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Article ; Online: The Case | Acute kidney injury following infective endocarditis.

Mousseaux, Cyril / Tang, Ellie / Tristant, Maxime / Luque, Yosu / Frochot, Vincent / Mesnard, Laurent / Bazin, Dominique / Rafat, Cédric / Buob, David / Letavernier, Emmanuel

Kidney international

2023 Volume 104, Issue 4, Page(s) 863–864

MeSH term(s)	Humans ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Endocarditis/complications ; Endocarditis/diagnosis
Language	English
Publishing date	2023-09-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2023.06.028
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Zs.A 797: Show issues

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Article ; Online: Management of severe hypercalcaemia: results of the French-speaking physicians' practice survey.

Mousseaux, Cyril / Arrestier, Romain / Chaibi, Khalil / Braconnier, Antoine / Hocine, Aldjia / Lanot, Antoine / Serre, Justine / Bobot, Mickaël

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2023 Volume 38, Issue 6, Page(s) 1571–1573

MeSH term(s)	Humans ; Hypercalcemia/diagnosis ; Hypercalcemia/etiology ; Hypercalcemia/therapy ; Physicians ; Surveys and Questionnaires ; Practice Patterns, Physicians'
Language	English
Publishing date	2023-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfad018
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Zs.A 2198: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 329: Show issues

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Article ; Online: Resolution of Pain after Percutaneous Image-Guided Cryoablation of Extraperitoneal Endometriosis.

Najdawi, Milan / Razakamanantsoa, Leo / Mousseaux, Cyril / Bendifallah, Sofiane / Touboul, Cyril / Thomassin-Naggara, Isabelle / Bazot, Marc / Barral, Matthias / Cornelis, Francois H

Journal of vascular and interventional radiology : JVIR

2023 Volume 34, Issue 7, Page(s) 1192–1198

Abstract: Purpose: To retrospectively evaluate the relief of pain after percutaneous image-guided cryoablation of symptomatic extraperitoneal endometriosis (EE).: Material and methods: From 2017 to 2022, cryoablation of EE was performed at a single institution ...

Abstract	Purpose: To retrospectively evaluate the relief of pain after percutaneous image-guided cryoablation of symptomatic extraperitoneal endometriosis (EE). Material and methods: From 2017 to 2022, cryoablation of EE was performed at a single institution on a total of 47 lesions in 42 consecutive patients (median age, 37 years; interquartile range [IQR], 33-39.5 years). Patient and procedural characteristics were reviewed retrospectively. Tolerance and outcomes in terms of pain and patient satisfaction were evaluated. Results: The median follow-up duration was 13.5 months (IQR, 1.1-37.7 months) after cryoablation. The median pain-free survival rate was 93.8% (95% confidence interval [CI], 77.3-98.4) at 6 months and 82.7% (95% CI, 58.8-93.5) after 12 months. Pain decreased from a median of 8/10 (IQR, 7-9) on the visual analog scale to 0/10 (IQR, 0-1) at the last follow-up (P < .0001). The median Patient Global Impression of Change score recorded at the last follow-up was 1/7 (IQR, 1-2). The efficacy rate of cryoablation to avoid secondary surgery was 92.8% (39/42) per patient and 93.6% (44/47) per nodule treated. Four patients (9.5%, 4/42) experienced an adverse event in the days following the procedure, and 1 patient (2%) experienced a severe adverse event. Conclusions: Percutaneous cryoablation is safe and effective in significantly reducing pain and obtaining local control of EE.
MeSH term(s)	Female ; Humans ; Adult ; Endometriosis/diagnostic imaging ; Endometriosis/surgery ; Endometriosis/etiology ; Cryosurgery/adverse effects ; Cryosurgery/methods ; Retrospective Studies ; Treatment Outcome ; Pain/etiology
Language	English
Publishing date	2023-03-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1137756-2
ISSN	1535-7732 ; 1051-0443
ISSN (online)	1535-7732
ISSN	1051-0443
DOI	10.1016/j.jvir.2023.03.025
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Zs.A 3720: Show issues

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Article ; Online: The Case | A lockdown-related metabolic acidosis.

