LIVIVO - Search results -

Search results

Result 1 - 10 of total 204

Search options

Book: Nutrient gene interactions in health and disease

Moustaïd-Moussa, Naïma

(Modern nutrition)

2001

Title variant	Nutrient-gene interactions in health and disease
Author's details	ed. by Naïma Moustaïd-Moussa
Series title	Modern nutrition
Keywords	Nutrition ; Adipose Tissue / metabolism ; Gene Expression Regulation ; Vitamins / physiology ; Ernährung ; Gen ; Wechselwirkung ; Lebensmittelinhaltsstoff ; Ernährungsphysiologie ; Genregulation ; Lipidstoffwechsel
Subject	Nutrition ; Ernährungsstatus ; Ernährungszustand ; Genetische Regulation ; Transkription ; Genaktivität ; Fettstoffwechsel ; Lipide ; Nahrungsphysiologie ; Lebensmittel ; Nahrungsmittelinhaltsstoff ; Nahrungsmittelbestandteil ; Wechselwirkungen ; Interaktion ; Erbanlage ; Erbeinheit ; Erbfaktor
Language	English
Size	472 S. : Ill., graph. Darst.
Publisher	CRC
Publishing place	Boca Raton u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT013013512
ISBN	0-8493-2216-2 ; 978-0-8493-2216-7
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

In stock of ZB MED Bonn / Germany

Shelf mark	Loan status	Location
058/1773	available for loan (reading room)	Freihandmagazin (U1)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Book: Nutrient gene interactions in health and disease

Moustaïd-Moussa, Naïma

(Modern nutrition)

2001

Title variant	Nutrient-gene interactions in health and disease
Author's details	ed. by Naïma Moustaïd-Moussa
Series title	Modern nutrition
Keywords	Nutrition ; Adipose Tissue / metabolism ; Gene Expression Regulation ; Vitamins / physiology ; Ernährung ; Gen ; Wechselwirkung ; Lebensmittelinhaltsstoff ; Ernährungsphysiologie ; Genregulation ; Lipidstoffwechsel
Subject	Nutrition ; Ernährungsstatus ; Ernährungszustand ; Genetische Regulation ; Transkription ; Genaktivität ; Fettstoffwechsel ; Lipide ; Nahrungsphysiologie ; Lebensmittel ; Nahrungsmittelinhaltsstoff ; Nahrungsmittelbestandteil ; Wechselwirkungen ; Interaktion ; Erbanlage ; Erbeinheit ; Erbfaktor
Language	English
Size	472 S. : Ill., graph. Darst.
Publisher	CRC
Publishing place	Boca Raton u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT013013512
ISBN	0-8493-2216-2 ; 978-0-8493-2216-7
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2001 A 5103	order for loan	Magazin

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Enhanced Metabolic Effects of Fish Oil When Combined with Vitamin D in Diet-Induced Obese Male Mice.

Ramalingam, Latha / Mabry, Brennan / Menikdiwela, Kalhara R / Moussa, Hanna / Moustaid-Moussa, Naima

Biomolecules

2024 Volume 14, Issue 4

Abstract: Vitamin D (vit D) and fish oil (FO) both offer unique health benefits, however, their combined effects have not been evaluated in obesity and nonalcoholic fatty liver disease (NAFLD). Hence, we hypothesized that vit D and FO supplementation would have ... ...

