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Article: Cerebral Necrotizing Encephalopathy in a 7-year-old Child after being Infected with COVID-19, A Case Report.

Movahedi, Zahra / Mollamohammadi, Mohsen / Hassanvand Amouzadeh, Masoud / Shakeri, Batool

2024 Volume 18, Issue 1, Page(s) 139–144

Abstract: New daily data on the COVID-19 pandemic are circulating globally. This disease usually appears with respiratory symptoms such as cough, shortness of breath, and fever. The neurological complications of the disease are somewhat known in adults but rarely ... ...

Abstract	New daily data on the COVID-19 pandemic are circulating globally. This disease usually appears with respiratory symptoms such as cough, shortness of breath, and fever. The neurological complications of the disease are somewhat known in adults but rarely reported in children. Acute necrotizing encephalopathy of childhood (ANEC) is one of the brain complications associated‌ with Coronavirus disease that usually has a poor prognosis in children. In this case, we report a rare case of a 7-year-old boy who was referred to the hospital with symptoms of convulsions after contracting COVID-19 and developed cerebral necrotizing encephalopathy caused by COVID-19 infection. Although ANEC is a rare disease, clinical examination and MRI and CT scan findings play an essentialrole in diagnosing and treating the disease.‌.
Language	English
Publishing date	2024-01-18
Publishing country	Iran
Document type	Case Reports
ZDB-ID	2542305-8
ISSN	2008-0700 ; 1735-4668
ISSN (online)	2008-0700
ISSN	1735-4668
DOI	10.22037/ijcn.v18i1.39927
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Article: Impact of

Mahmoodi, Nazanin / Movahedi, Zahra / Ghabooli, Mehdi

Frontiers in microbiology

2023 Volume 13, Page(s) 1091036

Abstract: As an essential nutrient for plant growth, nickel's (Ni) requirement is very low, and its augmented level causes environmental pollution and toxicity. Being a root endophytic fungus, ...

Abstract	As an essential nutrient for plant growth, nickel's (Ni) requirement is very low, and its augmented level causes environmental pollution and toxicity. Being a root endophytic fungus,
Language	English
Publishing date	2023-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.1091036
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Article ; Online: Contribution of Serendipita indica on growth improvement, antioxidative capacity of Dracocephalum kotschyi, and its resistance against cadmium stress.

Mehri, Mohammad / Ghabooli, Mehdi / Movahedi, Zahra

International microbiology : the official journal of the Spanish Society for Microbiology

2023 Volume 26, Issue 4, Page(s) 821–831

Abstract: Cadmium pollution is a severe issue worldwide which causes an elevated concern in agriculture. The utilization of plant-microbial interactions offers a promising approach for the remediation of cadmium-polluted soils. To elucidate the mechanism of ... ...

Abstract	Cadmium pollution is a severe issue worldwide which causes an elevated concern in agriculture. The utilization of plant-microbial interactions offers a promising approach for the remediation of cadmium-polluted soils. To elucidate the mechanism of Serendipita indica-mediated cadmium stress tolerance, a potting experiment was conducted to study the impact of S. indica on Dracocephalum kotschyi plants grown under different cadmium concentrations (0, 5, 10, and 20 mg/kg). The effects of cadmium and S. indica on plant growth, antioxidant enzyme activities, and accumulation of cadmium were investigated. The results showed that cadmium stress significantly decreases biomass, photosynthetic pigments, and carbohydrate content concomitantly with increasing antioxidant activities, electrolyte leakage, and hydrogen peroxide, proline, and cadmium content. Inoculation with S. indica alleviated the adverse effect of cadmium stress by enhancing shoot and root dry weight, photosynthetic pigments, and carbohydrate, proline, and catalase activity. Unlike cadmium stress, the presence of fungus led to a reduction in electrolyte leakage and hydrogen peroxide content as well as the content of cadmium in D. kotschyi leaf which mitigates cadmium-induced oxidative stress. Our findings demonstrated S. indica inoculation alleviates the adverse effects of cadmium stress in D. kotschyi plants which could prolong their survival under stressful conditions. Due to the importance of D. kotschyi and the effect of biomass increase on the amount of its medicinal substances, exploiting S. indica not only promotes plant growth, but also may be used as a potential eco-friendly method for relieving the phytotoxicity of Cd and remediating Cd-contaminated soil.
MeSH term(s)	Antioxidants ; Cadmium/toxicity ; Hydrogen Peroxide ; Carbohydrates ; Proline/pharmacology
Chemical Substances	Antioxidants ; Cadmium (00BH33GNGH) ; Hydrogen Peroxide (BBX060AN9V) ; Carbohydrates ; Proline (9DLQ4CIU6V)
Language	English
Publishing date	2023-02-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1454951-7
ISSN	1618-1905 ; 1139-6709
ISSN (online)	1618-1905
ISSN	1139-6709
DOI	10.1007/s10123-023-00339-z
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Article ; Online: Intermediate-aided allostery mechanism for α-glucosidase by Xanthene-11v as an inhibitor using residue interaction network analysis.