Mousseaux, Cyril / Schwarz, Chloë / Garcia, Hugo / Mohamadou, Inna / Mesnard, Laurent / Luque, Yosu

Kidney international

2021 Volume 99, Issue 1, Page(s) 273–274

MeSH term(s)	Acidosis/etiology ; Humans
Language	English
Publishing date	2021-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2020.07.051
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Zs.A 797: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Heterozygous expression of Cre recombinase in podocytes has no impact on the anti-glomerular basement membrane glomerulonephritis model in C57BL/6J mice.

Mousseaux, Cyril / Migeon, Tiffany / Frère, Perrine / Verpont, Marie Christine / Lutete, Elisabeth / Navarro, Claire / Louedec, Liliane / Hadchouel, Juliette

Physiological reports

2022 Volume 10, Issue 17, Page(s) e15443

Abstract: A recent article described a thickening of the glomerular basement membrane (GBM) along with changes in the expression of key components of the extracellular matrix in 6-month-old NPHS2-Cre transgenic mice, which express the Cre recombinase specifically ... ...

Abstract	A recent article described a thickening of the glomerular basement membrane (GBM) along with changes in the expression of key components of the extracellular matrix in 6-month-old NPHS2-Cre transgenic mice, which express the Cre recombinase specifically in podocytes. This transgenic line has been widely used to characterize the implication of candidate genes in glomerular diseases in younger mice. Using a different mouse strain (C57BL/6J) than the previous report (129S6/SvEvTac), we sought to characterize 3- and 6-month-old NPHS2-Cre
MeSH term(s)	Animals ; Disease Models, Animal ; Glomerular Basement Membrane/metabolism ; Glomerulonephritis/metabolism ; Integrases/genetics ; Integrases/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Podocytes/metabolism
Chemical Substances	Cre recombinase (EC 2.7.7.-) ; Integrases (EC 2.7.7.-)
Language	English
Publishing date	2022-09-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2724325-4
ISSN	2051-817X ; 2051-817X
ISSN (online)	2051-817X
ISSN	2051-817X
DOI	10.14814/phy2.15443
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Article ; Online: Severe HELLP syndrome masquerading as thrombocytopenic thrombotic purpura: a case report.

Mousseaux, Cyril / Joly, Bérangère S / Mohamadou, Inna / Arrestier, Romain / Hertig, Alexandre / Rafat, Cédric

BMC nephrology

2020 Volume 21, Issue 1, Page(s) 204

Abstract: Background: Thrombotic microangiopathies (TMAs) occurring in the postpartum period may be difficult to manage. They present as the combination of mechanical hemolytic anemia and consumption thrombocytopenia due to endothelial dysfunction. The cause of ... ...

Abstract	Background: Thrombotic microangiopathies (TMAs) occurring in the postpartum period may be difficult to manage. They present as the combination of mechanical hemolytic anemia and consumption thrombocytopenia due to endothelial dysfunction. The cause of this endothelial aggression can be multiple: thrombocytopenic thrombotic purpura (TTP), HELLP syndrome, antiphospholipid syndrome, atypical hemolytic and uremic syndrome or acute fatty liver of pregnancy. TTP results from a severe deficiency of ADAMTS13, which is a protease cleaving specifically von Willebrand factor chiefly produced by liver cells. There are two main causes, the production of anti-ADAMTS13 auto-antibodies and, more rarely, a genetic deficiency in ADAMTS13. First-line treatment is based on plasma exchange. HELLP syndrome occurs in the third trimester of pregnancy usually in association with preeclampsia and represents a form of TMA characterized by damage to the sinusoidal capillaries of the liver. Prompt delivery is the main treatment. We present a case illustrating the challenges in discriminating between different postpartum TMAs, with a focus on the distinction between TTP and HELLP syndrome. Specifically, we highlight how acute liver failure (ALF) stemming from HELLP may lead to TTP with a spectacular response to plasma exchanges. Case: A 28-year-old, 33 + 4 weeks pregnant woman presented with severe preeclampsia complicated by ALF in the setting of partial liver necrosis, disseminated intravascular coagulation, microangiopathic hemolytic anemia and acute kidney injury. Greatly diminished levels of ADAMTS13 (< 5%) activity and neurological impairment suggested an initial diagnosis of thrombotic thrombocytopenic purpura (TTP). Therapeutic plasma exchange (TPE) was initiated and complete renal, neurological, hematological and hepatic recovery was observed. Secondary TTP induced by ALF due to HELLP syndrome was the final diagnosis. Conclusion: Our case addresses the overlapping nature of postpartum TMAs and raises the possibility that HELLP-induced ALF may constitute an additional mechanism resulting in TTP, thereby opening a possible indication for TPE.
MeSH term(s)	ADAMTS13 Protein/immunology ; Adult ; Antibodies/blood ; Diagnosis, Differential ; Disseminated Intravascular Coagulation/etiology ; Female ; HELLP Syndrome/diagnosis ; HELLP Syndrome/therapy ; Humans ; Liver/pathology ; Liver Failure, Acute/complications ; Necrosis ; Plasma Exchange ; Pre-Eclampsia/etiology ; Pregnancy ; Purpura, Thrombotic Thrombocytopenic/diagnosis ; Purpura, Thrombotic Thrombocytopenic/etiology
Chemical Substances	Antibodies ; ADAMTS13 Protein (EC 3.4.24.87) ; ADAMTS13 protein, human (EC 3.4.24.87)
Language	English
Publishing date	2020-05-29
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-020-01865-y
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Article ; Online: Acute Kidney Injury After High Doses of Amoxicillin.

