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  1. Article ; Online: Antigen cross-presentation by dendritic cells: A critical axis in cancer immunotherapy.

    Moussion, Christine / Delamarre, Lélia

    Seminars in immunology

    2023  Volume 71, Page(s) 101848

    Abstract: Dendritic cells (DCs) are professional antigen-presenting cells that play a key role in shaping adaptive immunity. DCs have a unique ability to sample their environment, capture and process exogenous antigens into peptides that are then loaded onto major ...

    Abstract Dendritic cells (DCs) are professional antigen-presenting cells that play a key role in shaping adaptive immunity. DCs have a unique ability to sample their environment, capture and process exogenous antigens into peptides that are then loaded onto major histocompatibility complex class I molecules for presentation to CD8
    MeSH term(s) Humans ; Cross-Priming ; CD8-Positive T-Lymphocytes ; Antigen Presentation ; Antigens ; Neoplasms/therapy ; Immunotherapy ; Dendritic Cells
    Chemical Substances Antigens
    Language English
    Publishing date 2023-11-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2023.101848
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Tumour lymph vessels boost immunotherapy.

    Moussion, Christine / Turley, Shannon J

    Nature

    2020  Volume 552, Issue 7685, Page(s) 340–342

    Language English
    Publishing date 2020-02-21
    Publishing country England
    Document type News
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-017-08669-5
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  3. Article ; Online: The Dendritic Cell Strikes Back.

    Moussion, Christine / Mellman, Ira

    Immunity

    2019  Volume 50, Issue 2, Page(s) 533

    Language English
    Publishing date 2019-02-12
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2019.01.022
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  4. Article ; Online: Shape and Function of Interstitial Chemokine CCL21 Gradients Are Independent of Heparan Sulfates Produced by Lymphatic Endothelium.

    Vaahtomeri, Kari / Moussion, Christine / Hauschild, Robert / Sixt, Michael

    Frontiers in immunology

    2021  Volume 12, Page(s) 630002

    Abstract: Gradients of chemokines and growth factors guide migrating cells and morphogenetic processes. Migration of antigen-presenting dendritic cells from the interstitium into the lymphatic system is dependent on chemokine CCL21, which is secreted by ... ...

    Abstract Gradients of chemokines and growth factors guide migrating cells and morphogenetic processes. Migration of antigen-presenting dendritic cells from the interstitium into the lymphatic system is dependent on chemokine CCL21, which is secreted by endothelial cells of the lymphatic capillary, binds heparan sulfates and forms gradients decaying into the interstitium. Despite the importance of CCL21 gradients, and chemokine gradients in general, the mechanisms of gradient formation are unclear. Studies on fibroblast growth factors have shown that limited diffusion is crucial for gradient formation. Here, we used the mouse dermis as a model tissue to address the necessity of CCL21 anchoring to lymphatic capillary heparan sulfates in the formation of interstitial CCL21 gradients. Surprisingly, the absence of lymphatic endothelial heparan sulfates resulted only in a modest decrease of CCL21 levels at the lymphatic capillaries and did neither affect interstitial CCL21 gradient shape nor dendritic cell migration toward lymphatic capillaries. Thus, heparan sulfates at the level of the lymphatic endothelium are dispensable for the formation of a functional CCL21 gradient.
    MeSH term(s) Animals ; Cells, Cultured ; Chemokine CCL21/metabolism ; Chemotaxis ; Dendritic Cells/immunology ; Dermis/immunology ; Endothelium, Lymphatic/immunology ; Heparitin Sulfate/metabolism ; Lymphatic Vessels/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, CCR7/genetics
    Chemical Substances Ccr7 protein, mouse ; Chemokine CCL21 ; Receptors, CCR7 ; Heparitin Sulfate (9050-30-0)
    Language English
    Publishing date 2021-02-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.630002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The Dendritic Cell Strikes Back.

    Moussion, Christine / Mellman, Ira

    Immunity

    2018  Volume 49, Issue 6, Page(s) 997–999

    Abstract: The field of cancer immunotherapy and checkpoint blockade has focused largely on direct effects on T cells. In this issue of Immunity, Garris et al. (2018) show that the efficacy of anti-PD-1 therapy depends on a T-cell-dendritic-cell (DC) licensing loop ...