Moosavi-Movahedi, Zahra / Salehi, Najmeh / Habibi-Rezaei, Mehran / Qassemi, Farzad / Karimi-Jafari, Mohammad Hossein

Journal of molecular graphics & modelling

2023 Volume 122, Page(s) 108495

Abstract: Exploring allosteric inhibition and the discovery of new inhibitor binding sites are important studies in protein regulation mechanisms and drug discovery. Structural and network-based analyses of trajectories resulting from molecular dynamics (MD) ... ...

Abstract	Exploring allosteric inhibition and the discovery of new inhibitor binding sites are important studies in protein regulation mechanisms and drug discovery. Structural and network-based analyses of trajectories resulting from molecular dynamics (MD) simulations have been developed to discover protein dynamics, landscape, functions, and allosteric regions. Here, an experimentally suggested non-competitive inhibitor, xanthene-11v, was considered to explore its allosteric inhibition mechanism in α-glucosidase MAL12. Comparative structural and network analyses were applied to eight 250 ns independent MD simulations, four of which were performed in the free state and four of which were performed in ligand-bound forms. Projected two-dimensional free energy landscapes (FEL) were constructed from the probabilistic distribution of conformations along the first two principal components. The post-simulation analyses of the coordinates, side-chain torsion angles, non-covalent interaction networks, network communities, and their centralities were performed on α-glucosidase conformations and the intermediate sub-states. Important communities of residues have been found that connect the allosteric site to the active site. Some of these residues like Thr307, Arg312, TYR344, ILE345, Phe357, Asp406, Val407, Asp408, and Leu436 are the key messengers in the transition pathway between allosteric and active sites. Evaluating the probability distribution of distances between gate residues including Val407 in one community and Phe158, and Pro65 in another community depicted the closure of this gate due to the inhibitor binding. Six macro states of protein were deduced from the topology of FEL and analysis of conformational preference of free and ligand-bound systems to these macro states shows a combination of lock-and-key, conformational selection, and induced fit mechanisms are effective in ligand binding. All these results reveal structural states, allosteric mechanisms, and key players in the inhibition pathway of α-glucosidase by xanthene-11v.
MeSH term(s)	Allosteric Regulation ; alpha-Glucosidases/metabolism ; Ligands ; Molecular Dynamics Simulation ; Proteins/chemistry ; Proteins/metabolism
Chemical Substances	alpha-Glucosidases (EC 3.2.1.20) ; Ligands ; Proteins
Language	English
Publishing date	2023-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1396450-1
ISSN	1873-4243 ; 1093-3263
ISSN (online)	1873-4243
ISSN	1093-3263
DOI	10.1016/j.jmgm.2023.108495
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Article ; Online: Pediatric tuberculosis in Iran: a review of 10-years study in an Iranian referral hospital.

