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Artikel ; Online: New potential green, bioactive and antimicrobial nanocomposites based on cellulose and amino acid.

Hasanin, Mohamed S / Moustafa, Gaber O

International journal of biological macromolecules

2019 Band 144, Seite(n) 441–448

Abstract: The present study deals with novel synthesizing method of TEMPO oxidized cellulose (extracted from bagasse) (TOC) amino acids (l-phenyl alanine (Phe) and l-tryptophan (Trp)) nano-composites as potential antimicrobial biocompatible agents. The produced ... ...

Abstract	The present study deals with novel synthesizing method of TEMPO oxidized cellulose (extracted from bagasse) (TOC) amino acids (l-phenyl alanine (Phe) and l-tryptophan (Trp)) nano-composites as potential antimicrobial biocompatible agents. The produced nanocomposites were characterized via Fourier transform Infrared (FT-IR) spectroscopy, thermal analysis (TGA and DTGA), scanning electron microscope(SEM), and transmission electron microscope (TEM) which approved that the synthesis of composites in nano-scale in spherical shape with average particle size 72 and 44.37 nm for l-phenylalanine composite (Phe-TOC) and l-tryptophan composite (Trp-TOC) respectively. The antimicrobial studies were carried out on (i) Gram-negative bacteria: Escherichia coli (NCTC-10416) and Pseudomonas aeruginosa (NCID-9016); (ii) Gram-positive bacteria: Streptococcus aurous (NCTC-7447) and Bacillus subtilis (NCID-3610); (iii) unicellular fungi: namely, Candida albicans (NCCLS 11). The results were cleared that the both composites have high effective, rapid and broad-spectrum antimicrobial activity. The Trp-TOC showed slightly higher antimicrobial activity than Phe-TOC especially in time required of killing performance. The Phe-TOC has required 20 h for killing all microbial population while Trp-TOC required only 12 h. The MIC values were close in both nanocomposites with high clear zone measurements in the same concentration in the case of Trp-TOC.
Mesh-Begriff(e)	Anti-Infective Agents/chemical synthesis ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacokinetics ; Bacteria/growth & development ; Candida albicans/growth & development ; Cellulose/chemistry ; Cellulose/pharmacology ; Nanocomposites/chemistry ; Phenylalanine/chemistry ; Phenylalanine/pharmacology ; Tryptophan/chemistry ; Tryptophan/pharmacology
Chemische Substanzen	Anti-Infective Agents ; Phenylalanine (47E5O17Y3R) ; Tryptophan (8DUH1N11BX) ; Cellulose (9004-34-6)
Sprache	Englisch
Erscheinungsdatum	2019-12-17
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2019.12.133
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: New potential green, bioactive and antimicrobial nanocomposites based on cellulose and amino acid

