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  1. Article: A Case of Postoperative Biliary Leak in a Patient With Duplicated Cystic Ducts.

    Movva, Giri / Malone, Jordan C / John, Jaison S / Sweet, Patrick D

    Cureus

    2024  Volume 16, Issue 3, Page(s) e55854

    Abstract: Duplicated cystic ducts are a rare congenital malformation with less than 20 reported cases before 2019. This malformation is important to identify to reduce the risk of intraoperative complications such as bile duct injuries that can increase ... ...

    Abstract Duplicated cystic ducts are a rare congenital malformation with less than 20 reported cases before 2019. This malformation is important to identify to reduce the risk of intraoperative complications such as bile duct injuries that can increase postoperative morbidity and mortality. We present the case of a 62-year-old male with duplicated cystic ducts that were ligated during laparoscopic cholecystectomy and subsequently complicated by postoperative biloma formation. Treatment options for biliary leak include endoscopic retrograde cholangiopancreatography (ERCP) with stenting, percutaneous drainage, and duct embolization. Each carries the risk of complications such as infection, duct perforation, and stent/drain displacement. Roux-en-Y hepaticojejunostomy (RHYJ) tends to be the last resort when other minimally invasive procedures fail. It is imperative to identify postoperative complications related to cystic duct anomalies and the various treatment options available should these complications occur.
    Language English
    Publishing date 2024-03-09
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.55854
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Current Available Computer-Aided Detection Catches Cancer but Requires a Human Operator.

    Saenz Rios, Florentino / Movva, Giri / Movva, Hari / Nguyen, Quan D

    Cureus

    2020  Volume 12, Issue 12, Page(s) e12177

    Abstract: Introduction: This study intends to show that the current widely used computer-aided detection (CAD) may be helpful, but it is not an adequate replacement for the human input required to interpret mammograms accurately. However, this is not to discredit ...

    Abstract Introduction: This study intends to show that the current widely used computer-aided detection (CAD) may be helpful, but it is not an adequate replacement for the human input required to interpret mammograms accurately. However, this is not to discredit CAD's ability but to further encourage the adoption of artificial intelligence-based algorithms into the toolset of radiologists.
    Methods: This study will use Hologic (Marlborough, MA, USA) and General Electric (Boston, MA, USA) CAD read images provided by patients found to be Breast Imaging Reporting and Data System (BI-RADS) 6 from 2019 to 2020. In addition, patient information will be pulled from our institution's emergency medical record to confirm the findings seen in the pathologist report and the radiology read.
    Results: Data from a total of 24 female breast cancer patients from January 31st 2019 to April 31st 2020, was gathered from our institution's emergency medical record with restrictions in patient numbers due to coronavirus disease 2019 (COVID-19). Within our patient population, CAD imaging was shown to be statistically significant in misidentifying breast cancer, while radiologist interpretation still proves to be the most effective tool.
    Conclusion: Despite a low sample size due to COVID-19, this study found that CAD did have significant difficulty in differentiating benign vs. malignant lesions. CAD should not be ignored, but it is not specific enough. Although CAD often marks cancer, it also marks several areas that are not cancer. CAD is currently best used as an additional tool for the radiologist.
    Language English
    Publishing date 2020-12-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.12177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Comparing costs of renal preservation versus radical nephroureterectomy management among patients with non-metastatic upper tract urothelial carcinoma.

    Williams, Stephen B / Shan, Yong / Fero, Katherine E / Movva, Giri / Baillargeon, Jacques / Tyler, Douglas S / Chamie, Karim

    Urologic oncology

    2022  Volume 40, Issue 7, Page(s) 345.e1–345.e7

    Abstract: Background: To describe overall and categorical cost components in the management of patients with non-metastatic upper tract urothelial carcinoma (UTUC) according to treatment.: Methods: We identified 4,114 patients diagnosed with non-metastatic ... ...