Movahedi, Zahra / Mahmoudi, Shima / Banar, Maryam / Pourakbari, Babak / Aziz-Ahari, Alireza / Ramezani, Amitis / Mamishi, Setareh

Acta bio-medica : Atenei Parmensis

2022 Volume 93, Issue 2, Page(s) e2022035

Abstract: Introduction: Reductions in global tuberculosis incidence are considered as one of the End TB Strategy goal. The diagnosis of tuberculosis (TB) in children is challenging due to insufficient specimen material and the scarcity of bacilli in specimens. ... ...

Abstract	Introduction: Reductions in global tuberculosis incidence are considered as one of the End TB Strategy goal. The diagnosis of tuberculosis (TB) in children is challenging due to insufficient specimen material and the scarcity of bacilli in specimens. The purpose of this study was to evaluate the prevalence, characteristics, clinical profiles, laboratory findings and treatment outcomes of children infected with TB in an Iranian referral hospital during a 10-years period. Methods: This study was a retrospective analysis of the medical records of 90 children (£15 years) with a diagnosis of tuberculosis who were admitted to Children's Medical Center Hospital, Tehran, Iran, between March 2006 and March 2016. The patients' information such as demographic, clinical manifestations, laboratory, radiological and histological tests results, and treatment outcomes were extracted from medical records and were analyzed. Results: The total prevalence of TB was about 56.6 per 100,000 admitted patients. Most of the patients were between 5 to 12 years. Sixty-one percent were male. Twenty-two percent had the history of TB in their family. Underlying diseases were identified in 30 cases (33%). Thirty-four cases (38%) had pulmonary TB (PTB), 35 cases (39%) had extrapulmonary TB (EPTB), while disseminated TB (DTB) was found in 21 cases (23%). Distribution of DTB in males was higher than in females (36% vs. 6%). In patients < 1 year, DTB was the most frequent type (48 %); however, in patients > 1 year both PTB and EPTB had similar distributions (42%) and were more frequent than DTB (16%). Conclusions: The total prevalence rate of TB in our study was 56.6 per 100,000 admitted patients. Since the mortality rate was higher in infants, children with DTB and children with underlying diseases, early detection and treatment of these patients will help to reduce the mortality rate of TB disease.
MeSH term(s)	Child ; Female ; Hospitals, Pediatric ; Humans ; Infant ; Iran/epidemiology ; Male ; Referral and Consultation ; Retrospective Studies ; Tuberculosis/diagnosis ; Tuberculosis/epidemiology
Language	English
Publishing date	2022-05-11
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	2114240-3
ISSN	2531-6745 ; 0392-4203
ISSN (online)	2531-6745
ISSN	0392-4203
DOI	10.23750/abm.v93i2.11018
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Article ; Online: Coronavirus disease 2019 in a 13-year-old patient with acute lymphoblastic leukemia.

Eshagh Hossaini, Seyed Kamal / Movahedi, Zahra / Hormati, Ahmad / Heydari, Hosein / Eshagh Hosseini, Seyed Jalal / Khodadust, Fatemeh / Afifian, Mahboubeh / Ahmadpour, Sajjad

Clinical and experimental pediatrics

2021 Volume 64, Issue 5, Page(s) 247–250

Language	English
Publishing date	2021-03-08
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2713-4148
ISSN (online)	2713-4148
DOI	10.3345/cep.2020.01711
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Article ; Online: Multivariate statistical analysis of some traits of bread wheat for breeding under rainfed conditions

Janmohammadi Mohsen / Movahedi Zahra / Sabaghnia Naser

Journal of Agricultural Sciences (Belgrade), Vol 59, Iss 1, Pp 1-

2014 Volume 14

Abstract: In order to evaluate several agro-morphological traits in 56 wheat genotypes, an experiment based on randomized complete block design with three replications was carried out. Principal component analysis (PCA) and factor analysis were used for ... ...