    Abstract The field of cancer immunotherapy and checkpoint blockade has focused largely on direct effects on T cells. In this issue of Immunity, Garris et al. (2018) show that the efficacy of anti-PD-1 therapy depends on a T-cell-dendritic-cell (DC) licensing loop fueled by IFN-γ and IL-12, thereby establishing a central role for DCs in promoting anti-cancer T cell immunity during checkpoint blockade.
    MeSH term(s) Cytokines ; Dendritic Cells ; Immunotherapy ; Interleukin-12 ; Programmed Cell Death 1 Receptor ; T-Lymphocytes
    Chemical Substances Cytokines ; Programmed Cell Death 1 Receptor ; Interleukin-12 (187348-17-0)
    Language English
    Publishing date 2018-12-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2018.12.007
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  6. Article ; Online: Tumour lymph vessels boost immunotherapy.

    Moussion, Christine / Turley, Shannon J

    Nature

    2017  Volume 552, Issue 7685, Page(s) 340–342

    MeSH term(s) Humans ; Immunotherapy ; Lymphatic Vessels ; Neoplasms
    Language English
    Publishing date 2017--21
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-017-08669-5
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  7. Article ; Online: Nonclinical pharmacokinetics, pharmacodynamics and safety assessment of a FLT3L-Fc molecule for cancer immunotherapy.

    Wu, Kai Connie / Adedeji, Adeyemi O / Zabka, Tanja S / Hosseini, Iraj / Kenkre, Radhika / Getz, Jennifer A / Nguyen, Tien / Decalf, Jérémie / Bainbridge, Travis W / Chilton, Jennifer A / Moussion, Christine C / Rao, Gautham K

    Toxicology and applied pharmacology

    2024  Volume 483, Page(s) 116837

    Abstract: FLT3L-Fc is a cytokine-Fc fusion agonizing receptor-type tyrosine-protein kinase FLT3 (fms-related tyrosine kinase 3; CD135). FLT3 is expressed on dendritic cells (DCs) as well as myeloid and lymphoid progenitors. Nonclinical pharmacokinetics, ... ...

    Abstract FLT3L-Fc is a cytokine-Fc fusion agonizing receptor-type tyrosine-protein kinase FLT3 (fms-related tyrosine kinase 3; CD135). FLT3 is expressed on dendritic cells (DCs) as well as myeloid and lymphoid progenitors. Nonclinical pharmacokinetics, pharmacodynamics and safety of FLT3L-Fc were investigated in rats and cynomolgus monkeys. FLT3L-Fc induced robust pharmacodynamic responses, evidenced by marked expansion of peripheral blood cDC1s, cDC2s, and pDCs (up to 301-fold in rats and 378-fold in monkeys), peaking at 8-10 days after the first dose. FLT3L-Fc was well tolerated with no adverse findings at doses up to 10 mg/kg administered intravenously twice three weeks apart. In both species, major clinical pathology findings consisted of expansion of white blood cell (WBC) populations including lymphocytes, monocytes, neutrophils, basophils, and large unstained cells, which were pronounced after the first dose. The WBC findings were associated microscopically with histiocytic and mononuclear cell infiltrates in multiple organs. Tissue immunohistochemistry in monkeys showed that the leukocyte infiltrates consisted of hematopoietic progenitor cells and histiocytes with a reactive morphology and were associated with a slight stimulation of regional T and B cell populations. Additional FLT3L-Fc-associated changes included decreases in red blood cell (RBC) mass, increases in RBC distribution width, variable changes in reticulocytes, and transient alterations in platelet counts (rats only). The RBC and WBC findings were associated microscopically with increased hematopoietic cellularity of the bone marrow in both species and increased splenic megakaryocytic extramedullary hematopoiesis in rats. The totality of nonclinical safety data support the clinical development of FLT3L-Fc.
    MeSH term(s) Rats ; Animals ; Membrane Proteins ; Dendritic Cells ; Neoplasms ; Hematopoietic Stem Cells ; Immunotherapy
    Chemical Substances Membrane Proteins
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2024.116837
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  8. Article ; Online: Pattern recognition receptor agonists in pathogen vaccines mediate antitumor T-cell cross-priming.