Mousseaux, Cyril / Rafat, Cédric / Letavernier, Emmanuel / Frochot, Vincent / Kerroumi, Younes / Zeller, Valérie / Luque, Yosu

Kidney international reports

2020 Volume 6, Issue 3, Page(s) 830–834

Language	English
Publishing date	2020-12-13
Publishing country	United States
Document type	Journal Article
ISSN	2468-0249
ISSN (online)	2468-0249
DOI	10.1016/j.ekir.2020.11.040
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Article ; Online: The Case | A patient with acute tetraparesis.

Arrestier, Romain / Mucha, Simon / Mousseaux, Cyril / Mohamadou, Inna / Jamme, Matthieu / Rafat, Cédric

Kidney international

2018 Volume 94, Issue 6, Page(s) 1243–1244

MeSH term(s)	Acute Disease ; Adrenergic beta-Antagonists/therapeutic use ; Adult ; Antithyroid Agents/therapeutic use ; Arrhythmias, Cardiac/drug therapy ; Arrhythmias, Cardiac/etiology ; Arrhythmias, Cardiac/physiopathology ; Biomarkers/blood ; Graves Disease/blood ; Graves Disease/complications ; Graves Disease/diagnosis ; Graves Disease/drug therapy ; Humans ; Hypokalemia/blood ; Hypokalemia/diagnosis ; Hypokalemia/drug therapy ; Hypokalemia/etiology ; Male ; Potassium/blood ; Potassium/therapeutic use ; Quadriplegia/diagnosis ; Quadriplegia/drug therapy ; Quadriplegia/etiology ; Quadriplegia/physiopathology ; Recovery of Function ; Thyroid Hormones/blood ; Thyrotoxicosis/blood ; Thyrotoxicosis/diagnosis ; Thyrotoxicosis/drug therapy ; Thyrotoxicosis/etiology ; Treatment Outcome ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Dysfunction, Left/therapy
Chemical Substances	Adrenergic beta-Antagonists ; Antithyroid Agents ; Biomarkers ; Thyroid Hormones ; Potassium (RWP5GA015D)
Language	English
Publishing date	2018-11-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2018.07.017
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Article ; Online: Abdominal emergencies in cancer patients: Which criteria to decide for surgery?

Vincent, François / Bouguerba, Abdelaziz / Mousseaux, Cyril / Ayed, Soufia / Bornstain, Caroline

Surgery

2016 Volume 159, Issue 3, Page(s) 980–981

MeSH term(s)	Abdominal Injuries/surgery ; Abdominal Neoplasms/surgery ; Decision Support Techniques ; Female ; Humans ; Male ; Postoperative Complications/etiology
Language	English
Publishing date	2016-03
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	202467-6
ISSN	1532-7361 ; 0039-6060
ISSN (online)	1532-7361
ISSN	0039-6060
DOI	10.1016/j.surg.2015.08.008
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Uk I Zs.129: Show issues

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Article ; Online: Ockham's razor defeated: about two atypical cases of hemolytic uremic syndrome.