Abstract	In order to evaluate several agro-morphological traits in 56 wheat genotypes, an experiment based on randomized complete block design with three replications was carried out. Principal component analysis (PCA) and factor analysis were used for understanding the data structure and trait relations. The PCA showed that five components explained 69% of the total variation among traits. The first PCA was assigned 28% and the second PCA was assigned 13% of total variation among traits. The first PCA was more related to grain number, floret number, tiller number, stem diameter, leaf width and spikelet number. Therefore, the selection may be done according to the first component and it was helpful for a good breeding program for development of high yielding cultivars. The correlation coefficient between any two traits is approximated by the cosine of the angle between their vectors in the plot of the first two PCAs and the most prominent relations were between grain diameter and grain yield; and between grain length and 1,000 seed weight. The factor analysis divided the eighteen traits into five factors and the first factor included stem diameter, leaf width, tiller number, spike length, floret number, spikelet number, grain number and grain yield. The second factor was composed of some morphological traits and indicated the importance of the grain diameter, grain length, 1,000 seed weight and grain yield. The two PCA and factor analysis methods were found to give complementary information, and therefore such knowledge would assist the plant breeders in making their selection. In other words, this data reduction would let the plant breeder reduce field costs required to obtain the genetic parameter estimates necessary to construct selection indices.
Keywords	factor analysis ; morphological traits ; grain yield ; principal component analysis ; Agriculture ; S
Subject code	306
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	University of Belgrade - Faculty of Agriculture, Belgrade
Document type	Article ; Online
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Article ; Online: The Comparison the serum STREM1 levels between children with upper and lower UTI.

Noorbakhsh, Samileh / Ehsanipour, Fahime / Zarabi, Vida / Movahedi, Zahra / Rahimzadeh, Nahid

Current pediatric reviews

2017

Abstract: Back ground: UTI is a common and important clinical problem in Iranian children which is often difficult on clinical grounds. Distinguishing the upper UTI from lower UTI is very important for clinician. The aim of this study was to determine the ... ...

Abstract	Back ground: UTI is a common and important clinical problem in Iranian children which is often difficult on clinical grounds. Distinguishing the upper UTI from lower UTI is very important for clinician. The aim of this study was to determine the usefulness of serum STREM-1 level in patients with UTI to find out if it can use for distinguishing upper UTI from lower UTI or not. Methods: In this prospective cross sectional study (2010-2011) we compared the serum level of STREM-1 (pg. /ml) in 36 proven UTI cases (24 upper and 12 lower UTI ) with 25 normal children (without UTI) in Rasoul Akram hospital Tehran, Iran. The mean age of the subjects was 3.64 + years; 24 male and 37 female. Urinary analysis and culture were performed for all UTI cases and only the positive cultured cases with the same microorganism were enrolled in the study. Distinguishing the upper from lower UTI was done with the use of clinical signs and laboratory tests and confirmed Imaging studies (sonography /or DMSA scan). Blood sampling drawn from all children and centrifuged.STREM-1 level (pg /ml) in serum was measured by quantitative sandwich enzyme immunoassay technique (Human TREM-1 immunoassay, Quantikine, R&D systems, Minneapolis; USA). A ROC curve was constructed to illustrate various cut-offs of STREM-1 levels in differentiating between groups. Chi square values of CI! 95 %, p<0.05 were considered statistically significant. Results: There was significant difference in the mean of STREM-1 level between overall cases of UTI (427.72pg/ml) and controls (124.24 pg. /ml) P value =0.000, but it had not significantly difference between upper and lower UTI (500pg/ml vs. 283 pg. /ml, P value=0.1) A ROC curve analysis showed that the maximum power of sTREM-1 to discriminate between upper and lower UTI patients was 0.68 , the cutoff point 132 pg./ml had 83.3% sensitivity ;and 60 % specificity to distinguish upper UTI from lower UTI, but the maximum power of STREM-1 to discriminate between UTI patients and normal children was 0.76 , the cutoff point 111.5 pg./ml had 83.3% sensitivity; and 60 % specificity to distinguish UTI normal children Conclusion: Our study demonstrates that even low amount of serum STREM-1 (111.5 pg./ml ) has 83.3% sensitivity ;and 60 % specificity to distinguish the UTI from normal cases (P value =0.000) .But higher level (132 pg./ml ) was needed for definite diagnosis (83.3% sensitivity; 60 % specificity) of upper from lower UTI. It concluded that serum STREM-1 level test is a valuable tool for early distinction the normal cases with false positive urine culture, or in highly suspicious upper UTI cases with false negative urine culture. Indeed higher titer of it could be helpful for discriminate the upper from lower UTI .So we prefer to add this new biologic marker (STREM-1) to previous ones (CRP, PCT) to prevent the unnecessary hospital admission and empiric antibiotic therapy.
Language	English
Publishing date	2017-02-16
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	1875-6336
ISSN (online)	1875-6336
DOI	10.2174/1573396313666170216154528
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Article ; Online: Novel coronavirus disease 2019 (COVID-19) outbreak in children in Iran: Atypical CT manifestations and mortality risk of severe COVID-19 infection.

