSN (online)	1873-3441
ISSN	0939-6411
DOI	10.1016/j.ejpb.2022.02.005
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Article ; Online: Anti-inflammatory efficacy of Berberine Nanomicelle for improvement of cerebral ischemia: formulation, characterization and evaluation in bilateral common carotid artery occlusion rat model.

Azadi, Roza / Mousavi, Seyyedeh Elaheh / Kazemi, Negar Motakef / Yousefi-Manesh, Hasan / Rezayat, Seyed Mahdi / Jaafari, Mahmoud Reza

BMC pharmacology & toxicology

2021 Volume 22, Issue 1, Page(s) 54

Abstract: Background: Berberine (BBR) is a plant alkaloid that possesses anti-inflammatory and anti-oxidant effects with low oral bioavailability. In this study, micelle formulation of BBR was investigated to improve therapeutic efficacy and examined its effect ... ...

Abstract	Background: Berberine (BBR) is a plant alkaloid that possesses anti-inflammatory and anti-oxidant effects with low oral bioavailability. In this study, micelle formulation of BBR was investigated to improve therapeutic efficacy and examined its effect on the secretion of inflammatory cytokines in cerebral ischemia in the animal model. Material and methods: Nano formulation was prepared by thin-film hydration method, and characterized by particle size, zeta potential, morphology, encapsulation efficacy, and drug release in Simulated Gastric Fluid (SGF) and Simulated Intestine Fluid (SIF). Then, Wistar rats were pretreated with the drug (100 mg/kg) and nano-drug (25, 50, 75, 100 mg/kg) for 14 days. Then, on the fourteenth day, stroke induction was accomplished by Bilateral Common Carotid Artery Occlusion (BCCAO); after that, Tumor Necrosis Factor - Alpha (TNF-α), Interleukin - 1 Beta (IL-1ß), and Malondialdehyde (MDA) levels were measured in the supernatant of the whole brain, then the anti-inflammatory effect of BBR formulations was examined. Result and discussion: Micelles were successfully formed with appropriate characteristics and smaller sizes than 20 nm. The Poly Dispersity Index (PDI), zeta potential, encapsulation efficacy of micelles was 0.227, - 22 mV, 81%, respectively. Also, the stability of nano micelles was higher in SGF as compared to SIF. Our outcomes of TNF-a, IL-1B, and MDA evaluation show a significant ameliorating effect of the Berberine (BBR) and BBR-loaded micelles in pretreated groups. Conclusion: Our experimental data show that pretreated groups in different doses (nano BBR 100, 75, 50 mg/kg, and BBR 100 mg/kg) successfully showed decreased levels of the inflammatory factors in cerebral ischemia compared with the stroke group and pretreated group with nano BBR in the dose of 25 mg/kg. Nano BBR formulation with a lower dose can be a better candidate than conventional BBR formulation to reduce oxidative and inflammatory factors in cerebral ischemia. Therefore, BBR-loaded micelle formulation could be a promising protective agent on cerebral ischemia.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/administration & dosage ; Berberine/administration & dosage ; Brain/drug effects ; Brain/metabolism ; Brain Ischemia/drug therapy ; Brain Ischemia/metabolism ; Carotid Artery Diseases/drug therapy ; Carotid Artery Diseases/metabolism ; Disease Models, Animal ; Interleukin-1beta/metabolism ; Malondialdehyde/metabolism ; Micelles ; Nanoparticles/administration & dosage ; Rats, Wistar ; Tumor Necrosis Factor-alpha/metabolism ; Rats
Chemical Substances	Anti-Inflammatory Agents ; IL1B protein, rat ; Interleukin-1beta ; Micelles ; Tumor Necrosis Factor-alpha ; Berberine (0I8Y3P32UF) ; Malondialdehyde (4Y8F71G49Q)
Language	English
Publishing date	2021-10-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2680259-4
ISSN	2050-6511 ; 2050-6511
ISSN (online)	2050-6511
ISSN	2050-6511
DOI	10.1186/s40360-021-00525-7
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Article: Diazepam Loaded Solid Lipid Nanoparticles:

Faghihi, Sara / Awadi, Mohammad Reza / Mousavi, Seyyedeh Elaheh / Rezayat Sorkhabadi, Seyyed Mahdi / Karboni, Mandana / Azarmi, Shirzad / Ghaffari, Solmaz

Advanced pharmaceutical bulletin

2020 Volume 12, Issue 1, Page(s) 86–92

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2020-09-08
Publishing country	Iran
Document type	Journal Article
ZDB-ID	3018440-X
ISSN	2251-7308 ; 2228-5881
ISSN (online)	2251-7308
ISSN	2228-5881
DOI	10.34172/apb.2022.008
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Article: Erratum to "Nanotechnology in Wound Healing; Semisolid Dosage Forms Containing Curcumin-Ampicillin Solid Lipid Nanoparticles,

Ghaffari, Solmaz / Alihosseini, Faezeh / Rezayat Sorkhabadi, Seyed Mahdi / Arbabi Bidgoli, Sepideh / Mousavi, Seyyedeh Elaheh / Haghighat, Setareh / Afshar Nasab, Ahoo / Kianvash, Nooshin

Advanced pharmaceutical bulletin

2020 Volume 11, Issue 1, Page(s) 204

Abstract: This corrects the article DOI: 10.15171/apb.2018.046.]. ...

Abstract	[This corrects the article DOI: 10.15171/apb.2018.046.].
Language	English
Publishing date	2020-11-07
Publishing country	Iran
Document type	Published Erratum
ZDB-ID	3018440-X
ISSN	2251-7308 ; 2228-5881
ISSN (online)	2251-7308
ISSN	2228-5881
DOI	10.34172/apb.2021.088
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Article ; Online: Licofelone Attenuates LPS-induced Depressive-like Behavior in Mice: A Possible Role for Nitric Oxide.

Mousavi, Seyyedeh Elaheh / Saberi, Pegah / Ghasemkhani, Naeemeh / Fakhraei, Nahid / Mokhtari, Rezvan / Dehpour, Ahmad Reza

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

2018 Volume 21, Issue 1, Page(s) 184–194

Abstract: Purpose: Licofelone, a dual cyclooxygenase/5-lipoxygenase inhibitor, possesses antioxidant, antiapoptotic, neuroprotective, and anti-inflammatory properties. The aim of the present study was to investigate the effect of licofelone on lipopolysaccharide ( ...

Abstract	Purpose: Licofelone, a dual cyclooxygenase/5-lipoxygenase inhibitor, possesses antioxidant, antiapoptotic, neuroprotective, and anti-inflammatory properties. The aim of the present study was to investigate the effect of licofelone on lipopolysaccharide (LPS)-induced depression in a mouse model and also a possible role for nitric oxide (NO). Methods: To elucidate the role of NO on this effect of licofelone (5 and 20 mg/kg, i.p.), L-NAME, a non-specific NO synthase (NOS) inhibitor; aminoguanidine (AG), a specific inducible NOS (iNOS) inhibitor; 7-nitroindazole (7-NI) a preferential neuronal NOS inhibitor (nNOS) and; L-arginine (L-Arg), as a NO donor, were used. The animal's behaviors were evaluated employing forced swimming test (FST), tail suspension test (TST) and open field test (OFT). Results: LPS (0.83 mg/kg, i.p.) induced depressive-like behavior increasing immobility time in FST and TST. Conversely, licofelone (20 mg/kg i.p.) reversed the depressive effect of LPS and lowered the immobility time in FST and TST. On the other hand, pretreatment with L-Arg also reversed the antidepressant-like effect of licofelone (20 mg/kg) in FST and TST. On the other hand, L-NAME (10 and 30 mg/kg), AG (50 and 100 mg/kg) and 7-NI (60 mg/kg) could potentiate licofelone (5 mg/kg) and lowered the immobility duration. Conclusions: NO down-regulation possibly through iNOS and nNOS inhibition may involve in the antidepressant property of licofelone. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.
MeSH term(s)	Animals ; Antidepressive Agents/administration & dosage ; Antidepressive Agents/pharmacology ; Behavior, Animal/drug effects ; Depression/drug therapy ; Depression/metabolism ; Disease Models, Animal ; Injections, Intraperitoneal ; Lipopolysaccharides/antagonists & inhibitors ; Lipopolysaccharides/pharmacology ; Male ; Mice ; Nitric Oxide/antagonists & inhibitors ; Nitric Oxide/metabolism ; Pyrroles/administration & dosage ; Pyrroles/pharmacology
Chemical Substances	Antidepressive Agents ; Lipopolysaccharides ; Pyrroles ; Nitric Oxide (31C4KY9ESH) ; licofelone (P5T6BYS22Y)
Language	English
Publishing date	2018-07-25
Publishing country	Canada
Document type	Journal Article
ISSN	1482-1826
ISSN (online)	1482-1826
DOI	10.18433/jpps29770
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Article ; Online: Probing the interaction of silver nanoparticles with tau protein and neuroblastoma cell line as nervous system models.