    Abstract Background: To describe overall and categorical cost components in the management of patients with non-metastatic upper tract urothelial carcinoma (UTUC) according to treatment.
    Methods: We identified 4,114 patients diagnosed with non-metastatic UTUC from 2004 to 2013 in the Survival Epidemiology and End Results-Medicare linked database. Patients were stratified into renal preservation (RP) vs. radical nephroureterectomy (NU) groups. Total Medicare costs within 1 year of diagnosis were compared for patients managed with RP vs. NU using inverse probability of treatment-weighted propensity score models.
    Results: A total of 1,085 (26%) and 3,029 (74%) patients underwent RP and NU, respectively. Median costs were significantly lower for RP vs. NU at 90 days (median difference -$4,428, Hodges-Lehmann [H-L] 95% confidence interval [CI], -$7,236 to -$1,619) and 365 days (median difference -$7,430, H-L 95% CI, -$13,166 to -$1,695), respectively. Median costs according to categories of services were significantly less for RP vs. NU patients by hospitalization, office visits, emergency room/critical care, consultations, and anesthesia. The only category which was significantly higher for RP vs. NU was inpatient visits ($1,699 vs. $1,532; median difference $152; HL 95% CI, $19-$286).
    Conclusions: Median costs were significantly lower for RP vs. NU up to 1-year and by hospitalization, office visits, emergency room/critical care, consultations, and anesthesia costs. In appropriately selected patients, such as patients with low-risk disease, these findings suggest the utility of RP as a suitable high-value management option in UTUC.
    MeSH term(s) Aged ; Carcinoma, Transitional Cell/pathology ; Humans ; Medicare ; Nephroureterectomy ; Retrospective Studies ; Treatment Outcome ; United States ; Ureteral Neoplasms/pathology ; Urinary Bladder Neoplasms
    Language English
    Publishing date 2022-03-26
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 1336505-8
    ISSN 1873-2496 ; 1078-1439
    ISSN (online) 1873-2496
    ISSN 1078-1439
    DOI 10.1016/j.urolonc.2022.02.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Granulomatosis With Polyangiitis in a Pediatric Male.

    Saenz Rios, Florentino / Devaraj, Sandhya / Movva, Giri / Movva, Hari / Nguyen, Quan D

    Cureus

    2020  Volume 12, Issue 12, Page(s) e12055

    Abstract: Significant eosinophilia is a prominent feature in Churg-Strauss syndrome but has not been described in granulomatosis with polyangiitis (GPA) in a pediatric patient. We present a biopsy case that confirmed granulomatosis with polyangiitis with ... ...

    Abstract Significant eosinophilia is a prominent feature in Churg-Strauss syndrome but has not been described in granulomatosis with polyangiitis (GPA) in a pediatric patient. We present a biopsy case that confirmed granulomatosis with polyangiitis with significant eosinophilia > 30% on the initial presentation. Etiologies that could account for eosinophilia were excluded during workup. The patient's presentation of pulmonary alveolar hemorrhage, conjunctivitis arthritis, high-titer cytoplasmic antineutrophil, PR3-ANCA antibodies, and cytoplasmic antibodies (cANCA) was consistent with a clinical picture of atypical GPA in a pediatric patient. This case presents a rare opportunity not only due to GPA's low incidence in the pediatric population but due to the unusual nature of significant eosinophilia in GPA.
    Language English
    Publishing date 2020-12-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.12055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Treatment Patterns, Outcomes, and Costs Associated With Localized Upper Tract Urothelial Carcinoma.

    Fero, Katherine E / Shan, Yong / Lec, Patrick M / Sharma, Vidit / Srinivasan, Aditya / Movva, Giri / Baillargeon, Jacques / Chamie, Karim / Williams, Stephen B

    JNCI cancer spectrum

    2021  Volume 5, Issue 6

    Abstract: Background: Upper tract urothelial carcinoma (UTUC) is a heterogeneous disease that presents a clinical management challenge for the urologic surgeon. We assessed treatment patterns, costs, and survival outcomes among patients with nonmetastatic UTUC.!## ...