Abstract	Vitamin D (vit D) and fish oil (FO) both offer unique health benefits, however, their combined effects have not been evaluated in obesity and nonalcoholic fatty liver disease (NAFLD). Hence, we hypothesized that vit D and FO supplementation would have additive effects in reducing obesity-associated inflammation and NAFLD. Male C57BL6 mice were split into four groups and fed a high fat (HF) diet supplemented with a low (HF; +200 IU vit D) or high dose of vitamin D (HF + D; +1000 IU vit D); combination of vit D and FO (HF-FO; +1000 IU vit D); or only FO (HF-FO; +200 IU vit D) for 12 weeks. We measured body weight, food intake, glucose tolerance, and harvested epididymal fat pad and liver for gene expression analyses. Adiposity was reduced in groups supplemented with both FO and vit D. Glucose clearance was higher in FO-supplemented groups compared to mice fed HF. In adipose tissue, markers of fatty acid synthesis and oxidation were comparable in groups that received vit D and FO individually in comparison to HF. However, the vit D and FO group had significantly lower fatty acid synthesis and higher oxidation compared to the other groups. Vit D and FO also significantly improved fatty acid oxidation, despite similar fatty acid synthesis among the four groups in liver. Even though we did not find additive effects of vit D and FO, our data provide evidence that FO reduces markers of obesity in the presence of adequate levels of vit D.
MeSH term(s)	Animals ; Male ; Fish Oils/pharmacology ; Fish Oils/administration & dosage ; Vitamin D/pharmacology ; Vitamin D/administration & dosage ; Vitamin D/metabolism ; Obesity/metabolism ; Mice ; Mice, Inbred C57BL ; Diet, High-Fat/adverse effects ; Dietary Supplements ; Liver/metabolism ; Liver/drug effects ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/etiology ; Mice, Obese ; Adipose Tissue/metabolism ; Adipose Tissue/drug effects ; Body Weight/drug effects
Chemical Substances	Fish Oils ; Vitamin D (1406-16-2)
Language	English
Publishing date	2024-04-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom14040474
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The Complex Biology of the Obesity-Induced, Metastasis-Promoting Tumor Microenvironment in Breast Cancer.

Mubtasim, Noshin / Moustaid-Moussa, Naima / Gollahon, Lauren

International journal of molecular sciences

2022 Volume 23, Issue 5

Abstract: Breast cancer is one of the most prevalent cancers in women contributing to cancer-related death in the advanced world. Apart from the menopausal status, the trigger for developing breast cancer may vary widely from race to lifestyle factors. ... ...

Abstract	Breast cancer is one of the most prevalent cancers in women contributing to cancer-related death in the advanced world. Apart from the menopausal status, the trigger for developing breast cancer may vary widely from race to lifestyle factors. Epidemiological studies refer to obesity-associated metabolic changes as a critical risk factor behind the progression of breast cancer. The plethora of signals arising due to obesity-induced changes in adipocytes present in breast tumor microenvironment, significantly affect the behavior of adjacent breast cells. Adipocytes from white adipose tissue are currently recognized as an active endocrine organ secreting different bioactive compounds. However, due to excess energy intake and increased fat accumulation, there are morphological followed by secretory changes in adipocytes, which make the breast microenvironment proinflammatory. This proinflammatory milieu not only increases the risk of breast cancer development through hormone conversion, but it also plays a role in breast cancer progression through the activation of effector proteins responsible for the biological phenomenon of metastasis. The aim of this review is to present a comprehensive picture of the complex biology of obesity-induced changes in white adipocytes and demonstrate the relationship between obesity and breast cancer progression to metastasis.
MeSH term(s)	Adipose Tissue/metabolism ; Biology ; Breast Neoplasms/metabolism ; Female ; Humans ; Obesity/metabolism ; Tumor Microenvironment/physiology
Language	English
Publishing date	2022-02-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23052480
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Combinatorial Effects of the Natural Products Arctigenin, Chlorogenic Acid, and Cinnamaldehyde Commit Oxidation Assassination on Breast Cancer Cells.

Schuster, Caroline / Wolpert, Nicholas / Moustaid-Moussa, Naima / Gollahon, Lauren S

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 3

Abstract: Major obstacles in current breast cancer treatment efficacy include the ability of breast cancer cells to develop resistance to chemotherapeutic drugs and the off-target cytotoxicity of these drugs on normal cells, leading to debilitating side effects. ... ...