    Aleynick, Mark / Svensson-Arvelund, Judit / Pantsulaia, Gvantsa / Kim, Kristy / Rose, Samuel A / Upadhyay, Ranjan / Yellin, Michael / Marsh, Henry / Oreper, Daniel / Jhunjhunwala, Suchit / Moussion, Christine Carine / Merad, Miriam / Brown, Brian D / Brody, Joshua D

    Journal for immunotherapy of cancer

    2023  Volume 11, Issue 7

    Abstract: Background: Cancer immunotherapies are generally effective in patients whose tumors contain a priori primed T-cells reactive to tumor antigens (TA). One approach to prime TA-reactive T-cells is to administer immunostimulatory molecules, cells, or ... ...

    Abstract Background: Cancer immunotherapies are generally effective in patients whose tumors contain a priori primed T-cells reactive to tumor antigens (TA). One approach to prime TA-reactive T-cells is to administer immunostimulatory molecules, cells, or pathogens directly to the tumor site, that is, in situ vaccination (ISV). We recently described an ISV using Flt3L to expand and recruit dendritic cells (DC), radiotherapy to load DC with TA, and pattern recognition receptor agonists (PRRa) to activate TA-loaded DC. While ISV trials using
    Methods: To discover optimal DC activators and increase access to clinical grade reagents, we assessed whether viral or bacterial components found in common pathogen vaccines are an effective source of
    Results: We observed that vaccine naPRRa can be even more potent in activating Flt3L-expanded murine and human DCs than synthetic PRRa, promoting cross-priming of TA-reactive T-cells. We developed a mechanistically diverse naPRRa combination (BCG, PedvaxHIB, Rabies) and noted more potent T-cell cross-priming than with any single naPRRa. The naPRRa triplet-as part of Flt3L-primed ISV-induced greater intratumoral CD8 T-cell infiltration, T-cells reactive to a newly defined tumorous neoantigen, durable tumor regressions.
    Conclusions: This work provides rationale for the translation of pathogen vaccines as FDA-approved clinical-grade DC activators which could be exploited as immune-stimulants for early phase trials.
    MeSH term(s) Humans ; Animals ; Mice ; Cross-Priming ; CD8-Positive T-Lymphocytes ; Vaccination ; Gene Editing ; Immunization
    Language English
    Publishing date 2023-07-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2719863-7
    ISSN 2051-1426 ; 2051-1426
    ISSN (online) 2051-1426
    ISSN 2051-1426
    DOI 10.1136/jitc-2023-007198
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  9. Article ; Online: A conduit to amplify innate immunity.

    Moussion, Christine / Sixt, Michael

    Immunity

    2013  Volume 38, Issue 5, Page(s) 853–854

    Abstract: In this issue of Immunity, Py et al. (2013) report that upon bacterial infection, a fragment of the matrix protein cochlin is released from the conduits of B cell follicles to trigger protective cytokines in the periphery. ...

    Abstract In this issue of Immunity, Py et al. (2013) report that upon bacterial infection, a fragment of the matrix protein cochlin is released from the conduits of B cell follicles to trigger protective cytokines in the periphery.
    MeSH term(s) Animals ; Dendritic Cells, Follicular/metabolism ; Extracellular Matrix Proteins/metabolism ; Immunity, Innate ; Pseudomonas Infections/immunology ; Staphylococcal Infections/immunology ; Staphylococcus aureus/immunology
    Chemical Substances Coch protein, mouse ; Extracellular Matrix Proteins
    Language English
    Publishing date 2013-05-23
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2013.05.005
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  10. Article: Les vaisseaux sanguins HEV: des vaisseaux spécialisés dans le recrutement des lymphocytes.

    Moussion, Christine / Girard, Jean-Philippe

    Medecine sciences : M/S

    2012  Volume 28, Issue 4, Page(s) 347–349

    Title translation High endothelial venules (HEVs) and dendritic cells: a key functional unit for lymphocyte migration.
    MeSH term(s) Animals ; Cell Communication/immunology ; Cell Communication/physiology ; Cell Movement/immunology ; Cell Movement/physiology ; Chemotaxis, Leukocyte/physiology ; Dendritic Cells/physiology ; Endothelial Cells/physiology ; Humans ; Lymphocytes/physiology ; Mice ; Models, Biological ; Venules/physiology
    Language French
    Publishing date 2012-04
    Publishing country France
    Document type News
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2012284004
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