Hasanin, Mohamed S / Moustafa, Gaber O

International journal of biological macromolecules. 2020 Feb. 01, v. 144

2020

Abstract	The present study deals with novel synthesizing method of TEMPO oxidized cellulose (extracted from bagasse) (TOC) amino acids (l-phenyl alanine (Phe) and l-tryptophan (Trp)) nano-composites as potential antimicrobial biocompatible agents. The produced nanocomposites were characterized via Fourier transform Infrared (FT-IR) spectroscopy, thermal analysis (TGA and DTGA), scanning electron microscope(SEM), and transmission electron microscope (TEM) which approved that the synthesis of composites in nano-scale in spherical shape with average particle size 72 and 44.37 nm for l-phenylalanine composite (Phe-TOC) and l-tryptophan composite (Trp-TOC) respectively. The antimicrobial studies were carried out on (i) Gram-negative bacteria: Escherichia coli (NCTC-10416) and Pseudomonas aeruginosa (NCID-9016); (ii) Gram-positive bacteria: Streptococcus aurous (NCTC-7447) and Bacillus subtilis (NCID-3610); (iii) unicellular fungi: namely, Candida albicans (NCCLS 11). The results were cleared that the both composites have high effective, rapid and broad-spectrum antimicrobial activity. The Trp-TOC showed slightly higher antimicrobial activity than Phe-TOC especially in time required of killing performance. The Phe-TOC has required 20 h for killing all microbial population while Trp-TOC required only 12 h. The MIC values were close in both nanocomposites with high clear zone measurements in the same concentration in the case of Trp-TOC.
Schlagwörter	Bacillus subtilis ; Candida albicans ; Escherichia coli ; Fourier transform infrared spectroscopy ; Gram-negative bacteria ; Gram-positive bacteria ; Pseudomonas aeruginosa ; Streptococcus ; alanine ; antimicrobial properties ; bagasse ; cellulose ; fungi ; minimum inhibitory concentration ; nanocomposites ; oxidation ; particle size ; phenylalanine ; scanning electron microscopes ; scanning electron microscopy ; thermogravimetry ; transmission electron microscopes ; transmission electron microscopy ; tryptophan
Sprache	Englisch
Erscheinungsverlauf	2020-0201
Umfang	p. 441-448.
Erscheinungsort	Elsevier B.V.
Dokumenttyp	Artikel
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2019.12.133
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Design, Synthesis, Anticancer Evaluation, Enzymatic Assays, and a Molecular Modeling Study of Novel Pyrazole-Indole Hybrids.

Hassan, Ashraf S / Moustafa, Gaber O / Awad, Hanem M / Nossier, Eman S / Mady, Mohamed F

ACS omega

2021 Band 6, Heft 18, Seite(n) 12361–12374

Abstract: The molecular hybridization concept has recently emerged as a powerful approach in drug discovery. A series of novel indole derivatives linked to the pyrazole moiety were designed and ... ...

Abstract	The molecular hybridization concept has recently emerged as a powerful approach in drug discovery. A series of novel indole derivatives linked to the pyrazole moiety were designed and developed
Sprache	Englisch
Erscheinungsdatum	2021-04-29
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.1c01604
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Low-cost potentiometric paper-based analytical device based on newly synthesized macrocyclic pyrido-pentapeptide derivatives as novel ionophores for point-of-care copper(ii) determination.

Kamel, Ayman H / Amr, Abd El-Galil E / Almehizia, Abdulrahman A / Elsayed, Elsayed A / Moustafa, Gaber O

RSC advances

2021 Band 11, Heft 44, Seite(n) 27174–27182

Abstract: A simple, cost-effective, portable and disposable paper-based analytical device is designed and fabricated for copper(ii) determination. All solid-state ion-selective electrodes (ISEs) for copper and a Ag/AgCl reference electrode were constructed and ... ...

Abstract	A simple, cost-effective, portable and disposable paper-based analytical device is designed and fabricated for copper(ii) determination. All solid-state ion-selective electrodes (ISEs) for copper and a Ag/AgCl reference electrode were constructed and optimized on the paper substrate. The copper electrodes were built using carbon nano-tube ink as a conductive substrate and an ion-to electron transducer. A suitable polymeric membrane is drop-cast on the surface of the conductive carbon ink window. The copper-sensing membrane is based on newly synthesized macrocyclic pyrido-pentapeptide derivatives as novel ionophores for copper detection. Under the optimized conditions, the presented all-solid-state paper-based Cu
Sprache	Englisch
Erscheinungsdatum	2021-08-18
Erscheinungsland	England
Dokumenttyp	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d1ra04712d
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Low-cost potentiometric paper-based analytical device based on newly synthesized macrocyclic pyrido-pentapeptide derivatives as novel ionophores for point-of-care copper(ii) determination

Kamel, Ayman H. / Amr, Abd El-Galil E. / Almehizia, Abdulrahman A. / Elsayed, Elsayed A. / Moustafa, Gaber O.