Mamishi, Setareh / Heydari, Hosein / Aziz-Ahari, Alireza / Shokrollahi, Mohammad Reza / Pourakbari, Babak / Mahmoudi, Shima / Movahedi, Zahra

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

2020 Volume 54, Issue 5, Page(s) 839–844

Abstract: Background: During the coronavirus disease 2019 (COVID-19) pandemic, Iran reported its first confirmed cases of syndrome coronavirus 2 (SARS-CoV-2) infections on 19 February 2020 in Qom. Although the numbers of cases are increasing, no report about ... ...

Abstract	Background: During the coronavirus disease 2019 (COVID-19) pandemic, Iran reported its first confirmed cases of syndrome coronavirus 2 (SARS-CoV-2) infections on 19 February 2020 in Qom. Although the numbers of cases are increasing, no report about clinical manifestations, laboratory results, and imaging findings of the children infected with COVID-19 in Iran has been published. The aim of this study was to evaluate the epidemiological, clinical, and radiological and laboratory findings of 24 children who had proven SARS-CoV-2 infection and performed chest computed tomographic (CT) in Qom, Iran. Methods: Demographic information and clinical characteristics of the patients including signs and symptoms, chest CT scan manifestation, laboratory findings and clinical outcomes were collected. Diagnosing of the confirmed case was based on positive real-time reverse-transcriptase-polymerase-chain-reaction test for SARS-CoV-2. Findings: During the first 3 months of the epidemic in Qom, Iran, 24 children with confirmed diagnosis of COVID-19 were included. The median age of the cases was 6 years [inter-quartile range 3.5-9.5 years]. The most common presenting symptoms were fever (100%), dry cough (62.5%), tachypnea (29%), abdominal pain (21%), and vomiting (21%). Three cases (12.5%) presented with a history of diarrhea in addition to fever and cough. According to the chest CT findings, 2 cases (8%) showed no abnormality. Typical CT findings were found in 6 patients (25%), 2 patients showed indeterminate appearance, and 14 patients (58%) showed atypical findings. Two children with SARS-CoV-2 infection manifested as a hyperinflammatory syndrome with multi-organ involvement similar to Kawasaki disease shock syndrome. Seventy-one percent of the patients showed severe SARS-CoV-2 infection and the mortality of 12.5% (3 cases) were reported. Interpretation: High frequency of atypical chest CT finding in children should raise concern for pediatricians. Early recognition of patients with SARS-CoV-2 infection is of crucial importance in controlling of the outbreak and atypical imaging features should be interpreted with caution.
MeSH term(s)	Abdominal Pain/epidemiology ; COVID-19/diagnostic imaging ; COVID-19/epidemiology ; COVID-19/physiopathology ; Child ; Child, Preschool ; Diarrhea/epidemiology ; Female ; Fever/epidemiology ; Humans ; Iran/epidemiology ; Male ; Mortality ; Mucocutaneous Lymph Node Syndrome ; Pandemics ; SARS-CoV-2 ; Tachypnea/epidemiology ; Tomography, X-Ray Computed/methods ; Vomiting/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-08-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1497590-7
ISSN	1995-9133 ; 1684-1182 ; 0253-2662
ISSN (online)	1995-9133
ISSN	1684-1182 ; 0253-2662
DOI	10.1016/j.jmii.2020.07.019
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Article ; Online: The Coronavirus Disease 2019 (COVID-19) in Children