Rahmani, Sara / Mogharizadeh, Leila / Attar, Farnoosh / Rezayat, Seyed Mahdi / Mousavi, Seyyedeh Elaheh / Falahati, Mojtaba

Journal of biomolecular structure & dynamics

2017 Volume 36, Issue 15, Page(s) 4057–4071

Abstract: Interestingly pharmaceutical sciences are using nanoparticles (NPs) to design and develop nanomaterials-based drugs. However, up to recently, it has not been well realized that NPs themselves may impose risks to the biological systems. In this study, the ...

Abstract	Interestingly pharmaceutical sciences are using nanoparticles (NPs) to design and develop nanomaterials-based drugs. However, up to recently, it has not been well realized that NPs themselves may impose risks to the biological systems. In this study, the interaction of silver nanoparticles (AgNPs) with tau protein and SH-SY5Y neuroblastoma cell line, as potential nervous system models, was examined with a range of techniques including intrinsic fluorescence spectroscopy, circular dichroism (CD) spectroscopy, 3-(4,5-dimethylthiazol-2-Yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and acridine orange/ethidium bromide (AO/EB) dual staining method. Fluorescence study showed that AgNPs with a diameter of around 10-20 nm spontaneously form a static complex with tau protein via hydrogen bonds and van der Waals interactions. CD experiment revealed that AgNPs did not change the random coil structure of tau protein. Moreover, AgNPs showed to induce SH-SY5Y neuroblastoma cell mortality through fragmentation of DNA which is a key feature of apoptosis. In conclusion, AgNPs may induce slight changes on the tau protein structure. Also, the concentration of AgNPs is the main factor which influences their cytotoxicity. Since, all adverse effects of NPs are not well detected, so probably additional more specific testing would be needed.
MeSH term(s)	Apoptosis/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; DNA Fragmentation/drug effects ; DNA, Neoplasm/chemistry ; DNA, Neoplasm/drug effects ; DNA, Neoplasm/metabolism ; Gene Expression ; Humans ; Hydrogen Bonding ; Metal Nanoparticles/toxicity ; Metal Nanoparticles/ultrastructure ; Molecular Dynamics Simulation ; Neurons/drug effects ; Neurons/metabolism ; Neurons/pathology ; Protein Binding ; Protein Structure, Secondary ; Silver/toxicity ; Thermodynamics ; tau Proteins/chemistry ; tau Proteins/genetics ; tau Proteins/metabolism
Chemical Substances	DNA, Neoplasm ; MAPT protein, human ; tau Proteins ; Silver (3M4G523W1G)
Language	English
Publishing date	2017-12-21
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2017.1407673
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Article ; Online: The role of nitric oxide in anticonvulsant effect of nanocurcumine on pentylenetetrazole-induced seizure in mice.

