Artikel ; Online: Genotypic analysis of a localised hotspot of Pestivirus A (BVDV-1) infections in Northern Ireland.
2024 , Seite(n) e4150
Abstract: Background: Bovine viral diarrhoea (BVD) is caused by Pestivirus A and Pestivirus B. Northern Ireland (NI) embarked on a compulsory BVD eradication scheme in 2016, which continues to this day, so an understanding of the composition of the pestivirus ... ...
Abstract | Background: Bovine viral diarrhoea (BVD) is caused by Pestivirus A and Pestivirus B. Northern Ireland (NI) embarked on a compulsory BVD eradication scheme in 2016, which continues to this day, so an understanding of the composition of the pestivirus genotypes in the cattle population of NI is required. Methods: This molecular epidemiology study employed 5' untranslated region (5'UTR) genetic sequencing to examine the pestivirus genotypes circulating in samples taken from a hotspot of BVD outbreaks in the Enniskillen area in 2019. Results: Bovine viral diarrhoea virus (BVDV)-1e (Pestivirus A) was detected for the first time in Northern Ireland, and at a high frequency, in an infection hotspot in Enniskillen in 2019. There was no evidence of infection with BVDV-2 (Pestivirus B), Border disease virus (pestivirus D) or HoBi-like virus/BVDV-3 (pestivirus H). Limitations: Only 5'UTR sequencing was used, so supplementary sequencing, along with phylogenetic trees that include all BVDV-1 genotype reference strains, would improve accuracy. Examination of farm locations and animal movement/trade is also required. Conclusions: Genotype BVDV-1e was found for the first time in Northern Ireland, indicating an increase in the genetic diversity of BVDV-1, which could have implications for vaccine design and highlights the need for continued pestivirus genotypic surveillance. |
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Sprache | Englisch |
Erscheinungsdatum | 2024-05-01 |
Erscheinungsland | England |
Dokumenttyp | Journal Article |
ZDB-ID | 390015-0 |
ISSN | 2042-7670 ; 0042-4900 |
ISSN (online) | 2042-7670 |
ISSN | 0042-4900 |
DOI | 10.1002/vetr.4150 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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