Schwarz, Chloe / Brehon, Alice / Mousseaux, Cyril / Luque, Yosu / Senet, Patricia / Mariani, Patricia / Mohamadou, Inna / Zafrani, Lara / Frémeaux-Bacchi, Véronique / Rondeau, Eric / Buob, David / Rafat, Cédric

BMC nephrology

2020 Volume 21, Issue 1, Page(s) 269

Abstract: Background: Medical investigation is a favorite application of Ockham's razor, in virtue of which when presented with competing hypotheses, the solution with the fewest assumptions should be privileged. Hemolytic uremic syndrome (HUS) encompasses ... ...

Abstract	Background: Medical investigation is a favorite application of Ockham's razor, in virtue of which when presented with competing hypotheses, the solution with the fewest assumptions should be privileged. Hemolytic uremic syndrome (HUS) encompasses diseases with distinct pathological mechanisms, such as HUS due to shiga-like toxin-producing bacteria (STEC-HUS) and atypical HUS, linked to defects in the alternate complement pathway. Other etiologies such as Parvovirus B19 infection are exceptional. All these causes are rare to such extent that we usually consider them mutually exclusive. We report here two cases of HUS that could be traced to multiple causes. Cases presentation: Case 1 presented as vomiting and diarrhea. All biological characteristics of HUS were present. STEC was found in stool (by PCR and culture). After initial remission, a recurrence occurred and patient was started on Eculizumab. Genetic analysis revealed the heterozygous presence of a CFHR1/CFH hybrid gene. The issue was favorable under treatment. In case 2, HUS presented as fever, vomiting and purpura of the lower limbs. Skin lesions and erythroblastopenia led to suspect Parvovirus B19 primo-infection, which was confirmed by peripheral blood and medullar PCR. Concurrently, stool culture and PCR revealed the presence of STEC. Evolution showed spontaneous recovery. Conclusions: Both cases defy Ockham's razor in the sense that multiple causes could be traced to a single outcome; furthermore, they invite us to reflect on the physiopathology of HUS as they question the classical distinction between STEC-HUS and atypical HUS. We propose a two-hit mechanism model leading to HUS. Indeed, in case 1, HUS unfolded as a result of the synergistic interaction between an infectious trigger and a genetic predisposition. In case 2 however, it is the simultaneous occurrence of two infectious triggers that led to HUS. In dissent from Ockham's razor, an exceptional disease such as HUS may stem from the sequential occurrence or co-occurrence of several rare conditions.
MeSH term(s)	Adult ; Antibodies, Monoclonal, Humanized/therapeutic use ; Atypical Hemolytic Uremic Syndrome/complications ; Atypical Hemolytic Uremic Syndrome/drug therapy ; Atypical Hemolytic Uremic Syndrome/genetics ; Atypical Hemolytic Uremic Syndrome/physiopathology ; Complement C3b Inactivator Proteins/genetics ; Complement Factor H/genetics ; Diarrhea/physiopathology ; Erythema Infectiosum/complications ; Erythema Infectiosum/physiopathology ; Escherichia coli Infections/complications ; Escherichia coli Infections/drug therapy ; Escherichia coli Infections/microbiology ; Escherichia coli Infections/physiopathology ; Genetic Testing ; Hemolytic-Uremic Syndrome/drug therapy ; Hemolytic-Uremic Syndrome/etiology ; Hemolytic-Uremic Syndrome/physiopathology ; Heterozygote ; Humans ; Male ; Recurrence ; Shiga-Toxigenic Escherichia coli ; Vomiting/physiopathology
Chemical Substances	Antibodies, Monoclonal, Humanized ; CFH protein, human ; CFHR1 protein, human ; Complement C3b Inactivator Proteins ; Complement Factor H (80295-65-4) ; eculizumab (A3ULP0F556)
Language	English
Publishing date	2020-07-11
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-020-01926-2
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