Abstract	Major obstacles in current breast cancer treatment efficacy include the ability of breast cancer cells to develop resistance to chemotherapeutic drugs and the off-target cytotoxicity of these drugs on normal cells, leading to debilitating side effects. One major difference between cancer and normal cells is their metabolism, as cancer cells acquire glycolytic and mitochondrial metabolism alterations throughout tumorigenesis. In this study, we sought to exploit this metabolic difference by investigating alternative breast cancer treatment options based on the application of phytochemicals. Herein, we investigated three phytochemicals, namely cinnamaldehyde (CA), chlorogenic acid (CGA), and arctigenin (Arc), regarding their anti-breast-cancer properties. These phytochemicals were administered alone or in combination to MCF-7, MDA-MB-231, and HCC1419 breast cancer or normal MCF-10A and MCF-12F breast cells. Overall, our results indicated that the combination treatments showed stronger inhibitory effects on breast cancer cells versus single treatments. However, only treatments with CA (35 μM), CGA (250 μg/mL), and the combination of CA + CGA (35 μM + 250 μg/mL) showed no significant cytotoxic effects on normal mammary epithelial cells, suggesting that Arc was the driver of normal cell cytotoxicity in all other treatments. CA + CGA and, to a lesser extent, CGA alone effectively induced breast cancer cell death accompanied by decreases in mitochondrial membrane potential, increased mitochondrial superoxide, reduced mitochondrial and glycolytic ATP production, and led to significant changes in cellular and mitochondrial morphology. Altogether, the combination of CA + CGA was determined as the best anti-breast-cancer treatment strategy due to its strong anti-breast-cancer effects without strong adverse effects on normal mammary epithelial cells. This study provides evidence that targeting the mitochondria may be an effective anticancer treatment, and that using phytochemicals or combinations thereof offers new approaches in treating breast cancer that significantly reduce off-target effects on normal cells.
Language	English
Publishing date	2022-03-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11030591
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Long-term effects of adolescent exposure to olanzapine in C57BL/6 J mice and the impact of dietary fish oil supplementation.

Soto, Paul L / Ramalingam, Latha / George, Brianna / Moustaid-Moussa, Naima

Psychopharmacology

2022 Volume 239, Issue 10, Page(s) 3117–3131

Abstract: Rationale: Second-generation antipsychotic (SGA) medications can produce abnormal weight gain and metabolic dysfunction in children, but little is known about the post-treatment consequences of adolescent SGA exposure.: Objectives: The objective of ... ...

Abstract	Rationale: Second-generation antipsychotic (SGA) medications can produce abnormal weight gain and metabolic dysfunction in children, but little is known about the post-treatment consequences of adolescent SGA exposure. Objectives: The objective of this study was to determine the long-term, post-treatment effects of adolescent olanzapine exposure on weight and metabolic function and whether dietary fish oil (FO) modulated any observed effects of olanzapine. Methods: Male and female mice were fed a high-fat, high-sugar (HF-HS) diet or an HF-HS diet supplemented with fish oil (HF-HS-FO) and were treated with olanzapine or vehicle for 29 days beginning on postnatal day 37. Results: In male mice, adolescent olanzapine treatment suppressed weight gain during and after treatment and improved metabolic function in adulthood; dietary fish oil reduced weight gain, increased expression of fatty acid oxidation genes, and decreased expression of genes associated with fatty acid synthesis and inflammation. In contrast, few effects were observed in female mice. Conclusions: The current results suggest that adolescent olanzapine exposure can produce long-term alterations in weight and metabolic function in male mice and that dietary fish oil can reduce adverse effects of lifelong consumption of an HF-HS diet. Because expected adverse effects of adolescent olanzapine treatment were not observed, the potential beneficial effects of dietary fish oil for SGA-induced weight gain and metabolic dysfunction could not be evaluated.
MeSH term(s)	Animals ; Antipsychotic Agents/pharmacology ; Diet, High-Fat/adverse effects ; Dietary Supplements ; Fatty Acids ; Female ; Fish Oils/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Olanzapine ; Sugars ; Weight Gain
Chemical Substances	Antipsychotic Agents ; Fatty Acids ; Fish Oils ; Sugars ; Olanzapine (N7U69T4SZR)
Language	English
Publishing date	2022-07-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	130601-7
ISSN	1432-2072 ; 0033-3158
ISSN (online)	1432-2072
ISSN	0033-3158
DOI	10.1007/s00213-022-06193-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ui I Zs.240: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: The Negative Effects of High Rates of Biochar on Violas Can Be Counteracted with Fertilizer