Mahmoudi, Shima / Mehdizadeh, Mehrzad / Shervin Badv, Reza / Navaeian, Amene / Pourakbari, Babak / Rostamyan, Maryam / Sharifzadeh Ekbatani, Meisam / Eshaghi, Hamid / Abdolsalehi, Mohammad Reza / Alimadadi, Hosein / Movahedi, Zahra / Mamishi, Setareh

A Study in an Iranian Children’s Referral Hospital

2020

Abstract: Shima Mahmoudi,1 Mehrzad Mehdizadeh,2,3 Reza Shervin Badv,3 Amene Navaeian,4 Babak Pourakbari,1 Maryam Rostamyan,4 Meisam Sharifzadeh Ekbatani,3 Hamid Eshaghi,4 Mohammad Reza Abdolsalehi,4 Hosein Alimadadi,5 Zahra Movahedi,6 Setareh Mamishi1,4 1Tehran ... ...

Abstract	Shima Mahmoudi,1 Mehrzad Mehdizadeh,2,3 Reza Shervin Badv,3 Amene Navaeian,4 Babak Pourakbari,1 Maryam Rostamyan,4 Meisam Sharifzadeh Ekbatani,3 Hamid Eshaghi,4 Mohammad Reza Abdolsalehi,4 Hosein Alimadadi,5 Zahra Movahedi,6 Setareh Mamishi1,4 1Tehran University of Medical Sciences, Tehran, Iran; 2School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 3Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran; 4Department of Infectious Diseases, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran; 5Tehran University of Medical Sciences, Tehran, Iran; 6Department of Pediatric Infectious Disease, Faculty of Medicine, Qom University of Medical Sciences, Qom, IranCorrespondence: Setareh Mamishi Department of Infectious DiseasesPediatrics Center of Excellence, Children’s Medical Center Hospital, Keshavarz Boulevard, Tehran, IranTel/ Fax +98- 21- 6642- 8996Email smamishi@sina.tums.ac.irBackground: Despite the worldwide spread of the coronavirus disease 2019 (COVID-19), the epidemiological and clinical patterns of the COVID-19 infection remain largely unclear, particularly among children. In this study, we explored the epidemiological characteristics, clinical patterns, and laboratory and imaging findings of pediatric patients with COVID-19.Materials and Methods: From March 7 to March 30, 2020, there were a total of 35 patients who had confirmed COVID-19 infection by laboratory virus nucleic acid test (RT-PCR) assay with throat swab samples or typical chest CT manifestation compatible with COVID-19, in addition to a history of close contact with suspected or confirmed SARSâ€CoVâ€2 in family members. Information recorded included demographic data, medical history, exposure history, underlying comorbidities, symptoms, signs, laboratory findings and radiologic assessments, severity of disease, treatment, and mortality.Results: The median age of the patients was 7.5 years (IQR=4– 11; range=4 months to 15 years). A total of 63% were male. Cough was present in 80% of the patients, followed by fever (77%), nausea or vomiting (29%), diarrhea (26%), shortness of breath (29%), headache (20%), and myalgia (14%). Lymphopenia was present in 43% of the patients, thrombocytopenia in 9%, neutopenia in 8%, and leucopenia in 26%. We reported severe pneumonia in 40% of the hospitalized patients and 18 (51%) had underlying diseases. Of 35 patients, 11 had positive RT-PCR results (31%). The chest CT images of 24 patients (69%) suggested COVID-19, while their RT-PCR assays from throat swab samples were negative.Conclusion: This study demonstrates different clinical findings of pediatrics compared to the previous reports of children. Since a high rate of false negative RT-PCR test was observed, early detection of children with COVID-19 infection by CT is conducive to reasonable management and early treatment.Keywords: COVID-19, children, severe pneumonia, Iran
Keywords	Infection and Drug Resistance ; covid19
Subject code	610
Language	English
Publishing date	2020-07-31
Publisher	Dove Press
Publishing country	us
Document type	Article ; Online
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