RSC advances. 2021 Aug. 18, v. 11, no. 44

2021

Abstract	A simple, cost-effective, portable and disposable paper-based analytical device is designed and fabricated for copper(ii) determination. All solid-state ion-selective electrodes (ISEs) for copper and a Ag/AgCl reference electrode were constructed and optimized on the paper substrate. The copper electrodes were built using carbon nano-tube ink as a conductive substrate and an ion-to electron transducer. A suitable polymeric membrane is drop-cast on the surface of the conductive carbon ink window. The copper-sensing membrane is based on newly synthesized macrocyclic pyrido-pentapeptide derivatives as novel ionophores for copper detection. Under the optimized conditions, the presented all-solid-state paper-based Cu²⁺-ISEs showed a Nernstian response toward Cu²⁺ ions in 30 mM MES buffer, pH 7.0 over the linear range of 5.0 × 10⁻⁷–1.0 × 10⁻³ M with a limit of detection of 8.0 × 10⁻⁸ M. The copper-based sensors exhibited rapid detection of Cu²⁺ ions with a short response time (<10 s). The selectivity pattern of these new ionophores towards Cu²⁺ ions over many common mono-, di- and trivalent cations was evaluated using the modified separate solution method (MSSM). The presented paper-based analytical device exhibited good intra-day and inter day precision. The presented tool was successfully applied for trace Cu²⁺ detection in real samples of serum and whole blood collected from different children with autism spectrum disorder. The data obtained by the proposed potentiometric method were compared with those obtained by the inductively-coupled plasma (ICP) as a reference method. The presented copper paper-based analytical-device can be considered as an attractive tool for point-of-care copper determination because of its affordability, vast availability, and self-pumping ability, particularly when combined with potentiometric detection.
Schlagwörter	affordability ; autism ; blood serum ; carbon ; carbon nanotubes ; copper ; cost effectiveness ; detection limit ; ionophores ; pH ; point-of-care systems ; polymers ; rapid methods
Sprache	Englisch
Erscheinungsverlauf	2021-0818
Umfang	p. 27174-27182.
Erscheinungsort	The Royal Society of Chemistry
Dokumenttyp	Artikel
ISSN	2046-2069
DOI	10.1039/d1ra04712d
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Novel benzothiazole-based dual VEGFR-2/EGFR inhibitors targeting breast and liver cancers: Synthesis, cytotoxic activity, QSAR and molecular docking studies.

Abd El-Meguid, Eman A / Naglah, Ahmed M / Moustafa, Gaber O / Awad, Hanem M / El Kerdawy, Ahmed M

Bioorganic & medicinal chemistry letters

2022 Band 58, Seite(n) 128529

Abstract: A novel series of benzothiazole-based derivatives linked to various amino acids and their corresponding ethyl ester analogues were prepared and were initially evaluated for their anticancer activity againstMCF-7 and HepG-2 and were further assessed as ... ...

Abstract	A novel series of benzothiazole-based derivatives linked to various amino acids and their corresponding ethyl ester analogues were prepared and were initially evaluated for their anticancer activity againstMCF-7 and HepG-2 and were further assessed as VEGFR-2 inhibitors. All the newly synthesized benzothiazole derivatives showed promising cytotoxic activities against the tested cell lines. Derivatives exhibited potent cytotoxic and VEGFR-2 inhibitory activities were then evaluated further as anticancer agents against the resistant MDA-MB-231 and as EGFR inhibitors. The carboxylic acid derivatives 10-12 and their ester analogues 21-23 displayed the highest anticancer activities with IC
Mesh-Begriff(e)	Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Benzothiazoles/chemical synthesis ; Benzothiazoles/chemistry ; Benzothiazoles/pharmacology ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/metabolism ; Humans ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Quantitative Structure-Activity Relationship ; Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors ; Vascular Endothelial Growth Factor Receptor-2/metabolism
Chemische Substanzen	Antineoplastic Agents ; Benzothiazoles ; Protein Kinase Inhibitors ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; KDR protein, human (EC 2.7.10.1) ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1) ; benzothiazole (G5BW2593EP)
Sprache	Englisch
Erscheinungsdatum	2022-01-07
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2022.128529
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Synthesis, Characterization, In Vitro Anticancer Potentiality, and Antimicrobial Activities of Novel Peptide-Glycyrrhetinic-Acid-Based Derivatives.