Aminirad, Alireza / Mousavi, Seyyedeh Elaheh / Fakhraei, Nahid / Mousavi, Seyyedeh Mahbubeh / Rezayat, Seyed Mahdi

Neuroscience letters

2017 Volume 651, Page(s) 226–231

Abstract: A plant alkaloid obtained from Curcuma longa, curcumin possesses anti-oxidant and anti-inflammatory effects. Nanoformulations have been developed for preclinical studies which demonstrate enhanced therapeutic efficacy. Effect of acute intraperitoneal (i ... ...

Abstract	A plant alkaloid obtained from Curcuma longa, curcumin possesses anti-oxidant and anti-inflammatory effects. Nanoformulations have been developed for preclinical studies which demonstrate enhanced therapeutic efficacy. Effect of acute intraperitoneal (i.p.) administration of curcumin C3 complex nanoparticles [1,5, 10, 20, 40, 80mg/kg, (i.p.)] 75min prior to PTZ, on clonic seizure thresholds induced by intravenous infusion of pentylenetetrazole (PTZ) 0.5% was investigated in comparison with curcumin (40 and 80mg/kg, i.p.) in male mice. Moreover, to clarify the probable role of NO in the anticonvulsant property of nanocurcumin, non-effective doses of l-arginine (l-Arg), a NO donor; 7-nitroindazole, 7-NI, a preferential neuronal NO synthase inhibitor; L-NAME, a non-selective NO synthase inhibitor and aminoguanidine (AG), a selective inducible NO synthase inhibitor (iNOS), in combination with nanocurcumin (80mg/kg, i.p.), 15-30min before it were employed. Results: While curcumin did not show any anticonvulsant effect, nanocurcumin revealed dose-dependent anticonvulsant property at the doses 20, 40 and 80mg/kg, P<0.01, P<0.01 and P<0.001, respectively. l-Arg (30 and 60mg/kg) dose-dependently reversed the anticonvulsant effect of the most effective nanocurcumin dose (80mg/kg), P<0.01 and P<0.001, respectively. On the other hand, L-NAME (3 and 10mg/kg, i.p.) markedly potentiated the sub effective dose of nanocurcumin (10mg/kg), P<0.01 and P<0.001, respectively. Similarly, AG (50 and 100mg/kg, i.p.) profoundly augmented the seizure thresholds of nanocurcumin (10mg/kg), P<0.01 and P<0.001, respectively. In addition, 7-NI (10, 30 and 60mg/kg, i.p.) failed to influence the responses. Conclusion: These data may support excess of NO production following PTZ infusion probably resulting from iNOS source. Consequently, nanocurcumin probably down regulated NO. To conclude, nanocurcumin showed anticonvulsant effect. Furthermore, this effect was reversed following l-arginine as an external NO precursor. However, both the non-selective NOS inhibitor and selective iNOS inhibitor increased the thresholds. It is evident that nanocurcumin may influence the seizure thresholds at least in part through a decrease in NO.
MeSH term(s)	Animals ; Anticonvulsants/administration & dosage ; Convulsants/administration & dosage ; Curcumin/administration & dosage ; Dose-Response Relationship, Drug ; Indazoles/administration & dosage ; Male ; Mice ; Nanoparticles ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type I/antagonists & inhibitors ; Pentylenetetrazole/administration & dosage ; Seizures/chemically induced ; Seizures/drug therapy ; Seizures/metabolism
Chemical Substances	Anticonvulsants ; Convulsants ; Indazoles ; Nitric Oxide (31C4KY9ESH) ; Nitric Oxide Synthase Type I (EC 1.14.13.39) ; Curcumin (IT942ZTH98) ; 7-nitroindazole (UX0N37CMVH) ; Pentylenetetrazole (WM5Z385K7T)
Language	English
Publishing date	2017-05-10
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	194929-9
ISSN	1872-7972 ; 0304-3940
ISSN (online)	1872-7972
ISSN	0304-3940
DOI	10.1016/j.neulet.2017.05.018
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