    Abstract Background: Upper tract urothelial carcinoma (UTUC) is a heterogeneous disease that presents a clinical management challenge for the urologic surgeon. We assessed treatment patterns, costs, and survival outcomes among patients with nonmetastatic UTUC.
    Methods: We identified 4114 patients diagnosed with nonmetastatic UTUC from 2004 to 2013 in the Survival Epidemiology, and End Results-Medicare population-based database. Patients were stratified into low- or high-risk disease groups. Median total costs from 30 days prior to diagnosis through 365 days after diagnosis were compared between groups. Overall and cancer-specific survival were evaluated using Cox proportional hazards regression. All statistical tests were 2-sided.
    Results: After risk stratification, 1027 (24.9%) and 3087 (75.0%) patients were classified into low- vs high-risk UTUC groups. Most patients underwent at least 1 surgical intervention (95.1%); 68.4% underwent at least 1 endoscopic intervention. Patients diagnosed with high- vs low-risk UTUC were more likely to undergo nephroureterectomy (83.6% vs 72.0%;
    Conclusions: UTUC continues to be managed primarily with nephroureterectomy, regardless of risk stratification, and patients with high-risk UTUC have worse overall and cancer-specific survival. Substantial costs are associated with management of low- and high-risk UTUC, with the latter being more costly up to 1 year from diagnosis.
    MeSH term(s) Aged ; Aged, 80 and over ; Ambulatory Surgical Procedures/economics ; Carcinoma, Transitional Cell/economics ; Carcinoma, Transitional Cell/mortality ; Carcinoma, Transitional Cell/pathology ; Carcinoma, Transitional Cell/surgery ; Costs and Cost Analysis ; Female ; Hospitalization/economics ; Humans ; Kidney Neoplasms/economics ; Kidney Neoplasms/mortality ; Kidney Neoplasms/pathology ; Kidney Neoplasms/surgery ; Male ; Medicare/economics ; Nephroureterectomy/economics ; Nephroureterectomy/methods ; Nephroureterectomy/statistics & numerical data ; Organ Sparing Treatments/economics ; Proportional Hazards Models ; Retrospective Studies ; Risk Assessment ; SEER Program ; Sex Factors ; Treatment Outcome ; United States ; Ureteral Neoplasms/economics ; Ureteral Neoplasms/mortality ; Ureteral Neoplasms/pathology ; Ureteral Neoplasms/surgery
    Language English
    Publishing date 2021-10-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2515-5091
    ISSN (online) 2515-5091
    DOI 10.1093/jncics/pkab085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Geographic distribution of racial differences in mortality in muscle-invasive bladder cancer patients: an opportunity for improvement.

    Freudenburg, Elliott / Shan, Yong / Martinez, Ariza / Srinivasan, Aditya / Movva, Giri / Yu, Alexander / AlBayyaa, Mohanad / Klaassen, Zachary / Freedland, Stephen J / Kamat, Ashish M / Williams, Stephen B

    Cancer causes & control : CCC

    2022  Volume 33, Issue 4, Page(s) 613–622

    Abstract: Objectives: To determine the geographic distribution of muscle-invasive bladder cancer mortality according to race in the United States (US). African Americans (AAs) have up to two times the risk of bladder cancer mortality compared to Caucasians. ... ...

    Abstract Objectives: To determine the geographic distribution of muscle-invasive bladder cancer mortality according to race in the United States (US). African Americans (AAs) have up to two times the risk of bladder cancer mortality compared to Caucasians. Bladder cancer mortality increases exponentially once it invades the muscle. Geographic heterogeneity in bladder cancer mortality according to race remains to be determined.
    Design: Analysis of Surveillance, Epidemiology, and End Results (SEER)-Medicare data for 6,044 patients aged 66-85 diagnosed with clinical stage T2-T4 N0M0 bladder cancer from 1 January 2002 to 31 December 2011. Fine and Gray-competing risks regression models were used to assess the association of race with bladder cancer-specific mortality (BCSM) according to tumor registry.
    Results: Out of 6,044 patients, 5,408 (89.5%) were Caucasian, 352 (5.82%) were non-Hispanic AA, 85 (1.4%) were Hispanic, and 199 (3.29%) were other. Of the 18 registries, AAs with bladder cancer were largely concentrated in Louisiana (19%), New Jersey (17.9%), and Georgia (17.6%). New Jersey was the only registry where AAs had increased risk of BCSM than Caucasians and only for stage T2 disease: (AHR, 1.74; 95% CI 1.22-2.47, p = 0.002). According to treatment, AAs in New Jersey had worse BCSM than Caucasians when they underwent radical cystectomy (AHR, 2.05; 95% CI 1.26-3.35, p = 0.0039) and radiotherapy or chemotherapy alone (AHR, 1.55; 95% CI 1.03-2.35, p = 0.0367).
    Conclusions: We observed geographic variation in bladder cancer mortality which impacted only one registry with one of the largest population of AAs. These findings support further investigation into the social determinants of race (i.e., socioeconomic status and distance to healthcare facility) and culturally centered healthcare decision making which may drive these results.
    MeSH term(s) Aged ; Aged, 80 and over ; Humans ; Medicare ; Muscles/pathology ; Race Factors ; SEER Program ; United States/epidemiology ; Urinary Bladder Neoplasms/pathology
    Language English
    Publishing date 2022-01-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1064022-8
    ISSN 1573-7225 ; 0957-5243
    ISSN (online) 1573-7225
    ISSN 0957-5243
    DOI 10.1007/s10552-022-01553-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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