Moustafa, Gaber O / Shalaby, Ahmed / Naglah, Ahmed M / Mounier, Marwa M / El-Sayed, Heba / Anwar, Manal M / Nossier, Eman S

Molecules (Basel, Switzerland)

2021 Band 26, Heft 15

Abstract: Glycyrrhetinic acid (GA) is one of many interesting pentacyclic triterpenoids showing significant anticancer activity by triggering apoptosis in tumor cell lines. This study deals with the design and synthesis of new glycyrrhetinic acid (GA)-amino acid ... ...

Abstract	Glycyrrhetinic acid (GA) is one of many interesting pentacyclic triterpenoids showing significant anticancer activity by triggering apoptosis in tumor cell lines. This study deals with the design and synthesis of new glycyrrhetinic acid (GA)-amino acid peptides and peptide ester derivatives. The structures of the new derivatives were established through various spectral and microanalytical data. The novel compounds were screened for their in vitro cytotoxic activity. The evaluation results showed that the new peptides produced promising cytotoxic activity against the human breast MCF-7 cancer cell line while comparing to doxorubicin. On the other hand, only compounds
Mesh-Begriff(e)	Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/pharmacology ; Antifungal Agents/chemical synthesis ; Antifungal Agents/pharmacology ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Candida albicans/drug effects ; Candida albicans/growth & development ; Caspase 3/chemistry ; Caspase 3/genetics ; Caspase 3/metabolism ; Cell Line ; Cell Survival/drug effects ; Cytotoxins/chemical synthesis ; Cytotoxins/pharmacology ; Doxorubicin/pharmacology ; Drug Screening Assays, Antitumor ; Fibroblasts/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Glycyrrhetinic Acid/chemistry ; Glycyrrhetinic Acid/pharmacology ; Gram-Negative Bacteria/drug effects ; Gram-Negative Bacteria/growth & development ; Gram-Positive Bacteria/drug effects ; Gram-Positive Bacteria/growth & development ; HCT116 Cells ; Hep G2 Cells ; Humans ; MCF-7 Cells ; Microbial Sensitivity Tests ; Peptides/chemistry ; Peptides/pharmacology ; Protein Conformation ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism
Chemische Substanzen	Anti-Bacterial Agents ; Antifungal Agents ; Antineoplastic Agents ; BAX protein, human ; BCL2 protein, human ; Cytotoxins ; Peptides ; Proto-Oncogene Proteins c-bcl-2 ; Tumor Suppressor Protein p53 ; bcl-2-Associated X Protein ; Doxorubicin (80168379AG) ; CASP3 protein, human (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-) ; Glycyrrhetinic Acid (P540XA09DR)
Sprache	Englisch
Erscheinungsdatum	2021-07-28
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26154573
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Synthesis, anticancer evaluation and molecular docking of new benzothiazole scaffolds targeting FGFR-1.

Abd El-Meguid, Eman A / Mohi El-Deen, Eman M / Moustafa, Gaber O / Awad, Hanem M / Nossier, Eman S

Bioorganic chemistry

2021 Band 119, Seite(n) 105504

Abstract: This work deals with the design and synthesis of a series of new substituted 2-arylbenzothiazole compounds attached to 4-oxothiazolidin-2-ylidene ring 2-12 and chain elongation with different amino acids and their corresponding ester derivatives 13-18. ... ...