Regmi, Abishkar / Singh, Sukhbir / Moustaid-Moussa, Naima / Coldren, Cade / Simpson, Catherine

Plants. 2022 Feb. 11, v. 11, no. 4

2022

Abstract: Increasing costs and environmental issues regarding excessive use of peat moss is impacting the horticultural industry. Biochar is a valuable substrate additive that has the potential to reduce the use of peatmoss in greenhouse production. However, its ... ...

Abstract	Increasing costs and environmental issues regarding excessive use of peat moss is impacting the horticultural industry. Biochar is a valuable substrate additive that has the potential to reduce the use of peatmoss in greenhouse production. However, its varying effects on ornamentals requires that individual species and cultivars of crops must be evaluated to determine the threshold for benefits. Viola cornuta is a high value ornamental crop; however, information on how different rates of biochar rates affect productivity and physiology of Viola cultivars in container production is not known. To determine if biochar rates could increase the productivity of Viola, we mixed a peat-based substrate with 10, 25, and 50% (w:w) hardwood biochar in two studies on four cultivars. Without fertilizers, 10 and 25% biochar improved plant biomass, growth, root length, and flowering, but 50% biochar was found to have negative effects on plant growth and flowering. Cultivars varied in their response to biochar rates. When fertilizer was applied in the second experiment, biochar rates did not impact growth parameters or flowering. These results suggest that up to 25% biochar can be used in Viola production without detrimental impacts. However, 50% biochar can be used with the addition of fertilizer without negatively affecting plant growth. Biochar can have a short-term impact on the growth characteristics of Viola plants in container production, but fertilization and growing period of Viola may influence these effects. These results indicate that biochar could be the suitable replacement for peat moss, with up to 50% biochar rate in Viola production reducing the environmental and economic burden for peat moss.
Keywords	Sphagnum ; Viola cornuta ; biochar ; cultivars ; fertilizers ; greenhouse production ; hardwood ; horticulture ; industry ; ornamental plants ; phytomass ; plant growth
Language	English
Dates of publication	2022-0211
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants11040491
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article: Combinatorial Effects of the Natural Products Arctigenin, Chlorogenic Acid, and Cinnamaldehyde Commit Oxidation Assassination on Breast Cancer Cells

Schuster, Caroline / Wolpert, Nicholas / Moustaid-Moussa, Naima / Gollahon, Lauren S.