Abstract	This work deals with the design and synthesis of a series of new substituted 2-arylbenzothiazole compounds attached to 4-oxothiazolidin-2-ylidene ring 2-12 and chain elongation with different amino acids and their corresponding ester derivatives 13-18. All prepared derivatives were screened for their in vitro cytotoxicity activities against two cancer cell lines (HepG-2 and MCF-7) in comparison with doxorubicin; in addition to their safety towards thenormal cell line. Furthermore, all compounds 2-18 were evaluated as FGFR-1 inhibitors using AZD4547 as a reference. The 4-oxothiazolidin-2-ylidene derivatives 3 and 8 exhibited the highest cytotoxic activity (IC
Mesh-Begriff(e)	Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Benzothiazoles/chemical synthesis ; Benzothiazoles/chemistry ; Benzothiazoles/pharmacology ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Receptor, Fibroblast Growth Factor, Type 1/antagonists & inhibitors ; Receptor, Fibroblast Growth Factor, Type 1/metabolism ; Structure-Activity Relationship
Chemische Substanzen	Antineoplastic Agents ; Benzothiazoles ; Protein Kinase Inhibitors ; FGFR1 protein, human (EC 2.7.10.1) ; Receptor, Fibroblast Growth Factor, Type 1 (EC 2.7.10.1)
Sprache	Englisch
Erscheinungsdatum	2021-11-19
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2021.105504
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Synthesis, Docking, Computational Studies, and Antimicrobial Evaluations of New Dipeptide Derivatives Based on Nicotinoylglycylglycine Hydrazide.

Khalaf, Hemat S / Naglah, Ahmed M / Al-Omar, Mohamed A / Moustafa, Gaber O / Awad, Hassan M / Bakheit, Ahmed H

Molecules (Basel, Switzerland)

2020 Band 25, Heft 16

Abstract: Within a series of dipeptide derivatives ( ...

Abstract	Within a series of dipeptide derivatives (
Mesh-Begriff(e)	Anti-Infective Agents/chemical synthesis ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/metabolism ; Anti-Infective Agents/pharmacology ; Catalytic Domain ; Chemistry Techniques, Synthetic ; Cytochrome P450 Family 51/chemistry ; Cytochrome P450 Family 51/metabolism ; Drug Design ; Glycylglycine/chemical synthesis ; Glycylglycine/chemistry ; Glycylglycine/metabolism ; Glycylglycine/pharmacology ; Microbial Sensitivity Tests ; Molecular Docking Simulation ; Structure-Activity Relationship ; Thermodynamics
Chemische Substanzen	Anti-Infective Agents ; Glycylglycine (10525P22U0) ; Cytochrome P450 Family 51 (EC 1.14.14.154)
Sprache	Englisch
Erscheinungsdatum	2020-08-07
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules25163589
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Anticancer Activities of Newly Synthesized Chiral Macrocyclic Heptapeptide Candidates.

Abo-Ghalia, Mohamed H / Moustafa, Gaber O / Amr, Abd El-Galil E / Naglah, Ahmed M / Elsayed, Elsayed A / Bakheit, Ahmed H

Molecules (Basel, Switzerland)

2020 Band 25, Heft 5

Abstract: As important cancer therapeutic agents, macrocyclic peptides have recently drawn great attention, mainly because they are synthetically accessible and have lower toxicity towards normal cells. In the present work, we synthesized newly macrocyclic ... ...

Abstract	As important cancer therapeutic agents, macrocyclic peptides have recently drawn great attention, mainly because they are synthetically accessible and have lower toxicity towards normal cells. In the present work, we synthesized newly macrocyclic pyridoheptapeptide derivatives. The synthesized derivatives were characterized using standard chemical and spectroscopic analytical techniques, and their anticancer activities against human breast and hepatocellular cancer cells were investigated. Results showed that compounds 1a and 1b were the most effective against hepatocellular (HepG2) and breast (MCF-7) cancer cell lines, respectively.
Mesh-Begriff(e)	Antineoplastic Agents/pharmacology ; Breast Neoplasms/drug therapy ; Cell Line, Tumor ; Drug Screening Assays, Antitumor/methods ; Female ; Hep G2 Cells ; Humans ; Liver Neoplasms/drug therapy ; MCF-7 Cells ; Macrocyclic Compounds/pharmacology ; Molecular Docking Simulation/methods ; Peptide Fragments/physiology ; Structure-Activity Relationship
Chemische Substanzen	Antineoplastic Agents ; Macrocyclic Compounds ; Peptide Fragments
Sprache	Englisch
Erscheinungsdatum	2020-03-10
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules25051253
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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