Antioxidants. 2022 Mar. 20, v. 11, no. 3

2022

Abstract	Major obstacles in current breast cancer treatment efficacy include the ability of breast cancer cells to develop resistance to chemotherapeutic drugs and the off-target cytotoxicity of these drugs on normal cells, leading to debilitating side effects. One major difference between cancer and normal cells is their metabolism, as cancer cells acquire glycolytic and mitochondrial metabolism alterations throughout tumorigenesis. In this study, we sought to exploit this metabolic difference by investigating alternative breast cancer treatment options based on the application of phytochemicals. Herein, we investigated three phytochemicals, namely cinnamaldehyde (CA), chlorogenic acid (CGA), and arctigenin (Arc), regarding their anti-breast-cancer properties. These phytochemicals were administered alone or in combination to MCF-7, MDA-MB-231, and HCC1419 breast cancer or normal MCF-10A and MCF-12F breast cells. Overall, our results indicated that the combination treatments showed stronger inhibitory effects on breast cancer cells versus single treatments. However, only treatments with CA (35 μM), CGA (250 μg/mL), and the combination of CA + CGA (35 μM + 250 μg/mL) showed no significant cytotoxic effects on normal mammary epithelial cells, suggesting that Arc was the driver of normal cell cytotoxicity in all other treatments. CA + CGA and, to a lesser extent, CGA alone effectively induced breast cancer cell death accompanied by decreases in mitochondrial membrane potential, increased mitochondrial superoxide, reduced mitochondrial and glycolytic ATP production, and led to significant changes in cellular and mitochondrial morphology. Altogether, the combination of CA + CGA was determined as the best anti-breast-cancer treatment strategy due to its strong anti-breast-cancer effects without strong adverse effects on normal mammary epithelial cells. This study provides evidence that targeting the mitochondria may be an effective anticancer treatment, and that using phytochemicals or combinations thereof offers new approaches in treating breast cancer that significantly reduce off-target effects on normal cells.
Keywords	breast neoplasms ; breasts ; cancer therapy ; carcinogenesis ; cell death ; chlorogenic acid ; cytotoxicity ; drug therapy ; epithelium ; glycolysis ; membrane potential ; mitochondria ; mitochondrial membrane ; neoplasm cells ; oxidation ; phytochemicals
Language	English
Dates of publication	2022-0320
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11030591
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Omega-3 Fatty Acids and Adipose Tissue: Inflammation and Browning.

Kalupahana, Nishan Sudheera / Goonapienuwala, Bimba Lakmini / Moustaid-Moussa, Naima

Annual review of nutrition

2020 Volume 40, Page(s) 25–49

Abstract: White adipose tissue (WAT) and brown adipose tissue (BAT) are involved in whole-body energy homeostasis and metabolic regulation. Changes to mass and function of these tissues impact glucose homeostasis and whole-body energy balance during development of ...

Abstract	White adipose tissue (WAT) and brown adipose tissue (BAT) are involved in whole-body energy homeostasis and metabolic regulation. Changes to mass and function of these tissues impact glucose homeostasis and whole-body energy balance during development of obesity, weight loss, and subsequent weight regain. Omega-3 polyunsaturated fatty acids (ω-3 PUFAs), which have known hypotriglyceridemic and cardioprotective effects, can also impact WAT and BAT function. In rodent models, these fatty acids alleviate obesity-associated WAT inflammation, improve energy metabolism, and increase thermogenic markers in BAT. Emerging evidence suggests that ω-3 PUFAs can also modulate gut microbiota impacting WAT function and adiposity. This review discusses molecular mechanisms, implications of these findings, translation to humans, and future work, especially with reference to the potential of these fatty acids in weight loss maintenance.
MeSH term(s)	Adipose Tissue, Brown/physiology ; Adipose Tissue, White/physiology ; Animals ; Fatty Acids, Omega-3/administration & dosage ; Fatty Acids, Omega-3/pharmacology ; Humans ; Inflammation/metabolism
Chemical Substances	Fatty Acids, Omega-3
Language	English
Publishing date	2020-06-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	406980-8
ISSN	1545-4312 ; 0199-9885
ISSN (online)	1545-4312
ISSN	0199-9885
DOI	10.1146/annurev-nutr-122319-034142
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1786: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: The Negative Effects of High Rates of Biochar on Violas Can Be Counteracted with Fertilizer.

Regmi, Abishkar / Singh, Sukhbir / Moustaid-Moussa, Naima / Coldren, Cade / Simpson, Catherine

Plants (Basel, Switzerland)

2022 Volume 11, Issue 4

Abstract	Increasing costs and environmental issues regarding excessive use of peat moss is impacting the horticultural industry. Biochar is a valuable substrate additive that has the potential to reduce the use of peatmoss in greenhouse production. However, its varying effects on ornamentals requires that individual species and cultivars of crops must be evaluated to determine the threshold for benefits.
Language	English
Publishing date	2022-02-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants11040491
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito